trans-2-en-valproate has been researched along with tetramethylammonium* in 1 studies
1 other study(ies) available for trans-2-en-valproate and tetramethylammonium
| Article | Year |
|---|---|
Diffusion analysis of valproate and trans-2-en-valproate in agar and in cerebral cortex of the rat.
The diffusion of valproate (VPA) and trans-2-en-valproate were studied in agar gel and in the cerebral cortex of the rat using pressure microejection and VPA-selective microelectrodes. From the agar measurements a free diffusion coefficient for VPA of 6.52 x 10(-6) cm2.s-1 and for trans-2-en-VPA of 5.25 x 10(-6) cm2.s-1 for 37 degrees C was determined. The tortuosity value in the cortex was 1.92 for VPA and 1.67 for trans-2-en-VPA. The tortuosity values suggest that VPA and trans-2-en-VPA diffuse mainly in the extracellular space of the brain. Topics: Agar; Animals; Cerebral Cortex; Diffusion; Extracellular Space; Fatty Acids, Monounsaturated; Male; Microelectrodes; Microinjections; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Valproic Acid | 1993 |