trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride has been researched along with 7-dehydrocholesterol in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biade, S; Citadelle, D; Dupuis, R; Maziere, JC; Meier, M; Quiec, D; Repetto, M; Roux, C | 1 |
| Heuman, DM; Hylemon, PB; Pandak, WM; Vlahcevic, ZR | 1 |
| Elias, PM; Nemanic, MK; Whitney, J | 1 |
| Barbu, V; Maindrault, F; Mazière, C; Mazière, JC; Polonovski, J; Rampini, C; Roux, C | 1 |
| Barbu, V; Dupuis, R; Elefant, E; Gardette, J; Lambert, D; Maziere, C; Maziere, JC; Polonovski, J; Roux, C | 1 |
| Cenedella, RJ; Sarkar, CP | 1 |
| Chevy, F; Citadelle, D; Kolf-Clauw, M; Mulliez, N; Pham, J; Roux, C; Wolf, C | 1 |
| Chambers, CM; McLean, MP; Ness, GC | 1 |
| Chevy, F; Gaoua, W; Roux, C; Wolf, C | 1 |
| Fliesler, SJ; Miller, C; Peachey, NS; Richards, MJ | 1 |
| Chevy, F; Gaoua, W; Ilien, F; Roux, C; Wolf, C | 1 |
| Chevy, F; Citadelle, D; Cormier, V; Gaoua, W; Mulliez, N; Roux, C; Wolf, C | 1 |
| Bourguignon, L; Gaoua, W; Gofflot, F; Picard, JJ; Roux, C | 1 |
| Cortez, MA; Cunnane, SC; Snead, OC | 1 |
| Fliesler, SJ; Keller, RK; Small, M | 1 |
| Fliesler, SJ; Nagel, BA; Peachey, NS; Richards, MJ; Vaughan, DK | 1 |
| Cortez, MA; Cunnane, SC; Ryan, MA; Serbanescu, I; Shukla, R; Snead, OC | 1 |
| Chattopadhyay, A; Murty, MR; Paila, YD; Vairamani, M | 1 |
| Bergström, A; Kooshesh, M; Lauth, M; Rohnalter, V; Svenningsson, P; Toftgård, R | 1 |
| Fliesler, SJ; Liu, W; Porter, NA; Sheflin, LG; Xu, L | 1 |
| Fliesler, SJ; Porter, NA; Sheflin, LG; Xu, L | 1 |
| Fliesler, SJ; Goulah, CC; Keller, RK; Mitchell, DA | 1 |
| Fliesler, SJ; Keiko, U; Más Gómez, N; Mitchell, CH; Pfeffer, BA; Ramachandra Rao, S; Rowsam, AM; Skelton, LA; Sparrow, JR | 1 |
| Fliesler, SJ; Xu, L | 1 |
2 review(s) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and 7-dehydrocholesterol
| Article | Year |
|---|---|
Role of cholesterol in embryonic development.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Embryonic and Fetal Development; Fetus; Piperazines; Rats; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol | 2000 |
Oxysterols and Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome: Implications for an Improved Therapeutic Intervention.
Topics: Animals; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Lipid Metabolism; Oxysterols; Rats; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2018 |
22 other study(ies) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and 7-dehydrocholesterol
| Article | Year |
|---|---|
Teratogenic effect of the cholesterol synthesis inhibitor AY 9944 on rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Dehydrocholesterols; Embryonic and Fetal Development; Fetal Death; Holoprosencephaly; Morphogenesis; Organ Culture Techniques; Pituitary Gland; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |
Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis.
Topics: Acyl Coenzyme A; Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Dehydrocholesterols; Down-Regulation; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |
In vitro synthesis of vitamin D-3 by cultured human keratinocytes and fibroblasts: action spectrum and effect of AY-9944.
Topics: Aldehyde Oxidoreductases; Cells, Cultured; Cholecalciferol; Cholesterol; Cyclohexanes; Dehydrocholesterols; Ergosterol; Fibroblasts; Glycolaldehyde Dehydrogenase; Humans; Microscopy, Electron; Skin; Spectrum Analysis; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1985 |
Effect of AY 9944 and chlorpromazine on Concanavalin A-induced stimulation of human lymphocytes.
Topics: Autoradiography; Cells, Cultured; Chlorpromazine; Cholesterol; Chromatography, Thin Layer; Concanavalin A; Cyclohexanes; Dehydrocholesterols; DNA Replication; Humans; Lymphocyte Activation; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1987 |
Cholesterol prevents the teratogenic action of AY 9944: importance of the timing of cholesterol supplementation to rats.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Cyclohexanes; Dehydrocholesterols; Dose-Response Relationship, Drug; Female; Fetal Death; Pituitary Gland; Pregnancy; Rats; Rats, Inbred Strains; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1988 |
Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol.
Topics: Animals; Brain; Brain Chemistry; Cholesterol; Colorimetry; Dehydrocholesterols; Desmosterol; False Positive Reactions; Female; Lanosterol; Pregnancy; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1982 |
Changes in serum sterols of rats treated with 7-dehydrocholesterol-delta 7-reductase inhibitors: comparison to levels in humans with Smith-Lemli-Opitz syndrome.
Topics: Animals; Child; Cholestadienols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Female; Heterozygote; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1996 |
Smith-Lemli-Opitz syndrome produced in rats with AY 9944 treated by intravenous injection of lipoprotein cholesterol.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Combined Modality Therapy; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Injections, Intravenous; Lipoproteins; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1997 |
Oxidized derivatives of 7-dehydrocholesterol induce growth retardation in cultured rat embryos: a model for antenatal growth retardation in the Smith-Lemli-Opitz syndrome.
Topics: Animals; Antioxidants; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Embryo, Mammalian; Embryonic and Fetal Development; Female; Growth; Organ Culture Techniques; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Ultraviolet Rays; Vitamin E | 1999 |
Marked alteration of sterol metabolism and composition without compromising retinal development or function.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Electroretinography; Female; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1999 |
Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cholesterol, Dietary; Dehydrocholesterols; Disease Models, Animal; Embryo, Mammalian; Female; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Steroid Isomerases; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2000 |
Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Congenital Abnormalities; Dehydrocholesterols; Embryonic and Fetal Development; Embryonic Induction; Female; Gene Expression Regulation, Developmental; Hedgehog Proteins; Holoprosencephaly; Humans; In Situ Hybridization; Pregnancy; Proteins; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators | 2001 |
Brain sterols in the AY-9944 rat model of atypical absence seizures.
Topics: Animals; Anticholesteremic Agents; Brain Chemistry; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; Male; Phospholipids; Pregnancy; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2002 |
Enzyme blockade: a nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain.
Topics: Animals; Anticholesteremic Agents; Brain; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Enzyme Inhibitors; Kinetics; Male; Methods; Mice; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Retinal degeneration in a rodent model of Smith-Lemli-Opitz syndrome: electrophysiologic, biochemical, and morphologic features.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dark Adaptation; Dehydrocholesterols; Disease Models, Animal; Electrophysiology; Electroretinography; Female; Pigment Epithelium of Eye; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols.
Topics: Animals; Body Weight; Brain; Cholesterol; Dehydrocholesterols; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Epilepsy, Absence; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Models, Biological; Rats; Rats, Long-Evans; Sterols; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Signaling by the human serotonin(1A) receptor is impaired in cellular model of Smith-Lemli-Opitz Syndrome.
Topics: Animals; Anticholesteremic Agents; CHO Cells; Cricetinae; Cricetulus; Dehydrocholesterols; GTP-Binding Proteins; Humans; Ligands; Models, Biological; Protein Binding; Receptor, Serotonin, 5-HT1A; Signal Transduction; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2008 |
Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels.
Topics: Animals; Antipsychotic Agents; Dehydrocholesterols; Male; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Transcription Factors; Transcription, Genetic; Up-Regulation; Zinc Finger Protein GLI1 | 2010 |
Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.
Topics: Animals; Anticholesteremic Agents; Cholestenones; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Disease Models, Animal; Hydroxycholesterols; Ketocholesterols; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome; Spectrophotometry, Ultraviolet; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2011 |
7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Animals; Animals, Newborn; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Disease Models, Animal; Female; Humans; Ketocholesterols; Male; Mass Spectrometry; Molecular Structure; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2012 |
Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Dolichols; Humans; Liver; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome; Terpenes; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Ubiquinone | 2013 |
Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome.
Topics: Animals; Biomarkers; Cathepsin D; Cattle; Cell Culture Techniques; Dehydrocholesterols; Disease Models, Animal; Humans; Lysosomes; Membrane Fusion; Phagocytosis; Phagosomes; Protein Biosynthesis; Rats; Retinal Pigment Epithelium; Retinoids; Rod Cell Outer Segment; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Transcription, Genetic; Ubiquitinated Proteins | 2018 |