Compounds > trans-1,2-dihydro-1,2-naphthalenediol
Page last updated: 2024-09-02

trans-1,2-dihydro-1,2-naphthalenediol and pci 32765

trans-1,2-dihydro-1,2-naphthalenediol has been researched along with pci 32765 in 5 studies

Compound Research Comparison

Studies
(trans-1,2-dihydro-1,2-naphthalenediol)		Trials
(trans-1,2-dihydro-1,2-naphthalenediol)		Recent Studies (post-2010)
(trans-1,2-dihydro-1,2-naphthalenediol)		Studies
(pci 32765)		Trials
(pci 32765)		Recent Studies (post-2010) (pci 32765)
290151,9262431,895

Protein Interaction Comparison

ProteinTaxonomytrans-1,2-dihydro-1,2-naphthalenediol (IC50)pci 32765 (IC50)
Testosterone 17-beta-dehydrogenase 3Rattus norvegicus (Norway rat)0.0028
Solute carrier family 22 member 3Homo sapiens (human)7.9
Epidermal growth factor receptorHomo sapiens (human)0.0402
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)0.0104
Cytochrome P450 1A2Homo sapiens (human)0.019
Tyrosine-protein kinase LckHomo sapiens (human)0.018
Tyrosine-protein kinase FynHomo sapiens (human)0.096
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)5.545
Tyrosine-protein kinase YesHomo sapiens (human)0.0065
Tyrosine-protein kinase LynHomo sapiens (human)0.2
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.0262
Tyrosine-protein kinase HCKHomo sapiens (human)0.0095
Cytochrome P450 3A4Homo sapiens (human)0.089
Tyrosine-protein kinase FgrHomo sapiens (human)0.0021
Cytochrome P450 2C8Homo sapiens (human)3.9595
Cytochrome P450 2D6Homo sapiens (human)0.0769
Cytochrome P450 2C9 Homo sapiens (human)6.0643
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0768
Cytochrome P450 2B6Homo sapiens (human)0.101
Cytochrome P450 2C19Homo sapiens (human)0.0769
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.073
Tyrosine-protein kinase CSKHomo sapiens (human)0.0023
Tyrosine-protein kinase TecHomo sapiens (human)0.0092
Tyrosine-protein kinase TXKHomo sapiens (human)0.0025
Tyrosine-protein kinase FRKHomo sapiens (human)0.0541
Tyrosine-protein kinase BlkHomo sapiens (human)0.0004
Cytoplasmic tyrosine-protein kinase BMXHomo sapiens (human)0.002
Tyrosine-protein kinase JAK3Homo sapiens (human)0.0411
Tyrosine-protein kinase BTKHomo sapiens (human)0.0422
Tyrosine-protein kinase ITK/TSKHomo sapiens (human)0.0471
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)4.4
Protein-tyrosine kinase 6Homo sapiens (human)0.018
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)0.0066
Nuclear receptor subfamily 4 group A member 3Homo sapiens (human)0.078
Peroxiredoxin-like 2AHomo sapiens (human)0.9
Platelet glycoprotein VIHomo sapiens (human)0.12

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's3 (60.00)2.80

Authors

AuthorsStudies
Beijnen, JH; Rood, JJM; Schellens, JHM; Schinkel, AH; Sparidans, RW; van Hoppe, S1
Beijnen, JH; Dormans, PJA; Rood, JJM; Schellens, JHM; Sparidans, RW; van Haren, MJ1
Allal, B; Chatelut, E; De Barros, S; Despas, F; Dupré, L; Gallais, F; Obéric, L; Protin, C; Quillet-Mary, A; Thomas, F; White-Koning, M; Ysebaert, L1
Balogh, A; Bödör, C; Karvaly, GB; Köllő, Z; Vásárhelyi, B; Vincze, I1
Chen, XL; Guo, YJ; Ma, H; Qian, ZY; Shen, H; Sun, LN; Wang, YQ; Zhao, Y1

Other Studies

5 other study(ies) available for trans-1,2-dihydro-1,2-naphthalenediol and pci 32765

ArticleYear
Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.
    Journal of pharmaceutical and biomedical analysis, 2016, Jan-25, Volume: 118

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Chromatography, Liquid; Humans; Mice; Naphthalenes; Pilot Projects; Piperidines; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Tandem Mass Spectrometry

2016
Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Jul-15, Volume: 1090

    Topics: Adenine; Aged; Chromatography, Liquid; Drug Stability; Glutathione; Humans; Linear Models; Male; Naphthalenes; Piperidines; Pyrazoles; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2018
Population Pharmacokinetics of Ibrutinib and Its Dihydrodiol Metabolite in Patients with Lymphoid Malignancies.
    Clinical pharmacokinetics, 2020, Volume: 59, Issue:9

    Topics: Adenine; Adult; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Naphthalenes; Piperidines

2020
A High-Throughput Clinical Laboratory Methodology for the Therapeutic Monitoring of Ibrutinib and Dihydrodiol Ibrutinib.
    Molecules (Basel, Switzerland), 2022, Jul-25, Volume: 27, Issue:15

    Topics: Adenine; Humans; Laboratories, Clinical; Leukemia, Lymphocytic, Chronic, B-Cell; Naphthalenes; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines

2022
Simultaneous Determination of Orelabrutinib, Zanubrutinib, Ibrutinib and Its Active Metabolite in Human Plasma Using LC-MS/MS.
    Molecules (Basel, Switzerland), 2023, Jan-26, Volume: 28, Issue:3

    Topics: Acetonitriles; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Protein Kinase Inhibitors; Reproducibility of Results; Tandem Mass Spectrometry

2023