tranexamic acid has been researched along with aminocaproic acid in 224 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (17.41) | 18.7374 |
| 1990's | 46 (20.54) | 18.2507 |
| 2000's | 37 (16.52) | 29.6817 |
| 2010's | 73 (32.59) | 24.3611 |
| 2020's | 29 (12.95) | 2.80 |
| Authors | Studies |
|---|---|
| Castellino, FJ; Mathews, II; Tulinsky, A; Vanderhoff-Hanaver, P | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Boström, J; Cheng, L; Evertsson, E; Fex, T; Gustafsson, D; Hilgendorf, C; Jonforsen, M; Karle, M; Larsson, LO; Lindberg, W; Ohlsson, B; Pahlén, S; Pettersen, D; Plowright, AT; Schell, P; Thelin, A; Wahlund, G; Xue, Y | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Pilgram, O; Steinmetzer, T; Wenzel, BM; Wiedemeyer, SJA | 1 |
| Christensen, U | 1 |
| Cederholm-Williams, SA; Swain, A | 1 |
| Chandra, B | 1 |
| Billene, RN; Grinberg, AJ; López González, G; Ortíz Medina, AH; Parra, C | 1 |
| Matsuda, H; Ohashi, H; Takada, A; Takada, Y | 1 |
| Nakahara, M | 1 |
| Try, K | 1 |
| Schisano, G | 1 |
| Christensen, U; Mølgaard, L | 1 |
| Castellino, FJ; De Serrano, VS | 2 |
| Desroches, J; Hardy, JF | 1 |
| Anonick, PK; Gonias, SL; Vasudevan, J | 1 |
| Ambrus, CM; Ambrus, JL; Forgach, P; Halpern, J; Niswander, P; Sayyid, S; Stadler, S; Toumbis, C | 1 |
| Glasheen, WP; Gonias, SL; Hwang, LJ; Jane, JA; Matthew, TL; Pipan, CM; Spotnitz, WD | 1 |
| Carson, S; Glynn, MF; Ivanov, J; Sun, Z; Teasdale, SJ; Weisel, RD; Yau, TM; Yu, R | 1 |
| Gaffney, PJ; Longstaff, C | 1 |
| Hoffmann, JJ; Vijgen, M | 1 |
| Barthwal, M; Srivastava, K | 1 |
| Viets, JL; Yawn, DH | 1 |
| Bowden, JF; Bruchovsky, N; Cheng, H; Rennie, PS | 1 |
| Inada, M; Kita, T; Kusaka, S; Matsuo, K; Miyake, T; Murakami, M; Saita, H; Teramura, S; Yoo, JK | 1 |
| Verstraete, M | 1 |
| Atkinson, AJ; Cerullo, L; Cohen, I; Green, D; Ruo, TI; Ts'ao, CH | 1 |
| Björlin, G; Nilsson, IM | 1 |
| Vermylen, J; Vinckier, F | 1 |
| Pilgrim, H | 1 |
| Brown, DN; Moses, RA | 1 |
| Bottari, M; Donati, L; Gagnatelli, G | 1 |
| Basomba, A; Campos, A; García Villalmanzo, I; Guerrero, M; Peláez, A; Prieto, L | 1 |
| Bloom, BR; Brosnan, CF; Cammer, W; Norton, WT | 1 |
| Prentice, CR | 1 |
| Bergenholtz, A; Bye, FL; Caffesse, RG; Kowalski, CJ; Nasjleti, CE | 1 |
| Forbes, S; Greenburg, AG; Velky, TS; Yang, JC | 1 |
| Goulle, JP; Lacroix, C; Laine, G; Levert, P | 1 |
| Sugawara, Y; Takada, A; Takada, Y | 2 |
| Amaducci, LA; Smith, ME | 1 |
| Hagihara, Y; Makino, H; Nakamura, T; Yamaura, A | 1 |
| Pignanelli, M; Rota, LL; Santoro, F | 1 |
| Lundén, R; Wallén, P; Westlund, LE | 1 |
| Klöcking, HP; Markwardt, F; Richter, M | 1 |
| Nilsson, IM | 1 |
| Rizza, CR | 1 |
| Ramirez-Lassepas, M | 1 |
| Chowdhary, UM; Sayed, K | 1 |
| Fodstad, H | 1 |
| Smart, CJ | 1 |
| Hayashi, M; Isaji, M; Nakagawa, H; Tsurufuji, S | 1 |
| Alvarez Garijo, JA; Aznar, JA; Vilches, JJ | 1 |
| Christakis, GT; Fremes, SE; Goldman, BS; Lee, E; Mai, R; McLean, RF; Naylor, CD; Wong, BI | 1 |
| Bélisle, S; Hardy, JF | 2 |
| Longstaff, C | 1 |
| Royston, D | 3 |
| Caprara, E; Chiariello, L; Colantuono, G; De Paulis, R; Penta de Peppo, A; Pierri, MD; Scafuri, A; Tomai, F | 1 |
| Ali, IM; Landymore, RW | 1 |
| Alving, BM; Krishnamurti, C; Vukelja, SJ | 1 |
| Carroll, JA; Glynn, MF; Karski, JM; Norman, PH; Teasdale, SJ; Weisel, RD | 1 |
| Brown, AJ; Marshall, JM; Ponting, CP | 1 |
| Castellino, FJ; Hoover, GJ; Martin, A; Menhart, N; Warder, S | 1 |
| Fless, GM; Hoover-Plow, JL; Miles, LA; Plow, EF; Scanu, AM | 1 |
| Kang, Y | 1 |
| Harmon, DE | 1 |
| Matsuo, O; Okada, K; Ueshima, S | 1 |
| Cogliati, A; Criniti, A; Di Giovanni, C; Menichetti, A; Pacilli, M; Ruvolo, G; Speziale, G; Tritapepe, L | 1 |
| Simmet, T; Syrovets, T; Tippler, B; Weide, I | 1 |
| Carter, C; Landymore, RW; Lummis, H; Murphy, JT | 1 |
| Araki, H; Ishihara, N | 1 |
| Cogswell, M; Hurst, G; Kaspar, M; Nguyen, AT; Ramsay, KJ; Ramsay, MA | 1 |
| Nina, P; Schisano, G | 1 |
| Fless, GM; Furbee, J; Meredith, SC; Santiago, JY | 1 |
| Fergusson, D; Laupacis, A | 1 |
| Hijikata-Okunomiya, A; Okada, Y; Okamoto, S; Okamoto, U; Wanaka, K | 1 |
| Bélisle, S; Dupont, C; Gagnon, L; Hardy, JF; Harel, F; Robitaille, D; Roy, M | 1 |
| Crouch, ER; Williams, PB | 1 |
| Deeb, GM; Eaton, MP | 1 |
| Levy, JH | 3 |
| Acosta, F; Dalmau, A; Figueras, J; Garcia-Huete, L; Jaurrieta, E; Koo, M; Rafecas, A; Reche, M; Sabaté, A | 1 |
| Alfieri, O; Calori, G; Casati, V; Cossolini, M; Guzzon, D; Oppizzi, M; Torri, G | 1 |
| Acosta, F; Dalmau, A; Figueras, J; Garcia-Huete, L; Jaurrieta, E; Koo, M; Parrilla, P; Rafecas, A; Sabaté, A; Sansano, T | 1 |
| Gruber, EM; Hansen, DD; Hickey, PR; Reid, RW; Shukla, AC | 1 |
| Cattaneo, M; Mannucci, PM | 1 |
| Caccia, G; Chiaranda, M; Covaia, G; Crosta, A; Foresti, B; Luraschi, M; Maineri, P; Realini, M; Ucussich, E | 1 |
| Gaffney, PJ; Ries, M; Zenker, M | 1 |
| Carless, PA; Fergusson, D; Henderson, KM; Henry, DA; Laupacis, A; McClelland, B; Moxey, AJ; O'Connell, D; Sly, K | 1 |
| Hoover-Plow, J; Yuen, L | 1 |
| Gaubatz, JW; Ghazzaly, KG; Guevara, J; Hoffman, AS; Hoogeveen, RC; Koschinsky, ML; Morrisett, JD; Pownall, HJ | 1 |
| Farkas, H; Füst, G; Harmat, G; Varga, L; Visy, B | 1 |
| OKAMOTO, U; TAKATA, A; TAKATA, Y | 1 |
| Ritchie, BC | 1 |
| Tobias, JD | 1 |
| Bisoi, A; Chauhan, S; Das, SN; Kale, S; Kiran, U | 1 |
| Arora, RC; Buth, KJ; Hirsch, GM; Légaré, JF; Sullivan, JA | 1 |
| Steadman, RH; Xia, VW | 1 |
| Carless, PA; Henry, DA; Moxey, AJ; Stokes, BJ | 1 |
| Bodian, C; Reich, DL; Shore-Lesserson, L; Silvay, G; Vela-Cantos, F | 1 |
| Camarasa, MA; Martín, A; Ollé, G; Opisso, L; Pérez, A; Ricós, P; Sánchez, M; Serra-Prat, M | 1 |
| Ferri, JR; Gonzálvez, A; Martínez Rodríguez, E; Mato, M; Otero, J; Torres, LM | 1 |
| Aypar, U; Canbay, O; Celebi, N; Celebioglu, B; Karagoz, AH; Selcuk, M | 1 |
| Cortez, DS; Dick, EJ; Pusateri, AE; Ryan, KL | 1 |
| Groenland, TH; Porte, RJ | 1 |
| Alberca, I; Asuero, MS; Bóveda, JL; Carpio, N; Contreras, E; Fernández-Mondéjar, E; Forteza, A; García de Lorenzo, A; García-Erce, JA; Gomar, C; Gómez, A; Llau, JV; López-Fernández, MF; Moral, V; Muñoz, M; Páramo, JA; Quintana, M; Sánchez, C; Torrabadella, P | 1 |
| Auboyer, C; Decousus, H; Laporte, S; Merquiol, F; Mismetti, P; Molliex, S; Samama, CM; Zufferey, P | 1 |
| Body, SC; Mazer, CD | 1 |
| Groen, H; Molenaar, IQ; Porte, RJ; Slooff, MJ; Tenvergert, EM; Warnaar, N | 1 |
| Gunaydin, B; Ozkose, Z; Pezek, S | 1 |
| Daudén, E; García-Diez, A; Pedraz, J | 1 |
| Carless, PA; Fergusson, D; Henry, DA; Laupacis, A; McClelland, B; Moxey, AJ; O'Connell, D; Stokes, BJ | 1 |
| Stief, TW | 1 |
| Camarasa Godoy, MA; Palomera Fanegas, E; Serra-Prat, M | 1 |
| McMurdy, N; Trudell, J | 1 |
| McGarry, G; Melia, L | 1 |
| Chin, Y; Feng, D; Gill, JB; Levin, A | 1 |
| Carless, P; Fergusson, D; Henry, D; Laupacis, A | 1 |
| Bolliger, D; Ide, M; Taketomi, T; Tanaka, KA | 1 |
| Hunsaker, RB; Van Sickels, JE; Van Sickels, NJ | 1 |
| Eubanks, JD | 1 |
| Errico, TJ; Lonner, BS; Vaz, KM; Verma, K | 1 |
| Connelly, NR; Kanter, GJ; Raghunathan, K | 1 |
| Koster, A; Schirmer, U | 1 |
| Kouides, P; Mikhail, S | 1 |
| Breuer, T; Gertler, R; Hapfelmeier, A; Hess, J; Lange, R; Martin, K; Schreiber, C; Wiesner, G | 1 |
| Ali, A; Hoque, R; Rahman, M; Rahman, MS; Rahman, Z | 1 |
| Carless, PA; Fergusson, DA; Henry, DA; Ker, K; Moxey, AJ; O'Connell, D; Stokes, BJ | 2 |
| Beattie, WS; Karkouti, K | 1 |
| Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G | 1 |
| Beyersdorf, F; Keyl, C; Lehane, C; Stampf, S; Trenk, D; Uhl, R; Wiesenack, C | 1 |
| Berberich, N; Krombach, F; Lerchenberger, M; Rehberg, M; Reichel, CA; Uhl, B; Wymann, MP; Zahler, S | 1 |
| Gertler, R; Hörer, J; MacGuill, M; Martin, K; Schreiber, C; Sterner, A; Tassani, P; Vogt, M; Wiesner, G | 1 |
| Faraoni, D | 1 |
| Bronster, DJ; Chikwe, J; Goldstone, AB | 1 |
| Levy, JH; Sniecinski, RM | 1 |
| Bruzgo, I; Drozdowska, D; Kaczyńska, J; Markowska, A; Midura-Nowaczek, K | 1 |
| Abel, MF; Bastrom, T; Dabney, KW; Dhawale, AA; Gabos, PG; Miller, F; Neiss, G; Newton, PO; Shah, SA; Shufflebarger, H; Sponseller, PD; Yaszay, B; Yorgova, P | 1 |
| Al-Shahi Salman, R; Ross, J | 1 |
| Basta, MN; Stricker, PA; Taylor, JA | 1 |
| Fergusson, D; Hutton, B; Joseph, L; Mazer, CD; Shapiro, S; Tinmouth, A | 1 |
| Lecker, I; Mazer, CD; Orser, BA; Peterson, M; Romaschin, AD; Wang, DS | 1 |
| Cotton, BA; Holcomb, JB; Kostousov, V; Matijevic, N; Wade, CE; Wang, YW | 1 |
| Coats, T; Ker, K; Roberts, I; Shakur, H | 1 |
| Herrmann, E; Meybohm, P; Nierhoff, J; Zacharowski, K | 1 |
| Besser, MW; Klein, AA; Ortmann, E | 1 |
| Brunskill, SJ; Doree, C; Estcourt, LJ; Murphy, MF; Stanworth, S; Trivella, M; Wardrop, D | 1 |
| Hertfelder, HJ; Schindler, E | 1 |
| Algra, A; Baharoglu, MI; Germans, MR; Rinkel, GJ; Roos, YB; van Gijn, J; Vermeulen, M | 1 |
| Das, S; Kiran, U; Kumar Choudhary, S; Lakshmy, R; Makhija, N; Sarupria, A | 1 |
| Ishibashi, N; Jonas, RA; Korotcova, L; Lu, Z; Murata, A | 1 |
| Boenigk, K; Diefenbach, C; Dryer, J; Errico, T; Hoelscher, C; Huncke, T; Lonner, BS; Peters, A; Verma, K | 1 |
| Eastin, TR; Seupaul, RA; Snipes, CD | 1 |
| Beck, A; Breau, RH; Buenaventura, C; Cagiannos, I; Cowan, J; Fergusson, DA; Knoll, G; Kokolo, MB; Momoli, F; Morash, C; Niznick, N; Punjani, N; Ruzicka, M; Schachkina, S; Tinmouth, A; Xie, HY | 1 |
| Coelho, PG; Cuellar, JM; Errico, TJ; Jimbo, R; Kirsch, T; Quirno, M; Tovar, N; Vandeweghe, S; Yoo, A | 1 |
| Blackstock, KJ; Brainard, BM; Epstein, K; Fletcher, DJ | 1 |
| Falana, O; Patel, G | 1 |
| Cheriyan, T; Errico, T; Hoelscher, C; Huncke, T; Lafage, V; Lonner, B; Peters, A; Schwab, F; Slobodyanyuk, K; Verma, K | 1 |
| Coppola, A; Di Minno, MN; Tufano, A; Windyga, J; Yeung, C | 1 |
| Coats, TJ; Ker, K; Roberts, I; Shakur, H | 1 |
| Golembiewski, J | 1 |
| Harvey, R; Salehi, A | 1 |
| Faraday, N; Pustavoitau, A | 1 |
| Biswas, BK; Choudhuri, P | 1 |
| Engelen, ET; Mauser-Bunschoten, EP; Schutgens, RE; van Es, RJ; van Galen, KP | 1 |
| Brunskill, SJ; Desborough, M; Doree, C; Estcourt, LJ; Hopewell, S; Murphy, MF; Stanworth, SJ | 1 |
| Anderson, MJ; Carleton, MC; Churchill, JL; Meyer, ES; Puca, KE; Truchan, SL | 1 |
| Ames, CP; Bess, S; Burton, DC; Deviren, V; Errico, TJ; Gupta, MC; Hostin, R; Lafage, V; Mundis, GM; Oren, JH; Schwab, FJ; Shaffrey, CI; Smith, JS; Soroceanu, A | 1 |
| Blaine, KP; Hill, C; Lau, K; Press, C; Rao, VK; Sliwa, J | 1 |
| Cladis, FP; Fernandez, AM; Glover, CD; Goobie, SM; Huang, H; Reddy, SK; Stricker, PA; Zurakowski, D | 1 |
| Ahmadzia, HK; Grotegut, CA; Hoffman, MR; James, AH; Lockhart, EL; Murtha, AP; Swamy, GK; Thomas, SM; Welsby, IJ | 1 |
| Beacher, N; Watterson, C | 1 |
| Breau, RH; Cagiannos, I; Cnossen, S; Fergusson, DA; Fergusson, NA; Hutton, B; Lavallée, LT; Montroy, J; Morash, C | 1 |
| Dhakal, IB; Green, CL; Hobbs, JC; Wellman, SS; Welsby, IJ | 1 |
| Boese, CK; Centeno, L; Walters, RW | 1 |
| Moschetti, WE; Ramkumar, DB; Ramkumar, N; Tapp, SJ | 1 |
| Geng, P; Liu, Q; Shi, L; Wang, P; Wang, Q | 1 |
| Brown, S; Taub, PJ; Yao, A | 1 |
| Ford, PM; Nielsen, VG | 1 |
| Cybulski, KA; Faraoni, D; Rahe, C | 1 |
| Gharaibeh, A; Goldberg, MF; Lindsley, K; Savage, HI; Scherer, RW | 1 |
| Al-Samkari, H; Cardoni, L; Connors, JM; McMahon, L; Perkins, R; Pighetti, EH; Rits, S; Shin, K; Uluer, A | 1 |
| Azizi, A; Cheah, MA; Redett, RJ; Rosson, GD; Seal, SM; Siotos, C; Siotou, K | 1 |
| Chen, ZQ; Mai, S; Song, P; Tao, LY; Yuan, L; Zeng, Y; Zhang, XL | 1 |
| Aqil, A; Asmar, S; Brew, C; Grogan, R; Hahnel, J; Radcliffe, G; Riaz, O; Vanker, R | 1 |
| Attarian, DE; Bolognesi, MP; Bradley, KE; Grant, SA; Green, CL; Penrose, CT; Risoli, T; Ryan, SP; Wellman, SS | 1 |
| Acosta-Olivo, C; Cerda-Barbosa, JK; Espinoza-Galindo, AM; Garay-Mendoza, D; Garza-Ocañas, L; Marfil-Rivera, LJ; Morales-Avalos, R; Peña-Martínez, VM; Ramos-Morales, T; Valdés-González, NL; Vílchez-Cavazos, F | 1 |
| Asghar, J; Lonner, BS; Newton, PO; Ren, Y; Samdani, AF; Shah, SA | 1 |
| Oromendia, C; Rajwani, K; Ramos, LG; Sanso, LM; Simon, RP | 1 |
| Gochuico, BR; Huizing, M; Introne, WJ; Merideth, MA; O'Brien, KJ; Wang, JA | 1 |
| Breau, RH; Cagiannos, I; Fergusson, DA; Flaman, A; Hutton, B; Lavallée, LT; Montroy, J; Morash, C; Tinmouth, A | 1 |
| Acosta-Olivo, C; Espinoza-Galindo, AM; García-Pedro, JA; Morales-Avalos, R; Morcos-Sandino, M; Peña-Martínez, VM; Ramos-Morales, T; Rodríguez-Torres, RA; Silva-Ramos, HNG; Vilchez-Cavazos, F | 1 |
| Bonfield, CM; Borst, AJ; Deenadayalan, PS; Le, CH; Reddy, SK; Sobey, JH; Xu, M | 1 |
| Fenger-Eriksen, C; Hansen, AK; Hovgesen, NT; Hvas, AM; Larsen, JB | 1 |
| Hunt, BJ; Murdoch, IA; Sangaran, DP; Siemens, K; Tibby, SM | 1 |
| Ahlers, CG; Borst, AJ; Lan, M; Schoenecker, JG | 1 |
| Gaines, BA; Josephson, CD; Leeper, CM; Leonard, JC; Luther, JF; Spinella, PC; Wisniewski, SR | 1 |
| Li, W; Li, Z; Sun, X; Zhang, M | 1 |
| Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Singer, KE; Wallen, TE | 1 |
| Yang, ZQ; Zhang, J | 1 |
| Cook, BM; Dannemiller, RE; Goodberlet, MZ; Kelly, JM; Knowles, DM; Malloy, R | 1 |
| Benzon, HA; Goobie, SM; King, MR; Nelson, O; Pérez-Pradilla, C; Staffa, SJ; Stricker, PA | 1 |
| Demetres, M; Faraoni, D; Karam, O; Mayadunna, S; Nellis, ME; Schertz, K | 1 |
| Cheng, LL; Fu, WM; Gu, G; Jiang, NN; Tian, SM; Wang, BJ; Xie, H; Yang, YS; Zhao, DW | 1 |
| Balcells, M; Biarnés, X; Bosch-Sanz, O; Caveda, L; Martorell, J; Pedreño, J; Rabadà, Y; Sánchez-García, D | 1 |
| Liu, Y; Ma, J; Shen, B; Wu, L; Wu, Y; Xu, J; Zheng, C | 1 |
| Li, M; Liu, Y; Ma, J; Shen, B; Si, H; Xu, J; Zheng, C | 1 |
| Chen, T; Chen, Z; Pan, S; Tan, H; Wei, C | 1 |
| Li, M; Liu, Y; Ma, J; Shen, B; Wu, L; Wu, Y; Xu, J; Zheng, C | 1 |
| Gharaibeh, A; Goldberg, MF; Lindsley, KB; Ng, SM; Scherer, RW; Woreta, FA | 1 |
| Josephson, CD; Kolodziej, JH; Leeper, CM; Leonard, JC; Spinella, PC; Zenati, MS | 1 |
| Abbasi, RK; Mastropietro, CM; Tanis-Arens, CE; Walker, SG | 1 |
| Haibier, A; Qin, Q; Ran, J; Ren, Z; Yusufu, A; Zhang, Z; Zhou, Y | 1 |
| Barfield, D; Cutler, S; Manson, KC; Stanzani, G; Thomas, EK; Wahldén, L; Wilson, HE | 1 |
| Guo, Y; Li, J; Li, M | 1 |
79 review(s) available for tranexamic acid and aminocaproic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Natural and synthetic antifibrinolytics in cardiac surgery.
Topics: Aminocaproic Acid; Aprotinin; Cardiac Surgical Procedures; Hemostasis; Humans; Tranexamic Acid | 1992 |
Transfusion and coagulation: an overview and recent advances in practice modalities. Part II: Pharmacologic adjuncts, cell salvage mechanisms, alternatives in blood donation.
Topics: Adjuvants, Pharmaceutic; Aminocaproic Acid; Blood Component Removal; Blood Transfusion; Deamino Arginine Vasopressin; Humans; Tranexamic Acid | 1990 |
Clinical application of inhibitors of fibrinolysis.
Topics: 4-Aminobenzoic Acid; Aminocaproic Acid; Angioedema; Antifibrinolytic Agents; Aprotinin; Blood Preservation; Corneal Diseases; Drug Interactions; Epistaxis; Female; Hemophilia A; Hemorrhage; Humans; Intrauterine Devices; Kinetics; Male; Myocardial Infarction; Ovarian Neoplasms; Pancreatitis; para-Aminobenzoates; Postoperative Complications; Shock; Thrombophlebitis; Tranexamic Acid; Trypsin Inhibitors | 1985 |
Basis of antifibrinolytic therapy.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Caseins; Fibrin; Fibrinolysin; Fibrinolysis; Hemorrhage; Humans; Tranexamic Acid | 1980 |
Clinical pharmacology of aminocaproic and tranexamic acids.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Cyclohexanecarboxylic Acids; Fibrinolysis; Humans; In Vitro Techniques; Kinetics; Tranexamic Acid | 1980 |
Inhibitors of fibrinolysis in the treatment of haemophilia.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Hematuria; Hemophilia A; Humans; Surgical Procedures, Operative; Tooth Extraction; Tranexamic Acid | 1980 |
Antifibrinolytic therapy in subarachnoid hemorrhage caused by ruptured intracranial aneurysm.
Topics: Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Humans; Intracranial Aneurysm; Rupture, Spontaneous; Spinal Puncture; Subarachnoid Hemorrhage; Tranexamic Acid | 1981 |
Antifibrinolytic treatment in subarachnoid haemorrhage: present state.
Topics: 4-Aminobenzoic Acid; Aminocaproic Acid; Antifibrinolytic Agents; Clinical Trials as Topic; Humans; Random Allocation; Subarachnoid Hemorrhage; Tranexamic Acid | 1982 |
Metaanalysis of prophylactic drug treatment in the prevention of postoperative bleeding.
Topics: Aminocaproic Acid; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Coronary Artery Bypass; Deamino Arginine Vasopressin; Hemostatics; Humans; Postoperative Complications; Premedication; Tranexamic Acid | 1994 |
Natural and synthetic antifibrinolytics in adult cardiac surgery: efficacy, effectiveness and efficiency.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cost-Benefit Analysis; Drug Utilization; Humans; Tranexamic Acid | 1994 |
Blood-sparing drugs: aprotinin, tranexamic acid, and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Graft Occlusion, Vascular; Humans; Safety; Thrombosis; Tranexamic Acid | 1995 |
Clinical use of synthetic antifibrinolytic agents during liver transplantation.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Loss, Surgical; Clinical Trials as Topic; Fibrinolysis; Hemostasis, Surgical; Humans; Liver Transplantation; Thrombelastography; Tranexamic Acid | 1993 |
Drugs to minimize perioperative blood loss in cardiac surgery: meta-analyses using perioperative blood transfusion as the outcome. The International Study of Peri-operative Transfusion (ISPOT) Investigators.
Topics: Aminocaproic Acid; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Deamino Arginine Vasopressin; Hemostatics; Humans; Premedication; Randomized Controlled Trials as Topic; Tranexamic Acid; Treatment Outcome | 1997 |
Enzyme-controlling medicines: introduction.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Antithrombins; Arginine; Enzyme Inhibitors; Humans; Kallikreins; Phenylalanine; Pipecolic Acids; Sulfonamides; Tranexamic Acid | 1997 |
Aprotinin versus lysine analogues: the debate continues.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Transfusion; Cardiac Surgical Procedures; Hemostasis, Surgical; Hemostatics; Humans; Lysine; Tranexamic Acid | 1998 |
Current status of non-transfusional haemostatic agents.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Disorders; Blood Loss, Surgical; Cardiac Surgical Procedures; Contraindications; Deamino Arginine Vasopressin; Estrogens, Conjugated (USP); Hemorrhage; Hemostatics; Humans; Safety; Tranexamic Acid; Uremia | 1999 |
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Erythrocyte Transfusion; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid; Transplantation, Homologous | 2001 |
Clinical management of hereditary angio-oedema in children.
Topics: Adolescent; Aminocaproic Acid; Angioedema; Child; Child, Preschool; Complement C1 Inactivator Proteins; Danazol; Female; Humans; Infant; Male; Tranexamic Acid | 2002 |
Protease inhibitors in the treatment of hereditary angioedema.
Topics: Aminocaproic Acid; Angioedema; Antifibrinolytic Agents; Aprotinin; Clinical Trials as Topic; Complement C1 Inactivator Proteins; Humans; Protease Inhibitors; Tranexamic Acid | 2003 |
Antifibrinolytics.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Hemostasis; Hemostatics; Humans; Tranexamic Acid | 2003 |
Strategies for minimizing blood loss in orthopedic surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Disorders; Blood Loss, Surgical; Blood Transfusion, Autologous; Deamino Arginine Vasopressin; Factor VII; Factor VIIa; Hemodilution; Hemostatic Techniques; Hemostatics; Humans; Hypotension, Controlled; Orthopedic Procedures; Postoperative Care; Preoperative Care; Recombinant Proteins; Tranexamic Acid | 2004 |
Hemostatic agents.
Topics: Aminocaproic Acid; Aprotinin; Deamino Arginine Vasopressin; Hemostatics; Humans; Meta-Analysis as Topic; Tranexamic Acid | 2004 |
Antifibrinolytics in orthotopic liver transplantation: current status and controversies.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Humans; Liver Transplantation; Thromboembolism; Tranexamic Acid | 2005 |
Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Bayes Theorem; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Erythrocyte Transfusion; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid | 2005 |
Antifibrinolytics in liver transplantation.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Humans; Liver Transplantation; Thromboembolism; Tranexamic Acid | 2006 |
Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Transfusion; Erythrocyte Transfusion; Humans; Orthopedic Procedures; Postoperative Hemorrhage; Randomized Controlled Trials as Topic; Tranexamic Acid | 2006 |
Efficacy and safety of antifibrinolytic drugs in liver transplantation: a systematic review and meta-analysis.
Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Transfusion; Controlled Clinical Trials as Topic; Female; Hepatic Artery; Humans; Liver Transplantation; Male; Middle Aged; Survival Rate; Thromboembolism; Thrombosis; Tranexamic Acid; Treatment Outcome; Venous Thrombosis | 2007 |
[Practical management of C1 inhibitor deficiency].
Topics: Adolescent; Adult; Aminocaproic Acid; Angioedema; Bradykinin; Child; Child, Preschool; Complement C1 Inhibitor Protein; Complement C4; Danazol; Disease Management; Estrogens; Female; Humans; Intraoperative Complications; Male; Middle Aged; Serine Proteinase Inhibitors; Tranexamic Acid | 2007 |
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Erythrocyte Transfusion; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid; Transplantation, Homologous | 2007 |
Pharmacologic methods to reduce perioperative bleeding.
Topics: Aminocaproic Acid; Aprotinin; Deamino Arginine Vasopressin; Hemorrhage; Hemostatics; Humans; Meta-Analysis as Topic; Orthopedics; Perioperative Care; Postoperative Hemorrhage; Thoracic Surgery; Tranexamic Acid | 2008 |
Current antifibrinolytic therapy for coronary artery revascularization.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Coronary Artery Bypass; Humans; Lysine; Patient Selection; Postoperative Hemorrhage; Risk Factors; Safety Management; Serine Proteinase Inhibitors; Tranexamic Acid; Treatment Outcome | 2008 |
Epistaxis in adults: a clinical review.
Topics: Adult; Age Factors; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Embolization, Therapeutic; Emergency Medicine; Epistaxis; Humans; Middle Aged; Nose; Risk Factors; Secondary Prevention; Tranexamic Acid | 2008 |
The use of antifibrinolytic agents in spine surgery. A meta-analysis.
Topics: Adolescent; Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Humans; Middle Aged; Spine; Tranexamic Acid | 2008 |
The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: a meta-analysis.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Coronary Artery Bypass; Drug-Related Side Effects and Adverse Reactions; Hemostatics; Humans; Myocardial Infarction; Postoperative Hemorrhage; Survival Analysis; Tranexamic Acid; Treatment Outcome | 2009 |
Lessons from the aprotinin saga: current perspective on antifibrinolytic therapy in cardiac surgery.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Aprotinin; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Thrombosis; Tranexamic Acid | 2010 |
Hereditary angioedema: treatment, management, and precautions in patients presenting for dental care.
Topics: Acute Disease; Adult; Airway Obstruction; Aminocaproic Acid; Androgens; Angioedemas, Hereditary; Antifibrinolytic Agents; Chronic Disease; Complement C1 Inactivator Proteins; Complement C1 Inhibitor Protein; Complement Inactivating Agents; Dental Care for Chronically Ill; Estrogen Antagonists; Female; Humans; Laryngeal Edema; Middle Aged; Plasma; Tranexamic Acid | 2010 |
Antifibrinolytics in major orthopaedic surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Humans; Orthopedic Procedures; Plastic Surgery Procedures; Postoperative Hemorrhage; Tranexamic Acid | 2010 |
Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotinin era.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Postoperative Hemorrhage; Randomized Controlled Trials as Topic; Tranexamic Acid | 2011 |
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Erythrocyte Transfusion; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid; Transplantation, Homologous | 2011 |
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Erythrocyte Transfusion; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid; Transplantation, Homologous | 2011 |
Bleeding and management of coagulopathy.
Topics: Algorithms; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Disorders; Blood Component Transfusion; Blood Transfusion; Blood Volume; Cardiac Surgical Procedures; Deamino Arginine Vasopressin; Fibrinogen; Hemostatics; Recombinant Proteins; Thrombelastography; Tranexamic Acid | 2011 |
The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials.
Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Hemorrhage; Humans; Middle Aged; Models, Statistical; Subarachnoid Hemorrhage; Thrombosis; Tranexamic Acid | 2012 |
A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Child; Craniotomy; Face; Hemostatics; Humans; Spine; Tranexamic Acid | 2012 |
Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Humans; Myocardial Infarction; Odds Ratio; Postoperative Complications; Renal Insufficiency; Risk; Stroke; Tranexamic Acid | 2012 |
Antifibrinolytic drugs for acute traumatic injury.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Hemorrhage; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid; Wounds and Injuries | 2012 |
Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients.
Topics: Aminocaproic Acid; Aprotinin; Cardiac Surgical Procedures; Humans; Randomized Controlled Trials as Topic; Risk Factors; Tranexamic Acid | 2013 |
Antifibrinolytic agents in current anaesthetic practice.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Female; Hemorrhage; Humans; Liver; Neurosurgical Procedures; Orthopedic Procedures; Postoperative Hemorrhage; Postpartum Hemorrhage; Pregnancy; Tranexamic Acid; Wounds and Injuries | 2013 |
Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Erythrocyte Transfusion; Hematologic Diseases; Hemorrhage; Humans; Lysine; Platelet Transfusion; Thrombocytopenia; Tranexamic Acid | 2013 |
[Hemostasis and antifibrinolytic therapy in major pediatric surgery].
Topics: Adolescent; Age Factors; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Child; Child, Preschool; Hemostasis; Hemostatics; Humans; Infant; Pediatrics; Surgical Procedures, Operative; Tranexamic Acid | 2013 |
Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage.
Topics: Administration, Oral; Aminocaproic Acid; Antifibrinolytic Agents; Brain Ischemia; Confidence Intervals; Humans; Injections, Intravenous; Intracranial Aneurysm; Randomized Controlled Trials as Topic; Secondary Prevention; Subarachnoid Hemorrhage; Tranexamic Acid; Treatment Outcome | 2013 |
The effects of lysine analogs during pelvic surgery: a systematic review and meta-analysis.
Topics: Aminocaproic Acid; Blood Loss, Surgical; Blood Transfusion; Gynecologic Surgical Procedures; Hemorrhage; Humans; Lysine; Randomized Controlled Trials as Topic; Risk; Surgical Procedures, Operative; Thrombosis; Tranexamic Acid; Treatment Outcome; Urologic Surgical Procedures, Male | 2014 |
Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Factor VIIa; Hemophilia A; Hemophilia B; Hemostasis, Surgical; Humans; Randomized Controlled Trials as Topic; Recombinant Proteins; Surgical Procedures, Operative; Tooth Extraction; Tranexamic Acid | 2015 |
Antifibrinolytic drugs for acute traumatic injury.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Hemorrhage; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid; Wounds and Injuries | 2015 |
Antifibrinolytic Use in the Perioperative Setting: Aminocaproic Acid and Tranexamic Acid.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Humans; Perioperative Care; Tranexamic Acid | 2015 |
Con: Antifibrinolytics Should Not Be Used Routinely in Low-Risk Cardiac Surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Humans; Intraoperative Complications; Risk Factors; Tranexamic Acid | 2016 |
Pro: Antifibrinolytics Should Be Used in Routine Cardiac Cases Using Cardiopulmonary Bypass (Unless Contraindicated).
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiopulmonary Bypass; Humans; Intraoperative Complications; Randomized Controlled Trials as Topic; Tranexamic Acid | 2016 |
Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Factor IX; Factor VIII; Hemophilia A; Hemophilia B; Humans; Minor Surgical Procedures; Oral Hemorrhage; Postoperative Hemorrhage; Randomized Controlled Trials as Topic; Surgery, Oral; Tooth Extraction; Tranexamic Acid; von Willebrand Diseases | 2015 |
Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Erythrocyte Transfusion; Hematologic Diseases; Hemorrhage; Humans; Lysine; Platelet Transfusion; Thrombocytopenia; Thromboembolism; Tranexamic Acid | 2016 |
Preventing perioperative bleeding in patients with inherited bleeding disorders.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Hemophilia A; Humans; Postoperative Hemorrhage; Tooth Extraction; Tranexamic Acid | 2017 |
The Safety and Efficacy of Lysine Analogues in Cancer Patients: A Systematic Review and Meta-Analysis.
Topics: Adult; Aminocaproic Acid; Blood Loss, Surgical; Blood Transfusion; Erythrocyte Transfusion; Humans; Lysine; Neoplasms; Patient Safety; Platelet Transfusion; Randomized Controlled Trials as Topic; Tranexamic Acid; Treatment Outcome; Venous Thrombosis | 2017 |
Tranexamic acid versus aminocaproic acid for blood management after total knee and total hip arthroplasty: A systematic review and meta-analysis.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; Female; Hemoglobins; Humans; Length of Stay; Male; Middle Aged; Platelet Transfusion; Postoperative Complications; Postoperative Period; Pulmonary Embolism; Tranexamic Acid; Treatment Outcome; Venous Thrombosis | 2018 |
Antifibrinolytic Agents in Plastic Surgery: Current Practices and Future Directions.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Burns; Clinical Trials as Topic; Cohort Studies; Forecasting; Humans; Microsurgery; Orthognathic Surgical Procedures; Plastic Surgery Procedures; Tranexamic Acid | 2018 |
Use of antifibrinolytics in pediatric cardiac surgery: Where are we now?
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Tranexamic Acid | 2019 |
Medical interventions for traumatic hyphema.
Topics: Adrenal Cortex Hormones; Aminocaproic Acid; Antifibrinolytic Agents; Aspirin; Bandages; Bed Rest; Child; Estrogens, Conjugated (USP); Eye Injuries; Humans; Hyphema; Mydriatics; Patient Positioning; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Tranexamic Acid; Visual Acuity; Wounds, Nonpenetrating | 2019 |
The Role of Antifibrinolytics in Reducing Blood Loss During Craniofacial or Orthognathic Surgical Procedures: A Meta-Analysis.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Denmark; Humans; Orthognathic Surgery; Tranexamic Acid | 2019 |
Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Humans; Randomized Controlled Trials as Topic; Spine; Tranexamic Acid | 2019 |
Epsilon-aminocaproic acid versus tranexamic acid in total knee arthroplasty: a meta-analysis study.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; Female; Humans; Male; Postoperative Hemorrhage; Tranexamic Acid; Venous Thromboembolism | 2019 |
Efficacy and Safety of Antifibrinolytic Drugs in Pediatric Surgery: A Systematic Review.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Humans; Pharmaceutical Preparations; Postoperative Hemorrhage; Tranexamic Acid | 2021 |
Antifibrinolytic Drugs for the Prevention of Bleeding in Pediatric Cardiac Surgery on Cardiopulmonary Bypass: A Systematic Review and Meta-analysis.
Topics: Aminocaproic Acid; Anaphylaxis; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Humans; Pediatrics; Postoperative Hemorrhage; Tranexamic Acid | 2022 |
Blood Loss and Transfusion in a Pediatric Scoliosis Surgery Cohort in the Antifibrinolytic Era.
Topics: Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Humans; Retrospective Studies; Scoliosis; Tranexamic Acid; Treatment Outcome | 2022 |
Tranexamic Acid versus Epsilon-Aminocaproic Acid in Total Knee Arthroplasty: A Meta-Analysis.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Tranexamic Acid | 2021 |
[Hemostatic efficacy of tranexamic acid and ε-aminocaproic acid in hip and knee arthroplasty:a Meta-analysis].
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Hemoglobins; Hemostatics; Humans; Tranexamic Acid | 2022 |
Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Component Transfusion; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Humans; Plasma; Postoperative Hemorrhage; Tranexamic Acid | 2022 |
The optimal regimen, efficacy and safety of tranexamic acid and aminocaproic acid to reduce bleeding for patients after total hip arthroplasty: A systematic review and Bayesian network meta-analysis.
Topics: Administration, Intravenous; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Bayes Theorem; Blood Loss, Surgical; Humans; Network Meta-Analysis; Pulmonary Embolism; Tranexamic Acid | 2023 |
Comparative efficacy and safety of different hemostatic medications during spinal surgery: A network meta-analysis.
Topics: Aminocaproic Acid; Bayes Theorem; Hemostatics; Humans; Network Meta-Analysis; Tranexamic Acid | 2023 |
The Optimal Dose, Efficacy and Safety of Tranexamic Acid and Epsilon-Aminocaproic Acid to Reduce Bleeding in TKA: A Systematic Review and Bayesian Network Meta-analysis.
Topics: Administration, Intravenous; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Bayes Theorem; Blood Loss, Surgical; Humans; Network Meta-Analysis; Pulmonary Embolism; Tranexamic Acid; Venous Thrombosis | 2023 |
Medical interventions for traumatic hyphema.
Topics: Adrenal Cortex Hormones; Aminocaproic Acid; Antifibrinolytic Agents; Aspirin; Glaucoma; Humans; Hyphema; Mydriatics; Tranexamic Acid | 2023 |
Comparison of efficacy between tranexamic acid and epsilon-aminocaproic acid for total knee arthroplasty: A meta-analysis of randomized controlled trials.
Topics: Administration, Intravenous; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid | 2023 |
26 trial(s) available for tranexamic acid and aminocaproic acid
| Article | Year |
|---|---|
Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial.
Topics: Adult; Aged; Aminocaproic Acid; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Rupture, Spontaneous; Subarachnoid Hemorrhage; Tranexamic Acid | 1978 |
The effect of warm heart surgery on postoperative bleeding.
Topics: Aminocaproic Acid; Analysis of Variance; Blood Loss, Surgical; Blood Transfusion; Chi-Square Distribution; Coronary Artery Bypass; Humans; Hypothermia, Induced; Perfusion; Postoperative Complications; Time Factors; Tranexamic Acid | 1992 |
Comparative clinical trial of epsilon amino-caproic acid and tranexamic acid in the prevention of early recurrence of subarachnoid haemorrhage.
Topics: Adolescent; Adult; Aminocaproates; Aminocaproic Acid; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Female; Humans; Middle Aged; Recurrence; Subarachnoid Hemorrhage; Tranexamic Acid | 1981 |
Antifibrinolytic treatment in subarachnoid haemorrhage: present state.
Topics: 4-Aminobenzoic Acid; Aminocaproic Acid; Antifibrinolytic Agents; Clinical Trials as Topic; Humans; Random Allocation; Subarachnoid Hemorrhage; Tranexamic Acid | 1982 |
Intraoperative antifibrinolysis and blood-saving techniques in cardiac surgery. Prospective trial of 3 antifibrinolytic drugs.
Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Tests; Blood Loss, Surgical; Blood Transfusion, Autologous; Cardiopulmonary Bypass; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heart Diseases; Heart Valve Prosthesis; Humans; Male; Middle Aged; Postoperative Hemorrhage; Prospective Studies; Tranexamic Acid | 1995 |
Changes in coagulation patterns, blood loss and blood use after cardiopulmonary bypass: aprotinin vs tranexamic acid vs epsilon aminocaproic acid.
Topics: Aminocaproic Acid; Aprotinin; Blood Coagulation; Blood Loss, Surgical; Blood Transfusion; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Hemostatics; Humans; Male; Middle Aged; Postoperative Hemorrhage; Tranexamic Acid | 1996 |
Plasmin is a specific stimulus of the 5-lipoxygenase pathway of human peripheral monocytes.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Arachidonate 5-Lipoxygenase; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Fibrinolysin; Humans; Least-Squares Analysis; Leukotriene B4; Male; Monocytes; Reference Values; Serine Endopeptidases; Stimulation, Chemical; Tranexamic Acid | 1996 |
The use of low-dose aprotinin, epsilon-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Aspirin; Coronary Artery Bypass; Dose-Response Relationship, Drug; Humans; Postoperative Hemorrhage; Tranexamic Acid; Treatment Outcome | 1997 |
Continuous small-dose tranexamic acid reduces fibrinolysis but not transfusion requirements during orthotopic liver transplantation.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Antithrombins; Blood Coagulation; Blood Transfusion; Double-Blind Method; Female; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Follow-Up Studies; Humans; Infusions, Intravenous; Intraoperative Care; Ligation; Liver Transplantation; Male; Placebos; Portal Vein; Prospective Studies; Reperfusion; Thrombelastography; Tranexamic Acid | 1997 |
Prophylactic tranexamic acid and epsilon-aminocaproic acid for primary myocardial revascularization.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Postoperative Complications; Premedication; Prospective Studies; Reoperation; Tranexamic Acid | 1998 |
Comparative study of antifibrinolytic drugs in orthotopic liver transplantation.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Blood Transfusion; Double-Blind Method; Humans; Infusions, Intravenous; Liver Transplantation; Prospective Studies; Spain; Tranexamic Acid | 1999 |
Hemostatic effects of aprotinin, tranexamic acid and epsilon-aminocaproic acid in primary cardiac surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Cost-Benefit Analysis; Drug Costs; Female; Hemostatics; Humans; Male; Middle Aged; Tranexamic Acid | 1999 |
Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation.
Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation; Blood Component Transfusion; Blood Loss, Surgical; Double-Blind Method; Erythrocyte Transfusion; Female; Humans; Liver Transplantation; Male; Middle Aged; Prospective Studies; Tranexamic Acid | 2000 |
Postoperative bleeding after coronary revascularization. Comparison between tranexamic acid and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiopulmonary Bypass; Humans; Middle Aged; Postoperative Hemorrhage; Tranexamic Acid | 2000 |
Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery.
Topics: Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Tests; Blood Transfusion; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Child, Preschool; Female; Heart Defects, Congenital; Heparin Antagonists; Humans; Infant; Male; Postoperative Hemorrhage; Prospective Studies; Protamines; Time Factors; Tranexamic Acid; Treatment Outcome | 2004 |
Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial.
Topics: Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; Double-Blind Method; Female; Hemoglobins; Hemostasis, Surgical; Humans; Male; Middle Aged; Tranexamic Acid; Treatment Outcome | 2006 |
A prospective, randomized, double-blinded single-site control study comparing blood loss prevention of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) for corrective spinal surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Double-Blind Method; Female; Humans; Male; Middle Aged; Perioperative Care; Scoliosis; Spinal Fusion; Tranexamic Acid; Treatment Outcome | 2010 |
Blood conservation strategies for reducing peri-operative blood loss in open heart surgery.
Topics: Adult; Aminocaproic Acid; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Female; Humans; Male; Middle Aged; Tranexamic Acid | 2011 |
Comparison of epsilon aminocaproic acid and tranexamic Acid in thoracic aortic surgery: clinical efficacy and safety.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aorta, Thoracic; Blood Loss, Surgical; Blood Transfusion; Cardiopulmonary Bypass; Female; Fibrin Fibrinogen Degradation Products; Humans; Male; Middle Aged; Postoperative Care; Postoperative Complications; Prospective Studies; Renal Insufficiency; Sample Size; Tranexamic Acid; Vascular Surgical Procedures | 2013 |
The relative efficacy of antifibrinolytics in adolescent idiopathic scoliosis: a prospective randomized trial.
Topics: Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Double-Blind Method; Female; Hematocrit; Humans; Infusions, Intravenous; Male; Perioperative Care; Prospective Studies; Scoliosis; Spinal Fusion; Tranexamic Acid; Treatment Outcome | 2014 |
Antifibrinolytics reduce blood loss in adult spinal deformity surgery: a prospective, randomized controlled trial.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Blood Volume; Double-Blind Method; Female; Hematocrit; Humans; Intraoperative Care; Male; Middle Aged; Prospective Studies; Spinal Fusion; Spine; Tranexamic Acid | 2015 |
Intraoperative Use of Epsilon Amino Caproic Acid and Tranexamic Acid in Surgeries Performed Under Cardiopulmonary Bypass: a Comparative Study To Assess Their Impact On Reopening Due To Postoperative Bleeding.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Cardiopulmonary Bypass; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Prospective Studies; Tranexamic Acid | 2015 |
Blood Conservation Using Tranexamic Acid Is Not Superior to Epsilon-Aminocaproic Acid After Total Knee Arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Double-Blind Method; Female; Humans; Joint Diseases; Male; Middle Aged; Postoperative Hemorrhage; Prospective Studies; Tranexamic Acid | 2017 |
Tranexamic acid or epsilon-aminocaproic acid in total joint arthroplasty? A randomized controlled trial.
Topics: Administration, Intravenous; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; Female; Humans; Intraoperative Period; Male; Middle Aged; Postoperative Complications; Postoperative Hemorrhage; Prospective Studies; Tranexamic Acid | 2019 |
First Comparative Study of the Effectiveness of the Use of Tranexamic Acid against ε-Aminocapróic Acid via the Oral Route for the Reduction of Postoperative Bleeding in TKA: A Clinical Trial.
Topics: Administration, Oral; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Method; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Prospective Studies; Tranexamic Acid | 2021 |
Tranexamic acid versus aminocapróic acid in multiple doses via the oral route for the reduction of postoperative bleeding in total primary hip arthroplasty: a prospective, randomized, double-blind, controlled study.
Topics: Administration, Oral; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Double-Blind Method; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Prospective Studies; Tranexamic Acid; Treatment Outcome | 2021 |
120 other study(ies) available for tranexamic acid and aminocaproic acid
| Article | Year |
|---|---|
Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Kringles; Ligands; Models, Molecular; Molecular Structure; Plasminogen; Protein Conformation; Recombinant Proteins; Thermodynamics; Tranexamic Acid | 1996 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction.
Topics: | 2014 |
Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.
Topics: Animals; Antifibrinolytic Agents; Catalytic Domain; Crystallography, X-Ray; Fibrinolysin; Fibrinolysis; Hemorrhage; Humans; Ligands; Molecular Structure; Plasminogen; Protein Binding; Protein Domains | 2020 |
Allosteric effects of some antifibrinolytic amino acids on the catalytic activity of human plasmin.
Topics: Allosteric Regulation; Allosteric Site; Aminocaproic Acid; Antifibrinolytic Agents; Binding Sites; Catalysis; Enzyme Activation; Fibrinolysin; Humans; Kinetics; Lysine; Mathematics; Tranexamic Acid | 1978 |
The effect of fibrinogen degradation products and some lysine analogues on the dissociation of plasmin(ogen)-fibrin complexes.
Topics: Aminocaproic Acid; Animals; Cattle; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinolysin; Fibrinolysis; Humans; Lysine; Plasminogen; Protein Binding; Tranexamic Acid | 1979 |
[Actinic prurigo. Treatment with antifibribolytics].
Topics: Adolescent; Adult; Aminocaproic Acid; Antifibrinolytic Agents; Dermatitis, Atopic; Drug Evaluation; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Male; Prurigo; Sunlight; Tranexamic Acid | 1979 |
Effects of tranexamic acid, cis-AMCHA, and 6-aminohexanoic acid on the activation rate of plasminogen by urokinase in the presence of clot.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Antifibrinolytic Agents; Blood Coagulation; Cattle; Cyclohexanecarboxylic Acids; Endopeptidases; Humans; Isomerism; Lysine; Oligopeptides; Plasminogen; Thrombin; Tranexamic Acid; Urokinase-Type Plasminogen Activator | 1979 |
Effects of t-AMCHA and EACA on the plasma kallikrein system.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Cyclohexanecarboxylic Acids; Dogs; Esterases; Factor XII; Kallikreins; Kinins; Tranexamic Acid | 1977 |
Reference values for fibrinogen concentration and inhibitors of fibrinolysis.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Fibrinogen; Hematocrit; Humans; Methods; Tranexamic Acid | 1977 |
The use of antifibrinolytic drugs in aneurysmal subarachnoid hemorrhage.
Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Humans; Intracranial Aneurysm; Middle Aged; Rupture, Spontaneous; Subarachnoid Hemorrhage; Tranexamic Acid | 1978 |
Positive co-operative binding at two weak lysine-binding sites governs the Glu-plasminogen conformational change.
Topics: Aminocaproic Acid; Binding Sites; Fluorescence Polarization; Humans; Kinetics; Lysine; Peptide Fragments; Plasminogen; Protein Conformation; Tranexamic Acid | 1992 |
The cationic locus on the recombinant kringle 2 domain of tissue-type plasminogen activator that stabilizes its interaction with omega-amino acids.
Topics: Amino Acid Sequence; Amino Acids; Aminocaproic Acid; Base Sequence; Binding Sites; Cations; DNA; Enzyme Stability; Escherichia coli; Lysine; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Peptide Fragments; Plasmids; Recombinant Proteins; Tissue Plasminogen Activator; Tranexamic Acid | 1992 |
Antifibrinolytic activities of alpha-N-acetyl-L-lysine methyl ester, epsilon-aminocaproic acid, and tranexamic acid. Importance of kringle interactions and active site inhibition.
Topics: alpha-Macroglobulins; Amidohydrolases; Aminocaproic Acid; Binding Sites; Binding, Competitive; Blood Coagulation; Fibrinolysin; Fibrinolysis; Humans; Kinetics; Lysine; Peptide Fragments; Serum Globulins; Tranexamic Acid | 1992 |
Studies on tumor induced angiogenesis.
Topics: Adenocarcinoma; Aminocaproic Acid; Animals; Cornea; Ditiocarb; Humans; Kidney Neoplasms; Macaca; Mammary Neoplasms, Experimental; Melanoma; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Neuroblastoma; Pentoxifylline; Platelet-Derived Growth Factor; Rabbits; Rats; Rats, Inbred Strains; Recombinant Proteins; Tranexamic Acid; Transplantation, Heterologous; Wilms Tumor | 1992 |
Effects of antifibrinolytic agents on the life span of fibrin sealant.
Topics: Adhesives; Aminocaproic Acid; Animals; Antifibrinolytic Agents; Aprotinin; Blood Coagulation; Drug Stability; Fibrinogen; Fibrinolysis; Male; Rats; Rats, Sprague-Dawley; Serum Globulins; Thrombin; Time Factors; Tranexamic Acid | 1992 |
Serpin-serine protease binding kinetics: alpha 2-antiplasmin as a model inhibitor.
Topics: alpha-Macroglobulins; Aminocaproic Acid; Binding Sites; Chymotrypsin; Fibrinolysin; Humans; Kinetics; Lysine; Models, Biological; Structure-Activity Relationship; Thermodynamics; Tranexamic Acid | 1991 |
Prevention of in vitro fibrinogenolysis during laboratory monitoring of thrombolytic therapy with streptokinase or APSAC.
Topics: alpha-Macroglobulins; Aminocaproic Acid; Anistreplase; Aprotinin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Fibrinolysin; Humans; Plasminogen; Streptokinase; Thrombolytic Therapy; Tranexamic Acid | 1991 |
Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta).
Topics: Aminocaproic Acid; Animals; Anti-Inflammatory Agents; Antifibrinolytic Agents; Endometrium; Female; Ibuprofen; Indomethacin; Intrauterine Devices; Iron; Macaca mulatta; Menorrhagia; Menstrual Cycle; Menstruation; Naproxen; Plant Extracts; Tissue Plasminogen Activator; Tranexamic Acid | 1991 |
The relationship between inhibition of plasminogen-activator activity and prostatic involution.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Aprotinin; Cyclohexanecarboxylic Acids; Hydrocortisone; Male; Organ Size; Plasminogen Activators; Plasminogen Inactivators; Prostate; Prostatic Diseases; Rats; Rats, Inbred Strains; Tranexamic Acid | 1988 |
Cytoprotective effect of plasmin inhibitor on necrotizing agent-induced gastric lesions in rats.
Topics: Aminocaproic Acid; Ammonia; Animals; Cell Survival; Ethanol; Fibrinolysin; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; Tranexamic Acid | 1989 |
Clinical and laboratory investigation of the effects of epsilon-aminocaproic acid on hemostasis.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Aorta, Thoracic; Bleeding Time; Blood Platelets; Cattle; Endothelium; Epoprostenol; Hemostasis; Humans; In Vitro Techniques; Intracranial Aneurysm; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Subarachnoid Hemorrhage; Time Factors; Tranexamic Acid | 1985 |
The effect of antifibrinolytic agents on wound healing.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Cyclohexanecarboxylic Acids; Rats; Rats, Inbred Strains; Skin; Skin Physiological Phenomena; Tensile Strength; Tranexamic Acid; Wound Healing | 1988 |
Dental extractions in hemophilia: reflections on 10 years' experience.
Topics: Aminocaproic Acid; Bandages; Cellulose, Oxidized; Dental Care for Disabled; Factor IX; Factor VIII; Hemophilia A; Hemophilia B; Humans; Oral Hemorrhage; Thrombin; Tooth Extraction; Tranexamic Acid; von Willebrand Diseases | 1985 |
[The action of fibrinolysis inhibitors of the omega-aminocarboxylic acid type on the proliferation of in vitro cultured endothelial cells].
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Cell Division; Cyclohexanecarboxylic Acids; Endothelium; Humans; para-Aminobenzoates; Tranexamic Acid | 1986 |
Short-term re-epithelialization of the alkali-burned rabbit cornea.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Burns, Chemical; Corneal Injuries; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Eye Burns; Rabbits; Tranexamic Acid | 1985 |
[Disseminated intravascular coagulation as a complication of shock].
Topics: Aminocaproic Acid; Aprotinin; Disseminated Intravascular Coagulation; Heparin; Humans; Shock; Tranexamic Acid | 1973 |
[Familial angioedema (II). Treatment].
Topics: Aminocaproic Acid; Angioedema; Cinnarizine; Complement C1 Inactivator Proteins; Danazol; Histamine H1 Antagonists; Humans; Stanozolol; Tranexamic Acid | 1984 |
Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis.
Topics: Aminocaproic Acid; Animals; Aprotinin; Benzoates; Encephalomyelitis, Autoimmune, Experimental; Guanidines; Inflammation; Isomerism; Male; Pepstatins; Plasminogen Activators; Plasminogen Inactivators; Protease Inhibitors; Rats; Tranexamic Acid | 1980 |
The effect of antifibrinolytic agents on the healing of modified Widman flaps in monkeys.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Connective Tissue; Epithelial Attachment; Leucine; Macaca mulatta; Periodontal Diseases; Periodontium; Surgical Flaps; Tranexamic Acid; Wound Healing | 1984 |
Modulators of plasma fibronectin response during sepsis.
Topics: Aminocaproic Acid; Animals; Blood Coagulation; Cecum; Endotoxins; Escherichia coli; Fibronectins; Infections; Inflammation; Ligation; Male; Methylprednisolone; Protease Inhibitors; Rats; Rats, Inbred Strains; Tranexamic Acid | 1984 |
[Microanalysis of two antifibrinolytics (epsilon-aminocaproic acid and tranexamic acid) by liquid chromatography and fluorometry].
Topics: Aminocaproates; Aminocaproic Acid; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Humans; Spectrometry, Fluorescence; Tranexamic Acid | 1984 |
Fluorescence polarization and spectropolarimetric studies on the conformational changes induced by omega-aminoacids in two isozymes of Glu-plasminogen (I and II).
Topics: Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Fluorescence Polarization; Humans; Isoenzymes; Peptides; Plasminogen; Protein Conformation; Spectrophotometry, Ultraviolet; Tranexamic Acid | 1984 |
Fluorescence spectrophotometric studies on the conformational changes induced by omega-aminoacids in two isozymes of Glu-plasminogen (I and II).
Topics: Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Humans; Hydrolysis; Isoenzymes; Kinetics; Plasminogen; Protein Conformation; Spectrometry, Fluorescence; Tranexamic Acid | 1984 |
Observations on the effects of protease inhibitors on the suppression of experimental allergic encephalomyelitis.
Topics: Aminocaproic Acid; Animals; Anthraquinones; Benzoates; Body Weight; Encephalomyelitis, Autoimmune, Experimental; Pepstatins; Peptide Hydrolases; Polylysine; Protease Inhibitors; Rats; Rats, Inbred Lew; Spinal Cord; Tranexamic Acid | 1982 |
Cerebral complication of antifibrinolytic therapy in the treatment of ruptured intracranial aneurysm. Animal experiment and a review of literature.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Blood Pressure; Cerebral Cortex; Cisterna Magna; Cyclohexanecarboxylic Acids; Electroencephalography; Female; Humans; Injections, Intravenous; Injections, Spinal; Intracranial Aneurysm; Intracranial Pressure; Male; Rupture, Spontaneous; Seizures; Subarachnoid Hemorrhage; Tranexamic Acid | 1980 |
[Tooth extraction in patients with platelet disorders].
Topics: Adult; Aminocaproic Acid; Blood Platelet Disorders; Female; Hemostasis; Humans; Tooth Extraction; Tranexamic Acid | 1982 |
Effect of EACA, PAMBA, AMCA and AMBOCA on fibrinolysis induced by streptokinase, urokinase and tissue activator.
Topics: 4-Aminobenzoic Acid; Aminocaproates; Aminocaproic Acid; Animals; Bridged Bicyclo Compounds; Depression, Chemical; Fibrinolysis; Humans; para-Aminobenzoates; Plasminogen Activators; Streptokinase; Swine; Tranexamic Acid; Urokinase-Type Plasminogen Activator | 1982 |
[Pharmacokinetic studies with 3H-labelled synthetic antifibrinolytics].
Topics: 4-Aminobenzoic Acid; Aminocaproic Acid; Animals; Antifibrinolytic Agents; Kinetics; para-Aminobenzoates; Rabbits; Rats; Species Specificity; Tranexamic Acid | 1982 |
The use of frusemide and epsilon-amino-caproic-acid in transurethral prostatectomy. a review after 7 years.
Topics: Aged; Aminocaproates; Aminocaproic Acid; Furosemide; Hemorrhage; Humans; Male; Postoperative Complications; Prostatectomy; Thromboembolism; Tranexamic Acid | 1982 |
Selective inhibition of collagen breakdown by proteinase inhibitors in granulation tissue in rats.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Collagen; Granulation Tissue; Half-Life; Male; Phenanthrolines; Protease Inhibitors; Rats; Tranexamic Acid; Trypsin Inhibitor, Kunitz Soybean | 1981 |
Preoperative treatment of ruptured intracranial aneurysms with tranexamic acid and monitoring of fibrinolytic activity.
Topics: Aminocaproic Acid; Cyclohexanecarboxylic Acids; Fibrin Fibrinogen Degradation Products; Humans; Intracranial Aneurysm; Preoperative Care; Recurrence; Rupture, Spontaneous; Subarachnoid Hemorrhage; Tranexamic Acid | 1980 |
Studies on the mechanisms of action of aprotinin and tranexamic acid as plasmin inhibitors and antifibrinolytic agents.
Topics: Amino Acid Sequence; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Fibrinolysin; Humans; Kringles; Molecular Sequence Data; Peptide Fragments; Plasminogen; Tissue Plasminogen Activator; Tranexamic Acid | 1994 |
The use of tranexamic acid in cardiac operations.
Topics: Aminocaproic Acid; Cardiopulmonary Bypass; Coronary Artery Bypass; Hemorrhage; Humans; Postoperative Complications; Tranexamic Acid | 1994 |
Inhibitory effects of lysine analogues on t-PA induced whole blood clot lysis.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Humans; Reference Values; Thrombosis; Tissue Plasminogen Activator; Tranexamic Acid | 1994 |
Drugs for surgical blood loss.
Topics: Aminocaproic Acid; Blood Loss, Surgical; Humans; Serine Proteinase Inhibitors; Tranexamic Acid | 1993 |
Prevention of postbypass bleeding with tranexamic acid and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Blood Loss, Surgical; Blood Transfusion; Cardiopulmonary Bypass; Coronary Artery Bypass; Erythrocyte Transfusion; Fibrinolysis; Hemoglobins; Heparin; Humans; Injections, Intravenous; Intraoperative Care; Middle Aged; Myocardial Revascularization; Postoperative Care; Premedication; Retrospective Studies; Time Factors; Tranexamic Acid | 1993 |
Conformational studies of human plasminogen and plasminogen fragments: evidence for a novel third conformation of plasminogen.
Topics: Aminocaproic Acid; Benzamidines; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Chromatography, High Pressure Liquid; Humans; Light; Peptide Fragments; Plasminogen; Protein Conformation; Scattering, Radiation; Tranexamic Acid; X-Rays | 1994 |
Amino acids of the recombinant kringle 1 domain of human plasminogen that stabilize its interaction with omega-amino acids.
Topics: Amino Acid Sequence; Amino Acids; Aminocaproic Acid; Animals; Base Sequence; Binding Sites; Crystallography, X-Ray; Escherichia coli; Humans; Kringles; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasminogen; Recombinant Proteins; Species Specificity; Tranexamic Acid | 1993 |
Comparison of the lysine binding functions of lipoprotein(a) and plasminogen.
Topics: Acetylation; Amino Acid Sequence; Aminocaproic Acid; Binding Sites; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Kringles; Lipoprotein(a); Lysine; Molecular Sequence Data; Plasminogen; Sepharose; Sequence Homology; Structure-Activity Relationship; Tranexamic Acid | 1993 |
Specific anionic residues of the recombinant kringle 2 domain of tissue-type plasminogen activator that are responsible for stabilization of its interaction with omega-amino acid ligands.
Topics: Amino Acid Sequence; Amino Acids; Aminocaproic Acid; Anions; Base Sequence; Binding Sites; Escherichia coli; Lysine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Peptide Fragments; Recombinant Proteins; Thermodynamics; Tissue Plasminogen Activator; Tranexamic Acid; X-Ray Diffraction | 1993 |
Cost/benefit analysis of pharmacologic hemostasis.
Topics: Aminocaproic Acid; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Coronary Artery Bypass; Cost-Benefit Analysis; Deamino Arginine Vasopressin; Hemostasis, Surgical; Hemostatics; Humans; Reoperation; Tranexamic Acid | 1996 |
Stabilization of plasmin by lysine derivatives.
Topics: Amino Acid Sequence; Aminocaproic Acid; Animals; Cattle; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Enzyme Stability; Fibrinolysin; Hydrolysis; Molecular Sequence Data; Tranexamic Acid | 1996 |
Prolonged arterial occlusion caused by thrombus development at sites of arterial bifurcation.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Blood Platelets; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Rats; Rats, Wistar; Thrombosis; Time Factors; Tranexamic Acid | 1997 |
Antifibrinolytic therapy.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Humans; Recurrence; Subarachnoid Hemorrhage; Tranexamic Acid; Treatment Outcome | 1997 |
Specificity of ligand-induced conformational change of lipoprotein(a).
Topics: Aminocaproic Acid; Glutamic Acid; Ligands; Lipoprotein(a); Lysine; Models, Chemical; Molecular Weight; Osmolar Concentration; Particle Size; Proline; Protein Conformation; Protein Denaturation; Salts; Tranexamic Acid; Ultracentrifugation | 1997 |
Natural and synthetic antifibrinolytics: inert, poisonous or therapeutic agents?
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Transfusion; Cardiopulmonary Bypass; Drug Administration Schedule; Extracorporeal Circulation; Hemostasis, Surgical; Hemostatics; Humans; Plasminogen Activator Inhibitor 1; Research Design; Risk Factors; Serine Proteinase Inhibitors; Thoracic Surgery; Tranexamic Acid; Treatment Outcome | 1997 |
Aminocaproic acid and tranexamic acid increase the rate of acute corneal reepithelialization in Sprague Dawley rats.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Cell Division; Coloring Agents; Culture Techniques; Epithelium, Corneal; Female; Rats; Rats, Sprague-Dawley; Regeneration; Tranexamic Acid; Trypan Blue | 1998 |
Aprotinin versus epsilon-aminocaproic acid for aortic surgery using deep hypothermic circulatory arrest.
Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Aortic Aneurysm, Thoracic; Aprotinin; Cardiopulmonary Bypass; Female; Heart Arrest, Induced; Hemostatics; Humans; Male; Middle Aged; Retrospective Studies; Tranexamic Acid | 1998 |
Hemostatic agents and their safety.
Topics: Aminocaproic Acid; Aprotinin; Blood Component Transfusion; Cardiopulmonary Bypass; Hemostatics; Heparin Antagonists; Humans; Protamines; Tranexamic Acid | 1999 |
Synthetic antifibrinolytics are not associated with an increased incidence of baffle fenestration closure after the modified Fontan procedure.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Child, Preschool; Echocardiography, Transesophageal; Fontan Procedure; Hemodynamics; Humans; Infant; Retrospective Studies; Thromboembolism; Tranexamic Acid; Tricuspid Atresia | 2000 |
Differences between neonates and adults in the urokinase-plasminogen activator (u-PA) pathway of the fibrinolytic system.
Topics: Adult; Aging; Aminocaproic Acid; Dose-Response Relationship, Drug; Fetal Blood; Fibrin; Fibrinolysis; Humans; Infant, Newborn; Kinetics; Peptide Fragments; Plasminogen; Plasminogen Activators; Protein Isoforms; Solubility; Tranexamic Acid; Urokinase-Type Plasminogen Activator | 2000 |
Plasminogen binding is increased with adipocyte differentiation.
Topics: 3T3 Cells; Adipocytes; Aminocaproic Acid; Animals; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Ligands; Lysine; Mice; Mice, Knockout; Plasminogen; Protein Binding; Stromal Cells; Tranexamic Acid | 2001 |
Isolation, quantitation, and characterization of a stable complex formed by Lp[a] binding to triglyceride-rich lipoproteins.
Topics: Aminocaproic Acid; Apolipoproteins A; Arginine; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Hypertriglyceridemia; Immunoblotting; Lipoprotein(a); Lysine; Macromolecular Substances; Molecular Weight; Plasmapheresis; Proline; Protein Binding; Tranexamic Acid; Triglycerides; Ultracentrifugation | 2001 |
[A NEW METHOD OF THE ANALYSIS OF EPSILON-AMINOCAPROIC ACID (EACA) AND AMINOMETHYLCYCLOHEXANE CARBOXYLIC ACID (AMCHA), THE POTENT ANTIFIBRINOLYTIC AGENTS].
Topics: Aminocaproates; Aminocaproic Acid; Animals; Antifibrinolytic Agents; Blood Chemical Analysis; Carboxylic Acids; Chromatography; Fibrinolysis; Lagomorpha; Rabbits; Research; Tranexamic Acid | 1964 |
Identifying patients at risk of intraoperative and postoperative transfusion in isolated CABG: toward selective conservation strategies.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Anticoagulants; Blood Component Transfusion; Blood Loss, Surgical; Blood Transfusion; Comorbidity; Coronary Artery Bypass, Off-Pump; Databases, Factual; Emergencies; Female; Heparin; Hospitals, University; Humans; Intra-Aortic Balloon Pumping; Intraoperative Care; Logistic Models; Male; Middle Aged; Models, Theoretical; Nova Scotia; Plasma Substitutes; Postoperative Care; Postoperative Hemorrhage; Prospective Studies; Retrospective Studies; Risk Assessment; Tranexamic Acid | 2004 |
Antifibrinolytic use and bleeding during surgery on the descending thoracic aorta: a multivariate analysis.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Aortic Aneurysm, Thoracic; Blood Loss, Surgical; Drug Therapy, Combination; Female; Humans; Intraoperative Care; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Tranexamic Acid; Treatment Outcome | 2005 |
[Hemostatic drugs in a patient with antiphospholipid syndrome and clinically significant perioperative bleeding].
Topics: Adult; Aminocaproic Acid; Antiphospholipid Syndrome; Aprotinin; Blood Coagulation Tests; Blood Loss, Surgical; Combined Modality Therapy; Contraindications; Crystalloid Solutions; Deamino Arginine Vasopressin; Disseminated Intravascular Coagulation; Erythrocyte Transfusion; Factor VII; Factor VIIa; Female; Fluid Therapy; Hemorrhage; Hemostatics; Humans; Isotonic Solutions; Lupus Coagulation Inhibitor; Plasma; Platelet Transfusion; Pressure; Recombinant Proteins; Retroperitoneal Neoplasms; Shock; Thrombophlebitis; Tranexamic Acid | 2006 |
The role of antifibrinolytic agents in gynecologic cancer surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation; Colloids; Crystalloid Solutions; Female; Fibrinogen; Fibrinolysis; Genital Neoplasms, Female; Hematocrit; Hemoglobins; Humans; International Normalized Ratio; Isotonic Solutions; Partial Thromboplastin Time; Platelet Count; Pulmonary Embolism; Tranexamic Acid; Turkey | 2006 |
Efficacy of FDA-approved hemostatic drugs to improve survival and reduce bleeding in rat models of uncontrolled hemorrhage.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Aprotinin; Deamino Arginine Vasopressin; Disease Models, Animal; Drug Approval; Drug Therapy, Combination; Hemorrhage; Hemostatics; Infusions, Intravenous; Liver; Male; Rats; Rats, Sprague-Dawley; Survival Analysis; Tail; Tranexamic Acid; Wounds and Injuries | 2006 |
[The "Seville" Consensus Document on Alternatives to Allogenic Blood Transfusion. Sociedades españolas de Anestesiología (SEDAR), Medicina Intensiva (SEMICYUC), Hematología y Hemoterapia (AEHH), Transfusión sanguínea (SETS) Trombosis y Hemostasia (SETH)].
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Substitutes; Blood Transfusion, Autologous; Colloids; Crystalloid Solutions; Deamino Arginine Vasopressin; Evidence-Based Medicine; Factor VIIa; Hematinics; Hemodilution; Hemorrhage; Hemostatics; Humans; Iron; Isotonic Solutions; Operative Blood Salvage; Postoperative Hemorrhage; Premedication; Randomized Controlled Trials as Topic; Recombinant Proteins; Tranexamic Acid | 2006 |
Pro: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery.
Topics: Aminocaproic Acid; Animals; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Drug Hypersensitivity; Hemostatics; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Renal Insufficiency; Thrombosis; Tranexamic Acid; Treatment Outcome | 2006 |
Recombinant activated factor VII and epsilon aminocaproic acid treatment of a patient with Glanzmann's thrombasthenia for nasal polipectomy.
Topics: Adult; Aminocaproic Acid; Anesthesia, General; Antifibrinolytic Agents; Blood Loss, Surgical; Drug Therapy, Combination; Factor VII; Factor VIIa; Humans; Male; Nasal Polyps; Platelet Transfusion; Recombinant Proteins; Thrombasthenia; Tranexamic Acid | 2007 |
In vitro simulation of thrombolysis inhibition.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Humans; Lysine; Tranexamic Acid | 2008 |
[Effectiveness of tranexamic acid in routine performance of total knee replacement surgery].
Topics: Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Hematocrit; Hemoglobins; Humans; Intraoperative Care; Male; Middle Aged; Postoperative Period; Retrospective Studies; Tranexamic Acid | 2008 |
ε-Aminocaproic acid and clinical value in cardiac anesthesia.
Topics: Algorithms; Aminocaproic Acid; Anesthesia; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Humans; Multicenter Studies as Topic; Postoperative Hemorrhage; Randomized Controlled Trials as Topic; Tranexamic Acid; Treatment Outcome | 2011 |
von Willebrand disease in the pediatric and adolescent population.
Topics: Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Child; Contusions; Deamino Arginine Vasopressin; Epistaxis; Female; Hemostatics; Humans; Medical History Taking; Menorrhagia; Platelet Transfusion; Prevalence; Surveys and Questionnaires; Tranexamic Acid; von Willebrand Diseases; von Willebrand Factor | 2010 |
Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Transfusion; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cohort Studies; Drug Evaluation; Female; Humans; Infant; Infant, Newborn; Male; Postoperative Care; Postoperative Hemorrhage; Reoperation; Seizures; Tranexamic Acid; Treatment Outcome | 2011 |
The post-BART anti-fibrinolytic dilemma?
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Cardiac Surgical Procedures; Humans; Perioperative Care; Randomized Controlled Trials as Topic; Risk Assessment; Tranexamic Acid; Treatment Outcome | 2011 |
Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid.
Topics: Aged; Aminocaproic Acid; Anesthesia; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Procedures; Cohort Studies; Coronary Artery Bypass; Female; Hospital Mortality; Humans; Ischemic Attack, Transient; Male; Middle Aged; Postoperative Complications; Retrospective Studies; Risk Assessment; Seizures; Stroke; Tranexamic Acid; Treatment Outcome | 2011 |
High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement.
Topics: Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Aortic Valve; Drug Administration Schedule; Female; Heart Valve Prosthesis Implantation; Humans; Intraoperative Care; Male; Middle Aged; Postoperative Hemorrhage; Retrospective Studies; Seizures; Tranexamic Acid | 2011 |
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Aprotinin; Drug Evaluation, Preclinical; Leukocyte Count; Leukocytes; Male; Mice; Mice, Inbred C57BL; Microvessels; Myocardial Reperfusion Injury; Neutrophil Infiltration; Serine Proteinase Inhibitors; Tranexamic Acid | 2011 |
Comparison of blood-sparing efficacy of ε-aminocaproic acid and tranexamic acid in newborns undergoing cardiac surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Female; Germany; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Postoperative Hemorrhage; Prospective Studies; Time Factors; Tranexamic Acid; Treatment Outcome | 2011 |
Safety of tranexamic acid in pediatric cardiac surgery: what we do not know.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Female; Humans; Male; Postoperative Hemorrhage; Tranexamic Acid | 2011 |
Seizures after adult cardiac surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Female; Humans; Male; Postoperative Complications; Seizures; Tranexamic Acid | 2011 |
The effect of ε-aminocaproyl-S-benzyl-L-cysteine on the t-PA activity of human saliva.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Antifibrinolytic Agents; Blood Coagulation; Cattle; Cysteine; Fibrinogen; Fibrinolysis; Hemorrhage; Humans; Models, Biological; Peptides; Saliva; Time Factors; Tissue Plasminogen Activator; Tranexamic Acid | 2011 |
Are antifibrinolytics helpful in decreasing blood loss and transfusions during spinal fusion surgery in children with cerebral palsy scoliosis?
Topics: Adolescent; Aminocaproic Acid; Analysis of Variance; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Blood Transfusion, Autologous; Cerebral Palsy; Child; Databases, Factual; Humans; Length of Stay; Operative Blood Salvage; Retrospective Studies; Scoliosis; Spinal Fusion; Time Factors; Tranexamic Acid; Treatment Outcome; United States | 2012 |
Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Animals; Anticonvulsants; Aprotinin; Binding, Competitive; Cells, Cultured; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; In Vitro Techniques; Inhibitory Concentration 50; Inhibitory Postsynaptic Potentials; Isoflurane; Membrane Potentials; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Middle Aged; Neurons; Patch-Clamp Techniques; Propofol; Protein Binding; Receptors, GABA-A; Receptors, Glycine; Seizures; Spinal Cord; Synaptic Transmission; Tranexamic Acid; Young Adult | 2012 |
Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Colloids; Crystalloid Solutions; Female; Fibrinolysis; Humans; In Vitro Techniques; Isotonic Solutions; Male; Models, Biological; Pharmaceutical Solutions; Plasma; Thrombelastography; Tranexamic Acid; Wounds and Injuries | 2013 |
Aprotinin, but not ε-aminocaproic acid and tranexamic acid, exerts neuroprotection against excitotoxic injury in an in vitro neuronal cell culture model.
Topics: Aminocaproic Acid; Animals; Animals, Newborn; Antifibrinolytic Agents; Apoptosis; Aprotinin; Caspases; Cerebral Cortex; Coculture Techniques; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Agonists; Feeder Cells; Gestational Age; Mice; N-Methylaspartate; Neuroglia; Neurons; Neuroprotective Agents; Signal Transduction; Time Factors; Tranexamic Acid | 2014 |
Are antifibrinolytic agents effective in the treatment of aneurysmal subarachnoid hemorrhage?
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Humans; Subarachnoid Hemorrhage; Tranexamic Acid | 2014 |
The effects of Amicar and TXA on lumbar spine fusion in an animal model.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Blood Loss, Surgical; Calcification, Physiologic; Dose-Response Relationship, Drug; Fibrinolysin; Lumbar Vertebrae; Mice; Mice, Inbred C57BL; Osteoblasts; Random Allocation; Single-Blind Method; Spinal Fusion; Tomography, X-Ray Computed; Tranexamic Acid | 2014 |
Evaluation of tranexamic acid and ε-aminocaproic acid concentrations required to inhibit fibrinolysis in plasma of dogs and humans.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Dogs; Dose-Response Relationship, Drug; Fibrinolysis; Humans; Kaolin; Male; Plasma; Species Specificity; Thrombelastography; Tranexamic Acid | 2014 |
Efficacy and safety of tranexamic acid versus ϵ-aminocaproic acid in cardiovascular surgery.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Cardiopulmonary Bypass; Cardiovascular Surgical Procedures; Female; Humans; Male; Middle Aged; Reoperation; Retrospective Studies; Tranexamic Acid | 2014 |
Comparison of ε-Aminocaproic Acid and Tranexamic Acid in Reducing Postoperative Transfusions in Total Hip Arthroplasty.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Loss, Surgical; Blood Transfusion; Erythrocyte Transfusion; Female; Hemoglobins; Humans; Male; Middle Aged; Postoperative Period; Retrospective Studies; Tranexamic Acid | 2016 |
Effect of Antifibrinolytic Therapy on Complications, Thromboembolic Events, Blood Product Utilization, and Fusion in Adult Spinal Deformity Surgery.
Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Female; Humans; Male; Middle Aged; Platelet Transfusion; Postoperative Complications; Prospective Studies; Spinal Diseases; Spinal Fusion; Thromboembolism; Tranexamic Acid; Transfusion Reaction | 2016 |
Comparative effectiveness of epsilon-aminocaproic acid and tranexamic acid on postoperative bleeding following cardiac surgery during a national medication shortage.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cohort Studies; Comparative Effectiveness Research; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Retrospective Studies; Tranexamic Acid; Treatment Outcome | 2016 |
Safety of antifibrinolytics in cranial vault reconstructive surgery: a report from the pediatric craniofacial collaborative group.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Child, Preschool; Cooperative Behavior; Craniofacial Abnormalities; Databases, Factual; Female; Humans; Infant; Male; Pediatrics; Plastic Surgery Procedures; Registries; Skull; Tranexamic Acid | 2017 |
Using antifibrinolytics in the peripartum period - concern for a hypercoagulable effect?
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation; Case-Control Studies; Female; Fibrinolytic Agents; Humans; In Vitro Techniques; Obesity; Peripartum Period; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Thrombelastography; Tissue Plasminogen Activator; Tranexamic Acid; Young Adult | 2017 |
Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; Body Mass Index; Female; Hemoglobins; Humans; Male; Middle Aged; Postoperative Hemorrhage; Postoperative Period; Retrospective Studies; Tranexamic Acid | 2018 |
Pharmacologic Hemostatic Agents in Total Joint Arthroplasty-A Cost-Effectiveness Analysis.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; Cohort Studies; Cost-Benefit Analysis; Female; Humans; Male; Models, Economic; Tranexamic Acid | 2018 |
The ratio of concentrations of aminocaproic acid and tranexamic acid that prevent plasmin activation of platelets does not provide equivalent inhibition of plasmatic fibrinolysis.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Fibrinolysin; Fibrinolysis; Humans; Platelet Activation; Tissue Plasminogen Activator; Tranexamic Acid; Viscoelastic Substances | 2018 |
Antifibrinolytic Agents for Hemoptysis Management in Adults With Cystic Fibrosis.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Critical Pathways; Cystic Fibrosis; Drug Monitoring; Female; Hemoptysis; Humans; Male; Tranexamic Acid; Treatment Outcome; United States | 2019 |
Antifibrinolytic Therapy in Surgery for Adolescent Idiopathic Scoliosis Does the Level 1 Evidence Translate to Practice?
Topics: Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Cohort Studies; Female; Humans; Male; Practice Patterns, Physicians'; Registries; Scoliosis; Tranexamic Acid | 2018 |
Bronchoscopic delivery of aminocaproic acid as a treatment for pulmonary bleeding: A case series.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Bronchoscopy; Female; Hemoptysis; Hemorrhage; Humans; Lung; Male; Middle Aged; Postoperative Complications; Retrospective Studies; Tranexamic Acid; Treatment Outcome | 2020 |
Genetic variants associated with Hermansky-Pudlak syndrome.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Platelets; Carrier Proteins; Contusions; Deamino Arginine Vasopressin; Hemorrhage; Hermanski-Pudlak Syndrome; Humans; Hypopigmentation; Lysosomes; Nerve Tissue Proteins; Proteins; Tranexamic Acid | 2020 |
Lysine analogue use during cancer surgery: a survey from a Canadian tertiary care centre.
Topics: Aminocaproic Acid; Blood Loss, Surgical; Humans; Lysine; Neoplasms; Ontario; Surveys and Questionnaires; Tertiary Care Centers; Tranexamic Acid | 2020 |
ε-Aminocaproic acid versus tranexamic acid in children undergoing complex cranial vault reconstruction for repair of craniosynostosis.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Craniosynostoses; Humans; Retrospective Studies; Tranexamic Acid | 2021 |
Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study.
Topics: Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Child; Child, Preschool; Female; Hemorrhage; Humans; Infant; Infant, Newborn; Male; Prospective Studies; Tranexamic Acid | 2022 |
Effects of antifibrinolytics on systemic and cerebral inflammation after traumatic brain injury.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Brain Injuries, Traumatic; Chemokine CCL2; Chemokine CCL3; Cytokines; Inflammation; Interleukin-6; Mice; Tranexamic Acid; Tumor Necrosis Factor-alpha | 2022 |
Comparison of trauma-dosed tranexamic acid versus aminocaproic acid in cardiac surgery in the setting of drug shortage.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Procedures; Humans; Retrospective Studies; Tranexamic Acid | 2022 |
Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Craniosynostoses; Humans; Infant; Seizures; Tranexamic Acid | 2022 |
Tranexamic versus aminocaproic acids in patients with total hip arthroplasty: a retrospective study.
Topics: Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Loss, Surgical; Hemoglobins; Humans; Retrospective Studies; Tranexamic Acid | 2022 |
1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Fibrinolysis; Humans; Molecular Docking Simulation; Tranexamic Acid; Triazoles | 2022 |
Combination of Intravenous and Intra-Articular Application of Tranexamic Acid and Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.
Topics: Administration, Intravenous; Aminocaproic Acid; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid | 2023 |
Epsilon aminocaproic acid is associated with acute kidney injury after life-threatening hemorrhage in children.
Topics: Acute Kidney Injury; Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Female; Hemorrhage; Humans; Male; Tranexamic Acid | 2023 |
Antifibrinolytic agents and seizure risk in neonates undergoing cardiac surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Procedures; Humans; Infant, Newborn; Tranexamic Acid | 2023 |
Efficacy and safety of using aminocaproic acid and tranexamic acid during the perioperative period for treating trochanteric fractures in elderly femurs.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Hip Fractures; Humans; Postoperative Hemorrhage; Postoperative Period; Tranexamic Acid | 2023 |
Evaluation of Therapeutic Use of Antifibrinolytics in Cats.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Cats; Prospective Studies; Retrospective Studies; Tranexamic Acid | 2023 |