Page last updated: 2024-08-23

tramadol and o-demethyltramadol

tramadol has been researched along with o-demethyltramadol in 146 studies

Research

Studies (146)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (4.11)	18.2507
2000's	56 (38.36)	29.6817
2010's	70 (47.95)	24.3611
2020's	14 (9.59)	2.80

Authors

Authors	Studies
Driessen, B; Illes, P; Nieber, K; Sevcik, J	1
Blaschke, G; Elsing, B	1
Bamigbade, TA; Davidson, C; Langford, RM; Stamford, JA	1
Calvo, R; Campanero, MA; Pavón, JM; Trocóniz, IF; Valle, M	1
Blaschke, G; Kurth, B	1
Ceccato, A; Chiap, P; Crommen, J; Hubert, P; Toussaint, B	1
Calvo, R; Garrido, MJ; Pavón, JM; Trocóniz, IF; Valle, M	1
Booker, PD; Lintz, W; Murray, A; Murthy, BV; Pandya, KS; Terlinden, R	1
Friderichs, E; Löscher, W; Potschka, H	1
Calvo, R; Campanero, MA; Garrido, MJ; Trocóniz, IF; Valle, M	1
Ceccato, A; Pabst, JY; Streel, B; Vanderbist, F	1
Gan, SH; Ismail, R	1
Hou, YN; Liu, HC; Liu, TJ; Yang, YY	1
Hou, YN; Hu, YQ; Liu, CS; Liu, HC; Liu, JF; Wang, N	1
Hou, YN; Liu, HC; Wang, N; Yang, YY; Zhang, XJ	1
Borenstein, MR; Codd, EE; Coogan, TP; Desai-Krieger, D; Liao, S; Raffa, RB; Stone, DJ; Tao, Q	1
Hou, YN; Liu, HC; Wang, N; Yu, Y	1
Hou, YN; Liu, CS; Liu, HC; Wang, N	1
Hou, YN; Hu, YQ; Liu, HC; Liu, JF; Wang, N	1
Dios-Vieitez, MC; Garrido, MJ; Rapado, J; Renedo, MJ; Sayar, O; Segura, C; Troconiz, IF	1
Hou, YN; Liu, HC; Wang, N; Wang, YL; Yu, Y	1
Borlak, J; Erb, K; Hermann, R; Thum, T	1
Balzarini, P; Baratelli, E; Bianchi, M; Broggini, M; Ferrario, P; Panerai, AE; Sacerdote, P	1
Jin, SM; Liu, HC; Wang, YL	1
Hong-Yuan, X; Hui-Chen, L; Jian-Fang, L; Ming, D; Na, W; Yang, Y	1
KuKanich, B; Papich, MG	1
Chen, XY; Cui, JJ; Sunita, M; Zhao, LM; Zhong, DF	1
Jin, SM; Liu, HC	1
Fawcett, JP; Gu, Y	1
Horishita, T; Minami, K; Nakamura, M; Ogata, J; Okamoto, T; Sata, T; Shiraishi, M; Terada, T; Uezono, Y	1
Allegaert, K; de Hoon, J; Devlieger, H; Tibboel, D; Van den Anker, JN; Vanhole, C; Verbesselt, R	1
Barann, M; Bönisch, H; Brüss, M; Dorner, Z; Stamer, U; Urban, B	1
Allegaert, K; de Hoon, J; Devlieger, H; Naulaers, G; Rayyan, M; Tibboel, D; Van den Anker, JN; Verbesselt, R	1
Idle, JR; Kvetina, J; Mikoviny, R; Nobilis, M; Perlík, F; Slanar, O; Zima, T	1
Horishita, T; Minami, K; Ogata, J; Okamoto, T; Shigematsu, A; Shiraishi, M; Uezono, Y	1
Madea, B; Musshoff, F; Stamer, UM; Stuber, F	1
Allegaert, K; Cossey, V; de Hoon, J; Debeer, A; Devlieger, H; Tibboel, D; Van den Anker, JN; Verbesselt, R	1
Azanza, JR; Campanero, MA; Cardenas, E; García Quetglas, E; Sádaba, B	1
Ahlner, J; Hägg, S; Jönsson, AK; Tjäderborn, M	1
Hoeft, A; Kobilay, M; Madea, B; Musshoff, F; Stamer, UM; Stuber, F	1
Herbert, MK; Holzer, P; Weis, R	1
Allegaert, K; de Hoon, J; Debeer, A; Rayyan, M; Verbesselt, R	1
Ojanperä, I; Ojanperä, S; Pelander, A; Rasanen, I; Sistonen, J; Vuori, E	1
Ardakani, YH; Rouini, MR	1
de Sousa, AB; de Souza Spinosa, H; Florio, JC; Górniak, SL; Porta, V; Santos, AC; Schramm, SG	1
Ilkiw, JE; Pypendop, BH	1
Bauer, S; Brockmöller, J; Keulen, JT; Kirchheiner, J; Roots, I	1
Ardakani, YH; Foroumadi, A; Mehvar, R; Rouini, MR	1
Christmas, T; Chua, S; Goy, R; Ilett, KF; Kristensen, JH; Paech, MJ; Page-Sharp, M; Scott, KL; Sy, SK	1
Allegaert, K; Anderson, BJ; de Hoon, JN; Debeer, A; Naulaers, G; Tibboel, D; van den Anker, JN; van Schaik, RH	1
Giorgi, M; Kowalski, C; Lebkowska-Wieruszewska, B; Saccomanni, G	1
Raffa, RB	1
Allegaert, K; Cossey, V; de Hoon, J; van den Anker, JN; van Fessem, M; van Schaik, RH; Vanhole, C; Verbesselt, R; Vermeersch, S	1
Imre, S; Leucuta, SE; Vlase, L	1
Cox, SK; Greenacre, CB; Souza, MJ	1
Higashiyama, K; Miyoshi, K; Nakamura, A; Narita, M; Okutsu, D; Shindo, K; Suzuki, M; Suzuki, T	1
Clark, CR; Dowling, PM; Duke, T; Livingston, A; McMillan, CJ; Taylor, SM; Terlinden, R	1
Bressolle, F; Capdevila, X; Dadure, C; Khier, S; Ouaki, J; Rochette, A	1
Chytil, L; Matousková, O; Perlík, F; Slanar, O; Stícha, M	1
Daali, Y; Dayer, P; Desmeules, J; Kanaan, M	1
Del Carlo, S; Giorgi, M; Kowalski, CJ; Saccomanni, G; Łebkowska-Wieruszewska, B	1
Brosen, K; Damkier, P; Larsen, F; Noehr-Jensen, L; Sindrup, SH; Zwisler, ST	1
Cerná, O; Chytil, L; Matousková, O; Perlík, F; Pokorná, P; Slanar, O; Vobruba, V	1
Cronje, T; Groenewoud, G; Karhu, D; Potgieter, MA	1
Akgül, O; Aypar, U; Dogrul, A; Kozak, O; Kurt, E; Sahin, A; Seyrek, M; Sizlan, A; Yanarates, O; Yildirim, V	1
Brosen, K; Damkier, P; Nielsen, AG; Noehr-Jensen, L; Pedersen, RS	1
Guo, Y; Li, Q; Wang, R; Wang, S; Wen, S; Xu, L	1
Aitio, O; Finel, M; Kostiainen, R; Kurkela, M; Lehtonen, P; Sten, T; Vuorensola, K	1
Leppert, W; Mikolajczak, P	1
Charlier, C; De Backer, B; Denooz, R; Renardy, F	1
Arndt, T; Claussen, U; Güssregen, B; Schröfel, S; Stürzer, B; Werle, A; Wolf, G	1
Bansal, YK; Joshi, SS; Kadam, SS; Khandave, SS; Sawant, SV	1
Tytgat, J; Verplaetse, R	1
Black, PA; Cox, SK; Junge, RE; Macek, M; Tieber, A	1
Minami, K; Ogata, J; Uezono, Y; Yokoyama, T	1
Carvalho, TM; De Moraes, NV; Godoy, AL; Lanchote, VL; Marques, MP; Martinez, EZ	1
Ilett, KF; Paech, MJ; Page-Sharp, M; Salman, S; Sy, SK	1
Eriksson, A; Kronstrand, R; Roman, M; Thelander, G	1
Allorge, D; Broly, F; Elkalioubie, A; Fourrier, F; Garat, A; Robriquet, L; Wiart, JF	1
Boothe, DM; Cruz-Espindola, C; Mitchum, EJ; Springfield, J; Stewart, AJ	1
Püttmann, W; Rúa-Gómez, PC	3
Buono, C; Ly, BT; Stone, JA; Thornton, SL; Wu, AH	1
de Moraes, NV; Godoy, AL; Lanchote, VL; Lauretti, GR; Napolitano, MN; Santos, NR	1
Coller, JK; Colvill, J; Farquharson, AL; James, HM; Michalakas, JR; Somogyi, AA; White, JM	1
Häkkinen, M; Launiainen, T; Ojanperä, I; Vuori, E	1
Chericoni, S; El-Shihi, TH; Emara, MM; Giorgi, M; Giusiani, M; Mahdy, T	1
Hagelberg, NM; Laine, K; Neuvonen, M; Neuvonen, PJ; Olkkola, KT; Saari, TI; Saarikoski, T; Scheinin, M; Turpeinen, M	1
Baumgartner, MR; Guglielmello, R; Kraemer, T; Madry, MM; Rust, KY	1
Carvalho, F; Costa, I; Dinis-Oliveira, RJ; Gouveia, CA; Moreira, RF; Oliveira, A; Pinho, S	1
Button, J; El-Sayed, AA; Holt, DW; Mohamed, KM; Nasser, AY	1
Barbera, N; Bosco, A; Fisichella, M; Indorato, F; Romano, G; Spadaro, G	1
Arjunan, V; Marchewka, MK; Mohan, S; Santhanam, R	1
Cai, L; Cai, XJ; Jiang, B; Lv, XQ; Wang, GX; Xu, J; Xu, YY; Zhang, XC	1
Bastami, S; Haage, P; Kronstrand, R; Kugelberg, FC; Uppugunduri, S; Zackrisson, AL	1
Bronson, E; Cox, SK; Kilburn, JJ; Kottyan, J; Wack, AN	1
Giorgi, M; Kim, TW; Marini, C; Meligrana, M; Vullo, C	1
Logan, BK; Scott, TM; Yeakel, JK	1
Amorim, J; Axiak-Bechtel, SM; DeClue, A; Dodam, J; Donaldson, R; Honaker, A; Lino, G; Monibi, F; Tsuruta, K	1
Watterson, JH; Wiebe, TR	1
Cagnardi, P; Ferraresi, C; Pecile, A; Ravasio, G; Villa, R; Zani, DD; Zonca, A	1
Allegaert, K; Anderson, BJ; Beier, H; de Hoon, JN; Holford, N; Holford, S; Pedersen, RS; Rochette, A; Stamer, U; Stuber, F; Trocóniz, IF	1
Dong, G; Gao, X; Han, X; Li, J; Liu, M; Wang, Q; Wang, Y; Yue, J	1
Minami, K; Miyano, K; Murphy, RS; Sudo, Y; Uezono, Y	1
Erdem, AF; Yilmaz, B	1
Chae, SW; Im, YJ; Jeon, JY; Kim, EY; Kim, MG; Kim, Y; Oh, DJ; Shin, DH; Yoo, JS	1
Matoba, M; Minami, K; Miyano, K; Murakami, S; Ohbuchi, K; Shiraishi, S; Uezono, Y; Yamaguchi, T; Yamamoto, M; Yokoyama, T	1
Funai, Y; Funao, T; Mori, T; Nishikawa, K; Yamasaki, H	1
Cox, S; Hupp, A; Kaylor, M; Nelson, SE; Norton, TM; Sladky, KK; Thomas, R	1
Bortolami, E; De Benedictis, GM; Della Rocca, G; Di Salvo, A; Giorgi, M; Isola, M; Kim, TW	1
Benitez, ME; KuKanich, B; McMurphy, R; Roush, JK	1
Barbosa, L; Boonstra, JL; Cox, SK; Gulland, FM; Johnson, SP; Martin-Jimenez, T; Van Bonn, WG	1
Srinivas, NR	1
Beck, O; Meyer, MR; Rosenborg, S; Stenberg, M	1
Bouchard, S; Fradette, C; Mouksassi, MS; Skinner-Robertson, S; Varin, F	1
Carlsson, B; Haage, P; Josefsson, M; Kronstrand, R; Kugelberg, FC	1
Knych, HK; McKemie, DS; Steffey, EP; White, AM	1
Allegaert, K; Annaert, P; de Hoon, JN; de Wildt, SN; Elens, L; Matic, M; Tibboel, D; van Schaik, RH	1
Brockmöller, J; Musshoff, F; Stamer, UM; Steffens, M; Stüber, F; Tzvetkov, MV	1
Kästner, SBR; Schütter, AF; Tünsmeyer, J	1
Bairam, AF; Kurogi, K; Liu, MC; Rasool, MI	1
Arras, M; Avenel, F; Bergadano, A; Draganov, DI; Evangelista Vaz, R; Rapp, C; Steiner, G	1
Jang, JH; Jang, WJ; Jeong, CH; Lee, S; Park, B; Seo, YH; Yu, H	1
Arafa, MH; Atteia, HH	1
Encabo, M; Encina, G; Escriche, M; Gascon, N; Lahjou, M; Plata-Salamán, C; Sicard, E; Smith, K; Videla, S	1
Hiraide, T; Kawakami, J; Naito, T; Sato, H; Tanaka, H; Yamada, Y	1
Court, MH; Greene, SA; Grubb, TL; Joo, H; Kukanich, B; Mealey, KL; Perez Jimenez, TE	1
Agüera, A; Campos-Mañas, MC; Ferrer, I; Sánchez Pérez, JA; Thurman, EM	1
Heller, NM; Maher, DP; Walia, D	1
Johnson, MS; Kahn, SJ; Maeda, DY; Schuler, AD; Searle, SL; Webster, LR; Zebala, JA	1
Itoh, K; Kawakami, J; Naito, T; Suzuki, K; Tanaka, H; Yamada, Y	1
Govendir, M; Izes, AM; Kimble, B	1
Angelova, S; Gaugler, S; Längin, A; Luginbühl, M; Weinmann, W	1
Itoh, K; Kawakami, J; Naito, T; Shibata, K; Suzuki, K; Tanaka, H; Yamada, Y	1
Dang, LTVL; Haage, P; Johansen, SS; Kronstrand, R; Kugelberg, FC; Nielsen, MKK	1
Govendir, M; Kimble, B; Valtchev, P; Vogelnest, L	1
Bujalska-Zadrożny, M; Buś-Kwaśnik, K; Filist, M; Gilant, E; Jarus-Dziedzic, K; Leś, A; Nagraba, Ł; Rudzki, PJ; Sasinowska-Motyl, M	1
Al-Qurain, AA; Mackenzie, L; Roberts, MS; Wiese, MD; Williams, DB	1
Abd El Rahman, HA; Abdalla, HA; Ahmed, DAM; Helmy, MA	1
Cicali, B; Cristofoletti, R; Dow, P; Long, T; Michaud, V; Schmidt, S; Turgeon, J	1
Hua, AJ; Lim, LY; Nguyen, MN; Salman, S; Tang, EKY; von Ungern Sternberg, BS; Yoo, O	1
Castro, AL; da Costa, MJCSP; Franco, JM; Russo, F; Sousa, L; Tarelho, S	1
Aertgeerts, B; Bertels, X; Bonmariage, P; Boogaerts, T; Covaci, A; De Loof, H; Hamelinck, W; Lahousse, L; Pussig, B; Quireyns, M; Saevels, J; van Nuijs, ALN; Van Wichelen, N	1
Fu, W; Huang, X; Li, W; Liu, J; Qian, Y; Shen, Q; Xu, X	1
Fu, W; Huang, H; Li, W; Liu, J; Wang, W; Wang, Y; Xu, X; Zhu, C	1

Reviews

3 review(s) available for tramadol and o-demethyltramadol

Article	Year
Basic pharmacology relevant to drug abuse assessment: tramadol as example. Journal of clinical pharmacy and therapeutics, 2008, Volume: 33, Issue:2 Topics: Analgesics, Opioid; Animals; Brain; Cytochrome P-450 CYP2D6; Humans; Narcotics; Substance-Related Disorders; Tramadol	2008
Quantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication. Journal of analytical toxicology, 2010, Volume: 34, Issue:9 Topics: Adolescent; Aged; Analgesics, Opioid; Drug Overdose; Fatal Outcome; Female; Forensic Toxicology; Humans; Substance Abuse Detection; Tramadol	2010
HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Nov-01, Volume: 1184 Topics: Adult; Child; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Linear Models; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tramadol	2021

Trials

33 trial(s) available for tramadol and o-demethyltramadol

Article	Year
Pharmacokinetics of tramadol in children after i.v. or caudal epidural administration. British journal of anaesthesia, 2000, Volume: 84, Issue:3 Topics: Analgesia; Analgesia, Epidural; Analgesics, Opioid; Child; Child, Preschool; Half-Life; Humans; Infant; Injections, Intravenous; Tramadol	2000
Pharmacokinetics of enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in human subjects. Acta pharmacologica Sinica, 2001, Volume: 22, Issue:1 Topics: Adolescent; Adult; Analgesics, Opioid; Electrophoresis, Capillary; Humans; Male; Stereoisomerism; Tramadol	2001
A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol. Metabolism: clinical and experimental, 2003, Volume: 52, Issue:11 Topics: Adult; Alleles; Analgesics, Opioid; Area Under Curve; Biotransformation; Cost-Benefit Analysis; Cytochrome P-450 CYP2D6; DNA; Female; Genetic Testing; Genotype; Heterozygote; Humans; In Situ Hybridization; Male; Phenotype; Polymorphism, Restriction Fragment Length; Reverse Transcriptase Polymerase Chain Reaction; Tramadol	2003
Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol. International immunopharmacology, 2003, Volume: 3, Issue:13-14 Topics: Acetaminophen; Administration, Oral; Aged; Double-Blind Method; Female; Humans; Interleukin-6; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Prospective Studies; Substance P; Synovial Fluid; Time Factors; Tramadol	2003
Pharmacokinetics of the enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in healthy male and female chinese volunteers. Chirality, 2004, Volume: 16, Issue:2 Topics: Adolescent; Adult; Asian People; Body Weight; China; Chromatography, High Pressure Liquid; Female; Health; Humans; Male; Stereoisomerism; Tramadol	2004
Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs. Journal of veterinary pharmacology and therapeutics, 2004, Volume: 27, Issue:4 Topics: Administration, Oral; Analgesics, Opioid; Animals; Area Under Curve; Cross-Over Studies; Dogs; Female; Injections, Intravenous; Male; Tramadol	2004
O-demethylation of tramadol in the first months of life. European journal of clinical pharmacology, 2005, Volume: 61, Issue:11 Topics: Aging; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Half-Life; Humans; Infant; Infant, Newborn; Linear Models; Narcotics; Tramadol	2005
Stereoselective pharmacokinetic analysis of tramadol and its main phase I metabolites in healthy subjects after intravenous and oral administration of racemic tramadol. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:1 Topics: Administration, Oral; Adult; Analgesics, Opioid; Female; Humans; Infusions, Intravenous; Male; Models, Biological; Stereoisomerism; Tramadol	2007
Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes. Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:1 Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Genotype; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Phenotype; Polymorphism, Single Nucleotide; Stereoisomerism; Tandem Mass Spectrometry; Tramadol; Treatment Outcome	2007
Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:9 Topics: Administration, Oral; Adult; Analgesics, Opioid; Area Under Curve; Female; Half-Life; Humans; Iran; Male; Phenotype; Polymorphism, Genetic; Sex Factors; Tramadol	2007
Pharmacokinetics of tramadol and o-desmethyltramadol in goats after intravenous and oral administration. Journal of veterinary pharmacology and therapeutics, 2008, Volume: 31, Issue:1 Topics: Administration, Oral; Analgesics, Opioid; Animals; Area Under Curve; Female; Goats; Injections, Intravenous; Tramadol	2008
Pharmacokinetics of tramadol, and its metabolite O-desmethyl-tramadol, in cats. Journal of veterinary pharmacology and therapeutics, 2008, Volume: 31, Issue:1 Topics: Administration, Oral; Analgesics, Opioid; Animals; Area Under Curve; Cats; Female; Injections, Intravenous; Tramadol	2008
Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Pediatric research, 2008, Volume: 63, Issue:6 Topics: Analgesics, Opioid; Biotransformation; Birth Weight; Critical Illness; Cytochrome P-450 CYP2D6; Dealkylation; Drug Administration Schedule; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infusions, Intravenous; Models, Biological; Pharmacogenetics; Polymorphism, Genetic; Tramadol	2008
Pharmacokinetics of intravenous tramadol in dogs. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2008, Volume: 72, Issue:4 Topics: Analgesics, Opioid; Animals; Area Under Curve; Chromatography, Gas; Cross-Over Studies; Dogs; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Male; Respiration; Tramadol	2008
Pharmacokinetics of tramadol and its major metabolites following rectal and intravenous administration in dogs. New Zealand veterinary journal, 2009, Volume: 57, Issue:3 Topics: Administration, Rectal; Analgesics, Opioid; Animals; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Dogs; Half-Life; Injections, Intravenous; Male; Suppositories; Tramadol	2009
Escitalopram is a weak inhibitor of the CYP2D6-catalyzed O-demethylation of (+)-tramadol but does not reduce the hypoalgesic effect in experimental pain. Clinical pharmacology and therapeutics, 2009, Volume: 86, Issue:6 Topics: Adult; Analgesics, Opioid; Biotransformation; Citalopram; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dealkylation; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Pain; Pain Measurement; Reflex, Pupillary; Selective Serotonin Reuptake Inhibitors; Tramadol; Young Adult	2009
Enantiomeric determination of tramadol and O-desmethyltramadol in human plasma by fast liquid chromatographic technique coupled with mass spectrometric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Feb-01, Volume: 878, Issue:3-4 Topics: Calibration; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Humans; Limit of Detection; Mass Spectrometry; Phenotype; Reproducibility of Results; Solid Phase Extraction; Stereoisomerism; Time Factors; Tramadol	2010
Comparative bioavailability of two once-daily tramadol HCl 200 mg extended-release products in healthy volunteers. International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Analysis of Variance; Area Under Curve; Biological Availability; Chromatography, Liquid; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Male; Single-Blind Method; Tandem Mass Spectrometry; Therapeutic Equivalency; Tramadol; Young Adult	2010
Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's O-demethylation via CYP2D6. European journal of clinical pharmacology, 2010, Volume: 66, Issue:7 Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Paroxetine; Pupil; Tramadol	2010
Relationship of CYP2D6 genetic polymorphisms and the pharmacokinetics of tramadol in Chinese volunteers. Journal of clinical pharmacy and therapeutics, 2010, Volume: 35, Issue:2 Topics: Administration, Oral; Adult; Analgesics, Opioid; China; Cytochrome P-450 CYP2D6; Female; Heterozygote; Homozygote; Humans; Male; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Tramadol	2010
Comparative bioequivalence studies of tramadol hydrochloride sustained-release 200 mg tablets. Drug design, development and therapy, 2010, Nov-25, Volume: 4 Topics: Administration, Oral; Adult; Analgesics, Opioid; Chromatography, Liquid; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drugs, Generic; Humans; Least-Squares Analysis; Male; Mass Spectrometry; Solubility; Tablets; Therapeutic Equivalency; Tramadol; Young Adult	2010
Pharmacokinetics of tramadol hydrochloride and its metabolite O-desmethyltramadol in peafowl (Pavo cristatus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2010, Volume: 41, Issue:4 Topics: Administration, Oral; Analgesics, Opioid; Animals; Area Under Curve; Female; Galliformes; Half-Life; Male; Pilot Projects; Tramadol	2010
Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients. British journal of clinical pharmacology, 2012, Volume: 74, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Tramadol; Young Adult	2012
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction. European journal of clinical pharmacology, 2013, Volume: 69, Issue:4 Topics: Adult; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Humans; Itraconazole; Kidney; Male; Metabolic Clearance Rate; Oxidoreductases, N-Demethylating; Ticlopidine; Tramadol; Young Adult	2013
An assessment of the pharmacokinetics of a sustained-release formulation of a tramadol/acetaminophen combination in healthy subjects. Clinical therapeutics, 2015, Feb-01, Volume: 37, Issue:2 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Healthy Volunteers; Humans; Male; Middle Aged; Tablets; Tramadol	2015
PHARMACOKINETICS OF TRAMADOL AND O-DESMETHYLTRAMADOL IN LOGGERHEAD SEA TURTLES (CARETTA CARETTA). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2015, Volume: 46, Issue:2 Topics: Analgesics, Opioid; Animals; Cross-Over Studies; Half-Life; Statistics as Topic; Tramadol; Turtles	2015
Pharmacokinetics of hydrocodone and tramadol administered for control of postoperative pain in dogs following tibial plateau leveling osteotomy. American journal of veterinary research, 2015, Volume: 76, Issue:9 Topics: Acetaminophen; Analgesics, Opioid; Animals; Area Under Curve; Dogs; Half-Life; Hydrocodone; Hydromorphone; Osteotomy; Pain, Postoperative; Tramadol	2015
Effects of age on the pharmacokinetics of tramadol and its active metabolite, O-desmethyltramadol following intravenous administration to foals. Equine veterinary journal, 2016, Volume: 48, Issue:1 Topics: Analgesics, Opioid; Animals; Animals, Newborn; Area Under Curve; Female; Half-Life; Horse Diseases; Horses; Male; Tramadol	2016
Influence of tramadol on acute thermal and mechanical cutaneous nociception in dogs. Veterinary anaesthesia and analgesia, 2017, Volume: 44, Issue:2 Topics: Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Nociception; Skin; Skin Physiological Phenomena; Tramadol	2017
The Effect of Food on Tramadol and Celecoxib Bioavailability Following Oral Administration of Co-Crystal of Tramadol-Celecoxib (CTC): A Randomised, Open-Label, Single-Dose, Crossover Study in Healthy Volunteers. Clinical drug investigation, 2018, Volume: 38, Issue:9 Topics: Adolescent; Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Celecoxib; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Drug Combinations; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Male; Middle Aged; Tramadol; Young Adult	2018
Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:1 Topics: Administration, Oral; Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Drug Interactions; Female; Fluconazole; Male; Pain; Random Allocation; Tramadol	2019
Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials. The journal of pain, 2019, Volume: 20, Issue:10 Topics: Adult; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Double-Blind Method; Female; Humans; Male; Pain Perception; Tramadol; Young Adult	2019
Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies. Pharmacological reports : PR, 2021, Volume: 73, Issue:2 Topics: Administration, Oral; Adult; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Magnesium; Male; Tramadol; Young Adult	2021

Other Studies

110 other study(ies) available for tramadol and o-demethyltramadol

Article	Year
Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones. British journal of pharmacology, 1993, Volume: 110, Issue:1 Topics: Action Potentials; Animals; Extracellular Space; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Naloxone; Neurons; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Stereoisomerism; Tramadol; Yohimbine	1993
Achiral and chiral high-performance liquid chromatographic determination of tramadol and its major metabolites in urine after oral administration of racemic tramadol. Journal of chromatography, 1993, Feb-26, Volume: 612, Issue:2 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Stereoisomerism; Tramadol	1993
Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus. British journal of anaesthesia, 1997, Volume: 79, Issue:3 Topics: Analgesics, Opioid; Animals; Culture Techniques; Electric Stimulation; Male; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Tramadol	1997
Simultaneous determination of tramadol and its major active metabolite O-demethyltramadol by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical sciences and applications, 1999, Mar-05, Volume: 724, Issue:1 Topics: Analgesics, Opioid; Animals; Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tramadol	1999
Achiral and chiral determination of tramadol and its metabolites in urine by capillary electrophoresis. Electrophoresis, 1999, Volume: 20, Issue:3 Topics: Analgesics, Opioid; Calibration; Electrophoresis, Capillary; Humans; Molecular Structure; Tramadol	1999
Automated sample preparation techniques for the determination of drug enantiomers in biological fluids using liquid chromatography with chiral stationary phases. Enantiomer, 1999, Volume: 4, Issue:3-4 Topics: Buffers; Chromatography, Liquid; Humans; Mephobarbital; Oxprenolol; Pharmaceutical Preparations; Pindolol; Stereoisomerism; Tramadol	1999
Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effects of main active metabolites of tramadol, (+)-O-desmethyltramadol and (-)-O-desmethyltramadol, in rats. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:2 Topics: Algorithms; Analgesics, Opioid; Animals; Hydrogen-Ion Concentration; Male; Models, Biological; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Stereoisomerism; Time Factors; Tramadol	2000
Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy. British journal of pharmacology, 2000, Volume: 131, Issue:2 Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Kindling, Neurologic; Male; Rats; Rats, Wistar; Stereoisomerism; Tramadol	2000
Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1 Topics: Analgesics, Opioid; Animals; Drug Interactions; Male; Models, Biological; Neurotransmitter Uptake Inhibitors; Rats; Rats, Sprague-Dawley; Respiration; Stereoisomerism; Tramadol	2000
Enantiomeric determination of tramadol and its main metabolite O-desmethyltramadol in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications, 2000, Oct-01, Volume: 748, Issue:1 Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tramadol	2000
Validation of a high-performance liquid chromatography method for tramadol and o-desmethyltramadol in human plasma using solid-phase extraction. Journal of chromatography. B, Biomedical sciences and applications, 2001, Aug-15, Volume: 759, Issue:2 Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Humans; Pain, Postoperative; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tramadol	2001
Distribution of enantiomers of trans-tramadol and trans-O-demethyltramadol in central nervous system of rats. Acta pharmacologica Sinica, 2001, Volume: 22, Issue:10 Topics: Animals; Blood-Brain Barrier; Brain; Central Nervous System; Female; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tissue Distribution; Tramadol	2001
Stereoselectivity in renal clearance of trans-tramadol and its active metabolite, trans-O-demethyltramadol. Acta pharmacologica Sinica, 2002, Volume: 23, Issue:1 Topics: Analgesics, Opioid; Animals; Electrophoresis, Capillary; In Vitro Techniques; Kidney; Male; Metabolic Clearance Rate; Perfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol	2002
Differential tramadol and O-desmethyl metabolite levels in brain vs. plasma of mice and rats administered tramadol hydrochloride orally. Journal of clinical pharmacy and therapeutics, 2002, Volume: 27, Issue:2 Topics: Administration, Oral; Analgesics, Opioid; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Male; Mice; Rats; Tramadol	2002
Stereoselectivity in trans-tramadol metabolism and trans-O-demethyltramadol formation in rat liver microsomes. Acta pharmacologica Sinica, 2003, Volume: 24, Issue:1 Topics: Analgesics, Opioid; Animals; Dextromethorphan; Fluoxetine; Male; Microsomes, Liver; Propafenone; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol	2003
[Stereoselectivity in O-demethylation of trans tramadol in rat liver microsomes in vitro]. Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:3 Topics: Analgesics, Opioid; Animals; Cell Separation; Male; Microsomes, Liver; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol	2002
[Transportation of the enantiomers of trans tramadol and O-demethyltramadol across blood-brain barrier]. Yao xue xue bao = Acta pharmaceutica Sinica, 2001, Volume: 36, Issue:9 Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Cerebral Cortex; Cerebrospinal Fluid; Female; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol	2001
Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2 Topics: Algorithms; Analgesics, Opioid; Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Infusions, Intravenous; Male; Models, Biological; Quinine; Rats; Rats, Wistar; Tramadol	2003
[Stereoselectivity in biliary excretion of trans tramadol and trans O-demethyltramadol in rats]. Yao xue xue bao = Acta pharmaceutica Sinica, 2003, Volume: 38, Issue:6 Topics: Analgesics, Opioid; Animals; Bile; Female; Glucuronic Acid; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol	2003
Gender-related differences in pharmacokinetics of enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in rats. Acta pharmacologica Sinica, 2003, Volume: 24, Issue:12 Topics: Animals; Area Under Curve; Female; Male; Narcotics; Rats; Rats, Sprague-Dawley; Sex Factors; Stereoisomerism; Tramadol	2003
[Determination of tramadol and its active metabolite O-desmethyltramadol in plasma and amniotic fluid using LC/MS/MS]. Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:6 Topics: Amniotic Fluid; Chromatography, High Pressure Liquid; Female; Fetus; Gas Chromatography-Mass Spectrometry; Humans; Pregnancy; Spectrometry, Mass, Electrospray Ionization; Tramadol; Umbilical Arteries; Umbilical Veins	2004
[Gender-related differences in metabolism of the enantiomers of trans tramadol and trans O-demethyltramadol in rat liver microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:8 Topics: Analgesics, Opioid; Animals; Female; Glucuronic Acid; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sex Factors; Stereoisomerism; Tramadol	2004
Improved HPLC method for the simultaneous determination of tramadol and O-desmethyltramadol in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Jul-25, Volume: 821, Issue:2 Topics: Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Tramadol	2005
The effects of the tramadol metabolite O-desmethyl tramadol on muscarinic receptor-induced responses in Xenopus oocytes expressing cloned M1 or M3 receptors. Anesthesia and analgesia, 2005, Volume: 101, Issue:1 Topics: Acetylcholine; Animals; Cloning, Molecular; Female; Humans; Oocytes; Protein Kinase C; Receptor, Muscarinic M1; Receptor, Muscarinic M3; RNA, Complementary; Tramadol; Xenopus laevis	2005
Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis. European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3 Topics: Analgesics, Opioid; Cell Line; Citalopram; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Receptors, Serotonin, 5-HT3; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tramadol; Tritium; Vomiting	2006
Contribution of glucuronidation to tramadol disposition in early neonatal life. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:1 Topics: Analgesics, Opioid; Glucuronides; Glucuronosyltransferase; Humans; Infant; Infant, Newborn; Isoenzymes; Tramadol	2006
Miotic action of tramadol is determined by CYP2D6 genotype. Physiological research, 2007, Volume: 56, Issue:1 Topics: Adult; Alleles; Analgesics, Opioid; Area Under Curve; Biotransformation; Cytochrome P-450 CYP2D6; Dark Adaptation; Genotype; Half-Life; Humans; Reflex, Pupillary; Tramadol	2007
The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes. Pharmacology, 2006, Volume: 77, Issue:2 Topics: Animals; Female; In Vitro Techniques; Indoles; Maleimides; Oocytes; Protein Kinase C; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Tramadol; Xenopus laevis	2006
Enantiomeric determination of tramadol and O-desmethyltramadol by liquid chromatography- mass spectrometry and application to postoperative patients receiving tramadol. Journal of analytical toxicology, 2006, Volume: 30, Issue:7 Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Drug Monitoring; Humans; Isomerism; Mass Spectrometry; Pain, Postoperative; Postoperative Period; Reproducibility of Results; Tramadol	2006
Maturational changes in the in vivo activity of CYP3A4 in the first months of life. International journal of clinical pharmacology and therapeutics, 2006, Volume: 44, Issue:7 Topics: Age Factors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Infant, Newborn; Linear Models; Tramadol	2006
Fatal unintentional intoxications with tramadol during 1995-2005. Forensic science international, 2007, Dec-20, Volume: 173, Issue:2-3 Topics: Accidents; Adolescent; Adult; Aged; Analgesics, Opioid; Central Nervous System Depressants; Ethanol; Female; Forensic Toxicology; Humans; Male; Middle Aged; Substance-Related Disorders; Sweden; Tramadol	2007
The enantiomers of tramadol and its major metabolite inhibit peristalsis in the guinea pig small intestine via differential mechanisms. BMC pharmacology, 2007, Mar-16, Volume: 7 Topics: Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Intestine, Small; Male; Peristalsis; Stereoisomerism; Tramadol	2007
Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life. Methods and findings in experimental and clinical pharmacology, 2007, Volume: 29, Issue:4 Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Feasibility Studies; Glucuronosyltransferase; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Isoenzymes; Liver; Reproducibility of Results; Substrate Specificity; Tramadol	2007
Quantification of drugs in plasma without primary reference standards by liquid chromatography-chemiluminescence nitrogen detection: application to tramadol metabolite ratios. Therapeutic drug monitoring, 2007, Volume: 29, Issue:4 Topics: Analgesics, Opioid; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Humans; Luminescent Measurements; Nitrogen; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tramadol	2007
Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:1 Topics: Adolescent; Adult; Aged; Alleles; Analgesics, Opioid; Area Under Curve; Cytochrome P-450 CYP2D6; Gene Duplication; Genotype; Humans; Male; Middle Aged; Tramadol	2008
Enantioselective determination of tramadol and its main phase I metabolites in human plasma by high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Mar-15, Volume: 864, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Kinetics; Orosomucoid; Quality Control; Sensitivity and Specificity; Stereoisomerism; Tramadol	2008
Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk. British journal of clinical pharmacology, 2008, Volume: 65, Issue:5 Topics: Adult; Analgesics, Opioid; Breast Feeding; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Infant, Newborn; Milk, Human; Pregnancy; Tramadol	2008
Covariates of tramadol disposition in the first months of life. British journal of anaesthesia, 2008, Volume: 100, Issue:4 Topics: Aging; Analgesics, Opioid; Creatine; Cytochrome P-450 CYP2D6; Genotype; Humans; Infant; Infant, Newborn; Infant, Premature; Models, Biological; Prospective Studies; Tramadol	2008
Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study. Veterinary journal (London, England : 1997), 2009, Volume: 180, Issue:2 Topics: Animals; Delayed-Action Preparations; Dogs; Male; Pilot Projects; Tramadol	2009
Determination of tramadol and O-desmethyltramadol in human plasma by high-performance liquid chromatography with mass spectrometry detection. Talanta, 2008, May-30, Volume: 75, Issue:4 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Time Factors; Tramadol	2008
Pharmacokinetics of orally administered tramadol in domestic rabbits (Oryctolagus cuniculus). American journal of veterinary research, 2008, Volume: 69, Issue:8 Topics: Analgesia; Animals; Chromatography, High Pressure Liquid; Female; Humans; Narcotics; Rabbits; Tramadol	2008
Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice. Psychopharmacology, 2008, Volume: 200, Issue:3 Topics: Animals; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Subcutaneous; Ligation; Male; Mice; Mice, Inbred ICR; Neural Inhibition; Neuralgia; Nucleus Accumbens; Pain Threshold; Reaction Time; Receptors, Opioid, mu; Reward; Sciatic Nerve; Tramadol; Ventral Tegmental Area	2008
Population pharmacokinetics of the two enantiomers of tramadol and O-demethyl tramadol after surgery in children. British journal of anaesthesia, 2009, Volume: 102, Issue:3 Topics: Analgesics, Opioid; Body Weight; Child; Child, Preschool; Drug Administration Schedule; Gastroesophageal Reflux; Humans; Infant; Models, Chemical; Pain Measurement; Pain, Postoperative; Postoperative Care; Stereoisomerism; Tramadol	2009
Enatiomeric determination of tramadol and O-desmethyltramadol in human urine by gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Jul-01, Volume: 877, Issue:20-21 Topics: Analgesics, Opioid; Gas Chromatography-Mass Spectrometry; Humans; Solid Phase Extraction; Stereoisomerism; Tramadol	2009
Uptake/efflux transport of tramadol enantiomers and O-desmethyl-tramadol: focus on P-glycoprotein. Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:3 Topics: Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Electric Impedance; Humans; Hydrogen-Ion Concentration; Stereoisomerism; Tramadol	2009
Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, O-Desmethyltramadol, via activation of descending serotonergic pathways. Anesthesiology, 2010, Volume: 112, Issue:3 Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Neural Pathways; Pain; Pain Measurement; Pain, Postoperative; Reaction Time; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Tramadol	2010
Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, Nov-20, Volume: 41, Issue:3-4 Topics: Analgesics; Gene Expression Regulation, Enzymologic; Glucuronides; Glucuronosyltransferase; Humans; Molecular Structure; Protein Isoforms; Spectrometry, Mass, Electrospray Ionization; Tramadol	2010
Analgesic effects and assays of controlled-release tramadol and o-desmethyltramadol in cancer patients with pain. Current pharmaceutical biotechnology, 2011, Feb-01, Volume: 12, Issue:2 Topics: Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Codeine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Neoplasms; Pain; Pain Measurement; Tramadol	2011
Kratom alkaloids and O-desmethyltramadol in urine of a "Krypton" herbal mixture consumer. Forensic science international, 2011, May-20, Volume: 208, Issue:1-3 Topics: Adult; Alkaloids; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Mitragyna; Plant Extracts; Plant Leaves; Secologanin Tryptamine Alkaloids; Substance Abuse Detection; Substance-Related Disorders; Tramadol	2011
Development and validation of a sensitive UPLC-MS/MS method for the analysis of narcotic analgesics in urine and whole blood in forensic context. Forensic science international, 2012, Feb-10, Volume: 215, Issue:1-3 Topics: Analgesics, Opioid; Analysis of Variance; Buprenorphine; Chromatography, Liquid; Fentanyl; Forensic Toxicology; Humans; Meperidine; Pirinitramide; Regression Analysis; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tilidine; Tramadol	2012
The tramadol metabolite O-desmethyl tramadol inhibits substance P-receptor functions expressed in Xenopus oocytes. Journal of pharmacological sciences, 2011, Volume: 115, Issue:3 Topics: Analgesics, Opioid; Animals; Chloride Channels; Indoles; Maleimides; Neurokinin-1 Receptor Antagonists; Oocytes; Protein Kinase Inhibitors; Receptors, Neurokinin-1; Substance P; Tramadol; Xenopus	2011
Simultaneous analysis of tramadol, O-desmethyltramadol, and N-desmethyltramadol enantiomers in rat plasma by high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics. Chirality, 2011, Volume: 23, Issue:4 Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Chromatography, Liquid; Male; Plasma; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry; Tramadol	2011
Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk. European journal of clinical pharmacology, 2011, Volume: 67, Issue:9 Topics: Adult; Analgesics, Opioid; Cesarean Section; Cytochrome P-450 CYP2D6; Drug Administration Schedule; Female; Humans; Milk, Human; Models, Biological; Nonlinear Dynamics; Pain, Postoperative; Polymorphism, Genetic; Predictive Value of Tests; Tissue Distribution; Tramadol	2011
Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. Journal of analytical toxicology, 2011, Volume: 35, Issue:4 Topics: Adult; Diagnosis; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Narcotics; Plant Extracts; Secologanin Tryptamine Alkaloids; Tramadol; Young Adult	2011
Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer. European journal of clinical pharmacology, 2011, Volume: 67, Issue:8 Topics: Adult; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Drug Monitoring; Drug Overdose; Epinephrine; Female; Genotype; Heart Arrest; Humans; Metabolic Detoxication, Phase I; Myocardial Stunning; Opioid-Related Disorders; Tramadol; Young Adult	2011
Pharmacokinetics of tramadol and metabolites O-desmethyltramadol and N-desmethyltramadol in adult horses. American journal of veterinary research, 2011, Volume: 72, Issue:7 Topics: Analgesia; Analgesics, Opioid; Animals; Area Under Curve; Female; Half-Life; Horses; Male; Tramadol	2011
Occurrence and removal of lidocaine, tramadol, venlafaxine, and their metabolites in German wastewater treatment plants. Environmental science and pollution research international, 2012, Volume: 19, Issue:3 Topics: Absorption; Analgesics, Opioid; Anesthetics, Local; Antidepressive Agents, Second-Generation; Cyclohexanols; Desvenlafaxine Succinate; Gas Chromatography-Mass Spectrometry; Germany; Lidocaine; Limit of Detection; Sewage; Solid Phase Extraction; Solubility; Sonication; Tramadol; Venlafaxine Hydrochloride; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Pollution, Chemical	2012
False-positive urine phencyclidine immunoassay screen result caused by interference by tramadol and its metabolites. Annals of emergency medicine, 2012, Volume: 59, Issue:6 Topics: Adult; Emergency Service, Hospital; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Male; Phencyclidine; Phencyclidine Abuse; Tramadol	2012
Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jan-01, Volume: 880, Issue:1 Topics: Adult; Analgesics, Opioid; Chromatography, Liquid; Female; Humans; Limit of Detection; Linear Models; Male; Middle Aged; Neuralgia; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry; Tramadol; Ultrafiltration	2012
Impact of wastewater treatment plant discharge of lidocaine, tramadol, venlafaxine and their metabolites on the quality of surface waters and groundwater. Journal of environmental monitoring : JEM, 2012, Volume: 14, Issue:5 Topics: Cyclohexanols; Desvenlafaxine Succinate; Environmental Monitoring; Groundwater; Lidocaine; Rivers; Tramadol; Venlafaxine Hydrochloride; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Pollution, Chemical	2012
Comparison of fatal poisonings by prescription opioids. Forensic science international, 2012, Oct-10, Volume: 222, Issue:1-3 Topics: Accidents; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Central Nervous System Depressants; Codeine; Dextropropoxyphene; Drug Overdose; Ethanol; Fentanyl; Finland; Forensic Toxicology; Humans; Hypnotics and Sedatives; Methadone; Morphine; Opioid-Related Disorders; Oxycodone; Poisoning; Prescription Drug Misuse; Suicide; Tramadol; Young Adult	2012
Development and validation of a new GC-MS method for the detection of tramadol, O-desmethyltramadol, 6-acetylmorphine and morphine in blood, brain, liver and kidney of Wistar rats treated with the combination of heroin and tramadol. Journal of analytical toxicology, 2012, Volume: 36, Issue:8 Topics: Analgesics, Opioid; Animals; Brain; Brain Chemistry; Drug Therapy, Combination; Gas Chromatography-Mass Spectrometry; Heroin; Illicit Drugs; Injections, Intraperitoneal; Kidney; Liver; Morphine; Morphine Derivatives; Rats; Rats, Wistar; Substance Abuse Detection; Tissue Distribution; Tramadol	2012
Metabolite to parent drug concentration ratios in hair for the differentiation of tramadol intake from external contamination and passive exposure. Forensic science international, 2012, Nov-30, Volume: 223, Issue:1-3 Topics: Analgesics, Opioid; Chromatography, Liquid; Decontamination; Forensic Toxicology; Hair; Humans; Mass Spectrometry; Tramadol; Water; Workplace	2012
Degradation of lidocaine, tramadol, venlafaxine and the metabolites O-desmethyltramadol and O-desmethylvenlafaxine in surface waters. Chemosphere, 2013, Volume: 90, Issue:6 Topics: Cyclohexanols; Desvenlafaxine Succinate; Hydrogen-Ion Concentration; Lidocaine; Models, Chemical; Photochemical Processes; Rivers; Sunlight; Tramadol; Venlafaxine Hydrochloride; Water Pollutants, Chemical	2013
Simultaneous quantification of tramadol and O-desmethyltramadol in hair samples by gas chromatography-electron impact/mass spectrometry. Biomedical chromatography : BMC, 2013, Volume: 27, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Least-Squares Analysis; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tramadol	2013
Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, May-01, Volume: 926 Topics: Analgesics, Opioid; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Tramadol	2013
A suicidal poisoning due to tramadol. A metabolic approach to death investigation. Journal of forensic and legal medicine, 2013, Volume: 20, Issue:5 Topics: Analgesics, Opioid; Bile; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Humans; Middle Aged; Suicide; Tramadol	2013
Comprehensive quantum chemical and spectroscopic (FTIR, FT-Raman, 1H, 13C NMR) investigations of O-desmethyltramadol hydrochloride an active metabolite in tramadol--an analgesic drug. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2014, Mar-25, Volume: 122 Topics: Analgesics; Carbon-13 Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Proton Magnetic Resonance Spectroscopy; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Thermodynamics; Tramadol; Vibration	2014
Effect of the cytochrome P450 2D610 genotype on the pharmacokinetics of tramadol in post-operative patients. Die Pharmazie, 2014, Volume: 69, Issue:2* Topics: Adult; Aged; Analgesics, Opioid; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Female; Gastrointestinal Tract; Genotype; Half-Life; Humans; Male; Mass Spectrometry; Middle Aged; Pain, Postoperative; Polymorphism, Genetic; Tramadol	2014
Pharmacogenetic aspects of tramadol pharmacokinetics and pharmacodynamics after a single oral dose. Forensic science international, 2014, Volume: 238 Topics: Administration, Oral; Adult; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Female; Forensic Genetics; Forensic Toxicology; Genotype; Humans; Male; Mass Spectrometry; Pharmacogenetics; Polymorphism, Single Nucleotide; Random Allocation; Receptors, Opioid, mu; Tramadol	2014
Pharmacokinetics of tramadol and its primary metabolite O-desmethyltramadol in African penguins (Spheniscus demersus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2014, Volume: 45, Issue:1 Topics: Analgesics, Opioid; Animals; Pilocarpine; Spheniscidae; Tramadol	2014
Pharmacokinetics of tramadol and its major metabolite after intramuscular administration in piglets. Journal of veterinary pharmacology and therapeutics, 2014, Volume: 37, Issue:6 Topics: Analgesics, Opioid; Animals; Animals, Newborn; Injections, Intramuscular; Male; Swine; Tramadol	2014
Identification of mitragynine and O-desmethyltramadol in Kratom and legal high products sold online. Drug testing and analysis, 2014, Volume: 6, Issue:9 Topics: Cannabis; Chromatography, Thin Layer; Commerce; Gas Chromatography-Mass Spectrometry; Internet; Mitragyna; Plant Extracts; Plant Leaves; Secologanin Tryptamine Alkaloids; Tramadol; Yohimbine	2014
Effects of tramadol and o-desmethyltramadol on canine innate immune system function. Veterinary anaesthesia and analgesia, 2015, Volume: 42, Issue:3 Topics: Analgesics, Opioid; Animals; Cytokines; Dogs; Gene Expression Regulation; Immunity, Innate; Leukocytes; Tramadol	2015
Analysis of tramadol and O-desmethyltramadol in decomposed skeletal tissues following acute and repeated tramadol exposure by gas chromatography mass spectrometry. Forensic science international, 2014, Volume: 242 Topics: Analgesics, Opioid; Animals; Bone and Bones; Dose-Response Relationship, Drug; Drug Administration Schedule; Gas Chromatography-Mass Spectrometry; Postmortem Changes; Rats, Wistar; Solid Phase Extraction; Tramadol	2014
Clinical pharmacokinetics of tramadol and main metabolites in horses undergoing orchiectomy. The veterinary quarterly, 2014, Volume: 34, Issue:3 Topics: Analgesics, Opioid; Animals; Chromatography, High Pressure Liquid; Horses; Male; Orchiectomy; Pain Measurement; Tramadol	2014
Tramadol and o-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study. Clinical pharmacokinetics, 2015, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Child; Child, Preschool; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Infant; Male; Middle Aged; Models, Biological; Polymorphism, Genetic; Tramadol; Young Adult	2015
Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine. Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:4 Topics: Animals; Brain; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Male; Nicotine; Propranolol; Rats; Tandem Mass Spectrometry; Tramadol	2015
µ-Opioid receptor activation by tramadol and O-desmethyltramadol (M1). Journal of anesthesia, 2015, Volume: 29, Issue:3 Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Humans; Oocytes; Receptors, Opioid, mu; Signal Transduction; Tramadol; Xenopus laevis	2015
Simultaneous Determination of Tramadol and Its Metabolite in Human Urine by the Gas Chromatography-Mass Spectrometry Method. Journal of chromatographic science, 2015, Volume: 53, Issue:7 Topics: Analgesics, Opioid; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Liquid-Liquid Extraction; Reproducibility of Results; Tramadol	2015
Tramadol and its metabolite m1 selectively suppress transient receptor potential ankyrin 1 activity, but not transient receptor potential vanilloid 1 activity. Anesthesia and analgesia, 2015, Volume: 120, Issue:4 Topics: Analgesics, Opioid; Calcium; Calcium Channels; Capsaicin; Electrophysiological Phenomena; HEK293 Cells; Humans; Inflammation; Isothiocyanates; Membrane Potentials; Nerve Tissue Proteins; Patch-Clamp Techniques; Receptors, Opioid, mu; Tramadol; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels	2015
Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis. PloS one, 2015, Volume: 10, Issue:5 Topics: Analgesics; Animals; Excitatory Postsynaptic Potentials; Inhibitory Postsynaptic Potentials; Male; Neurons; Patch-Clamp Techniques; Rats, Sprague-Dawley; Substantia Gelatinosa; Synapses; Tramadol	2015
Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep. Veterinary journal (London, England : 1997), 2015, Volume: 205, Issue:3 Topics: Administration, Intravenous; Analgesics, Opioid; Animals; Female; Pain Measurement; Sheep; Sheep, Domestic; Tramadol	2015
PHARMACOKINETICS OF TRAMADOL HYDROCHLORIDE AND ITS METABOLITE O-DESMETHYLTRAMADOL FOLLOWING A SINGLE, ORALLY ADMINISTERED DOSE IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2015, Volume: 46, Issue:3 Topics: Administration, Oral; Analgesics, Opioid; Animals; Female; Male; Sea Lions; Tramadol	2015
Differential Consequences of Tramadol in Overdosing: Dilemma of a Polymorphic Cytochrome P450 2D6-Mediated Substrate. Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:3 Topics: Analgesics, Opioid; Cytochrome P-450 CYP2D6; Drug Overdose; Genotype; Humans; Phenotype; Tramadol	2015
First report on the pharmacokinetics of tramadol and O-desmethyltramadol in exhaled breath compared to plasma and oral fluid after a single oral dose. Biochemical pharmacology, 2015, Dec-01, Volume: 98, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Area Under Curve; Breath Tests; Female; Half-Life; Humans; Male; Middle Aged; Saliva; Tramadol	2015
Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects. Drugs & aging, 2015, Volume: 32, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Female; Half-Life; Humans; Male; Models, Biological; Renal Insufficiency; Tablets; Tramadol; Young Adult	2015
Quantitation of the enantiomers of tramadol and its three main metabolites in human whole blood using LC-MS/MS. Journal of pharmaceutical and biomedical analysis, 2016, Feb-05, Volume: 119 Topics: Administration, Oral; Analgesics, Opioid; Chromatography, Liquid; Forensic Toxicology; Healthy Volunteers; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry; Tramadol	2016
SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants. Therapeutic drug monitoring, 2016, Volume: 38, Issue:4 Topics: Analgesics, Opioid; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Infant; Infant, Newborn; Male; Octamer Transcription Factor-1; Organic Cation Transporter 1; Polymorphism, Single Nucleotide; Retrospective Studies; Tramadol	2016
Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption. Pain, 2016, Volume: 157, Issue:11 Topics: Adult; Aged; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Middle Aged; Organic Cation Transporter 1; Pain, Postoperative; Pharmacogenetics; Polymorphism, Single Nucleotide; Postoperative Nausea and Vomiting; Principal Component Analysis; Regression Analysis; Time Factors; Tramadol	2016
On the sulfation of O-desmethyltramadol by human cytosolic sulfotransferases. Pharmacological reports : PR, 2017, Volume: 69, Issue:5 Topics: Caco-2 Cells; Cytosol; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Intestine, Small; Kidney; Liver; Lung; Molecular Structure; Sulfotransferases; Tramadol	2017
Preliminary pharmacokinetics of tramadol hydrochloride after administration via different routes in male and female B6 mice. Veterinary anaesthesia and analgesia, 2018, Volume: 45, Issue:1 Topics: Administration, Oral; Animals; Female; Half-Life; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Tramadol	2018
Role of hair pigmentation in drug incorporation into hair. Forensic science international, 2017, Volume: 281 Topics: Analgesics, Opioid; Animals; Cells, Cultured; Hair; Hair Color; Humans; Rats, Long-Evans; Tramadol	2017
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6) are associated with long term tramadol treatment-induced oxidative damage and hepatotoxicity. Toxicology and applied pharmacology, 2018, 05-01, Volume: 346 Topics: Adult; Alleles; Analgesics, Opioid; Antioxidants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Polymorphism, Genetic; Tramadol	2018
Impact of CYP genotype and inflammatory markers on the plasma concentrations of tramadol and its demethylated metabolites and drug tolerability in cancer patients. European journal of clinical pharmacology, 2018, Volume: 74, Issue:11 Topics: Administration, Oral; Aged; Analgesics, Opioid; Asian People; C-Reactive Protein; Cancer Pain; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Interleukin-6; Male; Middle Aged; Neoplasms; Time Factors; Tramadol	2018
Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis. The Science of the total environment, 2019, May-10, Volume: 664 Topics: Analgesics, Opioid; Chromatography, Liquid; Codeine; Data Analysis; Environmental Monitoring; Fentanyl; Heroin; Hydrocodone; Hydromorphone; Minnesota; Morphine; Morphine Derivatives; Oxycodone; Retrospective Studies; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol; Wastewater; Water Pollutants, Chemical	2019
Suppression of Human Natural Killer Cells by Different Classes of Opioids. Anesthesia and analgesia, 2019, Volume: 128, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol	2019
A Reversed-Phase Mode LC-MS/MS Method Using a Polysaccharide Chiral Selector for Simultaneous Quantitation of Each Enantiomer of Tramadol and its Metabolites in Human Plasma and Evaluation of CYP-Mediated Stereoselective Demethylation. Therapeutic drug monitoring, 2020, Volume: 42, Issue:3 Topics: Analgesics, Opioid; Cancer Pain; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Polysaccharides; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry; Tramadol	2020
Intrinsic clearance rate of O-desmethyltramadol (M1) by glucuronide conjugation and phase I metabolism by feline, canine and common brush-tailed possum microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:7 Topics: Animals; Cats; Dogs; Glucuronides; Humans; Metabolic Clearance Rate; Microsomes; Tramadol; Trichosurus	2020
Automated high-throughput analysis of tramadol and O-desmethyltramadol in dried blood spots. Drug testing and analysis, 2020, Volume: 12, Issue:8 Topics: Automation; Chromatography, Liquid; Doping in Sports; Dried Blood Spot Testing; Female; High-Throughput Screening Assays; Humans; Male; Pilot Projects; Reproducibility of Results; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol	2020
Impact of CYP2D6 activity and cachexia progression on enantiomeric alteration of plasma tramadol and its demethylated metabolites and their relationships with central nervous system symptoms in head and neck cancer patients. Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:3 Topics: Aged; Cachexia; Cancer Pain; Cytochrome P-450 CYP2D6; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Stereoisomerism; Tramadol	2021
Temporal patterns of tramadol in hair after a single dose. Forensic science international, 2020, Volume: 316 Topics: Adult; Analgesics, Opioid; Chromatography, Liquid; Female; Hair; Healthy Volunteers; Humans; Male; Mass Spectrometry; Time Factors; Tramadol; Young Adult	2020
Pharmacokinetic profile of injectable tramadol in the koala (Phascolarctos cinereus) and prediction of its analgesic efficacy. PloS one, 2021, Volume: 16, Issue:3 Topics: Analgesics, Opioid; Animals; Animals, Zoo; Australia; Chromatography, High Pressure Liquid; Female; Half-Life; Injections, Subcutaneous; Male; Mass Spectrometry; Phascolarctidae; Tramadol; Treatment Outcome; Wounds and Injuries	2021
Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetr Journal of pharmaceutical and biomedical analysis, 2021, Sep-05, Volume: 203 Topics: Aged; Chromatography, Liquid; Fentanyl; Humans; Morphinans; Oxycodone; Oxymorphone; Reproducibility of Results; Tandem Mass Spectrometry; Tramadol	2021
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR. Xenobiotica; the fate of foreign compounds in biological systems, 2021, Volume: 51, Issue:9 Topics: Hep G2 Cells; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Tramadol	2021
Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6-Mediated Drug-Drug Interactions on Tramadol and O-Desmethyltramadol Exposures via Allosteric and Competitive Inhibition. Journal of clinical pharmacology, 2022, Volume: 62, Issue:1 Topics: Analgesics, Opioid; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Half-Life; Humans; Metabolic Clearance Rate; Metoprolol; Models, Biological; Quinidine; Tramadol	2022
Intoxication by 3-MeO-PCP and O-desmethyltramadol: an unusual NPS mix. International journal of legal medicine, 2022, Volume: 136, Issue:5 Topics: Humans; Male; Phencyclidine; Psychotropic Drugs; Tramadol	2022
Do the lockdown-imposed changes in a wastewater treatment plant catchment's socio-demographics impact longitudinal temporal trends in psychoactive pharmaceutical use? The Science of the total environment, 2023, Jun-10, Volume: 876 Topics: Biomarkers; Citalopram; Communicable Disease Control; COVID-19; Demography; Desvenlafaxine Succinate; Humans; Methadone; Pandemics; Pharmaceutical Preparations; Tramadol; Wastewater; Water Pollutants, Chemical	2023
Discovery of Potent and Selective Agonists of δ Opioid Receptor by Revisiting the "Message-Address" Concept. ACS medicinal chemistry letters, 2016, Apr-14, Volume: 7, Issue:4 Topics:	2016
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. European journal of medicinal chemistry, 2020, Mar-01, Volume: 189 Topics: Analgesics; Animals; Female; Ligands; Mice; Models, Molecular; Pain; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2020