Page last updated: 2024-08-23

tramadol and naloxone

tramadol has been researched along with naloxone in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (6.10)	18.7374
1990's	16 (19.51)	18.2507
2000's	25 (30.49)	29.6817
2010's	28 (34.15)	24.3611
2020's	8 (9.76)	2.80

Authors

Authors	Studies
Kolchin, VV; Zaĭtsev, AA	1
Korpás, J; Nosál'ová, G; Strapková, A	1
Besson, JM; Guilbaud, G; Kayser, V	1
Bromm, B; Herrmann, WM; Scharein, E	1
Friderichs, E; Hennies, HH; Schneider, J	1
Beutler, A; Bianchetti, MG; Ferrier, PE	1
Bernatzky, G; Jurna, I	1
Barth, H; Flohé, L; Giertz, H; Richter, W	1
Driessen, B; Illes, P; Nieber, K; Sevcik, J	1
Collart, L; Dayer, P; Favario-Constantin, C; Luthy, C	1
Driessen, B; Giertz, H; Reimann, W	1
Buben, JA; Codd, EE; Connelly, CD; Haslego, ML; Martinez, RP; Maryanoff, CA; Mckown, LA; Raffa, RB; Schupsky, JJ; Takacs, AN; Villani, FJ; Wu, WN	1
Collart, L; Dayer, P; Desmeules, JA; Piguet, V	1
Gebhart, GF; Stitt, S; Traub, RJ	1
Englberger, W; Frink, MC; Haurand, M; Hennies, HH; Wilffert, B	1
Jolly, BT; Sachdeva, DK	1
Anderson, DL; Benson, BE; Gorman, SE; Ruskosky, DR; Spiller, HA; Stancavage, MM; Villalobos, D	1
Bastanmehr, H; Bjorksten, AR; De Witte, JL; Kim, JS; Sessler, DI	1
Manocha, A; Mediratta, PK; Sharma, KK	1
Högger, P; Rohdewald, P	1
Freye, E; Latasch, L	1
de Wolff, MH; Leather, HA; Wouters, PF	1
Gillen, C; Haurand, M; Kobelt, DJ; Wnendt, S	1
Apaydin, S; Erhan, E; Karabay, NU; Tuglular, I; Uyar, M; Yegul, I	1
Chang, CJ; Cheng, JT; Chi, TC; Liu, IM; Lu, FH; Tzeng, TF	1
Minami, K; Sagata, K; Shigematsu, A; Shiraishi, M; Toyohira, Y; Ueno, S; Yanagihara, N	1
Dahan, A; Nieuwenhuijs, D; Olievier, CN; Teppema, LJ	1
Andersson, KE; Christoph, T; Friderichs, E; Pandita, RK; Pehrson, R	1
Brunnmüller, U	1
Planas, E; Pol, O; Poveda, R; Puig, MM; Romero, A; Sánchez, S	1
Jain, NK; Kulkarni, SK; Satyanarayana, PS; Singh, A	1
Dziedzicka-Wasylewska, M; Filip, M; Inan, SY; Przegaliński, E; Wydra, K	1
Oster, P; Schuler, M	1
Aguirre-Bañuelos, P; Arellano-Guerrero, A; de Pozos-Guillén, AJ; Hoyo-Vadillo, C; Pérez-Urizar, J	1
Antunes, F; Pontes, LB; Raimundo, JM; Sudo, RT; Trachez, MM; Zapata-Sudo, G	1
Bigelow, GE; Carroll, CP; Preston, KL; Strain, EC; Walsh, SL	1
Gibert-Rahola, J; Mico, JA; Rojas-Corrales, MO	1
Hama, A; Sagen, J	1
Berrocoso, E; De Benito, MD; Mico, JA	1
Bigelow, GE; Lofwall, MR; Strain, EC; Walsh, SL	1
Onal, A; Parlar, A; Ulker, S	1
Raffa, RB; Stone, DJ	1
Kumar, M; Rehni, AK; Singh, I	1
Böhme, K; Bolten, WW; Grifka, J; Schutter, U; Schwarz, H; Sittl, R; Sturm, D; Wahle, K	1
Avoli, M; Cruccu, G; Galeotti, F; Maluccio, MR; Panuccio, G; Sartucci, F; Truini, A	1
Ashby, R; Essary, AC; Ou, C; Stoehr, JD; Sucher, M	1
Grabnar, I; Grosek, S; Mozina, M; Primozic, J	1
Abbasi, S; Ahmadi, SF; Ghadiri, M; Saidi, H	1
Bigelow, GE; Lanier, RK; Lofwall, MR; Mintzer, MZ; Strain, EC	1
Guo, XY; Jia, DL; Ni, C; Xu, T; Zhang, LP	1
Heckes, B; Ritzdorf, I; Schutter, U	2
Asghari-Roodsari, A; Dehpour, AR; Javadi-Paydar, M; Khodadad, TK; Lesani, A; Norouzi, A; Shirkhodaei, M	1
Asinger, RW; Bertog, SC; Bilden, EF; Cole, JB; Sattiraju, S	1
Fan, HG; Kun, M; Lu, DZ; Ming, YS; Sheng, J; Song, ZL; Wang, HB	1
Cha, DS; Jeon, H; Park, HJ	1
Kawai, Y; Oka, M; Oyama, T	1
Jose, R; Peedicayil, J; Shah, NH; Thomas, E	1
Bednarova, R; Miceli, L; Rizzardo, A; Rocca, GD; Sandri, M	1
Fujimoto, Y; Funao, T; Mori, T; Nishikawa, K; Suehiro, K; Yamada, T	1
Cremer-Schaeffer, P; Glaeske, G; Greve, H; Grond, S; Hoffmann-Menzel, H; Münchberg, F; Radbruch, L; Scherbaum, N; Storz, E; Tholen, K; Zagermann-Muncke, P; Zieglgänsberger, W	1
Agrafiotis, M; Chassapidou, G; Galanou, A; Siopi, D; Tryfon, S; Tsara, V	1
Carrillo-Munguía, N; Díaz-Reval, MI; González-Trujano, ME; Huerta, M; Trujillo, X	1
Puig, MM; Romero, A; Romero-Alejo, E	1
Esquivel Franco, DC; Olivier, B; Olivier, JD; Oosting, R; Sarnyai, Z; Waldinger, M	1
Chen, G; Deng, H; Li, X; Liao, L; Wang, Z	1
Audi, EA; Fiaes, GCS; Maraschin, JC; Porcu, M; Roncon, CM; Sestile, CC; Souza, RLS	1
Chevillard, L; Indja, W; Lagard, C; Malissin, I; Mégarbane, B; Risède, P	1
André, M; Barreau, C; Carrière, A; Casteilla, L; Cousin, B; Dromard, C; Eddine, MA; Guissard, C; Labit, E; Lorsignol, A; Pénicaud, L; Pipy, B; Rabiller, L; Rampon, C; Vriz, S	1
Bigelow, GE; Dunn, KE; Huhn, AS; Schroeder, JR; Strain, EC; Tompkins, DA; Weerts, EM	1
Heller, NM; Maher, DP; Walia, D	1
El-Nabarawy, NA; Gouda, AS; Mégarbane, B	1
Bryant, SM; Chhabra, N; Pallasch, EM; Wahl, M	1
Carpenter, JE; Dunkley, CA; Kazzi, Z; Moran, TP; Murray, BP	1
Ramírez, T; Soto, E; Vega, R	1
Degenhardt, L; Gisev, N; Hall, WD; Roxburgh, A	1
Amirabadizadeh, A; Askari, M; Brent, J; Farrokhfall, K; Foadoddini, M; Megarbane, B; Mehrpour, O; Miri-Moghaddam, E; Nakhaee, S	1
Amirabadizadeh, A; Askari, M; Farrokhfall, K; Foadoddini, M; Mehrpour, O; Miri-Moghaddam, E; Nakhaee, S	1
Ahmed, A; Ali, G; Ali, I; Ayaz, M; Khan, I; Khan, R; Mosa, OF; Murthy, HCA; Nawaz, A; Rahman, K	1
Aldy, K; Brent, J; Calello, DP; Jefri, M; Krotulski, A; Logan, B; Manini, AF; Nguyen, TT; Walton, S; Wax, P	1
Akbarabadi, A; Hadjighassem, M; Hosseindoost, S; Khalifeh, S; Mokri, A; Mousavi, SM; Sadat-Shirazi, MS; Zarrindast, MR	1
Issazadeh, Y; Khakpai, F; Rezaei, N; Zarrindast, MR	1

Reviews

3 review(s) available for tramadol and naloxone

Article	Year
[Low-dose strong opioid (LDSO)--treatment of pain in osteoarthritis]. MMW Fortschritte der Medizin, 2008, Dec-11, Volume: 150, Issue:51-52 Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Cyclooxygenase 2 Inhibitors; Humans; Naloxone; Osteoarthritis; Pain; Risk Factors; Tilidine; Tramadol	2008
Isolated tramadol overdose associated with Brugada ECG pattern. Pacing and clinical electrophysiology : PACE, 2012, Volume: 35, Issue:8 Topics: Analgesics, Opioid; Brugada Syndrome; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Prescription Drug Misuse; Sodium Channel Blockers; Tramadol; Treatment Outcome	2012
Topical review on the abuse and misuse potential of tramadol and tilidine in Germany. Substance abuse, 2013, Volume: 34, Issue:3 Topics: Analgesics, Opioid; Drug Therapy, Combination; Fraud; Germany; Humans; Incidence; Naloxone; Opioid-Related Disorders; Pain; Self Medication; Tilidine; Tramadol	2013

Trials

13 trial(s) available for tramadol and naloxone

Article	Year
[Comparison of the action of 2 effective analgesics. Experimental study: tramadol versus tilidine/naloxone]. Fortschritte der Medizin, 1989, Jun-10, Volume: 107, Issue:17 Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Cyclohexanols; Double-Blind Method; Drug Combinations; Humans; Naloxone; Pain; Pain Measurement; Random Allocation; Tilidine; Tramadol	1989
Clinical investigation on the development of dependence during oral therapy with tramadol. Arzneimittel-Forschung, 1985, Volume: 35, Issue:11 Topics: Administration, Oral; Adult; Aged; Cyclohexanols; Double-Blind Method; Drug Administration Schedule; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Naloxone; Pain; Precipitin Tests; Random Allocation; Substance Withdrawal Syndrome; Substance-Related Disorders; Tramadol	1985
[Duality of the analgesic effect of tramadol in humans]. Schweizerische medizinische Wochenschrift, 1993, Nov-27, Volume: 123, Issue:47 Topics: Adult; Double-Blind Method; Humans; Male; Naloxone; Pupil; Quinidine; Reflex; Tramadol	1993
Contribution of monoaminergic modulation to the analgesic effect of tramadol. British journal of clinical pharmacology, 1996, Volume: 41, Issue:1 Topics: Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Drug Interactions; Humans; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Tramadol; Yohimbine	1996
Comparison of tilidine/naloxone, tramadol and bromfenac in experimental pain: a double-blind randomized crossover study in healthy human volunteers. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:8 Topics: Adult; Analgesics; Area Under Curve; Benzophenones; Bromobenzenes; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Evoked Potentials, Somatosensory; Female; Humans; Male; Naloxone; Pain; Tilidine; Tramadol	1999
Effects of tramadol and tilidine/naloxone on oral-caecal transit and pupillary light reflex. Arzneimittel-Forschung, 2000, Volume: 50, Issue:1 Topics: Adult; Analgesics, Opioid; Cecum; Cross-Over Studies; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Light; Male; Naloxone; Narcotic Antagonists; Reflex, Pupillary; Tilidine; Tramadol	2000
Modest opioid withdrawal suppression efficacy of oral tramadol in humans. Psychopharmacology, 2007, Volume: 194, Issue:3 Topics: Administration, Oral; Adult; Analgesics, Opioid; Cognition; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Psychomotor Performance; Substance Withdrawal Syndrome; Tramadol	2007
Laser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugs. European journal of pain (London, England), 2010, Volume: 14, Issue:2 Topics: Adult; Analgesics; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Electroencephalography; Evoked Potentials; Female; Humans; Lasers; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Tramadol	2010
Physical dependence potential of daily tramadol dosing in humans. Psychopharmacology, 2010, Volume: 211, Issue:4 Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydromorphone; Male; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome; Tramadol	2010
A small-dose naloxone infusion alleviates nausea and sedation without impacting analgesia via intravenous tramadol. Chinese medical journal, 2010, Volume: 123, Issue:13 Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Cervical Vertebrae; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Naloxone; Narcotic Antagonists; Nausea; Tramadol	2010
[The transdermal 7-day buprenorphine patch--an effective and safe treatment option, if tramadol or tilidate/naloxone is insufficient. Results of a non-interventional study]. MMW Fortschritte der Medizin, 2010, Aug-12, Volume: 152, Issue:31-33 Topics: Administration, Cutaneous; Analgesics, Opioid; Buprenorphine; Follow-Up Studies; Humans; Movement; Naloxone; Pain Measurement; Patient Compliance; Premedication; Quality of Life; Tilidine; Time Factors; Tramadol; Treatment Outcome	2010
Antagonistic effect of atipamezole, flumazenil and naloxone following anaesthesia with xylazine, tramadol and tiletamine/zolazepam combinations in pigs. Veterinary anaesthesia and analgesia, 2011, Volume: 38, Issue:4 Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia Recovery Period; Anesthetics; Animals; Cross-Over Studies; Drug Antagonism; Drug Combinations; Female; Flumazenil; GABA Modulators; Imidazoles; Male; Naloxone; Narcotic Antagonists; Prospective Studies; Swine; Tiletamine; Tramadol; Xylazine; Zolazepam	2011
Preliminary evidence of different and clinically meaningful opioid withdrawal phenotypes. Addiction biology, 2020, Volume: 25, Issue:1 Topics: Adult; Analgesics; Buprenorphine; Clonidine; Cluster Analysis; Double-Blind Method; Female; Humans; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Phenotype; Severity of Illness Index; Substance Withdrawal Syndrome; Tramadol; Treatment Outcome	2020

Other Studies

66 other study(ies) available for tramadol and naloxone

Article	Year
[The effect of microinjections of morphine and tramadol into the locus coeruleus on the nociceptive responses of the spinal cord neurons and on shifts in the arterial pressure]. Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:2 Topics: Animals; Blood Pressure; Cats; Electrophysiology; Locus Coeruleus; Microinjections; Morphine; Naloxone; Neurons; Nociceptors; Phentolamine; Spinal Cord; Tramadol	1991
Relationship between the antitussic and analgesic activity of substances. Acta physiologica Hungarica, 1991, Volume: 77, Issue:2 Topics: Analgesia; Analgesics; Animals; Antitussive Agents; Cats; Codeine; Cough; Female; Male; Naloxone; Pentazocine; Tilidine; Tramadol	1991
Effects of the analgesic agent tramadol in normal and arthritic rats: comparison with the effects of different opioids, including tolerance and cross-tolerance to morphine. European journal of pharmacology, 1991, Mar-19, Volume: 195, Issue:1 Topics: Animals; Arthritis; Buprenorphine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Nalbuphine; Naloxone; Pain Measurement; Rats; Rats, Inbred Strains; Tramadol	1991
Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittel-Forschung, 1988, Volume: 38, Issue:7 Topics: Animals; Antitussive Agents; Brain Chemistry; Codeine; Cyclohexanols; Dose-Response Relationship, Drug; Male; Membranes; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Tramadol	1988
[Acute poisoning with a narcotic (Tramadol) in an infant of five weeks]. Helvetica paediatrica acta, 1988, Volume: 43, Issue:3 Topics: Accidents; Administration, Rectal; Cyclohexanols; Humans; Infant; Male; Muscle Hypotonia; Naloxone; Respiratory Paralysis; Tramadol	1988
Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats. European journal of pharmacology, 1986, Jan-14, Volume: 120, Issue:1 Topics: Analgesics; Animals; Buprenorphine; Codeine; Depression, Chemical; Female; Injections, Spinal; Male; Naloxone; Nefopam; Rats; Reaction Time; Tilidine; Tramadol	1986
Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones. British journal of pharmacology, 1993, Volume: 110, Issue:1 Topics: Action Potentials; Animals; Extracellular Space; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Naloxone; Neurons; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Stereoisomerism; Tramadol; Yohimbine	1993
Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro. British journal of pharmacology, 1993, Volume: 108, Issue:3 Topics: 5-Hydroxytryptophan; Animals; Caudate Nucleus; Chinchilla; Cocaine; Dopamine; Female; In Vitro Techniques; Male; Morphine; Naloxone; Norepinephrine; Rabbits; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synaptosomes; Tramadol; Yohimbine	1993
Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3 Topics: Analgesics; Animals; Biological Transport; Dose-Response Relationship, Drug; Female; Liver; Male; Mice; Naloxone; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, mu; Tramadol	1996
Attenuation of c-Fos expression in the rat lumbosacral spinal cord by morphine or tramadol following noxious colorectal distention. Brain research, 1995, Dec-01, Volume: 701, Issue:1-2 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Colon; Dose-Response Relationship, Drug; Electromyography; Gene Expression; Genes, fos; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Rectum; Spinal Cord; Tramadol	1995
Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittel-Forschung, 1996, Volume: 46, Issue:11 Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dopamine; Male; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptosomes; Tramadol	1996
Tramadol overdose requiring prolonged opioid antagonism. The American journal of emergency medicine, 1997, Volume: 15, Issue:2 Topics: Adult; Analgesics, Opioid; Emergency Service, Hospital; Humans; Male; Naloxone; Narcotic Antagonists; Time Factors; Tramadol	1997
Prospective multicenter evaluation of tramadol exposure. Journal of toxicology. Clinical toxicology, 1997, Volume: 35, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Male; Middle Aged; Naloxone; Narcotic Antagonists; Poison Control Centers; Prospective Studies; Seizures; Tramadol	1997
Tramadol reduces the sweating, vasoconstriction, and shivering thresholds. Anesthesia and analgesia, 1998, Volume: 87, Issue:1 Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid; Sensory Thresholds; Shivering; Sweating; Tramadol; Vasoconstriction	1998
Tramadol, a centrally acting opioid: anticonvulsant effect against maximal electroshock seizure in mice. Indian journal of physiology and pharmacology, 1998, Volume: 42, Issue:3 Topics: Animals; Anticonvulsants; Benzomorphans; Drug Interactions; Electroshock; Female; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid, kappa; Seizures; Tramadol	1998
Effects of tramadol on minimum alveolar concentration (MAC) of isoflurane in rats. British journal of anaesthesia, 1999, Volume: 83, Issue:5 Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Drug Interactions; Isoflurane; Male; Morphine; Naloxone; Narcotic Antagonists; Pulmonary Alveoli; Rats; Rats, Wistar; Tramadol; Yohimbine	1999
Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:2 Topics: Analgesics, Opioid; Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naloxone; Narcotic Antagonists; Receptors, Opioid, mu; Tramadol	2000
The antinociceptive effect of tramadol on a model of neuropathic pain in rats. Life sciences, 2000, Volume: 66, Issue:17 Topics: Analgesics, Opioid; Animals; Male; Naloxone; Narcotic Antagonists; Nervous System Diseases; Pain; Pain Measurement; Pressure; Rats; Rats, Wistar; Tramadol; Vocalization, Animal	2000
Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats. Diabetes, 2001, Volume: 50, Issue:12 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gluconeogenesis; Glucose; Glucose Transporter Type 4; Glycogen; Hypoglycemic Agents; Injections, Intravenous; Kinetics; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Narcotics; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; Receptors, Opioid, mu; RNA, Messenger; Tramadol	2001
Tramadol inhibits norepinephrine transporter function at desipramine-binding sites in cultured bovine adrenal medullary cells. Anesthesia and analgesia, 2002, Volume: 94, Issue:4 Topics: Adrenal Medulla; Analgesics, Opioid; Animals; Binding, Competitive; Carrier Proteins; Cattle; Cell Membrane; Cells, Cultured; Desipramine; Dose-Response Relationship, Drug; Naloxone; Narcotic Antagonists; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Receptors, Drug; Symporters; Tramadol	2002
Respiratory depression by tramadol in the cat: involvement of opioid receptors. Anesthesiology, 2003, Volume: 98, Issue:2 Topics: Algorithms; Analgesics, Opioid; Animals; Carbon Dioxide; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Female; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid; Reflex; Respiratory Mechanics; Tramadol	2003
Actions of tramadol on micturition in awake, freely moving rats. British journal of pharmacology, 2003, Volume: 139, Issue:4 Topics: Animals; Deamino Arginine Vasopressin; Drug Administration Routes; Female; Morphine; Movement; Naloxone; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereoisomerism; Tramadol; Urinary Bladder; Urination; Urine; Urodynamics	2003
[Postoperative pain therapy in an accident surgery ward]. Der Unfallchirurg, 2003, Volume: 106, Issue:5 Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Combinations; Humans; Naloxone; Narcotics; Pain Measurement; Pain, Postoperative; Tilidine; Tramadol; Wounds and Injuries	2003
Interaction between metamizol and tramadol in a model of acute visceral pain in rats. European journal of pain (London, England), 2003, Volume: 7, Issue:5 Topics: Abdominal Pain; Acute Disease; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Synergism; Ethacrynic Acid; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Tramadol; Visceral Afferents	2003
Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice. Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:4 Topics: Acetic Acid; Algorithms; Analgesics, Opioid; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Female; Isoenzymes; Lactones; Male; Membrane Proteins; Mice; Naloxone; Naproxen; Narcotic Antagonists; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Sulfones; Tramadol	2004
Opioid and monoamine systems mediate the discriminative stimulus of tramadol in rats. European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3 Topics: Adrenergic Uptake Inhibitors; Analgesics, Opioid; Animals; Antidepressive Agents; Biogenic Monoamines; Conditioning, Operant; Cyclohexanols; Cyclopropanes; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Male; Milnacipran; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Nomifensine; Rats; Rats, Wistar; Reboxetine; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Sodium Chloride; Tramadol; Venlafaxine Hydrochloride	2004
[Increasing importance of opioids in geriatrics]. Schmerz (Berlin, Germany), 2005, Volume: 19, Issue:4 Topics: Aged; Analgesics, Opioid; Costs and Cost Analysis; Drug Prescriptions; Fentanyl; Geriatrics; Germany; Humans; Morphine; Naloxone; Oxycodone; Tramadol	2005
Evidence of self-synergism in the antinociceptive effect of tramadol in rats. Proceedings of the Western Pharmacology Society, 2004, Volume: 47 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Formaldehyde; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Tramadol	2004
In vitro and in vivo vasodilator activity of racemic tramadol and its enantiomers in Wistar rats. European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2 Topics: Acetylcholine; Analgesics, Opioid; Animals; Aorta, Thoracic; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Endothelium, Vascular; Heart Rate; In Vitro Techniques; Isometric Contraction; Male; Naloxone; Papillary Muscles; Phenylephrine; Rats; Rats, Wistar; Stereoisomerism; Tramadol; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2006
Assessment of agonist and antagonist effects of tramadol in opioid-dependent humans. Experimental and clinical psychopharmacology, 2006, Volume: 14, Issue:2 Topics: Adult; Analgesics, Opioid; Heart Rate; Humans; Hydromorphone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Tramadol	2006
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior. Psychopharmacology, 2007, Volume: 190, Issue:2 Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Indophenol; Levorphanol; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Stereotyped Behavior; Tics; Tourette Syndrome; Tramadol; Triazoles	2007
Altered antinociceptive efficacy of tramadol over time in rats with painful peripheral neuropathy. European journal of pharmacology, 2007, Mar-15, Volume: 559, Issue:1 Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Time Factors; Tramadol; Yohimbine	2007
Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats. Psychopharmacology, 2007, Volume: 193, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Chronic Disease; Disease Models, Animal; Drug Interactions; Male; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Opioid; Sciatic Nerve; Sciatic Neuropathy; Serotonin 5-HT1 Receptor Agonists; Tramadol	2007
Milnacipran attenuates hyperalgesia and potentiates antihyperalgesic effect of tramadol in rats with mononeuropathic pain. Pharmacology, biochemistry, and behavior, 2007, Volume: 88, Issue:2 Topics: Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Drug Synergism; Hyperalgesia; Male; Milnacipran; Naloxone; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Tramadol	2007
Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:2 Topics: Analgesics, Opioid; Animals; Codeine; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Hot Temperature; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Quinidine; Reserpine; Seizures; Stereoisomerism; Tramadol	2008
Tramadol-induced seizurogenic effect: a possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway. Basic & clinical pharmacology & toxicology, 2008, Volume: 103, Issue:3 Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; GABA Agents; Gabapentin; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Pentylenetetrazole; Receptors, GABA; Receptors, Opioid; Seizures; Tramadol	2008
The risk of tramadol abuse and dependence: findings in two patients. JAAPA : official journal of the American Academy of Physician Assistants, 2009, Volume: 22, Issue:7 Topics: Adult; Analgesics, Opioid; Buprenorphine; Counseling; Female; Headache; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse Detection; Tramadol	2009
Diagnostic and therapeutic value of naloxone after intoxication with tramadol in a young girl. Pediatrics international : official journal of the Japan Pediatric Society, 2009, Volume: 51, Issue:6 Topics: Analgesics, Opioid; Child, Preschool; Diagnosis, Differential; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Naloxone; Narcotic Antagonists; Tramadol	2009
Efficacy and safety of naloxone in the management of postseizure complaints of tramadol intoxicated patients: a self-controlled study. Emergency medicine journal : EMJ, 2010, Volume: 27, Issue:12 Topics: Adult; Analgesics, Opioid; Consciousness Monitors; Epilepsy; Female; Humans; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Tramadol	2010
Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice. Epilepsy & behavior : E&B, 2010, Volume: 19, Issue:3 Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Male; Mice; Mice, Inbred Strains; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Seizures; Signal Transduction; Time Factors; Tramadol	2010
[The transdermal 7-day buprenorphine patch--an effective and safe treatment option, if tramadol or tilidate/naloxone is insufficient. Results of a non-interventional study]. MMW Fortschritte der Medizin, 2010, Jul-01, Volume: 152 Suppl 2 Topics: Activities of Daily Living; Administration, Cutaneous; Aged; Aged, 80 and over; Analgesics, Opioid; Buprenorphine; Chronic Disease; Drug Substitution; Female; Germany; Humans; Long-Term Care; Male; Middle Aged; Naloxone; Pain; Pain Measurement; Prospective Studies; Quality of Life; Tilidine; Tramadol	2010
Antinociceptive and hypnotic properties of Celastrus orbiculatus. Journal of ethnopharmacology, 2011, Oct-11, Volume: 137, Issue:3 Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Hypnotics and Sedatives; Indomethacin; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Phenobarbital; Plant Extracts; Plants, Medicinal; Reaction Time; Sleep; Time Factors; Tramadol	2011
Tramadol enhances urethral continence function through µ-opioid receptors in rats. Neurourology and urodynamics, 2013, Volume: 32, Issue:1 Topics: Analgesics, Opioid; Animals; Female; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tramadol; Urinary Bladder; Urinary Incontinence, Stress; Urodynamics	2013
Tramadol inhibits the contractility of isolated human myometrium. Autonomic & autacoid pharmacology, 2013, Volume: 33, Issue:1-2 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; Isoproterenol; Methylene Blue; Middle Aged; Naloxone; Narcotic Antagonists; Nitric Oxide Synthase; Potassium Chloride; Propranolol; Receptors, Adrenergic, beta-1; Tramadol; Uterine Contraction	2013
Use of opioids for pain relief while driving: when the patient meets the police. Pain practice : the official journal of World Institute of Pain, 2013, Volume: 13, Issue:4 Topics: Aged; Analgesics, Opioid; Automobile Driving; Humans; Low Back Pain; Male; Naloxone; Oxycodone; Tramadol	2013
Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy. Life sciences, 2013, Jun-21, Volume: 92, Issue:23 Topics: Adrenergic Neurons; Analgesics; Animals; Clomipramine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; Hyperalgesia; Locus Coeruleus; Morphine; Naloxone; Norepinephrine; Rats; Rats, Sprague-Dawley; Tramadol	2013
Successful management of drug-induced hypercapnic acidosis with naloxone and noninvasive positive pressure ventilation. The American journal of emergency medicine, 2015, Volume: 33, Issue:2 Topics: Acidosis; Aged; Analgesics, Opioid; Combined Modality Therapy; Fentanyl; Humans; Hypercapnia; Male; Naloxone; Narcotic Antagonists; Positive-Pressure Respiration; Tramadol	2015
Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms. BioMed research international, 2015, Volume: 2015 Topics: Analgesics, Opioid; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Naloxone; Ondansetron; Pain; Pain Measurement; Rats; Tramadol	2015
Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation. The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:8 Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Combinations; Hyperalgesia; Ketoprofen; Male; Mice; Naloxone; Neuroglia; Pain Threshold; Pain, Postoperative; Tramadol	2016
Tramadol: Effects on sexual behavior in male rats are mainly caused by its 5-HT reuptake blocking effects. Neuropharmacology, 2017, Volume: 116 Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Ejaculation; Male; Naloxone; Narcotic Antagonists; Paroxetine; Piperazines; Pyridines; Random Allocation; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Sexual Behavior, Animal; Tramadol	2017
Involvement of opioid receptors in inhibition of bladder overactivity induced by sacral neuromodulation in pigs: A possible action mechanism. Neurourology and urodynamics, 2017, Volume: 36, Issue:7 Topics: Acetic Acid; Animals; Female; Male; Naloxone; Reflex; Sacrum; Spinal Nerves; Swine; Tramadol; Transcutaneous Electric Nerve Stimulation; Urinary Bladder, Overactive; Urination	2017
Panicolytic-like effect of tramadol is mediated by opioid receptors in the dorsal periaqueductal grey. Behavioural brain research, 2017, 05-30, Volume: 326 Topics: Analgesics, Opioid; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Male; Naloxone; Narcotic Antagonists; Panic; Periaqueductal Gray; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Opioid, mu; Serotonin 5-HT1 Receptor Antagonists; Serotonin and Noradrenaline Reuptake Inhibitors; Tramadol	2017
Is naloxone the best antidote to reverse tramadol-induced neuro-respiratory toxicity in overdose? An experimental investigation in the rat. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:8 Topics: Analgesics, Opioid; Animals; Antidotes; Drug Overdose; Naloxone; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency; Seizures; Tramadol	2018
Opioids prevent regeneration in adult mammals through inhibition of ROS production. Scientific reports, 2018, 08-15, Volume: 8, Issue:1 Topics: Adipose Tissue; Analgesics, Opioid; Animal Fins; Animals; Female; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Myocytes, Cardiac; Naloxone; Quaternary Ammonium Compounds; Reactive Oxygen Species; Regeneration; Tramadol; Zebrafish	2018
Suppression of Human Natural Killer Cells by Different Classes of Opioids. Anesthesia and analgesia, 2019, Volume: 128, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol	2019
Understanding the risk of seizure in tramadol overdose: still a long way to go. Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:12 Topics: Causality; Drug Overdose; Humans; Naloxone; Registries; Seizures; Tramadol	2019
Tramadol, naloxone, and seizures. Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:12 Topics: Causality; Humans; Naloxone; Registries; Seizures; Tramadol	2019
In reply to Dr. Chhabra, Dr. Mégarbane, and colleagues. Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:12 Topics: Causality; Humans; Naloxone; Registries; Seizures; Tramadol	2019
Opioid modulation of cochlear auditory responses in the rat inner ear. Synapse (New York, N.Y.), 2020, Volume: 74, Issue:1 Topics: Action Potentials; Analgesics, Opioid; Animals; Cochlea; Evoked Potentials, Auditory, Brain Stem; Fentanyl; Morphine; Naloxone; Narcotic Antagonists; Otoacoustic Emissions, Spontaneous; Rats; Rats, Long-Evans; Tramadol	2020
Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids. Drug and alcohol dependence, 2019, 12-01, Volume: 205 Topics: Adolescent; Adult; Analgesics, Opioid; Australia; Chronic Pain; Drug Overdose; Drug Prescriptions; Female; Fentanyl; Heroin; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Opioid-Related Disorders; Tramadol; Young Adult	2019
The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study. Behavioral and brain functions : BBF, 2021, May-29, Volume: 17, Issue:1 Topics: Animals; Diazepam; Male; Naloxone; Quercetin; Rats; Rats, Wistar; Seizures; Tramadol	2021
Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study). BMC endocrine disorders, 2021, Sep-06, Volume: 21, Issue:1 Topics: Analgesics, Opioid; Animals; Blood Glucose; Diazepam; Drug Overdose; Hyperglycemia; Hypnotics and Sedatives; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Tramadol	2021
Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates. Drug design, development and therapy, 2022, Volume: 16 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Edema; Formaldehyde; Naloxone; Stomach Ulcer; Tramadol; Ulcer	2022
Identification of a novel opioid, Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:9 Topics: Adult; Alprazolam; Analgesics, Opioid; Benzimidazoles; Cocaine; Codeine; Drug Overdose; Fentanyl; Heroin; Humans; Illicit Drugs; Levamisole; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Overdose; Phenacetin; Prospective Studies; Tramadol	2022
Effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: The possible role of µ-opioid receptor. Drug development research, 2022, Volume: 83, Issue:6 Topics: Analgesics, Opioid; Animals; Apoptosis; Hippocampus; Naloxone; Neurons; Rats; Receptors, Opioid; Tramadol	2022
Enhanced anxiolytic and analgesic effectiveness or a better safety profile of morphine and tramadol combination in cholestatic and addicted mice. Neuroreport, 2022, 11-02, Volume: 33, Issue:16 Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Cholestasis; Dose-Response Relationship, Drug; Mice; Morphine; Naloxone; Pain; Receptors, Opioid, mu; Tramadol	2022