Page last updated: 2024-08-21

toyocamycin and tubercidin

toyocamycin has been researched along with tubercidin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199016 (66.67)18.7374
1990's1 (4.17)18.2507
2000's4 (16.67)29.6817
2010's3 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Daunert, S; Drach, JC; Gupta, PK; Nassiri, MR; Townsend, LB; Wotring, LL1
Balzarini, J; De Clercq, E; Hansske, F; Madej, D; Robins, MJ1
Balzarini, J; Bergstrom, DE; Brattesani, AJ; De Clercq, E; Ogawa, MK; Reddy, PA; Schweickert, MJ1
Browne, CE; DaRe, JM; Erion, MD; Kopcho, JJ; Schanzer, JM; Ugarkar, BG; Wiesner, JB1
Barbeau, O; Burke, R; Cheeseman, MD; Collins, I; Dobson, S; Jeganathan, F; Jones, AM; Jones, K; Kadi, N; Rowlands, M; van Montfort, RL; Westwood, IM; Workman, P1
Bayle, ED; Fish, PV; Li, F; Schapira, M; Spurr, SS; Tempel, W; Vedadi, M; Yu, W1
Gupta, RS; Siminovitch, L1
Blakley, RL; Brinkley, SA; Critz, WJ; Lewis, A; Townsend, LB; Witt, LL1
Frye, RB; Fukui, T; Hawrelak, SD; Hecht, SM; Werner, D1
Granick, D2
Cohen, MB; Glazer, RI1
Gupta, RS; Mehta, KD4
Cha, S; el Kouni, MH; Messier, NJ1
Cheng, HW; Rice, A; Verham, R; Wang, AL; Wang, CC1
Ueda, T; Watanabe, S1
Gupta, RS1
Kato, A; Maeba, I; Nishimura, N1
Magnier, M; Mulligan, RC; Stockwell, BR; Weissleder, R; Yen, L1
Ciliberti, N; Durini, E; Manfredini, S; Vertuani, S1
Balzarini, J; Ortiz, H; Rayala, R; Robins, MJ; Theard, P; Wnuk, SF; Yao, S; Young, JD1

Other Studies

24 other study(ies) available for toyocamycin and tubercidin

ArticleYear
Synthesis, cytotoxicity, and antiviral activity of some acyclic analogues of the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics tubercidin, toyocamycin, and sangivamycin.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:2

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antiviral Agents; Cell Division; Humans; Mice; Pyrimidine Nucleosides; Structure-Activity Relationship; Toyocamycin; Tubercidin

1989
Nucleic acid related compounds. 51. Synthesis and biological properties of sugar-modified analogues of the nucleoside antibiotics tubercidin, toyocamycin, sangivamycin, and formycin.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antiviral Agents; Formycins; Leukemia L1210; Mice; Microbial Sensitivity Tests; Pyrimidine Nucleosides; Ribonucleosides; Structure-Activity Relationship; Toyocamycin; Tubercidin

1987
Antiviral activity of C-5 substituted tubercidin analogues.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antiviral Agents; Chlorocebus aethiops; DNA Viruses; HeLa Cells; Humans; Mice; Pyrimidine Nucleosides; Rabbits; Ribonucleosides; RNA Viruses; Toyocamycin; Tubercidin

1984
Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues.
    Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15

    Topics: Adenosine Kinase; Animals; Anticonvulsants; Electroshock; Enzyme Inhibitors; Humans; Male; Rats; Recombinant Proteins; Seizures; Structure-Activity Relationship; Tubercidin

2000
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.
    Journal of medicinal chemistry, 2016, 05-26, Volume: 59, Issue:10

    Topics: Adenosine; Crystallography, X-Ray; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Humans; Models, Molecular; Molecular Conformation; Structure-Activity Relationship

2016
New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.
    Bioorganic & medicinal chemistry letters, 2016, 09-15, Volume: 26, Issue:18

    Topics: Crystallography; Enzyme Inhibitors; Halogens; Histone-Lysine N-Methyltransferase; Methyltransferases; Nitriles; Small Molecule Libraries; Structure-Activity Relationship

2016
Genetic and biochemical studies with the adenosine analogs toyocamycin and tubercidin: mutation at the adenosine kinase locus in Chinese hamster cells.
    Somatic cell genetics, 1978, Volume: 4, Issue:6

    Topics: Adenosine Kinase; Animals; Antibiotics, Antineoplastic; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Female; Mutation; Ovary; Phenotype; Phosphotransferases; Ribonucleosides; Toyocamycin; Tubercidin

1978
Enzymatic preparation of the 5'-triphosphates of 2'-deoxytubercidin, 2'-deoxytoyocamycin, and 2'-deoxyformycin and the allosteric effects of these nucleotides on ribonucleotide reductase.
    Biochemistry, 1978, Jun-13, Volume: 17, Issue:12

    Topics: Antibiotics, Antineoplastic; Binding Sites; Cytidine Triphosphate; Deoxyribonucleotides; Formycins; Kinetics; Ribonucleosides; Ribonucleotide Reductases; Toyocamycin; Tubercidin

1978
Synthesis and biological activity of pyrazolo[3,4,-d]pyrimidine nucleosides and nucleotides related to tubercidin, toyocamycin, and sangivamycin.
    Biochemistry, 1976, Mar-09, Volume: 15, Issue:5

    Topics: Antibiotics, Antineoplastic; Enzyme Activation; Escherichia coli; Manganese; Micrococcus; Polyribonucleotide Nucleotidyltransferase; Protein Biosynthesis; Ribonucleosides; Ribosomes; RNA, Transfer; Spectrophotometry, Ultraviolet; Toyocamycin; Tubercidin

1976
Nucleolar necklaces in chick embryo fibroblast cells. II. Microscope observations of the effect of adenosine analogues on nucleolar necklace formation.
    The Journal of cell biology, 1975, Volume: 65, Issue:2

    Topics: Adenosine; Amanitins; Animals; Arginine; Benzimidazoles; Cell Nucleolus; Cells, Cultured; Chick Embryo; Cycloheximide; Dactinomycin; Deoxyadenosines; Fibroblasts; Liver; Lucanthone; Microscopy, Phase-Contrast; Muscles; Toyocamycin; Tubercidin

1975
Nucleolar necklaces in chick embryo fibroblast cells. I. Formation of necklaces by dichlororibobenzimidazole and other adenosine analogues that decrease RNA synthesis and degrade preribosomes.
    The Journal of cell biology, 1975, Volume: 65, Issue:2

    Topics: Adenosine; Amanitins; Animals; Benzimidazoles; Cell Nucleolus; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Liver; Methionine; Models, Biological; Ribosomes; RNA; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; Toyocamycin; Tubercidin; Uridine

1975
Cytotoxicity and the inhibition of ribosomal RNA processing in human colon carcinoma cells.
    Molecular pharmacology, 1985, Volume: 27, Issue:2

    Topics: Azacitidine; Azaguanine; Cell Survival; Cells, Cultured; Colonic Neoplasms; Fluorouracil; Humans; Protein Biosynthesis; Pyrimidine Nucleosides; RNA, Ribosomal; Toyocamycin; Tubercidin

1985
Involvement of adenosine kinase in the phosphorylation of formycin B in CHO cells.
    Biochemical and biophysical research communications, 1985, Jul-31, Volume: 130, Issue:2

    Topics: Adenosine; Adenosine Kinase; Amides; Animals; Antibiotics, Antineoplastic; Cell Line; Cricetinae; Drug Resistance; Female; Formycins; Methylthioinosine; Mutation; Ovary; Phosphorylation; Phosphotransferases; Pyrazoles; Ribonucleosides; Ribose; Toyocamycin; Tubercidin

1985
Immunological studies with different classes of mutants affected at the adenosine kinase locus in CHO cells.
    Somatic cell and molecular genetics, 1986, Volume: 12, Issue:3

    Topics: Adenosine Kinase; Amides; Animals; Antibody Specificity; Cell Line; Cricetinae; Cricetulus; Cross Reactions; Drug Resistance; Female; Formycins; Immunosorbent Techniques; Methylthioinosine; Mutation; Ovary; Phosphotransferases; Pyrazoles; Ribonucleosides; Ribose; Toyocamycin; Tubercidin

1986
Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors.
    Biochemical pharmacology, 1987, Nov-15, Volume: 36, Issue:22

    Topics: Adenosine; Animals; Biological Transport; Dilazep; Dipyridamole; Drug Therapy, Combination; Female; Mice; Purine Nucleosides; Ribonucleosides; Schistosoma mansoni; Schistosomiasis; Thioinosine; Thionucleotides; Toyocamycin; Tubercidin; Uracil

1987
Formycin B-resistant mutants of Chinese hamster ovary cells: novel genetic and biochemical phenotype affecting adenosine kinase.
    Molecular and cellular biology, 1983, Volume: 3, Issue:8

    Topics: Adenosine; Adenosine Kinase; Animals; Antibiotics, Antineoplastic; Biological Transport; Cell Line; Cells, Cultured; Cricetinae; Drug Resistance; Formycins; Mutation; Phosphotransferases; Toyocamycin; Tubercidin

1983
Differential effects of inhibitors of purine metabolism on two trichomonad species.
    Biochemical pharmacology, 1984, Apr-15, Volume: 33, Issue:8

    Topics: Alanine; Animals; Chromatography, High Pressure Liquid; Formycins; Glycine; Mycophenolic Acid; Purine Nucleotides; Purines; Pyrimidine Nucleosides; Species Specificity; Toyocamycin; Trichomonas vaginalis; Tritrichomonas; Tubercidin; Vidarabine

1984
Genetic and biochemical studies on mutants of CHO cells resistant to 7-deazapurine nucleosides: differences in the mechanisms of action of toyocamycin and tubercidin.
    Biochemical and biophysical research communications, 1984, Apr-16, Volume: 120, Issue:1

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Female; Macromolecular Substances; Mutation; Ovary; Pyrimidine Nucleosides; Ribonucleosides; Toyocamycin; Tubercidin

1984
Introduction of substituents to the 7(8)-position of 7-deazaadenosine (tubercidin): conversion to toyocamycin.
    Nucleic acids symposium series, 1980, Issue:8

    Topics: Indicators and Reagents; Methods; Ribonucleosides; Toyocamycin; Tubercidin

1980
Adenosine-AMP exchange activity is an integral part of the mammalian adenosine kinase.
    Biochemistry and molecular biology international, 1996, Volume: 39, Issue:3

    Topics: Adenosine; Adenosine Kinase; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arsenates; Cattle; CHO Cells; Cricetinae; Enzyme Inhibitors; Enzyme Stability; Kinetics; Liver; Magnesium; Mutation; Phosphates; Temperature; Toyocamycin; Tubercidin

1996
Synthesis of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides. Isosteres of sangivamycin, tubercidin, and toyocamycin.
    Carbohydrate research, 2001, Mar-09, Volume: 331, Issue:1

    Topics: Antibiotics, Antineoplastic; Indicators and Reagents; Pyrimidine Nucleosides; Ribonucleosides; Spectrometry, Mass, Fast Atom Bombardment; Stereoisomerism; Toyocamycin; Triazines; Tubercidin

2001
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
    RNA (New York, N.Y.), 2006, Volume: 12, Issue:5

    Topics: Acridine Orange; Adenosine; Animals; Antibiotics, Antineoplastic; beta-Galactosidase; Cell Line; Cytidine; Drug Evaluation, Preclinical; Enzyme Inhibitors; Ethidium; Fluorouracil; Gene Expression Regulation, Enzymologic; Guanine; Humans; Mice; Mice, Nude; Molecular Structure; RNA, Catalytic; Toyocamycin; Tubercidin; Uridine

2006
7-deazainosine derivatives: synthesis and characterization of 7- and 7,8-substituted pyrrolo [2,3-d]pyrimidine ribonucleosides.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:5

    Topics: Antiviral Agents; Drug Design; Inosine; Magnetic Resonance Spectroscopy; Pyrimidine Nucleosides; RNA Viruses; Toyocamycin; Tubercidin; Virus Replication

2008
Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells.
    ChemMedChem, 2014, Volume: 9, Issue:9

    Topics: Alkylation; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Equilibrative Nucleoside Transporter 1; Humans; Membrane Transport Modulators; Purine Nucleosides; Purines; Pyrimidine Nucleosides; Toyocamycin; Tubercidin

2014