tosyllysine chloromethyl ketone has been researched along with tosylphenylalanyl chloromethyl ketone in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (49.21) | 18.7374 |
| 1990's | 37 (29.37) | 18.2507 |
| 2000's | 19 (15.08) | 29.6817 |
| 2010's | 7 (5.56) | 24.3611 |
| 2020's | 1 (0.79) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Berggren, K; Björck, L; Fex, T; Johansson, B; Kihlberg, J; Luthman, K | 1 |
| Andary, TJ; Dabich, D | 1 |
| Goetzl, EJ | 1 |
| Arlinghaus, RB; Jamjoom, GA; Naso, RB | 1 |
| Chen, AB; Chen, LB; Moser, FG; Mosesson, MW | 1 |
| Vainionpää, R | 1 |
| Eberhard, A; Eberhard, T; Greiling, H; Stuhlsatz, HW | 1 |
| Grinnell, F | 1 |
| Black, PH; Chou, IN; Robin, R | 1 |
| Brown, F; Cavanagh, D; Rowlands, DJ; Sangar, DV | 1 |
| Fenwick, M; Pereira, L; Roizman, B; Wolff, MH | 1 |
| Kitagawa, S; Sakamoto, S; Takaku, F | 1 |
| Mehta, J; Simchowitz, L; Spilberg, I | 1 |
| Gani, V; Jiménez, JS; Kupfer, A; Shaltiel, S | 1 |
| Koch, MR; Lea, MA | 1 |
| Bendtzen, K | 1 |
| Austen, KF; Yurt, R | 1 |
| Venge, P | 1 |
| Cash, P; Preston, CM; Pringle, CR | 1 |
| Abramowitz, J; Birnbaumer, L | 1 |
| Lui, CW; Meizel, S | 1 |
| Buller, RM; Rose, JA | 1 |
| Smith, HJ | 1 |
| Foster, JA; Franzblau, C; Mecham, R | 1 |
| Baker, ME; Fanestil, DD | 1 |
| Gledhill, BL; Lake, S; Penn, A; Timourian, H | 1 |
| Hart, DA; Streilein, JS | 1 |
| Gall, WE; Ohsumi, Y | 1 |
| Aswanikumar, S; Corcoran, BA; Schiffmann, E; Wahl, SM | 1 |
| Adams, JM; Harris, AW; Schmeckpeper, BJ | 1 |
| Stotish, RL; Wang, CC | 1 |
| Hynes, RO; Pearistein, ES | 1 |
| Schulze, HU; Speth, M | 1 |
| Banerjee, RV; González, JC; Huang, S; Matthews, RG; Sumner, JS | 1 |
| Kantorski, J; Tchórzewski, H | 1 |
| Lodish, HF; Wikström, L | 3 |
| Leung, KH | 1 |
| Aoshiba, K; Nagai, A; Takizawa, T | 1 |
| Conseiller, EC; Lederer, F; Schott, D | 1 |
| Chida, K; Kato, N; Kuroki, T | 1 |
| Bukrinskaya, AG; Melnikova, EE; Ovcharenko, AV; Zhirnov, OP | 1 |
| Ennis, M; Heidtmann, HH; Hultsch, T | 1 |
| Conseiller, EC; Lederer, F | 1 |
| Arata, Y; Fukazawa, H; Mizuguchi, J; Nakanishi, M; Utsunomiya, N | 1 |
| Auberger, P; Aussel, C; Didier, J; Didier, M; Fehlmann, M | 1 |
| Berry, L; Brigham, KL; Meyrick, B; Tumen, J | 1 |
| Adams, LM; Baldwin, JK; Fischer, SM | 1 |
| Nakagawa, H; Sato, K; Watanabe, K | 1 |
| Collins, JF; Fine, R; Shaw, SL; Thoman, PJ | 1 |
| Lindquist, RN; McKerrow, J; Petitt, M; Senft, AW | 1 |
| Ballestrero, A; Dallegri, F; Frumento, G; Goretti, R; Patrone, F; Torresin, A | 1 |
| Nakagawa, H; Tsurufuji, S; Watanabe, K | 1 |
| Hubbard, JR; Kalimi, M | 1 |
| Dawson, MM; Moore, M; Shipton, U | 1 |
| Luftig, RB; Tsuzuki, J | 1 |
| O'Brian, CA; Solomon, DH; Weinstein, IB | 1 |
| Kovacs, G; Mathé, G; Stahl, KW | 1 |
| Elliott, WH; May, BK; Tabe, LM | 1 |
| Kinzel, V; König, N | 1 |
| Autor, AP; Hoffman, M | 1 |
| Tsan, MF | 1 |
| Hardy, B; Junga, I; Ma, L; Schrier, SL | 1 |
| Alhanaty, E; Sheetz, MP | 1 |
| Hass, GM; Ristow, SS; Starkey, JR | 1 |
| Bloom, BR; Ishizaka, T; Quan, PC | 1 |
| Hudig, D; Redelman, D | 1 |
| Chang, TW; Eisen, HN | 1 |
| Damerau, B; Grünefeld, E; Vogt, W | 1 |
| Leslie, RG | 1 |
| Das, KC; Lewis-Molock, Y; White, CW | 1 |
| Griscavage, JM; Ignarro, LJ; Wilk, S | 1 |
| Baek, KJ; Chang, KT; Kim, H; Ko, TH; Kwon, NS; Lee, HS | 1 |
| Beullens, M; Bollen, M; Jagiello, I; Stalmans, W | 1 |
| Cohen, GM; Dinsdale, D; Fearnhead, HO; Rivett, AJ | 1 |
| Mackman, N | 1 |
| Lunn, G; Sansone, EB | 1 |
| Ball, EH; Brickenden, A; Jain, N; Sanwal, BD | 1 |
| Cohen, GM; Dinsdale, D; Fearnhead, HO; MacFarlane, M | 1 |
| Adduci, A; Koval, D; Schlegel, R; Stöppler, H; Stöppler, MC | 1 |
| Cobb, RR; Felts, KA; Mackman, N; Parry, GC | 1 |
| McConkey, DJ | 1 |
| Blenis, J; Grammer, TC | 1 |
| Bagarozzi, DA; Pike, R; Potempa, J; Travis, J | 1 |
| Baez, I; Breithaupt, TB; Eylar, EH; Vazquez, A | 1 |
| Koval, D; Schlegel, R; Stöppler, H | 1 |
| Lotem, J; Sachs, L | 1 |
| Alugupalli, KR; Kalfas, S | 1 |
| Kojima, S; Miura, KI; Momose, H; Suzuki, M; Taguchi, S; Yamada, S | 1 |
| Gressner, AM; Wulbrand, U | 1 |
| Cengiz, D; Cokuğraş, AN; Kilinç, K; Tezcan, EF | 1 |
| Jeong, JY; Jue, DM; Kim, KU | 1 |
| Abate, A; Schröder, H | 1 |
| Fukushima, M; Hidaka, M; Kanda, H; Matsuda, A; Takatori, S; Tsutsumi, S; Wataya, Y | 1 |
| Cidlowski, JA; Evans-Storms, RB; Hughes, FM | 1 |
| Abate, A; Oberle, S; Schröder, H | 1 |
| Cidlowski, JA; Hughes, FM; Kugu, K; Perez, GI; Tilly, JL; Tilly, KI; Trbovich, AM | 1 |
| Chung, SW; Hwang, SY; Im, SY; Kang, BY; Kim, TS | 1 |
| Bestilny, LJ; Riabowol, KT | 1 |
| Finck, BN; Heyen, JR; Johnson, RW; Ye, S | 1 |
| Faden, AI; Fan, L; Movsesyan, VA; Yakovlev, AG | 1 |
| Fenucci, JL; Fernández Gimenez, AV; García-Carreño, FL; Navarrete del Toro, MA | 1 |
| Koike, T; Mitsui, C; Ninomiya, T; Sakai, K | 1 |
| Darzynkiewicz, Z; Dragan, M; Grabarek, J; Johnson, GL; Lee, BW | 1 |
| Havlícek, V; Linhartová, I; Osicka, R; Procházková, K; Sebo, P; Sulc, M | 1 |
| Callewaert, B; De Bruyne, G; Lauwaet, T; Leroy, A; Mareel, M; Oliveira, MJ | 1 |
| Cengiz, D; Cokuğraş, AN; Tezcan, EF | 1 |
| He, S; Xie, H | 1 |
| Mlejnek, P | 1 |
| de la Cruz Hernandez-Hernandez, F; Rodriguez, MC; Rodriguez, MH; Torres, JA | 1 |
| Hobbs, G; Hoskisson, PA; Sharples, GP | 1 |
| Heck, S; Lobo, CA; Montero, E; Rafiq, S | 1 |
| Frydrych, I; Mlejnek, P | 2 |
| Bosse, R; Pradel, G; Rupp, I; Schirmeister, T | 1 |
| Kitazumi, I; Maseki, Y; Nomura, Y; Shimanuki, A; Sugita, Y; Tsukahara, M | 1 |
| Hayakawa, T; Kawase, N; Kishi, J; Nakamura, H | 1 |
| Cuervo, P; de Jesus, JB; Domont, GB; Honorio, NA; Levy, CM; Mesquita-Rodrigues, C; Saboia-Vahia, L | 1 |
| Tao, J; Wang, Z; Wei, M; Zhang, Q; Zhu, W | 1 |
| Alavi, SM; Ciereszko, A; Hatef, A; Inaba, K; Linhart, O; Pěknicová, J; Postlerová-Maňásková, P; Pšenička, M | 1 |
| Culmsee, C; Dolga, AM; Ganjam, GK; Reuther, C | 1 |
| Khalfin, B; Nathan, I; Parola, AH; Shadrin, N; Shapira, MG; Uppalapati, L | 1 |
| Fujimuro, M; Hosokawa, K; Ishimaru, H; Sugimoto, A; Tanaka, R; Watanabe, T | 1 |
1 review(s) available for tosyllysine chloromethyl ketone and tosylphenylalanyl chloromethyl ketone
| Article | Year |
|---|---|
Influence of proteinase inhibitors on glucocorticoid receptor properties: recent progress and future perspectives.
Topics: Animals; Cell Nucleus; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Chromatography, Gel; Cytosol; DNA; Models, Chemical; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Receptors, Glucocorticoid; Receptors, Steroid; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1985 |
125 other study(ies) available for tosyllysine chloromethyl ketone and tosylphenylalanyl chloromethyl ketone
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant.
Topics: Bacterial Proteins; Binding Sites; Cysteine Endopeptidases; Cysteine Proteases; Cysteine Proteinase Inhibitors; Kinetics; Protein Binding; Streptococcus pyogenes; Structure-Activity Relationship; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Virulence | 2009 |
Tryptic- and chymotryptic-like proteinases in early and late preimplantation mouse blastocysts.
Topics: Animals; Benzoylarginine-2-Naphthylamide; Blastocyst; Cations, Divalent; Chymotrypsin; Embryonic Development; Endopeptidases; Female; Hydrogen-Ion Concentration; Mice; Pregnancy; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1976 |
Modulation of human neutrophil polymorphonuclear leucocyte migration by human plasma alpha-globulin inhibitors and synthetic esterase inhibitors.
Topics: alpha 1-Antitrypsin; Alpha-Globulins; Carbon Dioxide; Cell Migration Inhibition; Cell Movement; Chemotaxis; Complement C3; Complement C5; Esterases; Glucose; Humans; Macroglobulins; Neutrophils; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1975 |
Further characterization of intracellular precursor polyproteins of Rauscher leukemia virus.
Topics: Amino Acid Chloromethyl Ketones; Antigens, Viral; Canavanine; Cell Line; Epitopes; Immunoassay; Molecular Weight; Pactamycin; Protein Biosynthesis; Rauscher Virus; RNA-Directed DNA Polymerase; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Viral Proteins | 1977 |
Distribution of cell surface LETS protein in co-cultures of normal and transformed cells.
Topics: alpha-Macroglobulins; Aminocaproates; Aprotinin; Cell Line; Cell Transformation, Neoplastic; Fibrinolysis; Fluorescent Antibody Technique; gamma-Glutamyltransferase; Membrane Proteins; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin Inhibitors | 1977 |
Measles virus-specified polypeptides in infected cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Cell Line; Dimethyl Sulfoxide; Haplorhini; Kidney; Measles virus; Molecular Weight; Peptide Biosynthesis; Phenylalanine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Viral Proteins | 1979 |
Studies on the mechanism of hyaluronate lyase action.
Topics: Amino Acids; Depression, Chemical; Hyaluronic Acid; Hyaluronoglucosaminidase; Oxygen Consumption; Streptococcus pyogenes; Structure-Activity Relationship; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1975 |
Cell attachment to a substratum and cell surface proteases.
Topics: Cell Adhesion; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Kinetics; Peptide Hydrolases; Phenylmethylsulfonyl Fluoride; Polyomavirus; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1975 |
Proteolytic enzymes, cell surface changes, and viral transformation.
Topics: Binding Sites; Cell Adhesion; Cell Aggregation; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Glucose; Glycosaminoglycans; Lectins; Models, Biological; Peptide Hydrolases; Phenotype; Plasminogen; Protease Inhibitors; Proteins; Thrombin; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin Inhibitors; Viruses | 1975 |
Immunogenic and cell attachment sites of FMDV: further evidence for their location in a single capsid polypeptide.
Topics: Animals; Antibodies, Viral; Aphthovirus; Binding Sites, Antibody; Capsid; Cell Line; Chymotrypsin; Guinea Pigs; Hydrolysis; Molecular Weight; Neutralization Tests; Peptides; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin; Viral Proteins | 1977 |
Regulation of herpesvirus macromolecular synthesis. V. Properties of alpha polypeptides made in HSV-1 and HSV-2 infected cells.
Topics: Amino Acids; Canavanine; Carcinoma, Squamous Cell; Cell Line; Cycloheximide; Macromolecular Substances; Molecular Weight; Peptide Biosynthesis; Protein Biosynthesis; Simplexvirus; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Viral Proteins | 1977 |
Possible involvement of proteases in superoxide production by human polymorphonuclear leukocytes.
Topics: Adult; Endopeptidases; Humans; Kinetics; Neutrophils; Oxygen; Superoxides; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Xanthine Oxidase | 1979 |
Chemotactic factor-induced superoxide radical generation by human neutrophils: requirement for proteinase (esterase) activity.
Topics: Calcium; Chemotaxis, Leukocyte; Endopeptidases; Humans; In Vitro Techniques; Isoflurophate; Methionine; N-Formylmethionine; Neutrophils; Oligopeptides; Oxygen; Protease Inhibitors; Superoxides; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1979 |
Affinity labeling of the catalytic subunit of cyclic AMP-dependent protein kinase by N alpha-tosyl-L-lysine chloromethyl ketone.
Topics: Affinity Labels; Amino Acid Chloromethyl Ketones; Animals; Binding Sites; Cyclic AMP; In Vitro Techniques; Muscles; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Substrate Specificity; Sulfhydryl Compounds; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1979 |
Selective effects of two chloromethyl ketones on amino acid and phosphate uptake in rat liver and tumors.
Topics: Amino Acid Chloromethyl Ketones; Amino Acids; Animals; Liver; Liver Neoplasms, Experimental; Male; Phosphates; Rats; Rats, Inbred BUF; Thymidine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1979 |
Human leukocyte migration inhibitory factor (LIF) III. Further investigations on the serine protease nature of this lymphokine and its preference for arginine amides.
Topics: Amides; Arginine; Humans; Leukocytes; Macrophage Migration-Inhibitory Factors; Phenylmethylsulfonyl Fluoride; Physostigmine; Pralidoxime Compounds; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1977 |
Preparative purification of the rat mast cell chymase: characterization and interaction with granule components.
Topics: Animals; Benzamides; Chromatography; Chymosin; Cytoplasmic Granules; Female; Heparin; Histamine; Male; Mast Cells; Rats; Serotonin; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tyrosine | 1977 |
Kinetic studies of cell migration in a modified Boyden chamber: dependence on cell concentration and effects of the chymotrypsin-like cationic protein of human granulocytes.
Topics: Blood Proteins; Caseins; Cations; Cell Movement; Chymotrypsin; Dose-Response Relationship, Immunologic; Granulocytes; Humans; Immunologic Techniques; Kinetics; Lactoferrin; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1979 |
The polypeptides of human respiratory syncytial virus: products of cell-free protein synthesis and post-translational modifications.
Topics: Capsid; Cell-Free System; Humans; Phosphorylation; Protein Biosynthesis; Respiratory Syncytial Viruses; RNA, Messenger; RNA, Viral; Sulfates; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Viral Proteins | 1979 |
Effects of trypsin, protease inhibitors and ethanol on corpus luteum adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Chorionic Gonadotropin; Corpus Luteum; Ethanol; Female; Guanosine Triphosphate; Luteinizing Hormone; Protease Inhibitors; Rabbits; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1979 |
Further evidence in support of a role for hamster sperm hydrolytic enzymes in the acrosome reaction.
Topics: Acrosome; Animals; Benzamidines; Cricetinae; In Vitro Techniques; Ionophores; Male; Mesocricetus; Phospholipases; Serum Albumin, Bovine; Sperm Motility; Spermatozoa; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin Inhibitors | 1979 |
Characterization of adenovirus-associated virus-induced polypeptides in KB cells.
Topics: Adenoviruses, Human; Canavanine; Cell Line; Humans; Molecular Weight; Parvoviridae; Peptide Biosynthesis; Phenylmethylsulfonyl Fluoride; Satellite Viruses; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Viral Proteins; Virus Replication | 1978 |
Perspectives in the design of small molecule enzyme inhibitors as useful drugs.
Topics: Chemistry, Pharmaceutical; Enzyme Inhibitors; Enzymes; Glutathione; Kinetics; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1978 |
Proteolysis of tropoelastin.
Topics: Aminopropionitrile; Animals; Chelating Agents; Chickens; Elastin; Endopeptidases; Molecular Weight; Pancreatic Elastase; Protease Inhibitors; Protein Binding; Sulfhydryl Reagents; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tropoelastin | 1977 |
Effect of protease inhibitors and substrates on deoxycorticosterone binding to its receptor in dog MDCK kidney cells.
Topics: Binding, Competitive; Cell Line; Desoxycorticosterone; Enzyme Inhibitors; Kinetics; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Receptors, Steroid; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1977 |
Division delay in sea urchin embryos induced by a specific protease inhibitor.
Topics: Animals; Cell Division; DNA; Dose-Response Relationship, Drug; Female; Iodoacetamide; Iodoacetates; Lysine; Mitosis; Organoids; Peptide Hydrolases; Sea Urchins; Thymidine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin Inhibitors; Zygote | 1976 |
Effect of protease inhibitors on mitogen stimulation of hamster lymphoid cells.
Topics: Amino Acid Chloromethyl Ketones; Aminocaproates; Animals; Concanavalin A; Cricetinae; Dose-Response Relationship, Drug; Glutathione; Leucine; Lipopolysaccharides; Lymph Nodes; Lymphocyte Activation; Phenylmethylsulfonyl Fluoride; Spleen; Sulfones; Thymidine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1976 |
Decondensation of sperm nuclei in vitro.
Topics: Acrosome; Animals; Cell Membrane; Cell Nucleus; Dithiothreitol; Glutathione; Guinea Pigs; Hydrolases; Male; Mercaptoethanol; Mice; Peptide Hydrolases; Rabbits; Rats; Sperm Head; Spermatozoa; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1976 |
Role of a peptidase in phagocyte chemotaxis.
Topics: Animals; Chemotaxis; Complement C5; Guinea Pigs; Macrophages; N-Formylmethionine; Neutrophils; Peptide Hydrolases; Peptides; Rabbits; Structure-Activity Relationship; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1976 |
Effects of protease inhibitors on early stages of meiosis in Xenopus laevis oocytes.
Topics: Animals; Chymotrypsin; Female; Leucine; Meiosis; Metamorphosis, Biological; Oocytes; Ovary; Ovum; Peptide Hydrolases; Protease Inhibitors; Protein Biosynthesis; Time Factors; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transcription, Genetic; Tritium; Uridine; Xenopus | 1975 |
Detection of a possible precursor of immunoglobulin light chain in MOPC 41 A plasmacytoma cells.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Immunoglobulin Fragments; Mice; Mice, Inbred BALB C; Plasmacytoma; Precipitin Tests; Rabbits; Sodium Dodecyl Sulfate; Sulfur Radioisotopes; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1975 |
Pancreatic chymotrypsin as the essential enzyme for excystation of Eimeria tenella.
Topics: Animals; Chick Embryo; Chymotrypsin; Eimeria; Lipase; Oligopeptides; Pancreas; Phenylurea Compounds; Swine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin; Trypsin Inhibitors | 1975 |
Investigations of the possible role of proteases in altering surface proteins of virally transformed hamster fibroblasts.
Topics: Aminocaproates; Blood; Cell Division; Cell Line; Cell Transformation, Neoplastic; Fibrinolysis; Glycoproteins; Ovomucin; Peptide Hydrolases; Plasminogen; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin Inhibitors | 1976 |
Protease inhibitors but not proteases inhibit the glucose-6-phosphatase of native rat liver microsomes.
Topics: Animals; Endopeptidases; Glucose-6-Phosphatase; Microsomes, Liver; Oxidoreductases; Phosphoric Monoester Hydrolases; Protease Inhibitors; Protein Conformation; Rats; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1992 |
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alkylation; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Homocysteine; Iodoacetamide; Methionine; Molecular Sequence Data; Recombinant Proteins; Restriction Mapping; Tetrahydrofolates; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin; Vitamin B 12 | 1992 |
The effect of serine and thiol protease inhibitors on the chemiluminescence of human neutrophils in investigations in vitro.
Topics: Calcimycin; Cysteine Proteinase Inhibitors; Humans; In Vitro Techniques; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Respiratory Burst; Serine Proteinase Inhibitors; Tetradecanoylphorbol Acetate; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tyrosine; Zymosan | 1992 |
Endoplasmic reticulum degradation of a subunit of the asialoglycoprotein receptor in vitro. Vesicular transport from endoplasmic reticulum is unnecessary.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Biological Transport; Cell Line; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrolysis; Precipitin Tests; Receptors, Immunologic; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transfection | 1992 |
Human lymphokine-activated killer (LAK) cells: III. Effect of L-phenylalanine methyl ester on LAK cell activation from human peripheral blood mononuclear cells: possible protease involvement of monocytes, natural killer cells and LAK cells.
Topics: Chymotrypsin; Endopeptidases; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lymphocyte Activation; Monocytes; Phenylalanine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1991 |
Effects of proteinase inhibitors on polymorphonuclear neutrophil polarization.
Topics: alpha 1-Antitrypsin; Chemotaxis, Leukocyte; Colchicine; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protease Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1991 |
Nonlysosomal, pre-Golgi degradation of unassembled asialoglycoprotein receptor subunits: a TLCK- and TPCK-sensitive cleavage within the ER.
Topics: 2,4-Dinitrophenol; alpha-Glucosidases; Animals; Asialoglycoprotein Receptor; beta-Galactosidase; Cell Fractionation; Cell Line; Cycloheximide; Deoxyglucose; Dinitrophenols; Endoplasmic Reticulum; Fibroblasts; Golgi Apparatus; Humans; Kinetics; Lysosomes; Macromolecular Substances; Mice; Molecular Weight; Receptors, Immunologic; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transfection | 1991 |
Inhibition by aminoacyl-chloromethane protease inhibitors of superoxide anion production by phorbol-ester-stimulated human neutrophils. The labeled target is a membrane protein.
Topics: Borohydrides; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Humans; Membrane Proteins; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phorbol Esters; Superoxides; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1990 |
Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.
Topics: Animals; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cell Line; Chromatography, Gel; Cytosol; Diglycerides; Female; Keratins; Leupeptins; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylserines; Pregnancy; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Skin; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1986 |
Alphavirus replication in cultured cells and infected animals is inhibited by antiproteinase agents.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antiviral Agents; Aprotinin; Cells, Cultured; Chick Embryo; Mice; Sindbis Virus; Togaviridae Infections; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Viral Plaque Assay; Virus Replication | 1986 |
The effect of serine esterase inhibitors on ionophore-induced histamine release from human pulmonary mast cells.
Topics: Calcimycin; Esterases; Histamine Release; Humans; In Vitro Techniques; Isoflurophate; Lung; Mast Cells; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1988 |
Inhibition of NADPH oxidase by aminoacyl chloromethane protease inhibitors in phorbol-ester-stimulated human neutrophils: a reinvestigation. Are proteases really involved in the activation process?
Topics: Amino Acid Chloromethyl Ketones; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Peptide Hydrolases; Protease Inhibitors; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1989 |
Differential sensitivity of anti-IgM-induced and NaF-induced inositol phospholipid metabolism to serine protease inhibitors in BAL17 B lymphoma cells.
Topics: B-Lymphocytes; Calcium; Immunoglobulin M; Inositol Phosphates; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Activation; Phosphatidylinositols; Protease Inhibitors; Receptors, Antigen, B-Cell; Serine Endopeptidases; Signal Transduction; Sodium Fluoride; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured | 1989 |
A chymotryptic-type protease inhibitor decreases interleukin 2 synthesis and induces prostaglandin production in Jurkat T cells.
Topics: Amino Acid Chloromethyl Ketones; Arachidonic Acids; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Interleukin-2; Lymphocyte Activation; Prostaglandins; T-Lymphocytes; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1989 |
Antiproteinases protect cultured lung endothelial cells from endotoxin injury.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Chloromethyl Ketones; Animals; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Endotoxins; Female; L-Lactate Dehydrogenase; Protease Inhibitors; Pulmonary Artery; Superoxides; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1988 |
Effects of anti-promoters and strain of mouse on tumor promoter-induced oxidants in murine epidermal cells.
Topics: Animals; Antioxidants; Diglycerides; Female; Free Radicals; Luminescent Measurements; Male; Mice; Mice, Inbred Strains; Neutrophils; Skin; Skin Neoplasms; Species Specificity; Superoxides; Tetradecanoylphorbol Acetate; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trifluoperazine | 1986 |
Inhibitory action of synthetic proteinase inhibitors and substrates on the chemotaxis of rat polymorphonuclear leukocytes in vitro.
Topics: Animals; Chemotaxis, Leukocyte; Chymotrypsin; Endopeptidases; In Vitro Techniques; Neutrophils; Protease Inhibitors; Rats; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1988 |
Studies on the elastolytic activity of chymotrypsin.
Topics: Animals; Calcium; Cattle; Chymotrypsin; Elastin; In Vitro Techniques; Ligaments; Pancreatic Elastase; Solubility; Substrate Specificity; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1985 |
Schistosoma mansoni: purification and characterization of the major acidic proteinase from adult worms.
Topics: Animals; Chromatography, Gel; Cysteine Endopeptidases; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Female; Helminth Proteins; Hemoglobins; Hydrogen-Ion Concentration; Isoelectric Point; Kinetics; Leupeptins; Male; Molecular Weight; Peptides; Protease Inhibitors; Schistosoma mansoni; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1986 |
Antibody-dependent tumour cytolysis by human neutrophils: effect of synthetic serine esterase inhibitors and substrates.
Topics: Antibody-Dependent Cell Cytotoxicity; Cell Line; Cytotoxicity Tests, Immunologic; Esterases; Humans; Neutrophils; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1987 |
Vascular permeability changes by proteinase inhibitors in carrageenin-induced inflammation in rats.
Topics: Animals; Capillary Permeability; Carrageenan; Inflammation; Kinetics; Leupeptins; Protease Inhibitors; Rats; Rats, Inbred Strains; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1986 |
Involvement of cell surface macromolecules sensitive to alkylating ketones in lysis by human peripheral blood NK cells.
Topics: Amino Acid Chloromethyl Ketones; Cell Line; Cell Membrane; Concanavalin A; Cycloheximide; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Immunologic; Humans; Killer Cells, Natural; Kinetics; Lectins; Plant Lectins; Protease Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1985 |
Evidence for the ubiquitous presence of a protein kinase in human adenoviruses capable of preferentially phosphorylating capsid protein IIIa.
Topics: Adenoviruses, Human; Capsid; Cell Line; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Viral Proteins; Viral Structural Proteins | 1985 |
N-alpha-Tosyl-L-lysine chloromethyl ketone and N-alpha-tosyl-L-phenylalanine chloromethyl ketone inhibit protein kinase C.
Topics: Amino Acid Chloromethyl Ketones; Animals; Binding Sites; Brain; Calcium; Phospholipids; Protein Kinase C; Rats; Structure-Activity Relationship; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1985 |
Decrease of metastatogenic potential by pregraft treatment of Lewis lung carcinoma cells with proteinase and protein kinase affinity labels.
Topics: Affinity Labels; Animals; Female; Isoflurophate; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Protease Inhibitors; Protein Kinases; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1985 |
Inhibition of the pancreatic microsome enzyme release phenomenon by inhibitors of signal peptidase activity.
Topics: alpha-Amylases; Amylases; Animals; Aprotinin; Benzamidines; Chymotrypsin; In Vitro Techniques; Male; Microsomes; Pancreas; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Procaine; Rats; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin Inhibitors | 1980 |
Interaction of protease inhibitors with the catalytic subunit of cAMP-dependent protein kinase.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antipain; Buffers; Cyclic AMP; Dimethyl Sulfoxide; Leupeptins; Macromolecular Substances; Methanol; Muscles; Polyethylene Glycols; Protease Inhibitors; Protein Kinases; Rats; Solubility; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1980 |
Effect of cyclooxygenase inhibitors and protease inhibitors on phorbol-induced stimulation of oxygen consumption and superoxide production by rat pulmonary macrophages.
Topics: Animals; Aspirin; Ibuprofen; In Vitro Techniques; Lung; Macrophages; Oxygen; Oxygen Consumption; Oxygenases; Phorbols; Protease Inhibitors; Rats; Rats, Inbred Strains; Superoxides; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1982 |
Inhibition of neutrophil sulfhydryl groups by choloromethyl ketones. A mechanism for their inhibition of superoxide production.
Topics: Amino Acid Chloromethyl Ketones; Chemical Phenomena; Chemistry; Ethylmaleimide; Humans; In Vitro Techniques; Isoflurophate; Neutrophils; Oxygen; Sulfhydryl Compounds; Superoxides; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1983 |
Actin-activated ATPase in human red cell membranes.
Topics: Actins; Adenosine Triphosphatases; Animals; Erythrocyte Membrane; Erythrocytes; Filtration; Humans; Magnesium; Myosins; Rabbits; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1981 |
Cell membrane shape control--effects of chloromethyl ketone peptides.
Topics: 2,4-Dinitrophenol; Amino Acid Chloromethyl Ketones; Dinitrophenols; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Erythrocyte Membrane; Erythrocytes; Ethylmaleimide; Humans; Kinetics; Subcellular Fractions; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1984 |
In vitro effects of protease inhibitors on murine natural killer cell activity.
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; Molecular Weight; Protease Inhibitors; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1983 |
Studies on the mechanism of NK cell lysis.
Topics: Animals; Arginine; Calcium; Carbamates; Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Female; Immunity, Cellular; Indoles; Male; Mice; Mice, Inbred CBA; Nitrobenzoates; Phenylalanine; Phenylcarbamates; Protease Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tubercidin; Tyrosine | 1982 |
The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases.
Topics: Animals; Cell Membrane; Cytotoxicity, Immunologic; Diamide; Glutathione; Iodoacetamide; Macromolecular Substances; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred DBA; Peptide Hydrolases; Sulfhydryl Compounds; T-Lymphocytes; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin Inhibitors | 1980 |
Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes.
Topics: Amino Acid Chloromethyl Ketones; Animals; Calcium; Concanavalin A; Cytotoxicity, Immunologic; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Peptide Hydrolases; T-Lymphocytes; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin; Trypsin Inhibitors | 1980 |
Aggregation of leukocytes induced by the complement-derived peptides C3a and C5a and by three synthetic formyl-methionyl peptides.
Topics: Calcium; Cell Aggregation; Cell Movement; Complement C3; Complement C5; Desensitization, Immunologic; Dose-Response Relationship, Immunologic; Humans; Leukocytes; Magnesium; Methionine; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Serum Albumin; Sulfhydryl Reagents; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1980 |
Macrophage handling of soluble immune complexes. Use of specific inhibitors to study the biochemical events involved in complex catabolism.
Topics: Animals; Antigen-Antibody Complex; Ascitic Fluid; Cattle; Cell Survival; Cytochalasin B; Guinea Pigs; Lidocaine; Macrophages; Solubility; Temperature; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1980 |
Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.
Topics: Adenocarcinoma; Alkylating Agents; Base Sequence; Enzyme Induction; Humans; Interleukin-1; Isoenzymes; Lung Neoplasms; Manganese; Mitochondria; Molecular Sequence Data; NF-kappa B; Oxidants; Oxidation-Reduction; Promoter Regions, Genetic; Protease Inhibitors; Sulfhydryl Compounds; Superoxide Dismutase; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 1995 |
Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene.
Topics: Animals; Blotting, Northern; Cell Line; Cysteine Proteinase Inhibitors; Enzyme Induction; Gene Expression; Glycoproteins; Lipopolysaccharides; Macrophage Activation; Macrophages, Alveolar; Nitric Oxide; Nitric Oxide Synthase; Rats; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transcription, Genetic | 1995 |
Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa B.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Base Sequence; Cell Survival; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Macrophages; Mice; Molecular Sequence Data; NF-kappa B; Nitric Oxide Synthase; RNA, Messenger; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1995 |
Subunit structure and regulation of protein phosphatase-1 in rat liver nuclei.
Topics: Animals; Cell Nucleus; Cyclic AMP-Dependent Protein Kinases; Female; Liver; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Rats, Wistar; Substrate Specificity; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1995 |
A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli.
Topics: Animals; Apoptosis; Dexamethasone; DNA; Endopeptidases; Etoposide; Flow Cytometry; Male; Nucleosomes; Rats; Rats, Inbred F344; Thymus Gland; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1995 |
Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers.
Topics: Base Sequence; Cells, Cultured; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Humans; Immediate-Early Proteins; Lipopolysaccharides; Molecular Sequence Data; Monocytes; Protease Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; RNA, Messenger; Thromboplastin; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transcription Factors; Transcription, Genetic | 1994 |
Degradation and disposal of some enzyme inhibitors. Scientific note.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Enzyme Inhibitors; Hydrogen-Ion Concentration; Mutagens; Phenylmethylsulfonyl Fluoride; Sodium Hydroxide; Tosyl Compounds; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1994 |
Inhibition of procollagen I degradation by colligin: a collagen-binding serpin.
Topics: Amino Acid Sequence; Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Fibronectins; Glycoproteins; Humans; Hydrogen-Ion Concentration; Leupeptins; Microsomes, Liver; Molecular Sequence Data; Procollagen; Protease Inhibitors; Rats; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1994 |
Unfolded H2b asialoglycoprotein receptor subunit polypeptides are selectively degraded within the endoplasmic reticulum.
Topics: 3T3 Cells; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Calcium-Transporting ATPases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Macromolecular Substances; Mice; Protein Denaturation; Protein Folding; Protein Processing, Post-Translational; Receptors, Immunologic; Recombinant Proteins; Terpenes; Thapsigargin; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transfection | 1993 |
DNA degradation and proteolysis in thymocyte apoptosis.
Topics: Animals; Apoptosis; DNA; Endopeptidases; Male; Rats; Rats, Inbred F344; T-Lymphocytes; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1995 |
The serine protease inhibitors TLCK and TPCK react with the RB-binding core of HPV-18 E7 protein and abolish its RB-binding capability.
Topics: Antibodies, Viral; Base Sequence; Binding Sites; Cells, Cultured; Cysteine; DNA Primers; DNA-Binding Proteins; Humans; Keratinocytes; Male; Molecular Sequence Data; Molecular Weight; Oncogene Proteins, Viral; Protein Binding; Retinoblastoma Protein; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-kappa B.
Topics: Base Sequence; Biological Transport; Calpain; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Endothelium, Vascular; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; NF-kappa B; Plasminogen Activator Inhibitor 1; Protease Inhibitors; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; RNA, Messenger; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transfection; Vascular Cell Adhesion Molecule-1 | 1996 |
Calcium-dependent, interleukin 1-converting enzyme inhibitor-insensitive degradation of lamin B1 and DNA fragmentation in isolated thymocyte nuclei.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Aurintricarboxylic Acid; Calcium; Caspase 1; Cell Nucleus; Cysteine Endopeptidases; DNA Fragmentation; Histones; Humans; Lamin Type B; Lamins; Mice; Mice, Inbred BALB C; Nuclear Proteins; Protease Inhibitors; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Serine Endopeptidases; T-Lymphocytes; Thapsigargin; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation.
Topics: 3T3 Cells; Animals; Cell Line; Enzyme Activation; Mice; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Serine Proteinase Inhibitors; Signal Transduction; Sirolimus; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
Purification and characterization of a novel endopeptidase in ragweed (Ambrosia artemisiifolia) pollen.
Topics: Amino Acid Sequence; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Hydrogen-Ion Concentration; Isoflurophate; Molecular Sequence Data; Molecular Weight; Plants; Pollen; Protease Inhibitors; Serine Endopeptidases; Substrate Specificity; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
The suppression of T cell function and NF(kappa)B expression by serine protease inhibitors is blocked by N-acetylcysteine.
Topics: Acetylcysteine; Adult; DNA; Humans; Interferon-gamma; Interleukin-2; Interleukin-6; Mitogens; NF-kappa B; Serine Proteinase Inhibitors; T-Lymphocytes; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
The serine protease inhibitors TLCK and TPCK inhibit the in vitro immortalization of primary human keratinocytes by HPV-18 DNA.
Topics: Cell Division; Cell Line; Cell Transformation, Neoplastic; Humans; Keratinocytes; Papillomaviridae; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Butylated Hydroxyanisole; Caspase 1; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cytokines; Endopeptidases; Enzyme Precursors; Granulocyte-Macrophage Colony-Stimulating Factor; Granzymes; Humans; Interferon-gamma; Interleukin-6; Oligopeptides; Pepstatins; Protease Inhibitors; Serine Endopeptidases; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1996 |
Degradation of lactoferrin by periodontitis-associated bacteria.
Topics: Aggregatibacter actinomycetemcomitans; Bacteria; Bacteroides; Campylobacter; Capnocytophaga; Enzyme Inhibitors; Fusobacterium nucleatum; Humans; Iodoacetamide; Lactoferrin; Leupeptins; Peptostreptococcus; Periodontitis; Phenylmethylsulfonyl Fluoride; Porphyromonas gingivalis; Prevotella intermedia; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
A novel member of the subtilisin-like protease family from Streptomyces albogriseolus.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA, Bacterial; Hydrogen-Ion Concentration; Molecular Sequence Data; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Streptomyces; Substrate Specificity; Subtilisins; Temperature; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1997 |
Variation of immunocytochemical expression of transforming growth factor (TGF)-beta in hepatocytes in culture and liver slices.
Topics: Animals; Calcimycin; Calpain; Cells, Cultured; Coculture Techniques; Cycloheximide; Dactinomycin; Immunohistochemistry; Ionomycin; Ionophores; Liver; Male; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Staining and Labeling; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transforming Growth Factor beta | 1997 |
Histidine modification of human serum butyrylcholinesterase.
Topics: Binding Sites; Butyrylcholinesterase; Catalysis; Cholinesterase Inhibitors; Diethyl Pyrocarbonate; Enzyme Activation; Histidine; Humans; Kinetics; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1997 |
Tosylphenylalanine chloromethyl ketone inhibits TNF-alpha mRNA synthesis in the presence of activated NF-kappa B in RAW 264.7 macrophages.
Topics: Animals; Blotting, Northern; Cell Culture Techniques; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; NF-kappa B; RNA, Messenger; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tumor Necrosis Factor-alpha | 1997 |
Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.
Topics: Amino Acid Sequence; Animals; Cell Death; Cell Survival; Cells, Cultured; DNA-Binding Proteins; Drug Interactions; I-kappa B Proteins; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Peptides; Serine Proteinase Inhibitors; Signal Transduction; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1998 |
The characterization of cell death induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd) in FM3A cells.
Topics: Animals; Antineoplastic Agents; Cell Death; Cytidine; DNA Damage; Female; Mammary Neoplasms, Experimental; Mice; Nucleic Acid Synthesis Inhibitors; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured | 1998 |
Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Calpain; Caspase 1; Caspase 3; Caspase Inhibitors; Caspases; Cell Nucleolus; Chromatin; Cysteine Proteinase Inhibitors; DNA Fragmentation; Electrophoresis, Gel, Pulsed-Field; Endonucleases; HeLa Cells; Humans; Isoflurophate; Magnesium; Male; Oligopeptides; Peptide Fragments; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Serine Proteinase Inhibitors; Thymus Gland; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1998 |
Lipopolysaccharide-induced expression of cyclooxygenase-2 in mouse macrophages is inhibited by chloromethylketones and a direct inhibitor of NF-kappa B translocation.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Cell Survival; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Peptides; Prostaglandin-Endoperoxide Synthases; Subcellular Fractions; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1998 |
High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays.
Topics: Animals; Antirheumatic Agents; Apoptosis; Caspase 1; Caspase Inhibitors; Cell Nucleus; Cell-Free System; Cysteine Proteinase Inhibitors; Deoxyribonucleases; Diphenylamine; DNA; Endopeptidases; Female; Follicular Atresia; Gold Sodium Thiomalate; HeLa Cells; Humans; Molecular Weight; Oligopeptides; Ovarian Follicle; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1998 |
Chloromethyl ketones inhibit interleukin-12 production in mouse macrophages stimulated with lipopolysaccharide.
Topics: Animals; Dose-Response Relationship, Drug; Female; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred DBA; NF-kappa B; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1999 |
A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 cells.
Topics: Antigens, CD; Cell Differentiation; Cysteine Proteinase Inhibitors; Gene Expression Regulation; HL-60 Cells; Humans; Kinetics; Macrophage-1 Antigen; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfones; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transcription, Genetic | 2000 |
Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB.
Topics: Animals; Animals, Newborn; Brain; Cell Line; Cell Nucleus; Cells, Cultured; Cytoplasm; Gene Expression Regulation; Interleukin-10; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Microglia; NF-kappa B; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2000 |
Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis.
Topics: Animals; Apoptosis; Behavior, Animal; Brain Injuries; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Coumarins; Culture Media, Serum-Free; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Isocoumarins; Male; Motor Activity; Neurons; Nucleic Acid Synthesis Inhibitors; Potassium; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Serine Proteinase Inhibitors; Spatial Behavior; Staurosporine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Wounds, Nonpenetrating | 2001 |
Digestive proteinases of red shrimp Pleoticus muelleri (Decapoda, Penaeoidea): partial characterization and relationship with molting.
Topics: Animals; Chymotrypsin; Decapoda; Digestive System; Endopeptidases; Hydrogen-Ion Concentration; Molecular Weight; Molting; Protease Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 2001 |
Involvement of TLCK-sensitive serine protease in colchicine-induced cell death of sympathetic neurons in culture.
Topics: Animals; Animals, Newborn; Apoptosis; Bucladesine; Caspase 3; Caspases; Cells, Cultured; Colchicine; Enzyme Inhibitors; Immunohistochemistry; Microscopy, Electron; Microtubule Proteins; Necrosis; Nervous System; Neurons; Neuroprotective Agents; Potassium; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Serine Proteinase Inhibitors; Signal Transduction; Superior Cervical Ganglion; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2001 |
Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor.
Topics: Affinity Labels; Amino Acid Chloromethyl Ketones; Apoptosis; Binding Sites; Camptothecin; Enzyme Activation; Flow Cytometry; Fluorescein; HL-60 Cells; Humans; Serine Endopeptidases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
A novel "clip-and-link" activity of repeat in toxin (RTX) proteins from gram-negative pathogens. Covalent protein cross-linking by an Asp-Lys isopeptide bond upon calcium-dependent processing at an Asp-Pro bond.
Topics: Amino Acid Sequence; Bacterial Proteins; Calcium; Catalysis; Cytotoxins; Gram-Negative Bacteria; Membrane Proteins; Molecular Sequence Data; Molecular Weight; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2004 |
Proteinase inhibitors TPCK and TLCK prevent Entamoeba histolytica induced disturbance of tight junctions and microvilli in enteric cell layers in vitro.
Topics: Animals; Cells, Cultured; Cysteine Endopeptidases; Electric Impedance; Entamoeba histolytica; Enterocytes; Microfilament Proteins; Microvilli; Protein Synthesis Inhibitors; Tight Junctions; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2004 |
Do alkylating agents modify the histidine residue of the desensitized butyrylcholinesterase?
Topics: Alkylating Agents; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Dialysis; Histidine; Humans; Kinetics; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2004 |
Modulation of tryptase and histamine release from human lung mast cells by protease inhibitors.
Topics: Female; Histamine Release; Humans; Immunoglobulin E; Lung; Male; Mast Cells; Protease Inhibitors; Serine Endopeptidases; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tryptases | 2004 |
Can application of serine protease inhibitors TPCK and TLCK provide evidence for possible involvement of serine protease Omi/HtrA2 in imatinib mesylate-induced cell death of BCR-ABL-positive human leukemia cells?
Topics: Benzamides; High-Temperature Requirement A Serine Peptidase 2; Humans; Imatinib Mesylate; Leukemia; Mitochondrial Proteins; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Serine Endopeptidases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured | 2005 |
Plasmodium berghei: effect of protease inhibitors during gametogenesis and early zygote development.
Topics: Analysis of Variance; Animals; Gametogenesis; Leupeptins; Mice; Mice, Inbred BALB C; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Plasmodium berghei; Protease Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Zygote | 2005 |
Differentiation and protease production in Micromonospora echinospora (ATCC 15837).
Topics: Kinetics; Micromonospora; Peptide Hydrolases; Serine Proteinase Inhibitors; Spores, Bacterial; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2006 |
Inhibition of human erythrocyte invasion by Babesia divergens using serine protease inhibitors.
Topics: Animals; Babesia; Calcium; Erythrocytes; Flow Cytometry; Humans; In Vitro Techniques; Parasitology; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Virulence | 2007 |
Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases.
Topics: Apoptosis; Caspase Inhibitors; Caspases; HL-60 Cells; Humans; Membrane Potential, Mitochondrial; Recombinant Proteins; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2008 |
Effect of protease inhibitors on exflagellation in Plasmodium falciparum.
Topics: Animals; Aspartic Acid Endopeptidases; Cysteine Proteinase Inhibitors; Flagella; Metalloproteases; Parasitic Sensitivity Tests; Plasmodium falciparum; Protease Inhibitors; Reproduction; Serine Endopeptidases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2008 |
Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli.
Topics: Apoptosis; Caspase 3; Caspase 7; Caspase Inhibitors; HL-60 Cells; Humans; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2008 |
Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells.
Topics: Animals; Apoptosis; Base Sequence; Caspase 3; Caspase Inhibitors; CHO Cells; Cricetinae; Cricetulus; Cysteine Proteinase Inhibitors; DNA Fragmentation; DNA Primers; DNA, Complementary; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Peptide Hydrolases; Poly(ADP-ribose) Polymerases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2010 |
Collagenolytic activity in sonic extracts of Tannerella forsythia.
Topics: Bacteroides; Calcium Chloride; Cathepsins; Cell Line, Tumor; Chelating Agents; Collagen Type I; Cysteine; Cysteine Proteinase Inhibitors; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Ethylmaleimide; Gelatinases; Humans; Iodoacetamide; Iodoacetic Acid; Leucine; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2010 |
Expression of trypsin-like serine peptidases in pre-imaginal stages of Aedes aegypti (Diptera: Culicidae).
Topics: Aedes; Animals; Larva; Molecular Weight; Pepstatins; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Pupa; Serine Endopeptidases; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2011 |
Angiogenic changes in co-cultures of mast cells and myocardial microvascular endothelial cells under hyperglycemic conditions.
Topics: Animals; Coculture Techniques; Endothelial Cells; Gene Expression Regulation; Glucose; Hyperglycemia; Male; Mast Cells; Microvessels; Myocardium; Neovascularization, Physiologic; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Wound Healing | 2013 |
Protease in sturgeon sperm and the effects of protease inhibitors on sperm motility and velocity.
Topics: Acrosin; Acrosome; Analysis of Variance; Animals; Fishes; Histological Techniques; Male; Microscopy, Immunoelectron; Peptide Hydrolases; Protease Inhibitors; Rosaniline Dyes; Semen; Sperm Motility; Spermatozoa; Statistics, Nonparametric; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2014 |
The serine protease inhibitor TLCK attenuates intrinsic death pathways in neurons upstream of mitochondrial demise.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Cell Line; Cell Survival; Glutamic Acid; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mice; Mitochondria; Neurons; Oxidative Stress; Serine Proteinase Inhibitors; Signal Transduction; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2014 |
Serine protease inhibitors interact with IFN-γ through up-regulation of FasR; a novel therapeutic strategy against cancer.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Drug Synergism; Fas Ligand Protein; fas Receptor; HeLa Cells; HT29 Cells; Humans; Interferon-gamma; Neoplasms; RNA, Messenger; Serine Endopeptidases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Up-Regulation | 2015 |
MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway.
Topics: Animals; Antiviral Agents; Bortezomib; Caspases; Chlorocebus aethiops; DNA Replication; Enzyme Activation; Gene Expression Regulation, Viral; Hep G2 Cells; Herpesvirus 1, Human; Humans; Leucine; Leupeptins; MAP Kinase Signaling System; Models, Biological; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Polyubiquitin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Proteolysis; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Vero Cells; Virus Replication | 2020 |