torpedo has been researched along with piperidines in 53 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (32.08) | 18.7374 |
1990's | 22 (41.51) | 18.2507 |
2000's | 8 (15.09) | 29.6817 |
2010's | 6 (11.32) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Diebler, MF | 1 |
Bahr, BA; Clarkson, ED; Noremberg, K; Parsons, SM; Rogers, GA | 1 |
Parsons, SM; Rogers, GA | 2 |
Bahr, BA; Parsons, SM | 3 |
Dutta, AK; Efange, SM; Michelson, RH; Sipahimalani, AS; Thayer, SA; Werth, JL | 1 |
Dunant, Y; Girod, R; Loctin, F | 1 |
Hicks, BW; Parsons, SM; Rogers, GA | 1 |
Johnson, RG; Unsworth, CD | 1 |
Albuquerque, EX; Aronstam, RS; Daly, JW; Edwards, MW | 1 |
Diebler, MF; Gaudry-Talarmain, YM; O'Regan, S | 1 |
Diebler, MF; Gaudry-Talarmain, YM | 1 |
Noremberg, K; Parsons, SM | 1 |
Fehlmann, C; Kaufman, R; Parsons, SM; Rogers, GA | 1 |
Anderson, DC; Bahr, BA; Jacobs, RS; Kaufman, R; Kirtman, B; Kornreich, WD; Nilsson, LM; Parsons, SM; Rogers, GA | 1 |
Kornreich, WD; Parsons, SM | 1 |
Bahr, BA; Gracz, LM; Kaufman, R; Kornreich, WD; Nilsson, L; Parsons, SM; Rogers, GA | 1 |
Gracz, LM; Parsons, SM; Wang, WC | 1 |
Burstein, M; Licht, R; Michaelson, DM | 1 |
Anderson, DC; Bahr, BA; Parsons, SM | 1 |
Burstein, M; Michaelson, DM | 1 |
Carroll, PT | 1 |
Alkadhi, KA; Branisteanu, DD; Epstein, PM; Henderson, EG; Lambert, JJ; Reynolds, LS; Smilowitz, H; Volle, RL | 1 |
Anderson, DC; King, SC; Parsons, SM | 1 |
Akella, SK; Childers, SR; Efange, SM; Foulon, C; Khare, AB; Mach, RH; Parsons, SM; Smith, CR | 1 |
Marshall, IG; Nguyen, ML; Parsons, SM; Pemberton, KE; Prior, C | 1 |
Nguyen, ML; Parsons, SM | 1 |
Ishihara, Y; Kuntz, ID; Yamamoto, Y | 1 |
Bahr, BA; Clarkson, ED; Parsons, SM | 1 |
Bonner, TI; Diebler, MF; Eiden, LE; Erickson, JD; Meunier, FM; Rand, JB; Usdin, TB; Varoqui, H | 1 |
Hand, K; Kornreich, WD; Parsons, SM; Rogers, GA | 1 |
Bau, R; Efange, SM; Khare, A; Metzenthin, T; Parsons, SM | 1 |
Rícný, J; Whittaker, VP | 1 |
Gracz, LM; Parsons, SM | 1 |
Hopfinger, AJ; Inoue, A; Kawai, T; Kawakami, Y; Sugimoto, H; Wakita, M | 1 |
Gracz, LM; Parsons, SM; Rogers, GA | 1 |
Kryger, G; Silman, I; Sussman, JL | 1 |
Koellner, G; Kryger, G; Millard, CB; Silman, I; Steiner, T; Sussman, JL | 1 |
Keller, JE; Parsons, SM | 1 |
Bravo, DT; Keller, JE; Parsons, SM | 1 |
Efange, SM; Khare, AB; Mach, RH; Parsons, SM; Tu, Z | 1 |
Contreras, JM; Parrot, I; Rival, YM; Sippl, W; Wermuth, CG | 2 |
Efange, SM; Jones, LA; Li, S; Mach, RH; Parsons, SM; Tu, Z; Xu, J | 1 |
Arias, HR; Bouzat, C; Feuerbach, D; Gumilar, F; Jozwiak, K; Moaddel, R; Rosenberg, A; Targowska-Duda, KM; Wainer, IW | 1 |
Bartolucci, C; Fels, G; Haller, LA; Jordis, U; Lamba, D | 1 |
Efange, SM; Khare, AB; Mach, RH; Parsons, SM; Tu, Z; von Hohenberg, K | 1 |
Burshteyn, F; Cassidy, MS; Cheung, J; Franklin, MC; Gary, EN; Height, JJ; Love, J; Rudolph, MJ | 1 |
Ali, MR; Boutajangout, A; Mezei, M; Møller, SG; Sadoqi, M | 1 |
Caliandro, R; Cariati, L; Lamba, D; Oliverio, M; Pesaresi, A; Procopio, A | 1 |
Dallemagne, P; Davis, A; Karila, D; Lalut, J; Lecoutey, C; Maurice, T; Nachon, F; Rochais, C; Santoni, G; Silman, I; Sussman, J; Weik, M | 1 |
53 other study(ies) available for torpedo and piperidines
Article | Year |
---|---|
Effect of N,N'-dicyclohexylcarbodiimide on the binding of vesamicol, an inhibitor of acetylcholine transport into synaptic vesicles.
Topics: Acetylcholine; Animals; Biological Transport; Dicyclohexylcarbodiimide; Dose-Response Relationship, Drug; Electric Organ; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Membrane Proteins; Molecular Weight; Neuromuscular Depolarizing Agents; Piperidines; Protein Binding; Synaptic Vesicles; Torpedo | 1992 |
A kinetic and allosteric model for the acetylcholine transporter-vesamicol receptor in synaptic vesicles.
Topics: Acetylcholine; Allosteric Site; Animals; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Electric Organ; Kinetics; Membrane Transport Proteins; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1992 |
Photoaffinity labeling of the acetylcholine transporter.
Topics: Acetylcholine; Affinity Labels; Animals; Azides; Binding Sites; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Electric Organ; Electrophoresis, Polyacrylamide Gel; Kinetics; Membrane Transport Proteins; Photochemistry; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Spectrophotometry, Ultraviolet; Synaptic Vesicles; Torpedo; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1992 |
Purification of the vesamicol receptor.
Topics: Acetylcholine; Allosteric Site; Animals; Chromatography; Detergents; Electric Organ; Electrophoresis, Polyacrylamide Gel; Epitopes; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Synaptic Vesicles; Torpedo | 1992 |
Lipophilic amino alcohols with calcium channel blocking activity.
Topics: Amino Alcohols; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Torpedo; Tumor Cells, Cultured | 1992 |
Local anaesthetic activity of vesamicol in the electric organ of Torpedo.
Topics: Acetylcholine; Anesthetics, Local; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Electric Organ; Electric Stimulation; Piperidines; Synapses; Synaptic Transmission; Torpedo | 1991 |
Purification and characterization of a nonvesicular vesamicol-binding protein from electric organ and demonstration of a related protein in mammalian brain.
Topics: Animals; Binding, Competitive; Blotting, Western; Brain; Cattle; Chromatography, Affinity; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cross Reactions; Electric Organ; Electrophoresis, Polyacrylamide Gel; Immune Sera; Macromolecular Substances; Molecular Weight; Neuromuscular Depolarizing Agents; Piperidines; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Torpedo | 1991 |
Acetylcholine and ATP are coreleased from the electromotor nerve terminals of Narcine brasiliensis by an exocytotic mechanism.
Topics: Acetylcholine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcimycin; Electric Organ; Exocytosis; Ionomycin; Kinetics; Motor Neurons; Nerve Endings; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Potassium; Subcellular Fractions; Synaptosomes; Torpedo; Veratridine | 1990 |
Interactions of piperidine derivatives with the nicotinic cholinergic receptor complex from Torpedo electric organ.
Topics: Amphibian Venoms; Animals; Bungarotoxins; Electric Organ; Ion Channels; Piperidines; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo | 1988 |
Compared effects of two vesicular acetylcholine uptake blockers, AH5183 and cetiedil, on cholinergic functions in Torpedo synaptosomes: acetylcholine synthesis, choline transport, vesicular uptake, and evoked acetylcholine release.
Topics: Acetylcholine; Animals; Azepines; Biological Transport; Calcimycin; Choline; Electric Organ; Hydrogen-Ion Concentration; Kinetics; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Synaptic Vesicles; Synaptosomes; Torpedo | 1989 |
AH5183 and cetiedil: two potent inhibitors of acetylcholine uptake into isolated synaptic vesicles from Torpedo marmorata.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Azepines; Binding, Competitive; Biological Transport; Ca(2+) Mg(2+)-ATPase; Calcium; Electric Organ; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Synaptic Vesicles; Torpedo | 1989 |
Regulation of the vesamicol receptor in cholinergic synaptic vesicles by acetylcholine and an endogenous factor.
Topics: Acetylcholine; Animals; Binding, Competitive; Biological Transport, Active; Electric Organ; Kinetics; Neuromuscular Depolarizing Agents; Osmolar Concentration; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Torpedo | 1989 |
Fractional vesamicol receptor occupancy and acetylcholine active transport inhibition in synaptic vesicles.
Topics: Acetylcholine; Animals; Binding, Competitive; Biological Transport, Active; In Vitro Techniques; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Structure-Activity Relationship; Synaptic Vesicles; Torpedo | 1989 |
Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol).
Topics: Acetylcholine; Animals; Biological Transport; Chemical Phenomena; Chemistry; Electric Organ; Lethal Dose 50; Mice; Molecular Structure; Narcotics; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Stereoisomerism; Structure-Activity Relationship; Synaptic Vesicles; Torpedo; X-Ray Diffraction | 1989 |
Sidedness and chemical and kinetic properties of the vesamicol receptor of cholinergic synaptic vesicles.
Topics: Acetylcholine; Algorithms; Animals; Cholinergic Fibers; Electric Organ; Hydrogen-Ion Concentration; Kinetics; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Time Factors; Torpedo | 1988 |
Acetylcholine transport: fundamental properties and effects of pharmacologic agents.
Topics: Acetylcholine; Adenosine Triphosphatases; Animals; Biological Transport, Active; Electric Organ; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Torpedo | 1987 |
Cholinergic synaptic vesicle heterogeneity: evidence for regulation of acetylcholine transport.
Topics: Acetylcholine; Animals; Biological Transport, Active; Cholinergic Fibers; Electric Organ; Nigericin; Phencyclidine; Piperidines; Synaptic Vesicles; Torpedo | 1988 |
Demonstration of a receptor in Torpedo synaptic vesicles for the acetylcholine storage blocker L-trans-2-(4-phenyl[3,4-3H]-piperidino) cyclohexanol.
Topics: Acetylcholine; Animals; Binding, Competitive; Choline; Electric Organ; Kinetics; Phencyclidine; Piperidines; Receptors, Drug; Stereoisomerism; Synaptic Vesicles; Torpedo | 1986 |
Translocation of cytosolic acetylcholine into synaptic vesicles and demonstration of vesicular release.
Topics: Acetylcholine; Animals; Biological Transport; Cytosol; Electric Organ; Kinetics; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Synaptic Vesicles; Synaptosomes; Torpedo | 1986 |
Stoichiometries of acetylcholine uptake, release, and drug inhibition in Torpedo synaptic vesicles: heterogeneity in acetylcholine transport and storage.
Topics: Acetylcholine; Animals; Biological Transport, Active; Electric Organ; Hemicholinium 3; Phencyclidine; Piperidines; Quinacrine; Synaptic Vesicles; Torpedo | 1986 |
Acetylcholine transport and drug inhibition kinetics in Torpedo synaptic vesicles.
Topics: Acetylcholine; Allosteric Regulation; Animals; Biological Transport, Active; Electric Organ; Kinetics; Phencyclidine; Piperidines; Synaptic Vesicles; Torpedo | 1986 |
Biochemical evidence that acetylcholine release from cholinergic nerve terminals is mostly vesicular.
Topics: Acetates; Acetylcholine; Animals; Electric Organ; In Vitro Techniques; Phencyclidine; Piperidines; Synaptic Vesicles; Synaptosomes; Torpedo | 1985 |
The effect of the acetylcholine transport blocker 2-(4-phenylpiperidino) cyclohexanol (AH5183) on the subcellular storage and release of acetylcholine in mouse brain.
Topics: Acetylcholine; Animals; Biological Transport; Brain; Electric Organ; Mice; Mice, Inbred ICR; Phencyclidine; Piperidines; Potassium; Synaptic Vesicles; Torpedo; Veratridine | 1985 |
Ketamine and ditran block end-plate ion conductance and [3H]phencyclidine binding to electric organ membrane.
Topics: Animals; Drug Combinations; Electric Organ; Glycolates; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channels; Ketamine; Neurotransmitter Agents; Phencyclidine; Piperidines; Pyrrolidines; Rana pipiens; Receptors, Cholinergic; Torpedo | 1982 |
Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles.
Topics: Acetylcholine; Animals; Binding Sites; Biological Transport, Active; Electric Organ; In Vitro Techniques; Phencyclidine; Piperidines; Receptors, Cholinergic; Synaptic Vesicles; Torpedo | 1983 |
Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor.
Topics: Animals; Molecular Conformation; Neuromuscular Depolarizing Agents; Piperidines; Receptors, Cholinergic; Receptors, sigma; Structure-Activity Relationship; Torpedo | 1995 |
Effect of veratridine on miniature endplate current amplitudes at the rat neuromuscular junction and acetylcholine uptake by Torpedo synaptic vesicles.
Topics: Acetylcholine; Animals; Electric Organ; Electrophysiology; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Motor Endplate; Muscle Fibers, Skeletal; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Piperidines; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Tetrodotoxin; Torpedo; Veratridine | 1995 |
Effects of internal pH on the acetylcholine transporter of synaptic vesicles.
Topics: Acetylcholine; Animals; Biological Transport, Active; Carrier Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Membrane Transport Proteins; Methylamines; Nigericin; Piperidines; Synaptic Vesicles; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1995 |
Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety.
Topics: Acetylcholinesterase; Animals; Benzylamines; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Drug Design; Indans; Models, Chemical; Molecular Conformation; Phthalimides; Piperidines; Protein Binding; Structure-Activity Relationship; Torpedo | 1994 |
Classical noncholinergic neurotransmitters and the vesicular transport system for acetylcholine.
Topics: Acetylcholine; Animals; Biological Transport; Electric Organ; Glutamates; Glutamic Acid; Neurotransmitter Agents; Norepinephrine; Piperidines; Serotonin; Synaptic Vesicles; Torpedo | 1993 |
Cloning and expression of the vesamicol binding protein from the marine ray Torpedo. Homology with the putative vesicular acetylcholine transporter UNC-17 from Caenorhabditis elegans.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Cloning, Molecular; Glycoproteins; Helminth Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Neuropeptides; Piperidines; Receptors, Cholinergic; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins; Vesicular Transport Proteins | 1994 |
Photoaffinity labeling of the vesamicol receptor of cholinergic synaptic vesicles.
Topics: Acetylcholine; Affinity Labels; Animals; Autoradiography; Binding, Competitive; Biological Transport, Active; Electric Organ; Electrophoresis, Polyacrylamide Gel; Kinetics; Molecular Weight; Neuromuscular Depolarizing Agents; Piperidines; Receptors, Cholinergic; Synaptic Vesicles; Torpedo; Tritium | 1993 |
Kinetic and equilibrium characterization of vesamicol receptor-ligand complexes with picomolar dissociation constants.
Topics: Animals; Binding, Competitive; In Vitro Techniques; Kinetics; Ligands; Models, Chemical; Piperidines; Receptors, Cholinergic; Stereoisomerism; Structure-Activity Relationship; Synaptic Vesicles; Torpedo | 1993 |
Nonsymmetrical bipiperidyls as inhibitors of vesicular acetylcholine storage.
Topics: Acetylcholine; Animals; Crystallography; Neuromuscular Depolarizing Agents; Piperidines; Stereoisomerism; Structure-Activity Relationship; Synaptic Vesicles; Torpedo | 1993 |
Vesamicol blocks the recovery, by recycling cholinergic electromotor synaptic vesicles, of the biophysical characteristics of the reserve population.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cholinergic Fibers; Female; Neuromuscular Depolarizing Agents; Piperidines; Synaptic Vesicles; Torpedo | 1993 |
Purification of active synaptic vesicles from the electric organ of Torpedo californica and comparison to reserve vesicles.
Topics: Animals; Binding Sites; Cell Fractionation; Centrifugation, Density Gradient; Electric Organ; Electrophoresis, Polyacrylamide Gel; Glycerol; Light; Molecular Weight; Neuromuscular Depolarizing Agents; Peptides; Piperidines; Povidone; Scattering, Radiation; Silicon Dioxide; Synaptic Vesicles; Torpedo | 1996 |
The rationale for E2020 as a potent acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Indans; Models, Molecular; Piperidines; Protein Conformation; Software; Torpedo | 1996 |
Photoaffinity labeling of vesicular acetylcholine transporter from electric organ of Torpedo.
Topics: Acetylcholine; Affinity Labels; Animals; Azides; Carrier Proteins; Cell Fractionation; Electric Organ; Indicators and Reagents; Kinetics; Membrane Transport Proteins; Piperidines; Radioligand Assay; Synaptic Vesicles; Torpedo; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1998 |
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Indans; Macromolecular Substances; Mice; Models, Molecular; Nootropic Agents; Piperidines; Protein Conformation; Solvents; Structure-Activity Relationship; Substrate Specificity; Torpedo | 1999 |
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
Topics: Acetylcholinesterase; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Donepezil; Edrophonium; Hydrogen Bonding; Indans; Ligands; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Structure, Secondary; Reproducibility of Results; Sesquiterpenes; Static Electricity; Torpedo; Water | 2000 |
A critical histidine in the vesicular acetylcholine transporter.
Topics: Animals; Binding Sites; Carrier Proteins; Cysteine; Diethyl Pyrocarbonate; Electric Organ; Histidine; Hydrogen-Ion Concentration; Membrane Transport Proteins; Neuromuscular Depolarizing Agents; Piperidines; Protons; Synaptic Vesicles; Torpedo; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 2000 |
Modification of cysteines reveals linkage to acetylcholine and vesamicol binding sites in the vesicular acetylcholine transporter of Torpedo californica.
Topics: 4-Chloromercuribenzenesulfonate; Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Binding, Competitive; Carrier Proteins; Cysteine; Cytoplasm; Dose-Response Relationship, Drug; Glutathione; Membrane Transport Proteins; Methyl Methanesulfonate; Methylmercury Compounds; Molecular Sequence Data; Neuromuscular Depolarizing Agents; Organomercury Compounds; Phenylmercury Compounds; Piperidines; Protein Structure, Tertiary; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 2000 |
Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM).
Topics: Acetylcholine; Animals; Autoradiography; Binding, Competitive; Brain; Carrier Proteins; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Ligands; Liver; Membrane Transport Proteins; Piperidines; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, sigma; Synaptic Vesicles; Tissue Distribution; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 2000 |
Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Crystallography, X-Ray; Donepezil; Drug Design; Humans; Indans; Models, Molecular; Piperidines; Protein Conformation; Quantitative Structure-Activity Relationship; Thermodynamics; Torpedo | 2001 |
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Models, Molecular; Molecular Conformation; Piperidines; Pyridazines; Pyridines; Structure-Activity Relationship; Torpedo | 2001 |
Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter.
Topics: Animals; Autoradiography; Brain; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Fluorine Radioisotopes; Guinea Pigs; In Vitro Techniques; Ligands; Macaca mulatta; Male; Piperidines; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Tissue Distribution; Torpedo; Vesicular Acetylcholine Transport Proteins | 2009 |
Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.
Topics: Animals; Binding, Competitive; Biological Transport; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Calcium; Cell Line; Drug Discovery; Electric Conductivity; Humans; Imipramine; Immobilized Proteins; Ion Channel Gating; Kinetics; Mice; Models, Molecular; Muscles; Nicotinic Antagonists; Piperidines; Protein Binding; Protein Conformation; Pyridines; Receptors, Nicotinic; Thermodynamics; Torpedo | 2009 |
Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives.
Topics: Acetylcholinesterase; Animals; Catalytic Domain; Crystallography, X-Ray; Galantamine; Molecular Probes; Piperidines; Protein Binding; Structure-Activity Relationship; Torpedo | 2010 |
Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter.
Topics: Animals; Drug Discovery; Guinea Pigs; Inhibitory Concentration 50; Piperidines; Rats; Structure-Activity Relationship; Substrate Specificity; Torpedo; Vesicular Acetylcholine Transport Proteins | 2010 |
Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
Topics: Acetylcholinesterase; Acetylthiocholine; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Humans; Indans; Models, Molecular; Piperidines; Protein Conformation; Torpedo | 2012 |
Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Hydrogen Bonding; Indans; Molecular Conformation; Molecular Dynamics Simulation; Piperidines; Rivastigmine; Torpedo | 2017 |
Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Dose-Response Relationship, Drug; Indans; Kinetics; Molecular Docking Simulation; Molecular Structure; Piperidines; Structure-Activity Relationship; Torpedo | 2018 |
Novel multitarget-directed ligands targeting acetylcholinesterase and σ
Topics: Acetylcholinesterase; Alzheimer Disease; Aniline Compounds; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Design; Humans; Indoles; Ligands; Piperidines; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Torpedo | 2019 |