Page last updated: 2024-08-23

torpedo and piperidines

torpedo has been researched along with piperidines in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (32.08)	18.7374
1990's	22 (41.51)	18.2507
2000's	8 (15.09)	29.6817
2010's	6 (11.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Diebler, MF	1
Bahr, BA; Clarkson, ED; Noremberg, K; Parsons, SM; Rogers, GA	1
Parsons, SM; Rogers, GA	2
Bahr, BA; Parsons, SM	3
Dutta, AK; Efange, SM; Michelson, RH; Sipahimalani, AS; Thayer, SA; Werth, JL	1
Dunant, Y; Girod, R; Loctin, F	1
Hicks, BW; Parsons, SM; Rogers, GA	1
Johnson, RG; Unsworth, CD	1
Albuquerque, EX; Aronstam, RS; Daly, JW; Edwards, MW	1
Diebler, MF; Gaudry-Talarmain, YM; O'Regan, S	1
Diebler, MF; Gaudry-Talarmain, YM	1
Noremberg, K; Parsons, SM	1
Fehlmann, C; Kaufman, R; Parsons, SM; Rogers, GA	1
Anderson, DC; Bahr, BA; Jacobs, RS; Kaufman, R; Kirtman, B; Kornreich, WD; Nilsson, LM; Parsons, SM; Rogers, GA	1
Kornreich, WD; Parsons, SM	1
Bahr, BA; Gracz, LM; Kaufman, R; Kornreich, WD; Nilsson, L; Parsons, SM; Rogers, GA	1
Gracz, LM; Parsons, SM; Wang, WC	1
Burstein, M; Licht, R; Michaelson, DM	1
Anderson, DC; Bahr, BA; Parsons, SM	1
Burstein, M; Michaelson, DM	1
Carroll, PT	1
Alkadhi, KA; Branisteanu, DD; Epstein, PM; Henderson, EG; Lambert, JJ; Reynolds, LS; Smilowitz, H; Volle, RL	1
Anderson, DC; King, SC; Parsons, SM	1
Akella, SK; Childers, SR; Efange, SM; Foulon, C; Khare, AB; Mach, RH; Parsons, SM; Smith, CR	1
Marshall, IG; Nguyen, ML; Parsons, SM; Pemberton, KE; Prior, C	1
Nguyen, ML; Parsons, SM	1
Ishihara, Y; Kuntz, ID; Yamamoto, Y	1
Bahr, BA; Clarkson, ED; Parsons, SM	1
Bonner, TI; Diebler, MF; Eiden, LE; Erickson, JD; Meunier, FM; Rand, JB; Usdin, TB; Varoqui, H	1
Hand, K; Kornreich, WD; Parsons, SM; Rogers, GA	1
Bau, R; Efange, SM; Khare, A; Metzenthin, T; Parsons, SM	1
Rícný, J; Whittaker, VP	1
Gracz, LM; Parsons, SM	1
Hopfinger, AJ; Inoue, A; Kawai, T; Kawakami, Y; Sugimoto, H; Wakita, M	1
Gracz, LM; Parsons, SM; Rogers, GA	1
Kryger, G; Silman, I; Sussman, JL	1
Koellner, G; Kryger, G; Millard, CB; Silman, I; Steiner, T; Sussman, JL	1
Keller, JE; Parsons, SM	1
Bravo, DT; Keller, JE; Parsons, SM	1
Efange, SM; Khare, AB; Mach, RH; Parsons, SM; Tu, Z	1
Contreras, JM; Parrot, I; Rival, YM; Sippl, W; Wermuth, CG	2
Efange, SM; Jones, LA; Li, S; Mach, RH; Parsons, SM; Tu, Z; Xu, J	1
Arias, HR; Bouzat, C; Feuerbach, D; Gumilar, F; Jozwiak, K; Moaddel, R; Rosenberg, A; Targowska-Duda, KM; Wainer, IW	1
Bartolucci, C; Fels, G; Haller, LA; Jordis, U; Lamba, D	1
Efange, SM; Khare, AB; Mach, RH; Parsons, SM; Tu, Z; von Hohenberg, K	1
Burshteyn, F; Cassidy, MS; Cheung, J; Franklin, MC; Gary, EN; Height, JJ; Love, J; Rudolph, MJ	1
Ali, MR; Boutajangout, A; Mezei, M; Møller, SG; Sadoqi, M	1
Caliandro, R; Cariati, L; Lamba, D; Oliverio, M; Pesaresi, A; Procopio, A	1
Dallemagne, P; Davis, A; Karila, D; Lalut, J; Lecoutey, C; Maurice, T; Nachon, F; Rochais, C; Santoni, G; Silman, I; Sussman, J; Weik, M	1

Other Studies

53 other study(ies) available for torpedo and piperidines

Article	Year
Effect of N,N'-dicyclohexylcarbodiimide on the binding of vesamicol, an inhibitor of acetylcholine transport into synaptic vesicles. Neurochemistry international, 1992, Volume: 21, Issue:1 Topics: Acetylcholine; Animals; Biological Transport; Dicyclohexylcarbodiimide; Dose-Response Relationship, Drug; Electric Organ; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Membrane Proteins; Molecular Weight; Neuromuscular Depolarizing Agents; Piperidines; Protein Binding; Synaptic Vesicles; Torpedo	1992
A kinetic and allosteric model for the acetylcholine transporter-vesamicol receptor in synaptic vesicles. Biochemistry, 1992, Jun-30, Volume: 31, Issue:25 Topics: Acetylcholine; Allosteric Site; Animals; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Electric Organ; Kinetics; Membrane Transport Proteins; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	1992
Photoaffinity labeling of the acetylcholine transporter. Biochemistry, 1992, Jun-30, Volume: 31, Issue:25 Topics: Acetylcholine; Affinity Labels; Animals; Azides; Binding Sites; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Electric Organ; Electrophoresis, Polyacrylamide Gel; Kinetics; Membrane Transport Proteins; Photochemistry; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Spectrophotometry, Ultraviolet; Synaptic Vesicles; Torpedo; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	1992
Purification of the vesamicol receptor. Biochemistry, 1992, Jun-30, Volume: 31, Issue:25 Topics: Acetylcholine; Allosteric Site; Animals; Chromatography; Detergents; Electric Organ; Electrophoresis, Polyacrylamide Gel; Epitopes; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Synaptic Vesicles; Torpedo	1992
Lipophilic amino alcohols with calcium channel blocking activity. Biochemical pharmacology, 1992, Nov-17, Volume: 44, Issue:10 Topics: Amino Alcohols; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Torpedo; Tumor Cells, Cultured	1992
Local anaesthetic activity of vesamicol in the electric organ of Torpedo. European journal of pharmacology, 1991, Mar-19, Volume: 195, Issue:1 Topics: Acetylcholine; Anesthetics, Local; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Electric Organ; Electric Stimulation; Piperidines; Synapses; Synaptic Transmission; Torpedo	1991
Purification and characterization of a nonvesicular vesamicol-binding protein from electric organ and demonstration of a related protein in mammalian brain. Journal of neurochemistry, 1991, Volume: 57, Issue:2 Topics: Animals; Binding, Competitive; Blotting, Western; Brain; Cattle; Chromatography, Affinity; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cross Reactions; Electric Organ; Electrophoresis, Polyacrylamide Gel; Immune Sera; Macromolecular Substances; Molecular Weight; Neuromuscular Depolarizing Agents; Piperidines; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Torpedo	1991
Acetylcholine and ATP are coreleased from the electromotor nerve terminals of Narcine brasiliensis by an exocytotic mechanism. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:2 Topics: Acetylcholine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcimycin; Electric Organ; Exocytosis; Ionomycin; Kinetics; Motor Neurons; Nerve Endings; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Potassium; Subcellular Fractions; Synaptosomes; Torpedo; Veratridine	1990
Interactions of piperidine derivatives with the nicotinic cholinergic receptor complex from Torpedo electric organ. Neurochemical research, 1988, Volume: 13, Issue:2 Topics: Amphibian Venoms; Animals; Bungarotoxins; Electric Organ; Ion Channels; Piperidines; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo	1988
Compared effects of two vesicular acetylcholine uptake blockers, AH5183 and cetiedil, on cholinergic functions in Torpedo synaptosomes: acetylcholine synthesis, choline transport, vesicular uptake, and evoked acetylcholine release. Journal of neurochemistry, 1989, Volume: 52, Issue:3 Topics: Acetylcholine; Animals; Azepines; Biological Transport; Calcimycin; Choline; Electric Organ; Hydrogen-Ion Concentration; Kinetics; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Synaptic Vesicles; Synaptosomes; Torpedo	1989
AH5183 and cetiedil: two potent inhibitors of acetylcholine uptake into isolated synaptic vesicles from Torpedo marmorata. Journal of neurochemistry, 1989, Volume: 52, Issue:3 Topics: Acetylcholine; Adenosine Triphosphate; Animals; Azepines; Binding, Competitive; Biological Transport; Ca(2+) Mg(2+)-ATPase; Calcium; Electric Organ; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Synaptic Vesicles; Torpedo	1989
Regulation of the vesamicol receptor in cholinergic synaptic vesicles by acetylcholine and an endogenous factor. Journal of neurochemistry, 1989, Volume: 52, Issue:3 Topics: Acetylcholine; Animals; Binding, Competitive; Biological Transport, Active; Electric Organ; Kinetics; Neuromuscular Depolarizing Agents; Osmolar Concentration; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Torpedo	1989
Fractional vesamicol receptor occupancy and acetylcholine active transport inhibition in synaptic vesicles. Molecular pharmacology, 1989, Volume: 36, Issue:3 Topics: Acetylcholine; Animals; Binding, Competitive; Biological Transport, Active; In Vitro Techniques; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Structure-Activity Relationship; Synaptic Vesicles; Torpedo	1989
Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol). Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Acetylcholine; Animals; Biological Transport; Chemical Phenomena; Chemistry; Electric Organ; Lethal Dose 50; Mice; Molecular Structure; Narcotics; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Stereoisomerism; Structure-Activity Relationship; Synaptic Vesicles; Torpedo; X-Ray Diffraction	1989
Sidedness and chemical and kinetic properties of the vesamicol receptor of cholinergic synaptic vesicles. Biochemistry, 1988, Jul-12, Volume: 27, Issue:14 Topics: Acetylcholine; Algorithms; Animals; Cholinergic Fibers; Electric Organ; Hydrogen-Ion Concentration; Kinetics; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Time Factors; Torpedo	1988
Acetylcholine transport: fundamental properties and effects of pharmacologic agents. Annals of the New York Academy of Sciences, 1987, Volume: 493 Topics: Acetylcholine; Adenosine Triphosphatases; Animals; Biological Transport, Active; Electric Organ; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Vesicles; Torpedo	1987
Cholinergic synaptic vesicle heterogeneity: evidence for regulation of acetylcholine transport. Biochemistry, 1988, Jul-12, Volume: 27, Issue:14 Topics: Acetylcholine; Animals; Biological Transport, Active; Cholinergic Fibers; Electric Organ; Nigericin; Phencyclidine; Piperidines; Synaptic Vesicles; Torpedo	1988
Demonstration of a receptor in Torpedo synaptic vesicles for the acetylcholine storage blocker L-trans-2-(4-phenyl[3,4-3H]-piperidino) cyclohexanol. Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:7 Topics: Acetylcholine; Animals; Binding, Competitive; Choline; Electric Organ; Kinetics; Phencyclidine; Piperidines; Receptors, Drug; Stereoisomerism; Synaptic Vesicles; Torpedo	1986
Translocation of cytosolic acetylcholine into synaptic vesicles and demonstration of vesicular release. The Journal of biological chemistry, 1986, May-25, Volume: 261, Issue:15 Topics: Acetylcholine; Animals; Biological Transport; Cytosol; Electric Organ; Kinetics; Neuromuscular Depolarizing Agents; Phencyclidine; Piperidines; Synaptic Vesicles; Synaptosomes; Torpedo	1986
Stoichiometries of acetylcholine uptake, release, and drug inhibition in Torpedo synaptic vesicles: heterogeneity in acetylcholine transport and storage. Journal of neurochemistry, 1986, Volume: 46, Issue:4 Topics: Acetylcholine; Animals; Biological Transport, Active; Electric Organ; Hemicholinium 3; Phencyclidine; Piperidines; Quinacrine; Synaptic Vesicles; Torpedo	1986
Acetylcholine transport and drug inhibition kinetics in Torpedo synaptic vesicles. Journal of neurochemistry, 1986, Volume: 46, Issue:4 Topics: Acetylcholine; Allosteric Regulation; Animals; Biological Transport, Active; Electric Organ; Kinetics; Phencyclidine; Piperidines; Synaptic Vesicles; Torpedo	1986
Biochemical evidence that acetylcholine release from cholinergic nerve terminals is mostly vesicular. FEBS letters, 1985, Sep-02, Volume: 188, Issue:2 Topics: Acetates; Acetylcholine; Animals; Electric Organ; In Vitro Techniques; Phencyclidine; Piperidines; Synaptic Vesicles; Synaptosomes; Torpedo	1985
The effect of the acetylcholine transport blocker 2-(4-phenylpiperidino) cyclohexanol (AH5183) on the subcellular storage and release of acetylcholine in mouse brain. Brain research, 1985, Dec-09, Volume: 358, Issue:1-2 Topics: Acetylcholine; Animals; Biological Transport; Brain; Electric Organ; Mice; Mice, Inbred ICR; Phencyclidine; Piperidines; Potassium; Synaptic Vesicles; Torpedo; Veratridine	1985
Ketamine and ditran block end-plate ion conductance and [3H]phencyclidine binding to electric organ membrane. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:3 Topics: Animals; Drug Combinations; Electric Organ; Glycolates; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channels; Ketamine; Neurotransmitter Agents; Phencyclidine; Piperidines; Pyrrolidines; Rana pipiens; Receptors, Cholinergic; Torpedo	1982
Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles. Molecular pharmacology, 1983, Volume: 24, Issue:1 Topics: Acetylcholine; Animals; Binding Sites; Biological Transport, Active; Electric Organ; In Vitro Techniques; Phencyclidine; Piperidines; Receptors, Cholinergic; Synaptic Vesicles; Torpedo	1983
Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor. Biochemical pharmacology, 1995, Mar-15, Volume: 49, Issue:6 Topics: Animals; Molecular Conformation; Neuromuscular Depolarizing Agents; Piperidines; Receptors, Cholinergic; Receptors, sigma; Structure-Activity Relationship; Torpedo	1995
Effect of veratridine on miniature endplate current amplitudes at the rat neuromuscular junction and acetylcholine uptake by Torpedo synaptic vesicles. Brain research, 1995, Feb-13, Volume: 671, Issue:2 Topics: Acetylcholine; Animals; Electric Organ; Electrophysiology; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Motor Endplate; Muscle Fibers, Skeletal; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Piperidines; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Tetrodotoxin; Torpedo; Veratridine	1995
Effects of internal pH on the acetylcholine transporter of synaptic vesicles. Journal of neurochemistry, 1995, Volume: 64, Issue:3 Topics: Acetylcholine; Animals; Biological Transport, Active; Carrier Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Membrane Transport Proteins; Methylamines; Nigericin; Piperidines; Synaptic Vesicles; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	1995
Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety. Journal of medicinal chemistry, 1994, Sep-16, Volume: 37, Issue:19 Topics: Acetylcholinesterase; Animals; Benzylamines; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Drug Design; Indans; Models, Chemical; Molecular Conformation; Phthalimides; Piperidines; Protein Binding; Structure-Activity Relationship; Torpedo	1994
Classical noncholinergic neurotransmitters and the vesicular transport system for acetylcholine. Journal of neurochemistry, 1993, Volume: 61, Issue:1 Topics: Acetylcholine; Animals; Biological Transport; Electric Organ; Glutamates; Glutamic Acid; Neurotransmitter Agents; Norepinephrine; Piperidines; Serotonin; Synaptic Vesicles; Torpedo	1993
Cloning and expression of the vesamicol binding protein from the marine ray Torpedo. Homology with the putative vesicular acetylcholine transporter UNC-17 from Caenorhabditis elegans. FEBS letters, 1994, Mar-28, Volume: 342, Issue:1 Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Cloning, Molecular; Glycoproteins; Helminth Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Neuropeptides; Piperidines; Receptors, Cholinergic; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins; Vesicular Transport Proteins	1994
Photoaffinity labeling of the vesamicol receptor of cholinergic synaptic vesicles. Biochemistry, 1993, Aug-24, Volume: 32, Issue:33 Topics: Acetylcholine; Affinity Labels; Animals; Autoradiography; Binding, Competitive; Biological Transport, Active; Electric Organ; Electrophoresis, Polyacrylamide Gel; Kinetics; Molecular Weight; Neuromuscular Depolarizing Agents; Piperidines; Receptors, Cholinergic; Synaptic Vesicles; Torpedo; Tritium	1993
Kinetic and equilibrium characterization of vesamicol receptor-ligand complexes with picomolar dissociation constants. Molecular pharmacology, 1993, Volume: 44, Issue:3 Topics: Animals; Binding, Competitive; In Vitro Techniques; Kinetics; Ligands; Models, Chemical; Piperidines; Receptors, Cholinergic; Stereoisomerism; Structure-Activity Relationship; Synaptic Vesicles; Torpedo	1993
Nonsymmetrical bipiperidyls as inhibitors of vesicular acetylcholine storage. Journal of medicinal chemistry, 1993, Apr-16, Volume: 36, Issue:8 Topics: Acetylcholine; Animals; Crystallography; Neuromuscular Depolarizing Agents; Piperidines; Stereoisomerism; Structure-Activity Relationship; Synaptic Vesicles; Torpedo	1993
Vesamicol blocks the recovery, by recycling cholinergic electromotor synaptic vesicles, of the biophysical characteristics of the reserve population. Biochimica et biophysica acta, 1993, Jun-05, Volume: 1148, Issue:2 Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cholinergic Fibers; Female; Neuromuscular Depolarizing Agents; Piperidines; Synaptic Vesicles; Torpedo	1993
Purification of active synaptic vesicles from the electric organ of Torpedo californica and comparison to reserve vesicles. Biochimica et biophysica acta, 1996, Feb-08, Volume: 1292, Issue:2 Topics: Animals; Binding Sites; Cell Fractionation; Centrifugation, Density Gradient; Electric Organ; Electrophoresis, Polyacrylamide Gel; Glycerol; Light; Molecular Weight; Neuromuscular Depolarizing Agents; Peptides; Piperidines; Povidone; Scattering, Radiation; Silicon Dioxide; Synaptic Vesicles; Torpedo	1996
The rationale for E2020 as a potent acetylcholinesterase inhibitor. Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:9 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Indans; Models, Molecular; Piperidines; Protein Conformation; Software; Torpedo	1996
Photoaffinity labeling of vesicular acetylcholine transporter from electric organ of Torpedo. Methods in enzymology, 1998, Volume: 296 Topics: Acetylcholine; Affinity Labels; Animals; Azides; Carrier Proteins; Cell Fractionation; Electric Organ; Indicators and Reagents; Kinetics; Membrane Transport Proteins; Piperidines; Radioligand Assay; Synaptic Vesicles; Torpedo; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	1998
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure (London, England : 1993), 1999, Mar-15, Volume: 7, Issue:3 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Indans; Macromolecular Substances; Mice; Models, Molecular; Nootropic Agents; Piperidines; Protein Conformation; Solvents; Structure-Activity Relationship; Substrate Specificity; Torpedo	1999
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica. Journal of molecular biology, 2000, Feb-18, Volume: 296, Issue:2 Topics: Acetylcholinesterase; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Donepezil; Edrophonium; Hydrogen Bonding; Indans; Ligands; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Structure, Secondary; Reproducibility of Results; Sesquiterpenes; Static Electricity; Torpedo; Water	2000
A critical histidine in the vesicular acetylcholine transporter. Neurochemistry international, 2000, Volume: 36, Issue:2 Topics: Animals; Binding Sites; Carrier Proteins; Cysteine; Diethyl Pyrocarbonate; Electric Organ; Histidine; Hydrogen-Ion Concentration; Membrane Transport Proteins; Neuromuscular Depolarizing Agents; Piperidines; Protons; Synaptic Vesicles; Torpedo; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	2000
Modification of cysteines reveals linkage to acetylcholine and vesamicol binding sites in the vesicular acetylcholine transporter of Torpedo californica. Journal of neurochemistry, 2000, Volume: 74, Issue:4 Topics: 4-Chloromercuribenzenesulfonate; Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Binding, Competitive; Carrier Proteins; Cysteine; Cytoplasm; Dose-Response Relationship, Drug; Glutathione; Membrane Transport Proteins; Methyl Methanesulfonate; Methylmercury Compounds; Molecular Sequence Data; Neuromuscular Depolarizing Agents; Organomercury Compounds; Phenylmercury Compounds; Piperidines; Protein Structure, Tertiary; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	2000
Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM). Nuclear medicine and biology, 2000, Volume: 27, Issue:8 Topics: Acetylcholine; Animals; Autoradiography; Binding, Competitive; Brain; Carrier Proteins; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Ligands; Liver; Membrane Transport Proteins; Piperidines; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, sigma; Synaptic Vesicles; Tissue Distribution; Torpedo; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	2000
Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors. Journal of computer-aided molecular design, 2001, Volume: 15, Issue:5 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Crystallography, X-Ray; Donepezil; Drug Design; Humans; Indans; Models, Molecular; Piperidines; Protein Conformation; Quantitative Structure-Activity Relationship; Thermodynamics; Torpedo	2001
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors. Journal of medicinal chemistry, 2001, Aug-16, Volume: 44, Issue:17 Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Models, Molecular; Molecular Conformation; Piperidines; Pyridazines; Pyridines; Structure-Activity Relationship; Torpedo	2001
Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Animals; Autoradiography; Brain; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Fluorine Radioisotopes; Guinea Pigs; In Vitro Techniques; Ligands; Macaca mulatta; Male; Piperidines; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Tissue Distribution; Torpedo; Vesicular Acetylcholine Transport Proteins	2009
Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states. Biochemistry, 2009, Jun-02, Volume: 48, Issue:21 Topics: Animals; Binding, Competitive; Biological Transport; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Calcium; Cell Line; Drug Discovery; Electric Conductivity; Humans; Imipramine; Immobilized Proteins; Ion Channel Gating; Kinetics; Mice; Models, Molecular; Muscles; Nicotinic Antagonists; Piperidines; Protein Binding; Protein Conformation; Pyridines; Receptors, Nicotinic; Thermodynamics; Torpedo	2009
Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. Journal of medicinal chemistry, 2010, Jan-28, Volume: 53, Issue:2 Topics: Acetylcholinesterase; Animals; Catalytic Domain; Crystallography, X-Ray; Galantamine; Molecular Probes; Piperidines; Protein Binding; Structure-Activity Relationship; Torpedo	2010
Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter. Journal of medicinal chemistry, 2010, Apr-08, Volume: 53, Issue:7 Topics: Animals; Drug Discovery; Guinea Pigs; Inhibitory Concentration 50; Piperidines; Rats; Structure-Activity Relationship; Substrate Specificity; Torpedo; Vesicular Acetylcholine Transport Proteins	2010
Structures of human acetylcholinesterase in complex with pharmacologically important ligands. Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22 Topics: Acetylcholinesterase; Acetylthiocholine; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Humans; Indans; Models, Molecular; Piperidines; Protein Conformation; Torpedo	2012
Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies. Journal of molecular graphics & modelling, 2017, Volume: 76 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Hydrogen Bonding; Indans; Molecular Conformation; Molecular Dynamics Simulation; Piperidines; Rivastigmine; Torpedo	2017
Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Dose-Response Relationship, Drug; Indans; Kinetics; Molecular Docking Simulation; Molecular Structure; Piperidines; Structure-Activity Relationship; Torpedo	2018
Novel multitarget-directed ligands targeting acetylcholinesterase and σ European journal of medicinal chemistry, 2019, Jan-15, Volume: 162 Topics: Acetylcholinesterase; Alzheimer Disease; Aniline Compounds; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Design; Humans; Indoles; Ligands; Piperidines; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Torpedo	2019