Page last updated: 2024-08-24

topotecan and sn 38

topotecan has been researched along with sn 38 in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (10.00)	18.2507
2000's	14 (70.00)	29.6817
2010's	4 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL	1
Burke, TG; Mi, Z	1
Bingcang, AL; Bom, D; Burke, TG; Chavan, AJ; Curran, DP; Du, W; Fraley, KA; Kohlhagen, G; Kruszewski, S; Latus, LJ; Pommier, Y; Thompson Strode, J; Zimmer, SG	1
Beijnen, JH; de Jong, LA; Hausheer, FH; Maliepaard, M; Pluim, D; Schellens, JH; Tohgo, A; van Gastelen, MA; van Waardenburg, RC	1
Chang, K; Choi, WS; Im, GJ; Kim, DK; Kim, JS; Kim, TK; Kim, YW; Lee, JY; Lee, N; Ryu, DH	1
Beretta, G; Biasotti, B; Carenini, N; Carminati, P; Dallavalle, S; De Cesare, M; Ferrari, A; Gallo, G; Martinelli, R; Marzi, M; Merlini, L; Penco, S; Perego, P; Pisano, C; Pratesi, G; Tinti, MO; Zunino, F	1
Imai, Y; Sugimoto, Y; Tsukahara, S; Tsuruo, T; Ueda, K	1
Buchdunger, E; Germain, GS; Harwood, FC; Houghton, PJ; Schuetz, JD; Stewart, CF; Traxler, P	1
Chen, Y; Ding, J; Gao, H; Huang, M; Li, C; Lu, W; Shen, H; Sun, J; Zhang, X	1
Alloatti, D; Beretta, GL; Casati, A; Dallavalle, S; De Cesare, M; Giannini, G; Marastoni, E; Merlini, L; Morini, G; Musso, L; Penco, S; Pisano, C; Tinelli, S; Zunino, F	1
Beretta, G; Bianco, MA; Clericuzio, M; Pratesi, G; Tabasso, S; Tinelli, S; Vidari, G; Zunino, F	1
Battistuzzi, G; Beretta, GL; Cabri, W; De Cesare, M; Giannini, G; Marastoni, E; Marzi, M; Pisano, C; Vesci, L; Zunino, F	1
Beretta, GL; Dallavalle, S; Merlini, L; Morini, G; Musso, L; Penco, S; Rocchetta, DG; Tinelli, S; Zunino, F	1
Li, M; Lou, L; Tang, W; You, T; Zeng, F	1
Feng, W; LaVoie, EJ; Liu, AA; Liu, LF; Satyanarayana, M; Tsai, YC	1
Jiang, C; Jin, W; Li, M; Lou, L; Tang, W; You, T; Zheng, C	1
Artali, R; Beretta, GL; Cananzi, S; Dallavalle, S; Merlini, L; Zaffaroni, N	1
Alloatti, D; Badaloni, E; Cabri, W; Castorina, M; Giannini, G; Pisano, C; Vesci, L	1
Huang, Q; Lu, W; Wang, L	1
Benetti, E; Centamore, A; Collina, S; Della Volpe, S; Martino, E; Sakaj, M; Sala, A; Terribile, E	1

Reviews

2 review(s) available for topotecan and sn 38

Article	Year
Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. European journal of medicinal chemistry, 2013, Volume: 63 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors	2013
The long story of camptothecin: From traditional medicine to drugs. Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptotheca; Camptothecin; DNA Topoisomerases, Type I; Humans; Medicine, Traditional; Neoplasms; Structure-Activity Relationship	2017

Other Studies

18 other study(ies) available for topotecan and sn 38

Article	Year
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous	1991
The structural basis of camptothecin interactions with human serum albumin: impact on drug stability. Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1 Topics: Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Half-Life; Irinotecan; Kinetics; Lactones; Molecular Structure; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Topotecan	1994
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity. Journal of medicinal chemistry, 2000, Oct-19, Volume: 43, Issue:21 Topics: Animals; Antineoplastic Agents; Camptothecin; DNA; Drug Screening Assays, Antitumor; Drug Stability; Electrophoresis, Agar Gel; Humans; Hydrolysis; Kinetics; Mice; Mice, Nude; Organosilicon Compounds; Spectrometry, Fluorescence; Structure-Activity Relationship; Tumor Cells, Cultured	2000
Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:4 Topics: Acridines; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Survival; Drug Interactions; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Neoplasm Proteins; Tetrahydroisoquinolines; Tumor Cells, Cultured	2001
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues. Journal of medicinal chemistry, 2001, May-10, Volume: 44, Issue:10 Topics: Animals; Antineoplastic Agents; Camptothecin; Cholinesterase Inhibitors; Drug Screening Assays, Antitumor; Drug Stability; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Structure-Activity Relationship; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity. Journal of medicinal chemistry, 2001, Sep-27, Volume: 44, Issue:20 Topics: Animals; Antineoplastic Agents; Camptothecin; DNA; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Imines; Immunoblotting; Inhibitory Concentration 50; Mice; Mice, Nude; Quantitative Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Molecular cancer therapeutics, 2003, Volume: 2, Issue:1 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Breast Neoplasms; Cell Survival; Diethylstilbestrol; Drug Resistance, Neoplasm; Estrogen Antagonists; Estrogens; Estrone; Female; Humans; K562 Cells; Kinetics; Mitoxantrone; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Tamoxifen; Topotecan; Tumor Cells, Cultured	2003
Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer research, 2004, Apr-01, Volume: 64, Issue:7 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Bone Neoplasms; Camptothecin; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Imatinib Mesylate; Irinotecan; Neoplasm Proteins; Osteosarcoma; Piperazines; Pyrimidines; Topotecan	2004
Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin. Bioorganic & medicinal chemistry letters, 2005, Apr-15, Volume: 15, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Humans	2005
Synthesis and cytotoxic activity of polyamine analogues of camptothecin. Journal of medicinal chemistry, 2006, Aug-24, Volume: 49, Issue:17 Topics: Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Hydrolysis; Models, Molecular; Molecular Structure; Polyamines; Stereoisomerism; Structure-Activity Relationship; Time Factors	2006
Cucurbitane triterpenes from the fruiting bodies and cultivated mycelia of Leucopaxillus gentianeus. Journal of natural products, 2006, Volume: 69, Issue:12 Topics: Agaricales; Antineoplastic Agents; Drug Screening Assays, Antitumor; Fruiting Bodies, Fungal; Humans; Molecular Structure; Mycelium; Rome; Topoisomerase I Inhibitors; Topotecan; Triterpenes	2006
E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation. Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2008
Synthesis and cytotoxic activity of new 9-substituted camptothecins. Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Tumor Cells, Cultured	2008
Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin. Bioorganic & medicinal chemistry letters, 2008, Dec-15, Volume: 18, Issue:24 Topics: Antineoplastic Agents, Phytogenic; Camptotheca; Camptothecin; Cell Line, Tumor; DNA Topoisomerases, Type I; Drug Design; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Irinotecan; Lactones; Models, Chemical; Molecular Structure; Solubility; Structure-Activity Relationship	2008
12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. Bioorganic & medicinal chemistry, 2009, Apr-01, Volume: 17, Issue:7 Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type I; Humans; Phenanthridines; Topoisomerase I Inhibitors	2009
7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hydrolysis; Inhibitory Concentration 50; Irinotecan; Models, Chemical; Rhodamines; Structure-Activity Relationship; Topotecan	2009
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D. Bioorganic & medicinal chemistry, 2011, Aug-15, Volume: 19, Issue:16 Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Coumarins; DNA Topoisomerases, Type I; Heterocyclic Compounds, 4 or More Rings; Humans; Isoquinolines; Models, Molecular; Mollusca; Oceans and Seas; Simian virus 40; Structure-Activity Relationship; Topoisomerase I Inhibitors	2011
Camptothecins in tumor homing via an RGD sequence mimetic. Bioorganic & medicinal chemistry letters, 2012, Oct-15, Volume: 22, Issue:20 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Integrins; Male; Oligopeptides; Ovarian Neoplasms; Prostatic Neoplasms; Rats	2012