topotecan has been researched along with methotrexate in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 17 (53.13) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Beijnen, JH; Borst, P; Breedveld, P; Pluim, D; Schellens, JH; Schinkel, AH; Sönmezer, O; Tibben, MM; van Tellingen, O; Zelcer, N | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Benfenati, E; Raska, I; Toropov, AA; Toropova, AP | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jing, Y; Ojima, I; Wang, C; Wang, X | 1 |
| Basi, GS; Earnshaw, WC; Eischen, CM; Kaufmann, SH; Kottke, TJ; Leibson, PJ; Martins, LM; Tung, JS | 1 |
| Frei, E | 1 |
| Battmer, K; Dammann, E; Eder, M; Ganser, A; Hambach, L; Heil, G; Hertenstein, B; Stucki, A | 1 |
| Fleck, C; Hilger, R; Jurkutat, S; Karge, E; Merkel, U; Schimske, A; Schubert, J | 1 |
| Corbacioglu, S; Eber, S; Gungor, T; Hummerjohann, J; Niggli, F | 1 |
| Centurioni, R; Corvatta, L; Leoni, F; Leoni, P; Malerba, L; Marconi, M; Masia, MC; Mele, A; Offidani, M; Scortechini, A | 1 |
| Benda, JA; Bundy, BN; Eaton, LA; Fiorica, JV; Grendys, EC; Long, HJ; McMeekin, DS; Miller, DS; Sorosky, J | 1 |
| Pavlidis, N; Pentheroudakis, G | 1 |
| Eaton, LA; Fiorica, JV; Grendys, EC; Huang, HQ; Long, HJ; McMeekin, DS; Miller, DS; Monk, BJ; Sorosky, J | 1 |
| Beijnen, JH; Borst, P; Breedveld, P; Cipriani, G; Dahlhaus, F; de Wolf, CJ; Jansen, G; Kuil, A; Pluim, D; Scheffer, GL; Schellens, JH; van Eijndhoven, MA | 1 |
| Floros, KV; Scorilas, A; Talieri, M | 1 |
| Báthori, G; Gedey, S; Glavinas, H; Janáky, T; Krajcsi, P; Méhn, D; Mészáros, P; Molnár, E; Nagy, T; Pál, A; Szente, L; von Richter, O | 1 |
| Chen, ZS; Dai, CL; Fu, LW; Liang, YJ; Tiwari, AK; Tong, XZ; Wang, F; Wang, YS; Yan, YY | 1 |
| Yamanaka, R | 1 |
| Jafari, M; Kislukhin, G; Long, AD; Murphy, ML | 1 |
| Bonfill Cosp, X; Cortés-Jofré, M; Pelayo Alvarez, M; Westeel, V | 1 |
| Abramson, DH; Berry, JL; Cassoux, N; Francis, JH; Frenkel, S; Hadjistilianou, D; Ji, X; Munier, FL; Schefler, AC; Shields, CL; Teixeira, LF | 1 |
| Acosta, G; Fiani, B; Haynes, M; Nikolaidis, D; Rose, A; Runnels, J; Wong, A | 1 |
| Banerjee, S; Datta, S; Jahnavi, J; Maity, TR; Samanta, A | 1 |
| Bonnabry, P; Fleury-Souverain, S; Guillarme, D; Maurin, J; Rudaz, S | 1 |
8 review(s) available for topotecan and methotrexate
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
Topics: Animals; Antineoplastic Agents; Docetaxel; Drug Resistance, Neoplasm; Humans; Neoplasms; Paclitaxel; Taxoids | 2018 |
Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bone Marrow Transplantation; Combined Modality Therapy; Cyclosporine; Cystitis; Cytarabine; Cytomegalovirus Infections; DNA, Neoplasm; Female; Foscarnet; Ganciclovir; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Histocompatibility; Humans; Hydroxyurea; Immunosuppressive Agents; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Mitoxantrone; Neoplasms, Second Primary; Prednisolone; Prostaglandins; Remission Induction; Topotecan; Transplantation Conditioning; Transplantation, Homologous; Vidarabine; Whole-Body Irradiation | 2001 |
Management of leptomeningeal malignancy.
Topics: Adenocarcinoma; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Arachnoid Cysts; Carcinoma; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Delayed-Action Preparations; Enzyme Inhibitors; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Lymphoma; Meningeal Neoplasms; Methotrexate; Palliative Care; Randomized Controlled Trials as Topic; Thiotepa; Topoisomerase I Inhibitors; Topotecan | 2005 |
[Medical management of primary central nervous system lymphoma refractory or resistant to standard of care treatment].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Discovery; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Methotrexate; Neoplasm Recurrence, Local; Rituximab; Salvage Therapy; Temozolomide; Topotecan | 2009 |
Chemotherapy versus best supportive care for extensive small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Doxorubicin; Female; Humans; Lung Neoplasms; Male; Methotrexate; Organoplatinum Compounds; Randomized Controlled Trials as Topic; Survival Analysis; Topotecan | 2013 |
The role for intra-arterial chemotherapy for refractory retinoblastoma: a systematic review.
Topics: Antineoplastic Agents; Bronchial Spasm; Carboplatin; Drug Resistance, Neoplasm; Edema; Eyelashes; Febrile Neutropenia; Humans; Infusions, Intra-Arterial; Melphalan; Methotrexate; Nausea; Retinal Neoplasms; Retinoblastoma; Salvage Therapy; Topotecan; Vitreous Hemorrhage; Vomiting | 2021 |
3 trial(s) available for topotecan and methotrexate
| Article | Year |
|---|---|
High-dose daunorubicin as liposomal compound (Daunoxome) in elderly patients with acute lymphoblastic leukemia.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Betamethasone; Bone Marrow Diseases; Burkitt Lymphoma; Comorbidity; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Carriers; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Infections; Leukemia, T-Cell; Life Tables; Liposomes; Male; Methotrexate; Middle Aged; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Remission Induction; Safety; Survival Analysis; Topotecan; Treatment Outcome | 2003 |
Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group Study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Methotrexate; Middle Aged; Quality of Life; Survival Rate; Topotecan; Uterine Cervical Neoplasms; Vinblastine | 2005 |
Clinical results and quality of life analysis for the MVAC combination (methotrexate, vinblastine, doxorubicin, and cisplatin) in carcinoma of the uterine cervix: A Gynecologic Oncology Group study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Humans; Methotrexate; Quality of Life; Topotecan; Uterine Cervical Neoplasms; Vinblastine | 2006 |
21 other study(ies) available for topotecan and methotrexate
| Article | Year |
|---|---|
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Baculoviridae; Benzimidazoles; Biological Transport; Camptothecin; Cell Line; DNA, Complementary; Dogs; Drug Interactions; Enzyme Inhibitors; Humans; Irinotecan; Membrane Transport Proteins; Methotrexate; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Omeprazole; Pantoprazole; Spodoptera; Sulfoxides; Topotecan; Transfection | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Topics: Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Camptothecin; Caspase 3; Caspase 7; Caspases; Cisplatin; Cysteine Endopeptidases; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lamin Type B; Lamins; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured | 1997 |
Therapeutic innovation: the up-front window.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clinical Trials as Topic; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Topotecan | 1998 |
Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carcinoma, Renal Cell; Cisplatin; Dexamethasone; Epidermal Growth Factor; Female; Glucocorticoids; Humans; Kidney; Kidney Neoplasms; Methotrexate; Quinazolines; Rats; Rats, Wistar; Thiophenes; Topotecan; Triiodothyronine | 2002 |
Induction of long-term remission of a relapsed childhood B-acute lymphoblastic leukemia with rituximab chimeric anti-CD20 monoclonal antibody and autologous stem cell transplantation.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Burkitt Lymphoma; Child; Combined Modality Therapy; Cytarabine; Dexamethasone; Etoposide; Humans; Immunotherapy; Leukemic Infiltration; Male; Meninges; Methotrexate; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Rituximab; Salvage Therapy; Testis; Topotecan; Transplantation, Autologous; Vindesine | 2003 |
The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Breast Neoplasms; Cell Line; Cell Line, Tumor; Dogs; Female; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Methotrexate; Mitoxantrone; Neoplasm Proteins; Rabbits; Resveratrol; Stilbenes; Topotecan | 2007 |
Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells.
Topics: fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Muscle Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Topotecan | 2006 |
Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Baculoviridae; Benzimidazoles; Biological Transport, Active; Cell Line; Cell Membrane; Cholesterol; Estrone; Glycosylation; Humans; Kinetics; Methotrexate; Neoplasm Proteins; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Pharmaceutical Preparations; Prazosin; Spodoptera; Sulfasalazine; Topotecan | 2007 |
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Indoles; Inhibitory Concentration 50; Methotrexate; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; RNA, Messenger; Sunitinib; Time Factors; Topotecan; Transfection; Up-Regulation; Vincristine | 2009 |
Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster.
Topics: Animals; Carboplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Fertility; Floxuridine; Gemcitabine; High-Throughput Screening Assays; Humans; Methotrexate; Mitomycin; Models, Animal; Neoplasms; Topotecan | 2012 |
Risk of Extraocular Extension in Eyes With Retinoblastoma Receiving Intravitreous Chemotherapy.
Topics: Antineoplastic Agents; Child, Preschool; Cryotherapy; Female; Humans; Infant; Intravitreal Injections; Male; Melphalan; Methotrexate; Microscopy, Acoustic; Neoplasm Seeding; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Risk Factors; Topotecan | 2017 |
Towards establishment of a plant-based model to assess the novel anti-cancerous lead molecule(s): An in silico, in vivo and in vitro assessment of some potential anti-cancerous drugs on Lathyrus sativus L.
Topics: Colchicine; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Etoposide; Fluorouracil; Humans; Lathyrus; Methotrexate; Pemetrexed; Plant Proteins; RNA; Topotecan | 2022 |
Development and application of a liquid chromatography coupled to mass spectrometry method for the simultaneous determination of 23 antineoplastic drugs at trace levels.
Topics: Antineoplastic Agents; Busulfan; Carboplatin; Chromatography, Liquid; Cyclophosphamide; Cytarabine; Dacarbazine; Daunorubicin; Docetaxel; Doxorubicin; Epirubicin; Etoposide; Fluorouracil; Ganciclovir; Humans; Idarubicin; Ifosfamide; Irinotecan; Methanol; Methotrexate; Oxaliplatin; Paclitaxel; Pemetrexed; Tandem Mass Spectrometry; Topotecan; Vinblastine; Vincristine; Water | 2022 |