Page last updated: 2024-08-24

topotecan and men 4901

topotecan has been researched along with men 4901 in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (90.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Harada, M; Imai, J; Kawaguchi, T; Kiuchi, S; Okuno, S; Sakamura, Y; Tsuda, N; Tsujihara, K; Yano, S; Yano, T1
Harada, M; Imai, J; Okuno, S; Suzuki, T1
Harada, M; Okuno, S; Sakakibara, H; Suzuki, T; Yano, T1
Harada, M; Murata, J; Okuno, S; Sakakibara, H; Sakamura, Y; Suzuki, T1
Fujita, F; Fujita, M; Fujiwara, T; Kakushima, M; Kawaguchi, T; Kiuchi, S; Koike, M; Kudoh, S; Okuno, S; Sakamoto, Y; Yano, S; Yano, T1
Machida, Y; Onishi, H1
Bellarosa, D; Bigioni, M; Binaschi, M; Crea, A; Goso, C; Maggi, CA; Manzini, S; Palma, C; Parlani, M; Salvatore, C1
Animati, F; Beijnen, JH; Capriati, A; Crea, A; Schellens, JH; van den Heuvel, IJ; Veltkamp, SA; Voest, EE; Voogel-Fuchs, M; Witteveen, EO1
Animati, F; Bellarosa, D; Bigioni, M; Binaschi, M; Bressan, A; Bugianesi, R; Crea, A; Maggi, CA; Manzini, S; Parlani, M; Rivoltini, L1
Bouvet, M; Hoffman, RM; Kawaguchi, T; Li, X; Ma, H; Okuno, S; Yagi, S; Yang, Z1

Reviews

1 review(s) available for topotecan and men 4901

ArticleYear
Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy.
    Current drug discovery technologies, 2005, Volume: 2, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Dextrans; HT29 Cells; Humans; Liposomes; Nanostructures; Neoplasm Transplantation; Polymers; Polymethacrylic Acids; Prodrugs; Topotecan; Treatment Outcome

2005

Trials

1 trial(s) available for topotecan and men 4901

ArticleYear
Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Nov-15, Volume: 14, Issue:22

    Topics: Aged; Antineoplastic Agents; Dextrans; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Prodrugs; Topotecan

2008

Other Studies

8 other study(ies) available for topotecan and men 4901

ArticleYear
Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128).
    Cancer research, 2000, Jun-01, Volume: 60, Issue:11

    Topics: Animals; Breast Neoplasms; Camptothecin; Cell Cycle; Chromatography, Gel; Chromatography, High Pressure Liquid; Dextrans; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Rats; Rats, Wistar; Time Factors; Tissue Distribution; Topotecan; Tumor Cells, Cultured

2000
Macrophage-mediated activation of camptothecin analogue T-2513-carboxymethyl dextran conjugate (T-0128): possible cellular mechanism for antitumor activity.
    Journal of controlled release : official journal of the Controlled Release Society, 2000, Dec-03, Volume: 69, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Cell Line; Dextrans; Humans; Macrophages; Mice; Prodrugs; Topotecan

2000
Determinants for the drug release from T-0128, camptothecin analogue-carboxymethyl dextran conjugate.
    Journal of controlled release : official journal of the Controlled Release Society, 2000, Dec-03, Volume: 69, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cattle; Cysteine Endopeptidases; Dextrans; Dipeptides; Humans; Leucine; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Prodrugs; Rats; Solubility; Species Specificity; Topotecan

2000
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
    Journal of controlled release : official journal of the Controlled Release Society, 2001, Mar-12, Volume: 71, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Carbohydrate Sequence; Cell Line; Chromatography; Dextrans; Female; Half-Life; Macrophages; Molecular Sequence Data; Neoplasms, Experimental; Prodrugs; Rats; Rats, Wistar; Tissue Distribution; Topotecan

2001
MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Feb-15, Volume: 11, Issue:4

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Body Weight; Camptothecin; Cell Line, Tumor; Dextrans; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Time Factors; Topotecan; Treatment Outcome; Xenograft Model Antitumor Assays

2005
Human and murine macrophages mediate activation of MEN 4901/T-0128: a new promising camptothecin analogue-polysaccharide conjugate.
    Anti-cancer drugs, 2006, Volume: 17, Issue:10

    Topics: Animals; Camptothecin; Cathepsin B; Cells, Cultured; Dextrans; Humans; Immunity, Cellular; Macrophages; Mice; Models, Biological; Phagocytosis; Polysaccharides; Prodrugs; Topotecan

2006
Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants.
    International journal of cancer, 2009, Nov-15, Volume: 125, Issue:10

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dextrans; Female; Humans; Leukemia, Myeloid; Macrophages; Melanoma; Mice; Mice, Nude; Ovarian Neoplasms; Tissue Distribution; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2009
High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate.
    The Journal of surgical research, 2011, Volume: 171, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Body Weight; Camptothecin; Colonic Neoplasms; Dextrans; Dose-Response Relationship, Drug; Green Fluorescent Proteins; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; Prodrugs; Topotecan; Xenograft Model Antitumor Assays

2011