topotecan has been researched along with men 4901 in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (90.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harada, M; Imai, J; Kawaguchi, T; Kiuchi, S; Okuno, S; Sakamura, Y; Tsuda, N; Tsujihara, K; Yano, S; Yano, T | 1 |
| Harada, M; Imai, J; Okuno, S; Suzuki, T | 1 |
| Harada, M; Okuno, S; Sakakibara, H; Suzuki, T; Yano, T | 1 |
| Harada, M; Murata, J; Okuno, S; Sakakibara, H; Sakamura, Y; Suzuki, T | 1 |
| Fujita, F; Fujita, M; Fujiwara, T; Kakushima, M; Kawaguchi, T; Kiuchi, S; Koike, M; Kudoh, S; Okuno, S; Sakamoto, Y; Yano, S; Yano, T | 1 |
| Machida, Y; Onishi, H | 1 |
| Bellarosa, D; Bigioni, M; Binaschi, M; Crea, A; Goso, C; Maggi, CA; Manzini, S; Palma, C; Parlani, M; Salvatore, C | 1 |
| Animati, F; Beijnen, JH; Capriati, A; Crea, A; Schellens, JH; van den Heuvel, IJ; Veltkamp, SA; Voest, EE; Voogel-Fuchs, M; Witteveen, EO | 1 |
| Animati, F; Bellarosa, D; Bigioni, M; Binaschi, M; Bressan, A; Bugianesi, R; Crea, A; Maggi, CA; Manzini, S; Parlani, M; Rivoltini, L | 1 |
| Bouvet, M; Hoffman, RM; Kawaguchi, T; Li, X; Ma, H; Okuno, S; Yagi, S; Yang, Z | 1 |
1 review(s) available for topotecan and men 4901
| Article | Year |
|---|---|
Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Dextrans; HT29 Cells; Humans; Liposomes; Nanostructures; Neoplasm Transplantation; Polymers; Polymethacrylic Acids; Prodrugs; Topotecan; Treatment Outcome | 2005 |
1 trial(s) available for topotecan and men 4901
| Article | Year |
|---|---|
Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors.
Topics: Aged; Antineoplastic Agents; Dextrans; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Prodrugs; Topotecan | 2008 |
8 other study(ies) available for topotecan and men 4901
| Article | Year |
|---|---|
Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128).
Topics: Animals; Breast Neoplasms; Camptothecin; Cell Cycle; Chromatography, Gel; Chromatography, High Pressure Liquid; Dextrans; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Rats; Rats, Wistar; Time Factors; Tissue Distribution; Topotecan; Tumor Cells, Cultured | 2000 |
Macrophage-mediated activation of camptothecin analogue T-2513-carboxymethyl dextran conjugate (T-0128): possible cellular mechanism for antitumor activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Cell Line; Dextrans; Humans; Macrophages; Mice; Prodrugs; Topotecan | 2000 |
Determinants for the drug release from T-0128, camptothecin analogue-carboxymethyl dextran conjugate.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cattle; Cysteine Endopeptidases; Dextrans; Dipeptides; Humans; Leucine; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Prodrugs; Rats; Solubility; Species Specificity; Topotecan | 2000 |
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Carbohydrate Sequence; Cell Line; Chromatography; Dextrans; Female; Half-Life; Macrophages; Molecular Sequence Data; Neoplasms, Experimental; Prodrugs; Rats; Rats, Wistar; Tissue Distribution; Topotecan | 2001 |
MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude mice.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Body Weight; Camptothecin; Cell Line, Tumor; Dextrans; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Time Factors; Topotecan; Treatment Outcome; Xenograft Model Antitumor Assays | 2005 |
Human and murine macrophages mediate activation of MEN 4901/T-0128: a new promising camptothecin analogue-polysaccharide conjugate.
Topics: Animals; Camptothecin; Cathepsin B; Cells, Cultured; Dextrans; Humans; Immunity, Cellular; Macrophages; Mice; Models, Biological; Phagocytosis; Polysaccharides; Prodrugs; Topotecan | 2006 |
Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dextrans; Female; Humans; Leukemia, Myeloid; Macrophages; Melanoma; Mice; Mice, Nude; Ovarian Neoplasms; Tissue Distribution; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Body Weight; Camptothecin; Colonic Neoplasms; Dextrans; Dose-Response Relationship, Drug; Green Fluorescent Proteins; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; Prodrugs; Topotecan; Xenograft Model Antitumor Assays | 2011 |