Page last updated: 2024-08-24

topotecan and dactinomycin

topotecan has been researched along with dactinomycin in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's7 (50.00)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gibbons, S; Kaatz, GW; Zloh, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Weller, M; Winter, S1
Anderson, JR; Breneman, JC; Crist, WM; Donaldson, SS; Grier, HE; Link, MP; Maurer, HM; Paidas, CN; Pappo, AS; Qualman, SJ; Raney, RB; Smith, LM; Teot, LA; Wiener, ES1
Anderson, JR; Barr, FG; Crist, WM; Donaldson, SS; Maurer, HM; Pappo, AS; Qualman, SJ; Raney, RB; Wiener, ES1
Breitfeld, PP; Lyden, ER; Meyer, WH; Qualman, SJ; Walterhouse, DO; Wharam, MD1
Alders, M; Cransberg, K; Loos, WJ; Lugtenberg, RT; van den Heuvel-Eibrink, MM; Wagner, A1
Anderson, JR; Arndt, CA; Breneman, JC; Donaldson, SS; Hawkins, DS; Hayes-Jordan, AA; Meyer, WH; Paidas, CN; Parham, DM; Rodeberg, DA; Stoner, JA; Teot, LA; Wharam, MD1
Kumabe, T; Niizuma, H; Osawa, S; Saito, R; Sonoda, Y; Tominaga, T; Watanabe, M1
Anderson, JR; Arndt, CA; Donaldson, SS; Hawkins, DS; Lyden, ER; Morris, CD; Rodeberg, DA; Wolden, SL1
Brabetz, S; Chan, JA; Herold-Mende, C; Kool, M; Korshunov, A; Mack, N; Milde, T; Pfister, SM; Schmidt, C; Schubert, NA; Schwalm, B; Selt, F; Witt, O1

Reviews

2 review(s) available for topotecan and dactinomycin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Infant; Male; Melphalan; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Neoplasm Staging; Pilot Projects; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies; Rhabdomyosarcoma; Salvage Therapy; Sarcoma; Soft Tissue Neoplasms; Survival Rate; Topotecan; Treatment Outcome; Vincristine

2001

Trials

3 trial(s) available for topotecan and dactinomycin

ArticleYear
Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic rhabdomyosarcoma: a Children's Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Apr-15, Volume: 22, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Female; Humans; Male; Neoplasm Metastasis; Rhabdomyosarcoma; Survival Analysis; Topotecan; Vincristine

2004
Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-01, Volume: 27, Issue:31

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Neoplasm Staging; Rhabdomyosarcoma; Topotecan; Vincristine

2009
Local Control for Intermediate-Risk Rhabdomyosarcoma: Results From D9803 According to Histology, Group, Site, and Size: A Report From the Children's Oncology Group.
    International journal of radiation oncology, biology, physics, 2015, Dec-01, Volume: 93, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Disease Progression; Disease-Free Survival; Female; Humans; Infant; Lymph Nodes; Male; Meningeal Neoplasms; Radiotherapy Dosage; Retroperitoneal Neoplasms; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Topotecan; Treatment Failure; Tumor Burden; Vincristine

2015

Other Studies

9 other study(ies) available for topotecan and dactinomycin

ArticleYear
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates.
    Bioorganic & medicinal chemistry letters, 2004, Feb-23, Volume: 14, Issue:4

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, Microbial; Drug Resistance, Multiple; Ligands; Models, Molecular

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:11

    Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
Potentiation of CD95L-induced apoptosis of human malignant glioma cells by topotecan involves inhibition of RNA synthesis but not changes in CD95 or CD95L protein expression.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Fas Ligand Protein; fas Receptor; Glioma; Humans; Membrane Glycoproteins; Mice; Proto-Oncogene Proteins c-bcl-2; RNA; Topotecan; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Which patients with microscopic disease and rhabdomyosarcoma experience relapse after therapy? A report from the soft tissue sarcoma committee of the children's oncology group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Oct-15, Volume: 19, Issue:20

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Follow-Up Studies; Humans; Infant; Multivariate Analysis; Neoplasm Recurrence, Local; Prognosis; Rhabdomyosarcoma; Soft Tissue Neoplasms; Survival Rate; Topotecan; Treatment Failure; Vincristine

2001
Topotecan distribution in an anephric infant with therapy-resistant bilateral Wilms tumor with a novel germline WT1 gene mutation.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Dactinomycin; DNA, Neoplasm; Doxorubicin; Drug Resistance, Neoplasm; Exons; Female; Frameshift Mutation; Genes, Wilms Tumor; Germ-Line Mutation; Humans; Infant; Kidney Neoplasms; Loss of Heterozygosity; Metabolic Clearance Rate; Nephrectomy; Peritoneal Dialysis; Polymorphism, Single Nucleotide; RNA Splice Sites; Sequence Analysis, DNA; Topotecan; Vincristine; Wilms Tumor

2008
Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports.
    Brain tumor pathology, 2011, Volume: 28, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carboplatin; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Dactinomycin; Doxorubicin; Etoposide; Humans; Ifosfamide; Infant; Infratentorial Neoplasms; Irinotecan; Melphalan; Neoplasm Metastasis; Neuroblastoma; Rhabdomyosarcoma; Thiotepa; Topotecan; Vincristine

2011
Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.
    Neuro-oncology, 2017, Nov-29, Volume: 19, Issue:12

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Proliferation; Child, Preschool; Dactinomycin; Female; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Germ Cell and Embryonal; Neuroectodermal Tumors, Primitive; Pteridines; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2017