Compounds > topotecan
Page last updated: 2024-08-24

topotecan and chrysin

topotecan has been researched along with chrysin in 3 studies

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morris, ME; Sagawa, K; Wang, X; Zhang, S1
Boll, M; Hautzinger, A; Hertrampf, A; Holzhauser, S; Kuntz, S; Popovic, D; Rossmann, A; Schumacher, M; Wenzel, U1
Han, HK; Lee, SH; Lee, YS; Song, JG1

Other Studies

3 other study(ies) available for topotecan and chrysin

ArticleYear
Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3

    Topics: Acridines; Animals; Antineoplastic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Benzoflavones; Biological Availability; Cell Line, Tumor; Drug Interactions; Female; Flavonoids; Humans; Male; Mice; Mice, Knockout; Neoplasm Proteins; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Topotecan

2005
Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters.
    Biochemical pharmacology, 2010, Aug-15, Volume: 80, Issue:4

    Topics: Apoptosis; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cells, Cultured; Drug Antagonism; Drug Resistance, Neoplasm; Flavonoids; Humans; K562 Cells; Multidrug Resistance-Associated Protein 2; Topotecan

2010
Improved In vivo Effect of Chrysin as an Absorption Enhancer Via the Preparation of Ternary Solid Dispersion with Brij®L4 and Aminoclay.
    Current drug delivery, 2019, Volume: 16, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Availability; Clay; Detergents; Drug Compounding; Drug Evaluation, Preclinical; Flavonoids; HT29 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Male; Neoplasms; Polidocanol; Rats; Rats, Sprague-Dawley; Solubility; Topotecan; Water

2019