Compounds > topotecan
Page last updated: 2024-08-24

topotecan and arc111

topotecan has been researched along with arc111 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
LaVoie, EJ; Li, TK; Liu, A; Liu, LF; Ray, A; Ruchelman, AL; Singh, SK; Wu, X; Yang, JM1
LaVoie, EJ; Li, TK; Liu, A; Liu, LF; Ruchelman, AL; Singh, SK1
LaVoie, EJ; Liu, A; Liu, LF; Ruchelman, AL; Zhou, N; Zhu, S1
Houghton, PJ; LaVoie, EJ; Liu, A; Liu, LF; Ruchelman, AL; Zhou, N1
Feng, W; LaVoie, EJ; Liu, AA; Liu, LF; Satyanarayana, M; Tsai, YC2
Cheng, L; Feng, W; LaVoie, EJ; Liu, A; Liu, LF; Satyanarayana, M; Tsai, YC1
Agata, N; Bagley, RG; Battle, T; Crawford, J; Ewesuedo, R; Krumbholz, R; Kurtzberg, LS; Lavoie, EJ; Roth, S; Rouleau, C; Schmid, S; Teicher, BA; Wang, F; Yao, M; Yu, XJ1

Other Studies

8 other study(ies) available for topotecan and arc111

ArticleYear
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.
    Bioorganic & medicinal chemistry letters, 2002, Nov-18, Volume: 12, Issue:22

    Topics: Animals; Antineoplastic Agents; Aza Compounds; Cell Division; Chrysenes; DNA; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Topoisomerase I Inhibitors; Transplantation, Heterologous; Treatment Outcome; Tumor Cells, Cultured

2002
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
    Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11

    Topics: Amines; Antineoplastic Agents; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthyridines; Nitro Compounds; Structure-Activity Relationship; Tumor Cells, Cultured

2003
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
    Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22

    Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Naphthyridines; Phenanthridines; Structure-Activity Relationship; Topoisomerase I Inhibitors

2004
5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
    Journal of medicinal chemistry, 2005, Feb-10, Volume: 48, Issue:3

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; DNA Topoisomerases, Type I; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, SCID; Naphthyridines; Piperazines; Piperidines; Pyrrolidines; Structure-Activity Relationship; Transplantation, Heterologous

2005
11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.
    Bioorganic & medicinal chemistry, 2008, Sep-15, Volume: 16, Issue:18

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Leukemia, Lymphoid; Phenanthridines; Structure-Activity Relationship; Topoisomerase I Inhibitors

2008
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
    Bioorganic & medicinal chemistry, 2008, Oct-15, Volume: 16, Issue:20

    Topics: Alkylation; Amines; Antineoplastic Agents; Benzene; Cell Line, Tumor; Cell Survival; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Topoisomerase I Inhibitors

2008
12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.
    Bioorganic & medicinal chemistry, 2009, Apr-01, Volume: 17, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type I; Humans; Phenanthridines; Topoisomerase I Inhibitors

2009
Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:10

    Topics: Animals; Antineoplastic Agents; Body Weight; Bone Marrow; Camptothecin; Cell Line, Tumor; Cell Proliferation; Confidence Intervals; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inhibitory Concentration 50; Irinotecan; Male; Mice; Mice, Inbred BALB C; Naphthyridines; Neoplastic Stem Cells; Topoisomerase I Inhibitors; Topotecan; Weight Loss; Xenograft Model Antitumor Assays

2008