Compounds > topotecan
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topotecan and acridines

topotecan has been researched along with acridines in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's7 (70.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beijnen, JH; Brinkhuis, RF; Jonker, JW; Maliepaard, M; Schellens, JH; Schinkel, AH; Smit, JW1
Hudes, G1
Beijnen, JH; Jewell, RC; Kruijtzer, CM; Paul, EM; Rosing, H; Schellens, JH; Schot, M; ten Bokkel Huinink, WW1
Kaufmann, SH; Svingen, PA1
Bally, M; Hu, Y; Krishan, A; Mayer, LD; Nie, W; Sridhar, KS1
Morris, ME; Sagawa, K; Wang, X; Zhang, S1
Hardwick, LJ; van Veen, HW; Velamakanni, S1
Beijnen, JH; Jewell, RC; Kuppens, IE; Mangum, SG; Paul, EM; Radema, SA; Schellens, JH; Voest, EE; Witteveen, EO1
Fujinaga, M; Fukumura, T; Hatori, A; Kawamura, K; Nengaki, N; Ogawa, M; Wakizaka, H; Yamasaki, T; Yanamoto, K; Yoshida, Y; Yui, J; Zhang, MR1
Beijnen, JH; Iusuf, D; Lin, F; Marchetti, S; Mazzanti, R; Pluim, D; Schellens, JH; van Tellingen, O1

Reviews

1 review(s) available for topotecan and acridines

ArticleYear
The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2).
    British journal of pharmacology, 2007, Volume: 151, Issue:2

    Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Technology, Pharmaceutical; Tetrahydroisoquinolines; Topotecan

2007

Trials

2 trial(s) available for topotecan and acridines

ArticleYear
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jul-01, Volume: 20, Issue:13

    Topics: Acridines; Administration, Oral; Adult; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Breast Neoplasms; Drug Administration Schedule; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Isoquinolines; Middle Aged; Neoplasm Proteins; Tetrahydroisoquinolines; Topotecan

2002
A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jun-01, Volume: 13, Issue:11

    Topics: Acridines; Administration, Oral; Adult; Aged; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cohort Studies; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Proteins; Neoplasms; Research Design; Tetrahydroisoquinolines; Topotecan

2007

Other Studies

7 other study(ies) available for topotecan and acridines

ArticleYear
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.
    Journal of the National Cancer Institute, 2000, Oct-18, Volume: 92, Issue:20

    Topics: Acridines; Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; DNA, Complementary; Enzyme Inhibitors; Female; Fetus; Humans; Intestinal Absorption; Isoquinolines; Male; Mice; Mitoxantrone; Neoplasm Proteins; Placenta; Pregnancy; RNA, Messenger; Tetrahydroisoquinolines; Topotecan

2000
Boosting bioavailability of topotecan: what do we gain?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jul-01, Volume: 20, Issue:13

    Topics: Acridines; Administration, Oral; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Intestinal Absorption; Isoquinolines; Neoplasm Proteins; Tetrahydroisoquinolines; Topoisomerase I Inhibitors; Topotecan

2002
Immunoblot analysis and band depletion assays.
    Methods in molecular biology (Clifton, N.J.), 1999, Volume: 94

    Topics: Acridines; Antineoplastic Agents; DNA Adducts; DNA Topoisomerases, Type I; Humans; Immunoblotting; K562 Cells; Leukemia; Pyrazoles; Topotecan

1999
Synergistic cytotoxicity of pyrazoloacridine with doxorubicin, etoposide, and topotecan in drug-resistant tumor cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-01, Volume: 10, Issue:3

    Topics: Acridines; Agar; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Catalysis; Cell Line, Tumor; Cell Nucleus; Clinical Trials as Topic; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Superhelical; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Humans; Inhibitory Concentration 50; Pyrazoles; Topotecan

2004
Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3

    Topics: Acridines; Animals; Antineoplastic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Benzoflavones; Biological Availability; Cell Line, Tumor; Drug Interactions; Female; Flavonoids; Humans; Male; Mice; Mice, Knockout; Neoplasm Proteins; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Topotecan

2005
Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography.
    Nuclear medicine and biology, 2011, Volume: 38, Issue:5

    Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain; Carbon Radioisotopes; Cell Line, Tumor; Gene Knockout Techniques; Humans; Male; Mice; Neoplasm Proteins; Positron-Emission Tomography; Tetrahydroisoquinolines; Topotecan

2011
Abcc4 together with abcb1 and abcg2 form a robust cooperative drug efflux system that restricts the brain entry of camptothecin analogues.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Apr-15, Volume: 19, Issue:8

    Topics: Acridines; Administration, Intravenous; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Camptothecin; Chromatography, High Pressure Liquid; Irinotecan; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Tetrahydroisoquinolines; Topotecan

2013