topotecan has been researched along with acridines in 10 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (10.00) | 18.2507 |
2000's | 7 (70.00) | 29.6817 |
2010's | 2 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Beijnen, JH; Brinkhuis, RF; Jonker, JW; Maliepaard, M; Schellens, JH; Schinkel, AH; Smit, JW | 1 |
Hudes, G | 1 |
Beijnen, JH; Jewell, RC; Kruijtzer, CM; Paul, EM; Rosing, H; Schellens, JH; Schot, M; ten Bokkel Huinink, WW | 1 |
Kaufmann, SH; Svingen, PA | 1 |
Bally, M; Hu, Y; Krishan, A; Mayer, LD; Nie, W; Sridhar, KS | 1 |
Morris, ME; Sagawa, K; Wang, X; Zhang, S | 1 |
Hardwick, LJ; van Veen, HW; Velamakanni, S | 1 |
Beijnen, JH; Jewell, RC; Kuppens, IE; Mangum, SG; Paul, EM; Radema, SA; Schellens, JH; Voest, EE; Witteveen, EO | 1 |
Fujinaga, M; Fukumura, T; Hatori, A; Kawamura, K; Nengaki, N; Ogawa, M; Wakizaka, H; Yamasaki, T; Yanamoto, K; Yoshida, Y; Yui, J; Zhang, MR | 1 |
Beijnen, JH; Iusuf, D; Lin, F; Marchetti, S; Mazzanti, R; Pluim, D; Schellens, JH; van Tellingen, O | 1 |
1 review(s) available for topotecan and acridines
Article | Year |
---|---|
The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2).
Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Technology, Pharmaceutical; Tetrahydroisoquinolines; Topotecan | 2007 |
2 trial(s) available for topotecan and acridines
Article | Year |
---|---|
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
Topics: Acridines; Administration, Oral; Adult; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Breast Neoplasms; Drug Administration Schedule; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Isoquinolines; Middle Aged; Neoplasm Proteins; Tetrahydroisoquinolines; Topotecan | 2002 |
A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.
Topics: Acridines; Administration, Oral; Adult; Aged; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cohort Studies; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Proteins; Neoplasms; Research Design; Tetrahydroisoquinolines; Topotecan | 2007 |
7 other study(ies) available for topotecan and acridines
Article | Year |
---|---|
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.
Topics: Acridines; Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; DNA, Complementary; Enzyme Inhibitors; Female; Fetus; Humans; Intestinal Absorption; Isoquinolines; Male; Mice; Mitoxantrone; Neoplasm Proteins; Placenta; Pregnancy; RNA, Messenger; Tetrahydroisoquinolines; Topotecan | 2000 |
Boosting bioavailability of topotecan: what do we gain?
Topics: Acridines; Administration, Oral; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Intestinal Absorption; Isoquinolines; Neoplasm Proteins; Tetrahydroisoquinolines; Topoisomerase I Inhibitors; Topotecan | 2002 |
Immunoblot analysis and band depletion assays.
Topics: Acridines; Antineoplastic Agents; DNA Adducts; DNA Topoisomerases, Type I; Humans; Immunoblotting; K562 Cells; Leukemia; Pyrazoles; Topotecan | 1999 |
Synergistic cytotoxicity of pyrazoloacridine with doxorubicin, etoposide, and topotecan in drug-resistant tumor cells.
Topics: Acridines; Agar; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Catalysis; Cell Line, Tumor; Cell Nucleus; Clinical Trials as Topic; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Superhelical; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Humans; Inhibitory Concentration 50; Pyrazoles; Topotecan | 2004 |
Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.
Topics: Acridines; Animals; Antineoplastic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Benzoflavones; Biological Availability; Cell Line, Tumor; Drug Interactions; Female; Flavonoids; Humans; Male; Mice; Mice, Knockout; Neoplasm Proteins; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Topotecan | 2005 |
Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography.
Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain; Carbon Radioisotopes; Cell Line, Tumor; Gene Knockout Techniques; Humans; Male; Mice; Neoplasm Proteins; Positron-Emission Tomography; Tetrahydroisoquinolines; Topotecan | 2011 |
Abcc4 together with abcb1 and abcg2 form a robust cooperative drug efflux system that restricts the brain entry of camptothecin analogues.
Topics: Acridines; Administration, Intravenous; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Camptothecin; Chromatography, High Pressure Liquid; Irinotecan; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Tetrahydroisoquinolines; Topotecan | 2013 |