topiramate and phenyltrimethylammonium

topiramate has been researched along with phenyltrimethylammonium* in 1 studies

Other Studies

1 other study(ies) available for topiramate and phenyltrimethylammonium

Article	Year
Determination of topiramate in dried blood spots using single-quadrupole gas chromatography-mass spectrometry after flash methylation with trimethylanilinium hydroxide. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Mar-01, Volume: 1046 Dried blood spots (DBS) sampling obtained from fingerpricks is a promising and patient friendly alternative for obtaining samples for drug quantification, that could be of interest for topiramate (TOP) therapeutic drug monitoring. The aim of this study was to develop and validate a simple and fast GC-MS assay for TOP measurement in dried blood spots (DBS). The method uses a liquid extraction of one 8mm DBS, followed by a flash methylation with TMAH, and separation in a DB-5ms capillary column. Total analytical run time was 15min. Precision assays presented CV% lower than 9.1% and accuracy was in the range of 94.5-115%. TOP was stable at 25 and 45°C up to 21days. TOP presents saturable binding to red blood cells, resulting in a fraction in plasma (f Topics: Dried Blood Spot Testing; Fructose; Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Methylation; Quaternary Ammonium Compounds; Reproducibility of Results; Sensitivity and Specificity; Topiramate	2017

Article

Year

Determination of topiramate in dried blood spots using single-quadrupole gas chromatography-mass spectrometry after flash methylation with trimethylanilinium hydroxide.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Mar-01, Volume: 1046

Dried blood spots (DBS) sampling obtained from fingerpricks is a promising and patient friendly alternative for obtaining samples for drug quantification, that could be of interest for topiramate (TOP) therapeutic drug monitoring. The aim of this study was to develop and validate a simple and fast GC-MS assay for TOP measurement in dried blood spots (DBS). The method uses a liquid extraction of one 8mm DBS, followed by a flash methylation with TMAH, and separation in a DB-5ms capillary column. Total analytical run time was 15min. Precision assays presented CV% lower than 9.1% and accuracy was in the range of 94.5-115%. TOP was stable at 25 and 45°C up to 21days. TOP presents saturable binding to red blood cells, resulting in a fraction in plasma (f

Topics: Dried Blood Spot Testing; Fructose; Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Methylation; Quaternary Ammonium Compounds; Reproducibility of Results; Sensitivity and Specificity; Topiramate

2017