Compounds > top 53
Page last updated: 2024-09-05

top 53 and etoposide

top 53 has been researched along with etoposide in 7 studies

Compound Research Comparison

Studies
(top 53)		Trials
(top 53)		Recent Studies (post-2010)
(top 53)		Studies
(etoposide)		Trials
(etoposide)		Recent Studies (post-2010) (etoposide)
70018,3063,6934,900

Protein Interaction Comparison

ProteinTaxonomytop 53 (IC50)etoposide (IC50)
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]Homo sapiens (human)1.153
nuclear receptor coactivator 3 isoform aHomo sapiens (human)1.4284
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)3.187
Caspase-3Homo sapiens (human)1
DNA topoisomerase 2-betaHomo sapiens (human)0.4299
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)4.18

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's5 (71.43)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aoyagi, K; Kobunai, T; Oh-hara, T; Shibata, J; Sugimoto, Y; Terada, T; Tsuruo, T; Utsugi, T; Wierzba, K; Yamada, Y1
Bandoh, T; Kitamura, R; Satoh, T; Tsuda, M1
Aoyagi, K; Kobunai, T; Saito, H; Utsugi, T; Wierzba, K; Yamada, Y; Yoshida, M1
Byl, JA; Cline, SD; Kobunai, T; Osheroff, N; Utsugi, T; Yamada, Y1
Asai, T; Baba, K; Irimura, K; Oku, N; Shimizu, K; Takada, M1
Malik, M; Nitiss, JL1
Carr, AM; Hartsuiker, E; Neale, MJ1

Other Studies

7 other study(ies) available for top 53 and etoposide

ArticleYear
Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer.
    Cancer research, 1996, Jun-15, Volume: 56, Issue:12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; DNA, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Nude; Neoplasms, Experimental; Specific Pathogen-Free Organisms; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1996
Determination of a new podophyllotoxin derivative, TOP-53, and its metabolite in rat plasma and urine by high-performance liquid chromatography with electrochemical detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Mar-07, Volume: 690, Issue:1-2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Drug Stability; Electrochemistry; Etoposide; Glucuronates; Rats; Sensitivity and Specificity

1997
Specific distribution of TOP-53 to the lung and lung-localized tumor is determined by its interaction with phospholipids.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Etoposide; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Phospholipids; Quinidine; Tissue Distribution

2000
DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action.
    Biochemistry, 2001, Jan-23, Volume: 40, Issue:3

    Topics: Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; DNA Damage; DNA Ligases; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Fungal; Etoposide; Humans; Hydrolysis; Isoenzymes; Mutagenesis, Site-Directed; Recombinant Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2001
Potential usage of liposomal 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53) for cancer chemotherapy.
    Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:6

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Antineoplastic Agents; Blood Vessels; Body Weight; Enzyme Inhibitors; Etoposide; Liposomes; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Survival Analysis; Topoisomerase II Inhibitors

2002
DNA repair functions that control sensitivity to topoisomerase-targeting drugs.
    Eukaryotic cell, 2004, Volume: 3, Issue:1

    Topics: Camptothecin; Cell Cycle; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Etoposide; Genotype; Mutation; Plasmids; Recombination, Genetic; Schizosaccharomyces; Sensitivity and Specificity; Temperature; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; X-Rays

2004
Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
    Molecular cell, 2009, Jan-16, Volume: 33, Issue:1

    Topics: Camptothecin; Cell Nucleolus; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Fungal; Etoposide; Exodeoxyribonucleases; Gamma Rays; Methyl Methanesulfonate; Mutant Proteins; Mutation; Protein Binding; Schizosaccharomyces; Schizosaccharomyces pombe Proteins

2009