tomatine has been researched along with tomatidine in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (6.33) | 18.7374 |
| 1990's | 8 (10.13) | 18.2507 |
| 2000's | 12 (15.19) | 29.6817 |
| 2010's | 38 (48.10) | 24.3611 |
| 2020's | 16 (20.25) | 2.80 |
| Authors | Studies |
|---|---|
| Belic, I; Hirsl-Pintaric, V; Sociĭc, H; Vranjek, B | 1 |
| Baker, DC; Gaffield, W; Keeler, RF | 1 |
| Clarke, GF; Skuce, R; Thorne, HV | 1 |
| Gaberc-Porekar, V; Gottlieb, HE; Mervic, M | 1 |
| Jadhav, SJ; Salunkhe, DK; Sharma, RP | 1 |
| Belic, I; Gaberc-Porekar, V; Socic, H; Zakelj, M | 1 |
| Friedman, M; Henika, PR; Mackey, BE | 2 |
| Zimowski, J | 1 |
| Blankemeyer, JT; Friedman, M; Stringer, BK; White, JB | 1 |
| Beachy, PA; Cooper, MK; Porter, JA; Young, KE | 1 |
| Kim, SK; Melton, DA | 1 |
| Pérez-Espinosa, A; Roldán-Arjona, T; Ruiz-Rubio, M | 1 |
| Huopalahti, R; Kuronen, P; Laakso, I; Laurila, J; Pehu, E; Väänänen, T | 1 |
| Baylin, SB; Beachy, PA; Berman, DM; Burkholder, SG; Wang, B; Watkins, DN | 1 |
| Eto, T; Ikeda, T; Ito, S; Takahara, H; Tanaka, S; Yamauchi, N | 1 |
| Cleaver, A; Csukai, M; Latijnhouwers, M; Morrissey, JP; Osbourn, A; Simons, V; Yarrow, C | 1 |
| Fujiwara, Y; Fusyuku, A; Han, C; Ikeda, T; Matsushita, S; Nohara, T; Ojika, M; Ono, M; Yanai, Y | 1 |
| Boussif, N; Briquet, A; Chatel, G; Delacroix, L; Ganeff, C; Nolens, G; Winkler, R | 1 |
| Chiang, CT; Lin, JK; Tsai, SJ; Way, TD | 1 |
| Brown, AJ; McCarthy, FR | 1 |
| Chiu, FL; Lin, JK | 1 |
| Loria, R; Seipke, RF | 1 |
| Abrahamsson, A; Beachy, PA; Blum, J; Chen, A; Chute, JP; Fereshteh, M; Jamieson, CH; Kim, J; Kwon, HY; Munchhof, M; Reya, T; Rizzieri, D; VanArsdale, T; Zhao, C | 1 |
| Bee, WL; Copeland, RA; Davenport, EA; Gilmartin, A; Gontarek, R; Hornberger, KR; Kallal, LA; Lai, Z; Lawrie, K; Lu, Q; McMillan, L; Rominger, CM; Rominger, DH; Truong, M; Tummino, PJ; Turunen, B; Will, M; Zuercher, WJ | 1 |
| Buttyan, R; Chen, M; Levin, RM; Mechlin, CW; Mian, BM; Tanner, MJ | 1 |
| Bouarab, K; Gattuso, M; Grondin, G; Malouin, F; Marsault, É; Mitchell, G | 1 |
| Bouarab, K; Boulanger, S; Gattuso, M; Guay, I; Lafrance, M; Malouin, F; Marsault, E; Mitchell, G; Séguin, DL | 1 |
| Aharoni, A; Alkan, N; Aoki, K; Beekwilder, J; Burdman, S; de Vos, R; Iijima, Y; Itkin, M; Malitsky, S; Masini, L; Meir, S; Prusky, D; Rogachev, I; Rosenberg, T | 1 |
| Fujiwara, Y; Horlad, H; Ikeda, T; Kiyota, N; Nagai, R; Nohara, T; Takeya, M; Tsurushima, K; Yoshitomi, M | 1 |
| Ahn, JB; Choi, SH; Friedman, M; Kim, HJ; Kozukue, N; Levin, CE; Mizuno, M; Nishitani, Y; Zhang, L | 1 |
| Atella, GC; Barrabin, H; De Souza, W; Medina, JM; Rodrigues, JC | 1 |
| Felley-Bosco, E; Moura, U; Opitz, I; Rehrauer, H; Shi, Y; Soltermann, A; Stahel, RA; Thies, S; Weder, W | 1 |
| Bouwmeester, HJ; Collemare, J; de Vos, RCH; de Wit, PJGM; Etalo, DW; Joosten, MHAJ; Ökmen, B | 1 |
| Chen, PS; Huang, HC; Lee, LM; Li, CC; Lin, HT; Yan, KH; Yan, SH | 1 |
| Friedman, M | 1 |
| Andrade, PB; Ferreres, F; Sousa, C; Taveira, M; Teixeira, JP; Valentão, P | 1 |
| Adams, CM; Bongers, KS; Bullard, SA; Cook, DP; Dierdorff, JM; Dyle, MC; Ebert, SM; Fox, DK; Kunkel, SD | 1 |
| Bonin, MA; Bouarab, K; Chagnon, F; Guay, I; Malouin, F; Marsault, É; Mitchell, G | 1 |
| Afzal, S; Barozai, MY; Bashir, F; Behlil, F; Khan, M; Muzaffar, S | 1 |
| Cahill, MG; Caprioli, G; James, KJ; Logrippo, S | 1 |
| Atella, G; Barrabin, H; Medina, JM; Moreira, OC; Rodrigues, JC; Souza, Wd | 1 |
| Adams, CM; Dyle, MC; Ebert, SM | 1 |
| Chen, MW; Cheng, KJ; Jiang, QW; Shi, Z; Wei, X; Yu, PZ | 1 |
| Cahill, M; Caprioli, G; James, K; Logrippo, S | 1 |
| Kim, HA; Kim, MC; Kim, NY; Kim, Y | 1 |
| Adams, CM; Bongers, KS; Bullard, SA; Dierdorff, JM; Dyle, MC; Ebert, SM; Fox, DK; Lira, VA; Meyerholz, DK; Murry, DJ; Talley, JJ | 1 |
| Bouarab, K; Boulanger, S; Cantin, A; Déziel, E; Frost, EH; Malouin, F; Marsault, É; Mitchell, G | 1 |
| Alonso, PE; Rioja, LF | 1 |
| Carere, J; Colgrave, ML; Gardiner, DM; Kazan, K; Liu, C; Manners, JM; Stiller, J | 1 |
| Desneux, N; Han, P; Lavoir, AV; Michel, T; Niu, CY; Seassau, A; Wang, ZJ; Zheng, WY | 1 |
| Cheng, LW; Friedman, M; Kanetake, S; Land, KM; Liu, J; Tam, C; Wu, YH | 1 |
| Becker, KG; Bohr, VA; Eckley, DM; Fang, EF; Fivenson, EM; Goldberg, IG; Iser, WB; Kassahun, H; Kerr, JS; Lehrmann, E; Lu, Q; Marosi, K; Mattson, MP; Morevati, M; Nilsen, H; Scheibye-Knudsen, M; Waltz, TB; Wilson, MA; Wollman, BN; Zhang, Y | 1 |
| Becker, KG; Bohr, VA; Fang, EF; Fivenson, EM; Li, C; Morevati, M; Waltz, TB | 1 |
| Cichon, MJ; Clinton, SK; Francis, DM; Riedl, KM; Schwartz, SJ; Thomas-Ahner, JM; Wan, L | 1 |
| Chen, LC; Huang, WC; Kuo, CY; Kuo, ML; Liou, CJ; Shen, JJ | 1 |
| Bouarab, K; Boulanger, S; Brouillette, E; Chagnon, F; Guay, I; Isabelle, C; Malouin, F; Marsault, E | 1 |
| Beauregard, PB; Bouarab, K; Boudreault, PL; Boyapelly, K; Brouillette, E; Brzezinski, R; Guay, I; Isabelle, C; Jacques, PÉ; Lamontagne Boulet, M; Langlois, JP; Malouin, F; Marsault, É; Rodrigue, S | 1 |
| Banerjee, R; Dhayani, A; Lohchania, B; Marepally, S; Rachamalla, HR; Rangasami, VK; Thangavel, S; Vemula, PK; Voshavar, C | 1 |
| Cai, X; Hu, B; Jiang, G; Li, S; Meng, J; Shi, Z; Sun, X; Wu, F; Wu, H; Yan, S; Yang, Y; Ying, Z; Zhao, X; Zhou, C; Zhu, H | 1 |
| Diosa-Toro, M; Heberle, AM; Smit, JM; Thedieck, K; Troost, B; Urcuqui-Inchima, S; van de Pol, D | 1 |
| Akagawa, M; Harada, N; Kudo, M; Kusu, H; Okuyama, M; Tsuji-Naito, K; Yoshida, H | 1 |
| Jeon, S; Kim, MM | 1 |
| Chang, HR; Hsieh, MH; Hsieh, YH; Lin, RC; Lu, KH; Yang, JS; Yang, SF | 1 |
| Diosa-Toro, M; Mulder, LM; Rodenhuis-Zybert, IA; Smit, JM; Troost, B; van de Pol, D | 1 |
| Chen, K; He, W; Li, B; Li, Z; Wu, Q; Xia, J; Xu, S; Yang, Y; You, X; Yu, T; Zhao, Y; Zhou, H; Zhu, H | 1 |
| Chu, X; Huang, X; Ni, B; Xi, Y; You, H; Yu, T; Zhang, R | 1 |
| Ahn, J; Ha, T; Jung, CH; Kim, JS; Lee, H; Nirmala, FS | 1 |
| Bai, J; Jiang, P; Liu, X; Wang, M; Wang, P; Wang, X | 1 |
| Chen, YL; Huang, WC; Liou, CJ; Shen, SC; Wu, SJ; Yeh, KW; Yu, MC | 1 |
| Ahsan, A; Feng, Z; Li, Y; Lyu, XC; Wang, YT; Zhang, LN; Zhang, X | 1 |
| Chen, YL; Huang, WC; Lin, CF; Liou, CJ; Wu, SJ | 1 |
| Ahmad, I; Algahtani, FD; Aouadi, K; Iriti, M; Kadri, A; Noumi, E; Patel, H; Saeed, M; Snoussi, M; Sulaiman, S; Tasleem, M; Zrieq, R | 1 |
| Boudreault, PL; Normandin, C | 1 |
| Bailly, C | 1 |
| Borggrewe, M; Merits, A; Rodenhuis-Zybert, IA; Smit, JM; Troost-Kind, B; van de Pol, D; van der Ende-Metselaar, H; van Hemert, MJ | 1 |
| Fujimaki, J; Kamei, Y; Miura, S; Morita, A; Nonaka, M; Nukaya, H; Oyabu, M; Sato, T; Sayama, N; Shiotani, S; Suzuki, T; Uezono, Y; Wakabayashi, K | 1 |
| Choi, S; Han, J; Heo, SC; Hyun, SA; Kim, D; Kim, DH; Kim, HK; Kim, JH; Kim, YS; Seo, JW; Yoon, JW; Youm, JB | 1 |
| Hui, CW; Kishino, S; Nakatani, Y; Ogawa, J | 1 |
7 review(s) available for tomatine and tomatidine
| Article | Year |
|---|---|
Spirosolane-containing Solanum species and induction of congenital craniofacial malformations.
Topics: Animals; Craniofacial Dysostosis; Cricetinae; Female; Gas Chromatography-Mass Spectrometry; Glycosides; Plants, Toxic; Pregnancy; Solanaceous Alkaloids; Solanum tuberosum; Teratogens; Tomatine | 1990 |
Naturally occurring toxic alkaloids in foods.
Topics: Alkaloids; Animals; Chemical Phenomena; Chemistry; Humans; Light; Solanaceous Alkaloids; Solanine; Tomatine; Vegetables | 1981 |
Anticarcinogenic, cardioprotective, and other health benefits of tomato compounds lycopene, α-tomatine, and tomatidine in pure form and in fresh and processed tomatoes.
Topics: Animals; Anticarcinogenic Agents; Biological Availability; Cardiotonic Agents; Carotenoids; Diet; Food Handling; Humans; Lycopene; Solanum lycopersicum; Tomatine | 2013 |
Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy.
Topics: Drug Discovery; Gene Expression; Humans; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; RNA, Messenger; Signal Transduction; Tomatine; Triterpenes; Ursolic Acid | 2015 |
Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases.
Topics: Alkaloids; Androgens; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Diosgenin; Estrogens; Humans; Mice; Neoplasms; Solanaceous Alkaloids; Steroids; Tomatine; Veratrum Alkaloids | 2016 |
Sarcopenia, Aging and Prospective Interventional Strategies.
Topics: Aging; Animals; Coumarins; Humans; Mitochondria; Molecular Structure; Niacinamide; Sarcopenia; Tomatine | 2018 |
The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiparasitic Agents; Humans; Insecticides; Molecular Conformation; Solanum lycopersicum; Tomatine | 2021 |
72 other study(ies) available for tomatine and tomatidine
| Article | Year |
|---|---|
Microbial cleavage of the tomatidine spiroketal sidechain.
Topics: Alkaloids; Androstadienes; Arthrobacter; Cholesterol; Tomatine | 1975 |
The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids.
Topics: Animals; Cell Line; Cell Membrane; Cell Survival; Chlorocebus aethiops; Diosgenin; Erythrocyte Membrane; Monosaccharides; Sheep; Simplexvirus; Solanaceous Alkaloids; Solanine; Structure-Activity Relationship; Tomatine | 1985 |
A new microbial degradation pathway of steroid alkaloids.
Topics: Alkaloids; Ascomycota; Biotransformation; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrophotometry; Tomatine | 1983 |
Transformation of tomatidine by Gymnoascus reesii.
Topics: Alkaloids; Ascomycota; Biodegradation, Environmental; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Tomatine | 1982 |
Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice.
Topics: Alkaloids; Animals; Body Weight; Dehydroepiandrosterone; Diosgenin; Eating; Female; Liver; Mice; Organ Size; Plants, Edible; Solanaceous Alkaloids; Solanine; Solanum lycopersicum; Solanum tuberosum; Structure-Activity Relationship; Tomatine; Vegetables | 1996 |
Enzymatic glycosylation of tomatidine in tomato plants.
Topics: Autoradiography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Thin Layer; Galactosyltransferases; Glycosylation; Glycosyltransferases; Molecular Weight; Solanum lycopersicum; Subcellular Fractions; Tomatine | 1996 |
Effect of alpha-tomatine and tomatidine on membrane potential of frog embryos and active transport of ions in frog skin.
Topics: Animals; Antifungal Agents; Embryo, Nonmammalian; Membrane Potentials; Rana pipiens; Skin; Tomatine | 1997 |
Teratogen-mediated inhibition of target tissue response to Shh signaling.
Topics: Abnormalities, Drug-Induced; Animals; Cell Membrane; Central Nervous System; Chick Embryo; Cholesterol; Culture Techniques; DNA-Binding Proteins; Endoplasmic Reticulum; Hedgehog Proteins; Hepatocyte Nuclear Factor 3-beta; Holoprosencephaly; Homeodomain Proteins; LIM-Homeodomain Proteins; Membrane Proteins; Muscle Proteins; Nerve Tissue Proteins; Nuclear Proteins; Patched Receptors; PAX7 Transcription Factor; Proteins; Receptors, Cell Surface; Signal Transduction; Teratogens; Tomatine; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators; Transcription Factors; Triparanol; Veratrum Alkaloids | 1998 |
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.
Topics: Animals; Chick Embryo; Choristoma; Embryonic Induction; Endoderm; Gene Expression Regulation, Developmental; Glucagon; Hedgehog Proteins; Insulin; Islets of Langerhans; Mesoderm; Pancreas; Proteins; Signal Transduction; Stomach Diseases; Teratogens; Tomatine; Trans-Activators; Veratrum Alkaloids | 1998 |
Tomatinase from Fusarium oxysporum f. sp. lycopersici defines a new class of saponinases.
Topics: Amino Acid Sequence; Base Sequence; Carbohydrate Sequence; Fusarium; Gene Library; Glycoside Hydrolases; Molecular Sequence Data; Sequence Alignment; Sequence Homology, Amino Acid; Solanum lycopersicum; Substrate Specificity; Tomatine | 1999 |
Determination of solanidine- and tomatidine-type glycoalkaloid aglycons by gas Chromatography/Mass spectrometry.
Topics: Diosgenin; Gas Chromatography-Mass Spectrometry; Reproducibility of Results; Solanaceous Alkaloids; Tomatine | 1999 |
Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.
Topics: Abortion, Veterinary; Adenocarcinoma; Animals; Body Weight; Breast Neoplasms; Cell Division; Diosgenin; Dose-Response Relationship, Drug; Female; Fertility; Hepatomegaly; Humans; Litter Size; Liver; Mice; Organ Size; Pregnancy; Pregnancy Outcome; Random Allocation; Receptors, Estrogen; Solanaceous Alkaloids; Structure-Activity Relationship; Tomatine; Tumor Cells, Cultured | 2003 |
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
Topics: Animals; Carcinoma, Small Cell; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Coculture Techniques; Disease Models, Animal; Epithelial Cells; Hedgehog Proteins; Humans; Lung; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Oncogene Proteins; Signal Transduction; Stem Cells; Tomatine; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2003 |
Tomatidine and lycotetraose, hydrolysis products of alpha-tomatine by Fusarium oxysporum tomatinase, suppress induced defense responses in tomato cells.
Topics: Fusarium; Glycoside Hydrolases; Hydrolysis; Oligosaccharides; Plant Diseases; Solanum lycopersicum; Tomatine | 2004 |
Dual effects of plant steroidal alkaloids on Saccharomyces cerevisiae.
Topics: Alkaloids; Antifungal Agents; Carbohydrate Sequence; Cell Membrane Permeability; Gene Expression Regulation, Fungal; Genes, Fungal; Hydrogen-Ion Concentration; Molecular Structure; Saccharomyces cerevisiae; Saponins; Substrate Specificity; Tomatine | 2006 |
Efficient conversion of tomatidine into neuritogenic pregnane derivative.
Topics: Acetic Acid; Acetylation; Animals; Cell Line; Molecular Structure; Nerve Growth Factors; Neurites; PC12 Cells; Plant Components, Aerial; Pregnanes; Pyridines; Rats; Solanum lycopersicum; Tomatine | 2007 |
Hedgehog signaling pathway is inactive in colorectal cancer cell lines.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Patched Receptors; Patched-1 Receptor; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tomatine; Transcription Factors; Transcription, Genetic; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2007 |
Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diosgenin; Down-Regulation; Drug Screening Assays, Antitumor; Fatty Acid Synthases; Humans; JNK Mitogen-Activated Protein Kinases; Palmitic Acid; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Solanaceous Alkaloids; Tomatine; TOR Serine-Threonine Kinases; Up-Regulation | 2007 |
Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells.
Topics: Cell Line, Tumor; Genes, Reporter; Hedgehog Proteins; Humans; Luciferases; Male; Prostatic Neoplasms; Signal Transduction; Tomatine; Veratrum Alkaloids | 2008 |
Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Dinoprostone; Diosgenin; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Octamer Transcription Factor-2; Proto-Oncogene Proteins c-jun; Signal Transduction; Solanaceous Alkaloids; Tomatine | 2008 |
Streptomyces scabies 87-22 possesses a functional tomatinase.
Topics: Amino Acid Sequence; Bacterial Proteins; Gene Expression Regulation, Bacterial; Glycoside Hydrolases; Molecular Sequence Data; Molecular Structure; Streptomyces; Tomatine | 2008 |
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Hedgehog Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Mice; Neoplastic Stem Cells; Nerve Tissue Proteins; Proto-Oncogene Proteins c-abl; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor; Tomatine; Veratrum Alkaloids | 2009 |
Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
Topics: Anilides; Animals; Benzamides; Benzimidazoles; beta-Lactamases; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cyclohexylamines; Genes, Reporter; Humans; Kinetics; Mice; Molecular Structure; Morpholines; NIH 3T3 Cells; Piperazines; Purines; Pyrazoles; Pyridines; Radioligand Assay; Receptors, G-Protein-Coupled; Recombinant Proteins; Smoothened Receptor; Thiophenes; Tomatine; Transfection; Veratrum Alkaloids | 2009 |
Gli2 expression and human bladder transitional carcinoma cell invasiveness.
Topics: Blotting, Western; Carcinoma, Transitional Cell; Cell Line, Tumor; Dioxoles; Gene Expression Profiling; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Linear Models; Neoplasm Invasiveness; Nuclear Proteins; Piperazines; Pyridines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tomatine; Urinary Bladder Neoplasms; Veratrum Alkaloids; Zinc Finger Protein Gli2 | 2010 |
Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.
Topics: Cell Line; Cystic Fibrosis; Gentamicins; Humans; Hydroxyquinolines; Microbial Sensitivity Tests; Microscopy, Fluorescence; Molecular Structure; Staphylococcal Infections; Staphylococcus aureus; Tomatine | 2011 |
Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Culture Media; Drug Resistance, Multiple, Bacterial; Drug Synergism; Erythrocytes; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Hemolysin Proteins; Hemolysis; Horses; Microbial Sensitivity Tests; Microbial Viability; Real-Time Polymerase Chain Reaction; Staphylococcus aureus; Time Factors; Tomatine; Virulence; Virulence Factors | 2012 |
GLYCOALKALOID METABOLISM1 is required for steroidal alkaloid glycosylation and prevention of phytotoxicity in tomato.
Topics: Alkaloids; Base Sequence; Colletotrichum; Escherichia coli; Ethylenes; Fruit; Galactosyltransferases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Gene Silencing; Genes, Plant; Glycosylation; Membrane Proteins; Metabolome; Molecular Sequence Data; Phenotype; Phytosterols; Plant Leaves; Plant Proteins; Plant Roots; Plants, Genetically Modified; Recombinant Proteins; Solanum lycopersicum; Tomatine | 2011 |
Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT).
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Line; Cholesterol Esters; Cricetinae; Disease Models, Animal; Down-Regulation; Female; Foam Cells; Humans; Hyperlipidemias; Mice; Mice, Inbred C57BL; Mice, Knockout; Plant Extracts; Solanum lycopersicum; Sterol O-Acyltransferase; Tomatine | 2012 |
Structure-activity relationships of α-, β(1)-, γ-, and δ-tomatine and tomatidine against human breast (MDA-MB-231), gastric (KATO-III), and prostate (PC3) cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Male; Molecular Structure; Plant Extracts; Prostate; Prostatic Neoplasms; Solanum lycopersicum; Stomach Neoplasms; Tomatine | 2012 |
Tomatidine promotes the inhibition of 24-alkylated sterol biosynthesis and mitochondrial dysfunction in Leishmania amazonensis promastigotes.
Topics: Adenosine Triphosphate; Antiparasitic Agents; Cholesterol, LDL; Iodine Radioisotopes; Leishmania; Membrane Potential, Mitochondrial; Mitochondria; Sterols; Tomatine | 2012 |
Role of hedgehog signaling in malignant pleural mesothelioma.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Anilides; Animals; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Male; Mesothelioma; Mice; Middle Aged; NIH 3T3 Cells; Phosphoproteins; Pleural Effusion, Malignant; Pyridines; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction; Smoothened Receptor; Survivin; Tomatine; Transcription Factors; Transplantation, Heterologous; Veratrum Alkaloids; YAP-Signaling Proteins; Zinc Finger Protein GLI1 | 2012 |
Detoxification of α-tomatine by Cladosporium fulvum is required for full virulence on tomato.
Topics: Cladosporium; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Glycoside Hydrolases; Mutation; Phylogeny; Plant Leaves; Solanum lycopersicum; Tomatine; Virulence | 2013 |
Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Tomatine | 2013 |
Neuroprotective effect of steroidal alkaloids on glutamate-induced toxicity by preserving mitochondrial membrane potential and reducing oxidative stress.
Topics: Caco-2 Cells; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Glutamic Acid; Humans; Membrane Potential, Mitochondrial; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Plant Leaves; Tomatine | 2014 |
Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy.
Topics: Animals; Cell Line; Cell Line, Tumor; Cells, Cultured; Drug Discovery; Gene Expression; HL-60 Cells; Humans; Immunoblotting; Male; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Myoblasts, Skeletal; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tomatine; TOR Serine-Threonine Kinases | 2014 |
Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Staphylococcus aureus; Structure-Activity Relationship; Tomatine | 2014 |
In-silico identification and characterization of organic and inorganic chemical stress responding genes in yeast (Saccharomyces cerevisiae).
Topics: Computer Simulation; Gene Expression Regulation, Fungal; Gene Ontology; Genes, Fungal; Inorganic Chemicals; Lactic Acid; Lithium Chloride; Oligonucleotide Array Sequence Analysis; Organic Chemicals; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stress, Physiological; Tomatine; Transcriptome | 2014 |
High-performance liquid chromatography LTQ-Orbitrap mass spectrometry method for tomatidine and non-target metabolites quantification in organic and normal tomatoes.
Topics: Chromatography, High Pressure Liquid; Fruit; Limit of Detection; Mass Spectrometry; Solanum lycopersicum; Tomatine | 2014 |
Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine.
Topics: Cell Membrane; Cell Proliferation; Cholesterol; Growth Inhibitors; Methyltransferases; Microscopy, Electron, Transmission; Plant Diseases; Solanum lycopersicum; Sterols; Tomatine; Trypanosomatina | 2015 |
Elucidation of the mass fragmentation pathways of tomatidine and β1-hydroxytomatine using orbitrap mass spectrometry.
Topics: Mass Spectrometry; Molecular Structure; Tomatine | 2015 |
Inhibition of hedgehog signaling reduces the side population in human malignant mesothelioma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Molecular Targeted Therapy; Signal Transduction; Tomatine; Veratrum Alkaloids | 2015 |
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy.
Topics: Activating Transcription Factor 4; Aging; Animals; Gene Expression; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; RNA, Messenger; Sarcopenia; Tomatine; Triterpenes; Ursolic Acid | 2015 |
Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Coculture Techniques; Drug Synergism; Hydroxyquinolines; Metalloproteases; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mutation; Pseudomonas aeruginosa; Quorum Sensing; Tobramycin; Tomatine; Trans-Activators; Virulence Factors | 2015 |
Solanidine and tomatidine trigger scar pruritus.
Topics: Administration, Cutaneous; Adult; Aged; Burns; Cicatrix, Hypertrophic; Diosgenin; Female; Humans; Keloid; Male; Middle Aged; Prospective Studies; Pruritus; Single-Blind Method; Solanaceae; Solanaceous Alkaloids; Surgical Wound; Tomatine; Young Adult | 2016 |
Enzyme-driven metabolomic screening: a proof-of-principle method for discovery of plant defence compounds targeted by pathogens.
Topics: Enzymes; Fungal Proteins; Mass Spectrometry; Metabolomics; Phytochemicals; Solanum lycopersicum; Tomatine; Triticum | 2016 |
Increased water salinity applied to tomato plants accelerates the development of the leaf miner Tuta absoluta through bottom-up effects.
Topics: Agricultural Irrigation; Animals; Herbivory; Host-Parasite Interactions; Larva; Moths; Salinity; Sodium Chloride; Solanum lycopersicum; Tomatine; Water | 2016 |
Antiprotozoal Effects of the Tomato Tetrasaccharide Glycoalkaloid Tomatine and the Aglycone Tomatidine on Mucosal Trichomonads.
Topics: Animals; Antiprotozoal Agents; Plant Extracts; Solanum lycopersicum; Tomatine; Trichomonadida | 2016 |
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; DNA-Binding Proteins; Gene Expression Regulation; Longevity; Mitochondria; Mitophagy; Muscles; NF-E2-Related Factor 2; Organelle Biogenesis; Reactive Oxygen Species; Signal Transduction; Stress, Physiological; Tomatine; Transcription Factors; Transcriptome | 2017 |
Plasma Metabolomics Reveals Steroidal Alkaloids as Novel Biomarkers of Tomato Intake in Mice.
Topics: Alkaloids; Animals; Biomarkers; Body Weight; Carotenoids; Chromatography, High Pressure Liquid; Dietary Supplements; Lycopene; Male; Mass Spectrometry; Metabolomics; Mice, Inbred C57BL; Solanum lycopersicum; Tomatine | 2017 |
Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophils; Female; Lung; Mice; Mice, Inbred BALB C; Th2 Cells; Tomatine | 2017 |
Tomatidine and analog FC04-100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp.
Topics: Anti-Bacterial Agents; Bacillales; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Tomatine | 2018 |
Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mitochondrial Proton-Translocating ATPases; Mutation; Staphylococcus aureus; Tomatine | 2018 |
Exploring membrane permeability of Tomatidine to enhance lipid mediated nucleic acid transfections.
Topics: Alkaloids; beta-Galactosidase; Cations; Cell Membrane; Cell Membrane Permeability; Endocytosis; Endosomes; Fluorescence Resonance Energy Transfer; Gene Transfer Techniques; Green Fluorescent Proteins; HEK293 Cells; Humans; Lipids; Liposomes; MCF-7 Cells; Membrane Fusion; Nucleic Acids; Plasmids; Steroids; Tomatine; Transfection | 2019 |
Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss by modulating TRAF6-mediated signaling.
Topics: Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Estrogens; Female; Gene Expression Regulation; Humans; Mice, Inbred C57BL; NF-kappa B; Osteoclasts; Osteogenesis; Ovariectomy; Signal Transduction; TNF Receptor-Associated Factor 6; Tomatine | 2019 |
Tomatidine, a novel antiviral compound towards dengue virus.
Topics: Activating Transcription Factor 4; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue; Dengue Virus; Drug Discovery; Serogroup; Tomatine; Vero Cells; Virus Attachment; Virus Replication; Zika Virus | 2019 |
Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes.
Topics: AMP-Activated Protein Kinases; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Enzyme Activation; Forkhead Box Protein O1; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Palmitates; Receptors, Calcitriol; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Tomatine | 2019 |
Tomatidine inhibits cell invasion through the negative modulation of gelatinase and inactivation of p38 and ERK.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Nucleus; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Tetradecanoylphorbol Acetate; Tomatine; Transcription Factor AP-1; Vascular Endothelial Growth Factor A | 2019 |
Tomatidine Represses Invasion and Migration of Human Osteosarcoma U2OS and HOS Cells by Suppression of Presenilin 1 and c-Raf-MEK-ERK Pathway.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Osteosarcoma; Presenilin-1; Proto-Oncogene Proteins c-raf; Tomatine | 2020 |
Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro.
Topics: Alkaloids; Animals; Chikungunya Fever; Chikungunya virus; Chlorocebus aethiops; Humans; Steroids; Tomatine; Vero Cells; Virus Internalization; Virus Replication | 2020 |
Tomatidine Alleviates Osteoporosis by Downregulation of p53.
Topics: Computational Biology; Down-Regulation; Humans; Osteoporosis; Tomatine; Tumor Suppressor Protein p53 | 2020 |
Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats.
Topics: Animals; Cartilage; Cells, Cultured; Chondrocytes; Disease Models, Animal; Inflammation; Interleukin-1beta; Male; Matrix Metalloproteinases; Osteoarthritis; Rats; Rats, Sprague-Dawley; Signal Transduction; Tomatine | 2020 |
Green Tomato Extract Prevents Bone Loss in Ovariectomized Rats, a Model of Osteoporosis.
Topics: Animals; Bone Density; Bone Morphogenetic Protein 2; Bone Resorption; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Female; Humans; Osteogenesis; Osteoporosis, Postmenopausal; Osteoprotegerin; Ovariectomy; Phytotherapy; Plant Extracts; RANK Ligand; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins, Receptor-Regulated; Solanum lycopersicum; Tomatine; Weight Gain | 2020 |
Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease.
Topics: Antiviral Agents; Peptide Hydrolases; Plant Extracts; Porcine epidemic diarrhea virus; Tomatine; Viral Proteins; Virus Replication | 2020 |
Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice.
Topics: Animals; Anti-Inflammatory Agents; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Tomatine | 2021 |
Tomatidine provides mitophagy-independent neuroprotection after ischemic injury.
Topics: Animals; Brain Ischemia; Cell Line, Tumor; Cell Survival; Glucose; Humans; Mice; Mitochondria; Mitophagy; Neurons; Neuroprotective Agents; Oxygen; Tomatine | 2021 |
Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury.
Topics: A549 Cells; Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cell Adhesion; Chemokines; Cytokines; Glutathione; Humans; Inflammation; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neutrophils; NF-kappa B p50 Subunit; Oxidative Stress; Peroxidase; Pneumonia; Superoxide Dismutase; Tomatine | 2021 |
Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Coronavirus Papain-Like Proteases; COVID-19; COVID-19 Drug Treatment; Endoribonucleases; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; SARS-CoV-2; Sesquiterpenes; Tomatine; Viral Nonstructural Proteins | 2021 |
Concise Large-Scale Synthesis of Tomatidine, A Potent Antibiotic Natural Product.
Topics: Anti-Bacterial Agents; Biological Products; Molecular Structure; Tomatine | 2021 |
Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression.
Topics: Animals; Antiviral Agents; Cell Line; Chikungunya virus; Chlorocebus aethiops; Gene Expression; Humans; Proteomics; RNA, Viral; Tomatine; Vero Cells; Viral Proteins; Virus Internalization; Virus Release; Virus Replication | 2021 |
The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes.
Topics: Alkaloids; Animals; Humans; Interferons; Mice; Plant Extracts; Solanum lycopersicum; Stomach Neoplasms; Tomatine | 2022 |
Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction.
Topics: Cardiotoxicity; Cell Differentiation; Human Embryonic Stem Cells; Humans; Mitochondria; Myocytes, Cardiac; Tomatine | 2022 |
α-Tomatine degradation to tomatidine by food-related Aspergillus species belonging to the section Nigri.
Topics: Aspergillus; Tomatine | 2023 |