Compounds > tomatine
Page last updated: 2024-08-23

tomatine and cyclopamine

tomatine has been researched along with cyclopamine in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's5 (45.45)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beachy, PA; Cooper, MK; Porter, JA; Young, KE1
Kim, SK; Melton, DA1
Baylin, SB; Beachy, PA; Berman, DM; Burkholder, SG; Wang, B; Watkins, DN1
Boussif, N; Briquet, A; Chatel, G; Delacroix, L; Ganeff, C; Nolens, G; Winkler, R1
Brown, AJ; McCarthy, FR1
Abrahamsson, A; Beachy, PA; Blum, J; Chen, A; Chute, JP; Fereshteh, M; Jamieson, CH; Kim, J; Kwon, HY; Munchhof, M; Reya, T; Rizzieri, D; VanArsdale, T; Zhao, C1
Bee, WL; Copeland, RA; Davenport, EA; Gilmartin, A; Gontarek, R; Hornberger, KR; Kallal, LA; Lai, Z; Lawrie, K; Lu, Q; McMillan, L; Rominger, CM; Rominger, DH; Truong, M; Tummino, PJ; Turunen, B; Will, M; Zuercher, WJ1
Buttyan, R; Chen, M; Levin, RM; Mechlin, CW; Mian, BM; Tanner, MJ1
Felley-Bosco, E; Moura, U; Opitz, I; Rehrauer, H; Shi, Y; Soltermann, A; Stahel, RA; Thies, S; Weder, W1
Chen, MW; Cheng, KJ; Jiang, QW; Shi, Z; Wei, X; Yu, PZ1
Kim, HA; Kim, MC; Kim, NY; Kim, Y1

Reviews

1 review(s) available for tomatine and cyclopamine

ArticleYear
Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases.
    Medicinal research reviews, 2016, Volume: 36, Issue:1

    Topics: Alkaloids; Androgens; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Diosgenin; Estrogens; Humans; Mice; Neoplasms; Solanaceous Alkaloids; Steroids; Tomatine; Veratrum Alkaloids

2016

Other Studies

10 other study(ies) available for tomatine and cyclopamine

ArticleYear
Teratogen-mediated inhibition of target tissue response to Shh signaling.
    Science (New York, N.Y.), 1998, Jun-05, Volume: 280, Issue:5369

    Topics: Abnormalities, Drug-Induced; Animals; Cell Membrane; Central Nervous System; Chick Embryo; Cholesterol; Culture Techniques; DNA-Binding Proteins; Endoplasmic Reticulum; Hedgehog Proteins; Hepatocyte Nuclear Factor 3-beta; Holoprosencephaly; Homeodomain Proteins; LIM-Homeodomain Proteins; Membrane Proteins; Muscle Proteins; Nerve Tissue Proteins; Nuclear Proteins; Patched Receptors; PAX7 Transcription Factor; Proteins; Receptors, Cell Surface; Signal Transduction; Teratogens; Tomatine; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators; Transcription Factors; Triparanol; Veratrum Alkaloids

1998
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Oct-27, Volume: 95, Issue:22

    Topics: Animals; Chick Embryo; Choristoma; Embryonic Induction; Endoderm; Gene Expression Regulation, Developmental; Glucagon; Hedgehog Proteins; Insulin; Islets of Langerhans; Mesoderm; Pancreas; Proteins; Signal Transduction; Stomach Diseases; Teratogens; Tomatine; Trans-Activators; Veratrum Alkaloids

1998
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
    Nature, 2003, Mar-20, Volume: 422, Issue:6929

    Topics: Animals; Carcinoma, Small Cell; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Coculture Techniques; Disease Models, Animal; Epithelial Cells; Hedgehog Proteins; Humans; Lung; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Oncogene Proteins; Signal Transduction; Stem Cells; Tomatine; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Veratrum Alkaloids; Zinc Finger Protein GLI1

2003
Hedgehog signaling pathway is inactive in colorectal cancer cell lines.
    International journal of cancer, 2007, Dec-15, Volume: 121, Issue:12

    Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Patched Receptors; Patched-1 Receptor; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tomatine; Transcription Factors; Transcription, Genetic; Veratrum Alkaloids; Zinc Finger Protein GLI1

2007
Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells.
    Biochemical and biophysical research communications, 2008, Aug-15, Volume: 373, Issue:1

    Topics: Cell Line, Tumor; Genes, Reporter; Hedgehog Proteins; Humans; Luciferases; Male; Prostatic Neoplasms; Signal Transduction; Tomatine; Veratrum Alkaloids

2008
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.
    Nature, 2009, Apr-09, Volume: 458, Issue:7239

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Hedgehog Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Mice; Neoplastic Stem Cells; Nerve Tissue Proteins; Proto-Oncogene Proteins c-abl; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor; Tomatine; Veratrum Alkaloids

2009
Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3

    Topics: Anilides; Animals; Benzamides; Benzimidazoles; beta-Lactamases; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cyclohexylamines; Genes, Reporter; Humans; Kinetics; Mice; Molecular Structure; Morpholines; NIH 3T3 Cells; Piperazines; Purines; Pyrazoles; Pyridines; Radioligand Assay; Receptors, G-Protein-Coupled; Recombinant Proteins; Smoothened Receptor; Thiophenes; Tomatine; Transfection; Veratrum Alkaloids

2009
Gli2 expression and human bladder transitional carcinoma cell invasiveness.
    The Journal of urology, 2010, Volume: 184, Issue:1

    Topics: Blotting, Western; Carcinoma, Transitional Cell; Cell Line, Tumor; Dioxoles; Gene Expression Profiling; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Linear Models; Neoplasm Invasiveness; Nuclear Proteins; Piperazines; Pyridines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tomatine; Urinary Bladder Neoplasms; Veratrum Alkaloids; Zinc Finger Protein Gli2

2010
Role of hedgehog signaling in malignant pleural mesothelioma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Sep-01, Volume: 18, Issue:17

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Anilides; Animals; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Male; Mesothelioma; Mice; Middle Aged; NIH 3T3 Cells; Phosphoproteins; Pleural Effusion, Malignant; Pyridines; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction; Smoothened Receptor; Survivin; Tomatine; Transcription Factors; Transplantation, Heterologous; Veratrum Alkaloids; YAP-Signaling Proteins; Zinc Finger Protein GLI1

2012
Inhibition of hedgehog signaling reduces the side population in human malignant mesothelioma cell lines.
    Cancer gene therapy, 2015, Volume: 22, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Molecular Targeted Therapy; Signal Transduction; Tomatine; Veratrum Alkaloids

2015