Page last updated: 2024-09-05

tolvaptan and opc 21268

tolvaptan has been researched along with opc 21268 in 2 studies

Compound Research Comparison

Studies (tolvaptan)	Trials (tolvaptan)	Recent Studies (post-2010) (tolvaptan)	Studies (opc 21268)	Trials (opc 21268)	Recent Studies (post-2010) (opc 21268)
967	172	786	133	3	6

Protein Interaction Comparison

Protein	Taxonomy	tolvaptan (IC50)	opc 21268 (IC50)
Vasopressin V1a receptor	Rattus norvegicus (Norway rat)		0.44

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hirano, T; Itai, A; Kan, K; Kondo, K; Kurimura, M; Mori, T; Nakamura, S; Ogawa, H; Shinohara, T; Tanada, Y; Tominaga, M; Yamamura, Y; Yamashita, H	1
Akahoshi, Y; Fujiki, H; Ikeda, T; Iwanaga, Y; Miyazaki, S; Morooka, H; Watanabe, H	1

Other Studies

2 other study(ies) available for tolvaptan and opc 21268

Article	Year
Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template. Journal of medicinal chemistry, 2000, Nov-16, Volume: 43, Issue:23 Topics: Administration, Oral; Animals; Arginine Vasopressin; Benzazepines; Cyclic AMP; Diuresis; Drug Design; Female; HeLa Cells; Humans; Models, Molecular; Molecular Conformation; Radioligand Assay; Rats; Receptors, Vasopressin; Structure-Activity Relationship	2000
Effects of Long-term Blockade of Vasopressin Receptor Types 1a and 2 on Cardiac and Renal Damage in a Rat Model of Hypertensive Heart Failure. Journal of cardiovascular pharmacology, 2015, Volume: 66, Issue:5 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hemodynamics; Hypertension; Hypertrophy, Left Ventricular; Kidney; Kidney Diseases; Male; Piperidines; Quinolones; Rats, Inbred Dahl; Receptors, Vasopressin; Time Factors; Tolvaptan; Ventricular Function, Left; Ventricular Remodeling	2015

Article

Year

Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template.

Journal of medicinal chemistry, 2000, Nov-16, Volume: 43, Issue:23

Topics: Administration, Oral; Animals; Arginine Vasopressin; Benzazepines; Cyclic AMP; Diuresis; Drug Design; Female; HeLa Cells; Humans; Models, Molecular; Molecular Conformation; Radioligand Assay; Rats; Receptors, Vasopressin; Structure-Activity Relationship

2000

Effects of Long-term Blockade of Vasopressin Receptor Types 1a and 2 on Cardiac and Renal Damage in a Rat Model of Hypertensive Heart Failure.

Journal of cardiovascular pharmacology, 2015, Volume: 66, Issue:5

Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hemodynamics; Hypertension; Hypertrophy, Left Ventricular; Kidney; Kidney Diseases; Male; Piperidines; Quinolones; Rats, Inbred Dahl; Receptors, Vasopressin; Time Factors; Tolvaptan; Ventricular Function, Left; Ventricular Remodeling

2015