Page last updated: 2024-09-05

tolvaptan and bumetanide

tolvaptan has been researched along with bumetanide in 3 studies

Compound Research Comparison

Studies (tolvaptan)	Trials (tolvaptan)	Recent Studies (post-2010) (tolvaptan)	Studies (bumetanide)	Trials (bumetanide)	Recent Studies (post-2010) (bumetanide)
967	172	786	2,033	150	354

Protein Interaction Comparison

Protein	Taxonomy	tolvaptan (IC50)	bumetanide (IC50)
Solute carrier family 12 member 2	Homo sapiens (human)		0.8

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Fuentes, J; Mancera, JM; MartínezRodríguez, G; Martos-Sitcha, JA	1

Reviews

1 review(s) available for tolvaptan and bumetanide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

2 other study(ies) available for tolvaptan and bumetanide

Article	Year
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
AVT and IT regulate ion transport across the opercular epithelium of killifish (Fundulus heteroclitus) and gilthead sea bream (Sparus aurata). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2015, Volume: 182 Topics: Animals; Benzazepines; Bumetanide; Chlorides; Dose-Response Relationship, Drug; Epithelium; Fish Proteins; Fundulidae; Indoles; Ion Transport; Oxytocin; Pyrrolidines; Receptors, Vasopressin; Sea Bream; Tolvaptan; Vasotocin	2015

Article

Year

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013

AVT and IT regulate ion transport across the opercular epithelium of killifish (Fundulus heteroclitus) and gilthead sea bream (Sparus aurata).

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2015, Volume: 182

Topics: Animals; Benzazepines; Bumetanide; Chlorides; Dose-Response Relationship, Drug; Epithelium; Fish Proteins; Fundulidae; Indoles; Ion Transport; Oxytocin; Pyrrolidines; Receptors, Vasopressin; Sea Bream; Tolvaptan; Vasotocin

2015