toluene has been researched along with mk-8141 in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davies, IW; Gauvreau, D; Hughes, GJ; Lau, SY; McKay, DJ; O'Shea, PD; Sidler, RR; Yu, B | 1 |
| Binkert, C; Dingemanse, J; Gutierrez, MM; Nicolas, LB | 1 |
| Binkert, C; Dingemanse, J; Gutierrez, M; Nicolas, LB | 1 |
| Cavallaro, M; Dingemanse, J; Eydeler, U | 1 |
3 trial(s) available for toluene and mk-8141
| Article | Year |
|---|---|
Entry-into-humans study with a new direct renin inhibitor.
Topics: Administration, Oral; Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area Under Curve; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Enalapril; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Renin; Switzerland; Toluene; Young Adult | 2012 |
Pharmacokinetics, pharmacodynamics, and tolerability of ACT-077825, a new direct renin inhibitor after multiple-ascending doses in healthy subjects.
Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area Under Curve; Biomarkers; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Enalapril; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Renin; Renin-Angiotensin System; Switzerland; Toluene; Young Adult | 2013 |
Single-dose pharmacokinetics of the renin inhibitor ACT-077825 in elderly and young subjects of both sexes.
Topics: Adult; Age Factors; Aged; Antihypertensive Agents; Female; Humans; Male; Renin; Sex Factors; Toluene | 2014 |
1 other study(ies) available for toluene and mk-8141
| Article | Year |
|---|---|
Practical synthesis of a renin inhibitor via a diastereoselective Dieckmann cyclization.
Topics: Azo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Cyclization; Molecular Conformation; Molecular Structure; Protease Inhibitors; Renin; Stereoisomerism; Toluene | 2010 |