Page last updated: 2024-08-21

toluene 2,4-diisocyanate and 2,4-diaminotoluene

toluene 2,4-diisocyanate has been researched along with 2,4-diaminotoluene in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.50)18.7374
1990's13 (54.17)18.2507
2000's5 (20.83)29.6817
2010's3 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, AW; Lebherz, WB; Pienta, RJ; Shah, MJ1
Brorson, T; Sangö, C; Skarping, G2
Boorman, GA; Dieter, MP; Huff, JE; Jameson, CW; Matthews, HB1
Candura, F; Moscato, G1
Asakura, S; Okazaki, S1
Bartels, MJ; Smith, FA; Timchalk, C2
Benoit, FM1
Berode, M; Maître, A; Perdrix, A; Romazini, S; Savolainen, H1
Dalene, M; Hagmar, L; Lind, P; Skarping, G1
Dalene, M; Lind, P; Skarping, G; Tinnerberg, H1
Bradley, D1
Fischer, A; Frossard, N; Lugnier, A; Pons, F1
Hirvonen, A; Kääriä, K; Norppa, H; Piirilä, P; Rosenberg, C; Vainio, H1
Kim, Y; Morita, Y; Sakai, T; Tao, YX1
Kim, H; Kim, Y; Morita, Y; Roh, J; Sakai, T1
Chen, HT; Chiung, YM; Kao, YY; Liu, PS1
De Vooght, V; Hoet, PH; Nemery, B; Synhaeve, N; Vanoirbeek, JA1
Axmon, A; Broberg, KE; Jönsson, BA; Littorin, M; Rannug, A; Sennbro, CJ; Tinnerberg, H; Warholm, M1
Schupp, T1
Goodman, JE; Prueitt, RL; Rhomberg, LR1

Reviews

1 review(s) available for toluene 2,4-diisocyanate and 2,4-diaminotoluene

ArticleYear
Hypothesis-based weight-of-evidence evaluation of the human carcinogenicity of toluene diisocyanate.
    Critical reviews in toxicology, 2013, Volume: 43, Issue:5

    Topics: Administration, Oral; Animals; Carcinogens; Humans; Inhalation Exposure; Mice; Neoplasms; Occupational Exposure; Phenylenediamines; Rats; Species Specificity; Toluene 2,4-Diisocyanate

2013

Other Studies

23 other study(ies) available for toluene 2,4-diisocyanate and 2,4-diaminotoluene

ArticleYear
Correlation of bacterial mutagenicity and hamster cell transformation with tumorigenicity induced by 2,4-toluenediamine.
    Cancer letters, 1977, Volume: 3, Issue:1-2

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Phenylenediamines; Rats; Salmonella typhimurium; Toluene 2,4-Diisocyanate

1977
Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate.
    International archives of occupational and environmental health, 1991, Volume: 63, Issue:2

    Topics: Adult; Air Pollutants, Occupational; Chromatography, High Pressure Liquid; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Male; Maximum Allowable Concentration; Metabolic Clearance Rate; Middle Aged; Occupational Exposure; Phenylenediamines; Risk Factors; Toluene 2,4-Diisocyanate

1991
Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate.
    International archives of occupational and environmental health, 1991, Volume: 63, Issue:4

    Topics: Adult; Air Pollutants; Environmental Monitoring; Humans; Male; Phenylenediamines; Toluene 2,4-Diisocyanate

1991
NIOSH Current Intelligence Bulletin 53: toluene diisocyanate (TDI) and toluenediamine (TDA); evidence of carcinogenicity.
    MMWR. Morbidity and mortality weekly report, 1991, Mar-22, Volume: 40, Issue:11

    Topics: Animals; Hazardous Substances; Humans; National Institute for Occupational Safety and Health, U.S.; Neoplasms; Neoplasms, Experimental; Occupational Exposure; Phenylenediamines; Toluene 2,4-Diisocyanate; United States

1991
The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 2,4- and 2,6-TDI isomers.
    Toxicology and industrial health, 1990, Volume: 6, Issue:6

    Topics: Animals; Body Weight; Carcinogens; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phenylenediamines; Rats; Rats, Inbred Strains; Survival Analysis; Toluene 2,4-Diisocyanate

1990
Toluene diisocyanate.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1986, Volume: 39

    Topics: Air Pollution; Animals; Chemical Phenomena; Chemistry; Cyanates; Environmental Exposure; Humans; Lethal Dose 50; Mice; Mutagenicity Tests; Phenylenediamines; Polyurethanes; Rats; Rats, Inbred F344; Rubber; Toluene 2,4-Diisocyanate

1986
Do amines induce occupational asthma in workers manufacturing polyurethane foams?
    British journal of industrial medicine, 1984, Volume: 41, Issue:4

    Topics: Amines; Asthma; Chemical Industry; Humans; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Phenylenediamines; Polyurethanes; Toluene 2,4-Diisocyanate

1984
Biodegradation of toluene diamine (TDA) in activated sludge acclimated with aniline and TDA.
    Chemosphere, 1995, Volume: 30, Issue:11

    Topics: Aniline Compounds; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Hydrolysis; Industrial Waste; Kinetics; Oxygen Consumption; Phenylenediamines; Toluene 2,4-Diisocyanate; Waste Disposal, Fluid

1995
Route-dependent comparative metabolism of [14C]toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats.
    Toxicology and applied pharmacology, 1994, Volume: 124, Issue:2

    Topics: Administration, Inhalation; Administration, Oral; Animals; Body Weight; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Injections, Intravenous; Male; Phenylenediamines; Rats; Rats, Inbred F344; Tissue Distribution; Toluene 2,4-Diisocyanate

1994
Degradation of polyurethane foams used in the Même breast implant.
    Journal of biomedical materials research, 1993, Volume: 27, Issue:10

    Topics: Biocompatible Materials; Drug Contamination; Female; Humans; Mammaplasty; Phenylenediamines; Polyurethanes; Prostheses and Implants; Toluene 2,4-Diisocyanate

1993
Biological monitoring of occupational exposure to toluene diisocyanate.
    International archives of occupational and environmental health, 1993, Volume: 65, Issue:2

    Topics: Air Pollutants, Occupational; Environmental Monitoring; Humans; Maximum Allowable Concentration; Occupational Exposure; Phenylenediamines; Skin Absorption; Toluene 2,4-Diisocyanate

1993
Gas chromatographic/tandem mass spectrometric identification and quantitation of metabolic 4-acetyltoluene-2,4-diamine from the F344 rat.
    Biological mass spectrometry, 1993, Volume: 22, Issue:3

    Topics: Animals; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Isomerism; Male; Phenylenediamines; Rats; Rats, Inbred F344; Toluene 2,4-Diisocyanate; Toluidines

1993
Toxicokinetics of 2,4- and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4- and 2,6- toluene diisocyanate.
    Occupational and environmental medicine, 1996, Volume: 53, Issue:2

    Topics: Air Pollution; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydrolysis; Isomerism; Occupational Exposure; Phenylenediamines; Toluene 2,4-Diisocyanate

1996
Biomarkers in hydrolysed urine, plasma and erythrocytes among workers exposed to thermal degradation products from toluene diisocyanate foam.
    The Analyst, 1997, Volume: 122, Issue:1

    Topics: Biomarkers; Carcinogens; Chemical Industry; Erythrocytes; Gas Chromatography-Mass Spectrometry; Half-Life; Hot Temperature; Humans; Mutagens; Occupational Exposure; Phenylenediamines; Polyurethanes; Toluene 2,4-Diisocyanate

1997
Linking isocyanates and asthma.
    Analytical chemistry, 1997, Jun-01, Volume: 69, Issue:11

    Topics: Asthma; Blood Proteins; Carcinogens; Gas Chromatography-Mass Spectrometry; Humans; Occupational Exposure; Phenylenediamines; Polymers; Stereoisomerism; Sweden; Toluene 2,4-Diisocyanate

1997
Effect of toluene diisocyanate and its corresponding amines on viability and growth of human lung fibroblasts in culture.
    Cell biology and toxicology, 1999, Volume: 15, Issue:5

    Topics: Asthma; Carcinogens; Cell Division; Cell Survival; Cells, Cultured; Coloring Agents; Cytotoxins; Fibroblasts; Humans; Hydrogen Peroxide; Lung; Occupational Diseases; Oxidants; Phenylenediamines; Tetrazolium Salts; Thiazoles; Toluene 2,4-Diisocyanate

1999
Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA).
    The Analyst, 2001, Volume: 126, Issue:7

    Topics: Adult; Air Pollutants, Occupational; Chemical Industry; Chromatography, High Pressure Liquid; Environmental Monitoring; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Occupational Exposure; Phenylenediamines; Toluene 2,4-Diisocyanate

2001
LC-MS determination of urinary toluenediamine in workers exposed to toluenediisocyanate.
    Toxicology letters, 2002, Aug-05, Volume: 134, Issue:1-3

    Topics: Chromatography, Liquid; Environmental Monitoring; Humans; Inhalation Exposure; Mass Spectrometry; Occupational Exposure; Phenylenediamines; Toluene 2,4-Diisocyanate

2002
Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate.
    International archives of occupational and environmental health, 2005, Volume: 78, Issue:6

    Topics: Air Pollutants, Occupational; Biomarkers; Creatinine; Gas Chromatography-Mass Spectrometry; Humans; Male; Occupational Exposure; Phenylenediamines; Specific Gravity; Toluene 2,4-Diisocyanate

2005
2,4-Toluene diisocyanate suppressed the calcium signaling of ligand gated ion channel receptors.
    Toxicology, 2006, Feb-15, Volume: 219, Issue:1-3

    Topics: Animals; Calcium; Calcium Signaling; Catecholamines; Cattle; Cell Line, Tumor; Chromaffin Cells; Chromatography, High Pressure Liquid; HeLa Cells; Humans; Ion Channel Gating; Ion Channels; Ligands; PC12 Cells; Phenylenediamines; Rats; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Purinergic P2; Toluene 2,4-Diisocyanate

2006
Is toluene diamine a sensitizer and is there cross-reactivity between toluene diamine and toluene diisocyanate?
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:2

    Topics: Animals; Antigens, CD; Asthma; Cells, Cultured; Cross Reactions; Cytokines; Disease Models, Animal; Immunoglobulins; Local Lymph Node Assay; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phenylenediamines; Statistics, Nonparametric; Toluene 2,4-Diisocyanate

2009
The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:2

    Topics: Adult; Amino Acid Substitution; Biomarkers; Female; Genotype; Glutathione S-Transferase pi; Humans; Isoleucine; Male; Middle Aged; Phenylenediamines; Polymorphism, Single Nucleotide; Toluene 2,4-Diisocyanate; Valine; Young Adult

2010
Modeling formation and distribution of toluene-2,4-diamine (TDA) after spillage of toluene-2,4-diisocyanate (TDI) into a river.
    Journal of hazardous materials, 2013, May-15, Volume: 252-253

    Topics: Hydrolysis; Models, Theoretical; Phenylenediamines; Rivers; Toluene 2,4-Diisocyanate; Water; Water Pollutants, Chemical

2013