tolterodine-tartrate and carbene

tolterodine-tartrate has been researched along with carbene* in 1 studies

Other Studies

1 other study(ies) available for tolterodine-tartrate and carbene

Article	Year
Chiral Diarylmethanes via Copper-Catalyzed Asymmetric Allylic Arylation with Organolithium Compounds. Organic letters, 2016, Jan-15, Volume: 18, Issue:2 A highly enantioselective copper/N-heterocyclic carbene catalyzed allylic arylation with organolithium compounds is presented. The use of commercial or readily prepared aryllithium reagents in the reaction with allyl bromides affords a variety of chiral diarylvinylmethanes, comprising a privileged structural motif in pharmaceuticals, in high yields with good to excellent regio- and enantioselectivities. The versatility of this new transformation is illustrated in the formal synthesis of the marketed drug tolterodine (Detrol). Topics: Allyl Compounds; Catalysis; Copper; Indicators and Reagents; Lithium; Methane; Molecular Structure; Organometallic Compounds; Stereoisomerism; Tolterodine Tartrate	2016

Article

Year

Chiral Diarylmethanes via Copper-Catalyzed Asymmetric Allylic Arylation with Organolithium Compounds.

Organic letters, 2016, Jan-15, Volume: 18, Issue:2

A highly enantioselective copper/N-heterocyclic carbene catalyzed allylic arylation with organolithium compounds is presented. The use of commercial or readily prepared aryllithium reagents in the reaction with allyl bromides affords a variety of chiral diarylvinylmethanes, comprising a privileged structural motif in pharmaceuticals, in high yields with good to excellent regio- and enantioselectivities. The versatility of this new transformation is illustrated in the formal synthesis of the marketed drug tolterodine (Detrol).

Topics: Allyl Compounds; Catalysis; Copper; Indicators and Reagents; Lithium; Methane; Molecular Structure; Organometallic Compounds; Stereoisomerism; Tolterodine Tartrate

2016