tolrestat has been researched along with sorbitol in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (32.14) | 18.7374 |
| 1990's | 11 (39.29) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 4 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Flam, BR; Sawicki, DR; Sredy, J | 1 |
| Burg, MB; Garcia-Perez, A; Moriyama, T; Olson, AD | 1 |
| Allison, W; Chang, K; Eades, D; Kilo, C; Ostrow, E; Sherman, WR; Williamson, JR | 1 |
| Capogreco, C; Fisher, E; Heffernan, S; McLennan, S; Ross, GR; Turtle, JR; Yue, DK | 1 |
| Chang, K; Eades, DM; Kilo, C; Province, MA; Pugliese, G; Sherman, WR; Tilton, RG; Williamson, JR | 1 |
| Odom, JD; Williams, WF | 1 |
| Dvornik, D; Kemper, C | 1 |
| Bellomo, G; Comstock, JP; Hazelwood, RL; Wen, D | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
| Dubuc, J; Dvornik, D; Greselin, E; Simard-Duquesne, N | 1 |
| Challis, P; Dvornik, D; Gonzalez, R; Hicks, D; Mullane, JF; Raskin, P; Rosenstock, J; Ryder, S; Smith, T | 1 |
| Abraham, N; Bellini, F; Dvornik, D; Fung, S; Humber, L; Sestanj, K; Simard-Duquesne, N; Treasurywala, A | 1 |
| Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG | 1 |
| Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T | 1 |
| Chatzilias, AA; Whiteside, CI | 1 |
| Chibber, R; Kohner, EM; Mirlees, D; Molinatti, PA; Wong, JS | 1 |
| Chiang, ST; Cohen, AF; Jusko, WJ; Kroon, R; Lemkes, HH; van Griensven, JM; Verhorst, CJ | 1 |
| Flores, LE; Gagliardino, JJ; Malaisse, WJ; Sener, A | 1 |
| Babazono, T; Dlugosz, JA; Hohman, T; Kapor-Drezgic, J; Whiteside, C; Zhou, X | 1 |
| Coppey, L; Hofmeyer, TG; Oskarsson, HJ; Yorek, MA | 1 |
| Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF | 1 |
| Bhatnagar, A; Chandra, D; Jackson, EB; Kelley, R; Ramana, KV; Srivastava, SK | 1 |
| Jusko, WJ; Krzyzanski, W; Yao, Z | 1 |
| Bhatnagar, A; Kaiserova, K; Srivastava, S; Tang, XL | 1 |
| Blessing, K; Kador, PF; Marx, DB; O'Meara, JD; Reinhardt, RA | 1 |
| Kador, PF; Zhang, P; Zhang, Z | 1 |
2 review(s) available for tolrestat and sorbitol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
1 trial(s) available for tolrestat and sorbitol
| Article | Year |
|---|---|
Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Erythrocytes; Half-Life; Humans; Male; Matched-Pair Analysis; Naphthalenes; Sorbitol | 1995 |
25 other study(ies) available for tolrestat and sorbitol
| Article | Year |
|---|---|
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sucrose | 1991 |
Intracellular betaine substitutes for sorbitol in protecting renal medullary cells from hypertonicity.
Topics: Aldehyde Reductase; Animals; Betaine; Cell Division; Cell Line; Cell Survival; Clone Cells; Glycerylphosphorylcholine; Inositol; Kidney Medulla; Naphthalenes; Rabbits; Saline Solution, Hypertonic; Sorbitol | 1991 |
Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Capillary Permeability; Diabetic Angiopathies; Glucose; Glycosylation; Male; Microcirculation; Naphthalenes; Rats; Rats, Inbred Strains; Serum Albumin; Sorbitol; Stereoisomerism; Sugar Alcohol Dehydrogenases | 1990 |
Ascorbic acid metabolism and polyol pathway in diabetes.
Topics: Aldehyde Reductase; Animals; Ascorbic Acid; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Female; Galactose; Inositol; Kidney Cortex; Kidney Medulla; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Sorbitol | 1989 |
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.
Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes; Glomerular Filtration Rate; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Iodine Radioisotopes; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Strontium; Sugar Alcohol Dehydrogenases; Vascular Resistance | 1989 |
Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy.
Topics: Acetaminophen; Aldehyde Reductase; Animals; Ibuprofen; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Naphthalenes; Organ Culture Techniques; Rabbits; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Prevention of neural myoinositol depletion in diabetic rats by aldose reductase inhibition with tolrestat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Prolonged fructose feeding and aldose reductase inhibition: effect on the polyol pathway in kidneys of normal rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Dietary Carbohydrates; Fructose; Glucose; Inositol; Kidney; L-Iditol 2-Dehydrogenase; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Erythrocytes; Galactosemias; Humans; In Vitro Techniques; Lens, Crystalline; Naphthalenes; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Effect of tolrestat on red blood cell sorbitol levels in patients with diabetes.
Topics: Administration, Oral; Adult; Biological Availability; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus; Drug Evaluation; Female; Humans; Kinetics; Male; Middle Aged; Naphthalenes; Random Allocation; Sorbitol | 1985 |
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Galactitol; Isoquinolines; Lens, Crystalline; Naphthalenes; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; Body Weight; Capillary Permeability; Citrulline; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Imidazoles; Imidazolidines; Inositol; Iodine Radioisotopes; Male; Methylguanidine; Naphthalenes; Nitric Oxide Synthase; omega-N-Methylarginine; Phthalazines; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Serum Albumin, Bovine; Sorbitol; Thiazoles; Uvea | 1993 |
Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats.
Topics: Aldehyde Reductase; Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Female; Formaldehyde; Galactose; Hyperalgesia; Hyperglycemia; Naphthalenes; Neural Pathways; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sorbitol | 1994 |
Cellular mechanisms of glucose-induced myo-inositol transport upregulation in rat mesangial cells.
Topics: Aldehyde Reductase; Animals; Biological Transport; Galactose; Glomerular Mesangium; Glucose; In Vitro Techniques; Inositol; Intracellular Membranes; Kinetics; Male; Naphthalenes; Rats; Rats, Sprague-Dawley; Sorbitol; Time Factors; Up-Regulation | 1994 |
The effect of aminoguanidine and tolrestat on glucose toxicity in bovine retinal capillary pericytes.
Topics: Aldehyde Reductase; Animals; Capillaries; Cattle; Cell Division; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Glucose; Glycation End Products, Advanced; Guanidines; Kinetics; Muscle, Smooth, Vascular; Naphthalenes; Retinal Vessels; Sorbitol; Time Factors | 1994 |
Effects of two aldose reductase inhibitors upon sorbitol output, D-glucose metabolism and insulin release in islets from normal and hereditarily diabetic rats.
Topics: Aldehyde Reductase; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Naphthalenes; Rats; Rats, Wistar; Sorbitol | 1998 |
Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glomerular Mesangium; Glucose; Isoenzymes; Male; Microscopy, Confocal; Naphthalenes; Polymers; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Sorbitol | 1999 |
Effect of protein kinase C and phospholipase A2 inhibitors on the impaired ability of human diabetic platelets to cause vasodilation.
Topics: Adolescent; Adult; Aged; Animals; Blood Platelets; Diabetes Mellitus; Diglycerides; Female; Glucose; Humans; Male; Middle Aged; Naphthalenes; Phospholipases A; Phospholipases A2; Protein Kinase C; Rabbits; Sorbitol; Terpenes; Vasodilation | 1999 |
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence | 2000 |
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Glucose; Imidazoles; Imidazolidines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Sorbitol | 2002 |
Assessment of basic indirect pharmacodynamic response models with physiological limits.
Topics: 5-alpha Reductase Inhibitors; Adult; Aldehyde Reductase; Algorithms; Enzyme Inhibitors; Erythrocytes; Homeostasis; Humans; Indolizines; Injections, Intravenous; Male; Middle Aged; Models, Biological; Naphthalenes; Pharmaceutical Preparations; Sorbitol | 2006 |
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.
Topics: Aldehyde Reductase; Animals; Bradykinin; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Glucose; Hesperidin; Hypoglycemic Agents; Imidazolidines; Insulin; Lipid Peroxidation; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sorbitol; Vasodilator Agents | 2008 |
Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
Topics: Aldehyde Reductase; Alveolar Bone Loss; Animals; Antioxidants; Citric Acid Cycle; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes; Glycolysis; Hydantoins; Lipopolysaccharides; Male; Naphthalenes; Periodontitis; Quercetin; Rats; Rats, Sprague-Dawley; Sorbitol | 2011 |
Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells.
Topics: Aldehyde Reductase; Animals; Capillaries; Cell Line; Endothelial Cells; Fluorenes; Galactitol; Galactose; Glucose; Hydantoins; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Naphthalenes; Pericytes; Rats; Rats, Transgenic; Retinal Vessels; Sorbitol | 2014 |