tolrestat and nadp
tolrestat has been researched along with nadp in 13 studies
Research
Studies (13)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Matsuura, Y; Nishimura, C; Tanimoto, T; Yamaoka, T; Yamashita, K | 1 |
| Deck, LM; Hunsaker, LA; Robinson, B; Stangebye, LA; Vander Jagt, DL | 1 |
| Balsano, F; Bravi, C; De Mattia, G; Ghiselli, A; Iuliano, L; Laurenti, O | 1 |
| Bhatnagar, A; Chakrabarti, B; Liu, SQ; Srivastava, SK; Ueno, N | 1 |
| Barth, P; Biellmann, JF; Potier, N; Tritsch, D; Van Dorsselaer, A | 1 |
| Burgan, J; Faller, A; Obrosova, I; Ostrow, E; Williamson, JR | 1 |
| Barbanton, J; Barth, P; Biellmann, JF; Mitschler, A; Moras, D; Podjarny, A; Tête-Favier, F; Urzhumtsev, A; Urzhumtseva, L | 1 |
| Basili, S; Bravi, MC; Cassone-Faldetta, M; De Mattia, G; Ferri, C; Laurenti, O; Pietrangeli, P | 1 |
| Carper, DA; El-Kabbani, O; Hohman, TC; Lai, K; Malamas, MS; McGowan, MH; Putilina, T; Wane, YQ | 1 |
| Chen, Z; Kador, PF; Lee, YS; Sugiyama, K | 1 |
| Bruno, G; Costantino, L; Curinga, C; Maccari, R; Monforte, F; Nicoló, F; Ottanà, R; Vigorita, MG | 1 |
| Hodoscek, M; Kador, PF; Lee, YS; Sugiyama, K | 1 |
| Cousido-Siah, A; Farrés, J; Mitschler, A; Parés, X; Podjarny, A; Ruiz, FX | 1 |
Trials
1 trial(s) available for tolrestat and nadp
| Article | Year |
|---|---|
Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients.
Topics: Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 2; Double-Blind Method; Enzyme Inhibitors; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Humans; Male; Middle Aged; NADP; Naphthalenes; Oxidation-Reduction; Reference Values | 1997 |
Other Studies
12 other study(ies) available for tolrestat and nadp
| Article | Year |
|---|---|
Site-directed mutagenesis of His-42, His-188 and Lys-263 of human aldose reductase.
Topics: Aldehyde Reductase; Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Fluorenes; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Naphthalenes; Structure-Activity Relationship | 1992 |
Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms.
Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Chromatography, High Pressure Liquid; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Female; Glyceraldehyde; Humans; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Immunoenzyme Techniques; Kinetics; NADP; Naphthalenes; Phthalazines; Placenta; Pregnancy; Substrate Specificity; Sugar Alcohol Dehydrogenases | 1990 |
Effect of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients.
Topics: Aged; Aldehyde Reductase; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Erythrocytes; Female; Glutathione; Humans; Male; Middle Aged; NADP; Naphthalenes; Oxidation-Reduction | 1994 |
Human placental aldose reductase: role of Cys-298 in substrate and inhibitor binding.
Topics: Aldehyde Reductase; Aldehydes; Circular Dichroism; Cysteine; Deuterium; Female; Humans; Imidazoles; Imidazolidines; Iodoacetates; Iodoacetic Acid; Kinetics; NADP; Naphthalenes; Placenta; Pregnancy; Quercetin; Spectrophotometry, Ultraviolet | 1994 |
Study of non-covalent enzyme-inhibitor complexes of aldose reductase by electrospray mass spectrometry.
Topics: Acetates; Aldehyde Reductase; Animals; Apoenzymes; Enzyme Inhibitors; Furans; Imidazoles; Imidazolidines; Lens, Crystalline; Mass Spectrometry; NADP; Naphthalenes; Rhodanine; Swine; Thiazoles; Thiazolidines | 1997 |
Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Energy Metabolism; Enzyme Inhibitors; Galactitol; Galactose; Galactosemias; Gas Chromatography-Mass Spectrometry; Glycolysis; Inositol; Lens, Crystalline; Male; NADP; Naphthalenes; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1997 |
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Topics: Aldehyde Reductase; Animals; Binding Sites; Computer Simulation; Crystallography; Enzyme Inhibitors; Imidazoles; Imidazolidines; Lens, Crystalline; Models, Molecular; Molecular Conformation; Molecular Sequence Data; NADP; Naphthalenes; Swine | 1997 |
Probing the inhibitor-binding site of aldose reductase with site-directed mutagenesis.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Computer Simulation; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Kinetics; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; NADP; Naphthalenes; Phthalazines; Recombinant Proteins; Thiazoles | 1998 |
Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex.
Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Fluorenes; Humans; Hydantoins; Lens, Crystalline; Models, Molecular; Muscles; NADP; Naphthalenes; Phthalazines; Rats | 2000 |
Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.
Topics: Aldehyde Reductase; Animals; Cattle; Enzyme Inhibitors; Hypoglycemic Agents; Imidazoles; Imidazolidines; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; NADP; Naphthalenes; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2002 |
Hydrogen bonding interactions between aldose reductase complexed with NADP(H) and inhibitor tolrestat studied by molecular dynamics simulations and binding assay.
Topics: Aldehyde Reductase; Enzyme Inhibitors; Hydrogen Bonding; Models, Molecular; NADP; Naphthalenes; Protein Binding | 2003 |
X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Imidazolidines; Inhibitory Concentration 50; NADP; Naphthalenes | 2013 |