tolmetin glucuronide has been researched along with tolmetin in 8 studies
| Studies (tolmetin glucuronide) | Trials (tolmetin glucuronide) | Recent Studies (post-2010) (tolmetin glucuronide) | Studies (tolmetin) | Trials (tolmetin) | Recent Studies (post-2010) (tolmetin) |
|---|---|---|---|---|---|
| 8 | 0 | 1 | 1,317 | 433 | 32 |
| Protein | Taxonomy | tolmetin glucuronide (IC50) | tolmetin (IC50) |
|---|---|---|---|
| Interleukin-8 | Homo sapiens (human) | 0.09 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.041 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benet, LZ; McDonagh, AF; Munafo, A; Smith, PC | 1 |
| Benet, LZ; Hyneck, ML; McDonagh, AF; Munafo, A; Smith, PC | 1 |
| Benet, LZ; Burlingame, AL; Ding, A; McDonagh, AF; Zia-Amirhosseini, P | 1 |
| Benet, LZ; Burlingame, AL; Ding, A; McDonagh, AF; Ojingwa, JC | 1 |
| Benet, LZ; Burlingame, AL; Qiu, Y | 1 |
| Lindon, JC; Nicholson, JK; Skordi, E; Wilson, ID | 1 |
| Obach, RS | 1 |
| Buch, A; Camilleri, P; Hutt, AJ; Soldo, B | 1 |
1 review(s) available for tolmetin glucuronide and tolmetin
| Article | Year |
|---|---|
The influence of physicochemical properties on the reactivity and stability of acyl glucuronides
Topics: Animals; Carbon; Drug Stability; Fatty Acids; Glucuronides; Half-Life; Humans; Structure-Activity Relationship; Tolmetin | 2018 |
7 other study(ies) available for tolmetin glucuronide and tolmetin
| Article | Year |
|---|---|
Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro.
Topics: Albumins; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isomerism; Protein Binding; Tolmetin | 1990 |
Disposition and irreversible plasma protein binding of tolmetin in humans.
Topics: Adult; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Female; Half-Life; Humans; Male; Pyrroles; Tolmetin | 1988 |
Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry.
Topics: Amino Acid Sequence; Binding Sites; Chemical Fractionation; Humans; Mass Spectrometry; Molecular Sequence Data; Peptides; Protein Binding; Serum Albumin; Tolmetin | 1995 |
Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.
Topics: Acylation; Amino Acid Sequence; Binding Sites; Carbohydrate Conformation; Chromatography, High Pressure Liquid; Glucuronates; Humans; Lysine; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Serum Albumin; Tolmetin; Trypsin | 1993 |
Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry.
Topics: Amino Acid Sequence; Anti-Inflammatory Agents; Binding Sites; Borohydrides; Glucuronates; Humans; Lysine; Molecular Sequence Data; Molecular Structure; Peptide Fragments; Propionates; Protein Binding; Serum Albumin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tolmetin; Trypsin | 1998 |
Kinetic studies on the intramolecular acyl migration of beta-1-O-acyl glucuronides: application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy.
Topics: Buffers; Glucuronic Acid; Ketoprofen; Kinetics; Magnetic Resonance Spectroscopy; Stereoisomerism; Tolmetin | 2005 |
Glycerolysis of acyl glucuronides as an artifact of in vitro drug metabolism incubations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Artifacts; Biological Assay; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Diclofenac; Glucuronates; Glucuronides; Glycerol; Humans; In Vitro Techniques; Mass Spectrometry; Mefenamic Acid; Microsomes, Liver; Naproxen; Propionates; Tolmetin; Uridine Diphosphate Glucuronic Acid | 2009 |