Page last updated: 2024-08-16

tolmetin and zomepirac

tolmetin has been researched along with zomepirac in 181 studies

Research

Studies (181)

Timeframe	Studies, this research(%)	All Research%
pre-1990	143 (79.01)	18.7374
1990's	14 (7.73)	18.2507
2000's	12 (6.63)	29.6817
2010's	12 (6.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bu, X; Cao, Y; Hu, X; Luo, M; Ren, Y; Song, Y; Wang, X; Xu, Q; Yuan, M	1
Cheng, YK; Hu, X; Li, Z; Liu, M; Luo, HB; Yuan, M	1
Kumar, M; Sinha, VR; Thareja, S	1
Gussin, RZ; Migdalof, BH; O'Neill, PJ; Yorgey, KA	1
Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL	2
Ng, KT; Snyderman, T	1
Colatsky, TJ; Kitzen, JM; McCallum, JD; Pirozzi, CT	1
Cooper, SA; Kupperman, A	1
Davis, DL	1
Benet, LZ; McDonagh, AF; Smith, PC	2
Beall, GN; Casaburi, R; Singer, A	1
Flannery, DB	1
Campbell, RL; Giglio, JA	1
Ellis, E; Scott, R; Upton, LG	1
Boyle, EA; Mangan, FR; Markwell, RE; Smith, SA; Thomson, MJ; Ward, RW; Wyman, PA	1
Anderson, RE; Hansen, RB; Stevens, MK; Yaksh, TL	1
Stevens, MK; Yaksh, TL	1
Corre, KA; Spielberg, TE	1
Carson, JL; Morse, ML; Soper, KA; Strom, BL; West, SL	1
Dong, WK; Halpern, LM	1
Laska, EM; Marrero, I; McCormick, N; Olson, N; Sunshine, A	1
Biron, P	1
Kunitake, LM; Pallasch, TJ	1
Hattori, T; Kawai, K; Kurita, K; Shimogo, K; Sugiura, M	1
Cater, M; O'Brien, PM; Pickvance, NJ	1
Bander, SJ	1
Anderson, LK; Bennett, MJ; Ebertz, JM; Hanifin, JM; Hirshman, CA; McMillan, JC	1
Sandler, RH	1
Ellis, HD; Wilcock, SE; Zaman, SA	1
Bullingham, RE; Carroll, D; Collin, J; Evans, PJ; Lloyd, JW; McQuay, HJ; Moore, RA; O'Sullivan, G	1
Müller, H; Zulliger, HW	1
Graman, HB; Haines, DE; Uphold, RE; Witte, GN	1
Joubert, DW	1
Aceto, MD; Harris, LS; Jacobson, AE; Medzihradsky, F; Smith, CB; Woods, JH; Young, AM	1
Inman, WH; Rawson, NS	1
Paulus, HE	1
Dunn, GL; Fargas-Babjak, AM; Goldsmith, CH; Morison, DH	1
Jefferson, WL; Steele, CE	1
Lacher, JW; Miller, FC; Schorr, WJ	1
Moretti, B; Patella, V; Pesce, V; Pipino, F	1
Bigby, M; Stern, RS	1
Gardocki, JF; Muschek, LD; Pruss, TP; Taylor, RJ	1
Gross, JI; Vogel, RI	1
Bergman, SA; Crossley, HL; Wynn, RL	1
Cooper, SA	3
Akamine, A; Aono, M; Haraga, Y; Honda, N; Kaida, H; Kishi, T; Maeda, K; Nagamine, N; Onimura, K; Yamamoto, J	1
Wallenstein, SL	1
Bender, WL; Beschorner, WE; Darwish, MO; Hall-Craggs, M; Solez, K; Whelton, A	1
Kumar, K; Laing, GS; Peters, K; Yates, DW	1
Harvengt, C	1
Ochoa, JL; Schady, W; Torebjörk, HE	1
Lumry, WR; Pleskow, WW; Simon, RA	1
Levy, DB; Vasilomanolakis, EC	1
Schady, W; Torebjörk, HE	1
Schütz, H; Suphachearabhan, S	1
Court, H; Volans, GN	1
Lupo, G; Mirisola, F	1
Cohn, P; Cooper, SA; Dyer, C; Gelb, S; Goldman, E	1
ElAttar, TM; Lin, HS; Tira, DE	1
Hagiwara, S; Ishikawa, I; Kinoshita, S; Kowashi, Y; Miyagawa, M; Noguchi, T; Uraguchi, R; Yamazaki, M	1
Offerhaus, L	1
Benet, LZ; Hasegawa, J; Langendijk, PN; Smith, PC	1
Ahmad, S	1
Vandemark, RM	1
Affrime, MB; Lowenthal, DT; O'Neill, PJ; Pritchard, JF	1
Kalbron, JJ; Ng, KT	1
Amankwa, L; Chatten, LG; Pons, S	1
Agulló García, M; Amador Barciela, L; Llinares Mondéjar, P; Martínez Debén, F; Sesma Sánchez, P; Suárez Sambade, D	1
Imazu, C; Ishii, K; Kadokawa, T; Nakamura, H; Shimizu, M; Yokoyama, Y	1
Botha, JJ; Weich, DJ	1
Cesario, T; Darwish, R; Gupta, S; Licorish, K; Novey, H; Powers, D; Spear, GS; Vaziri, ND	1
Creasy, GW; Kousen, M; Walker, WR	1
Grindel, JM; Muschek, LD	1
Forrest, WH	2
Knoop, FC; Thomas, DD	1
Haertzen, CA; Henningfield, JE; Jasinski, DR; Johnson, RE; Makhzoumi, HM; Miyasato, K	1
Honig, WJ	1
Valdez, EV	1
Boike, SC; Rybak, MJ; Tintinalli, JE; Veneri, R	1
Lisker, WH	1
Grindel, JM; Hills, JF; Renzi, NL	1
Kiani, R; Kushner, M	1
Jacobs, RL; Rake, GW	1
Mosley, C; Warren, SE	1
Hannaway, PJ; Hopper, GD	1
Guerrero, MM	1
Dunn, GL; Fargas-Babjak, AM; Morison, DH	1
De Castro, A; De Sarrazin, C; Laska, EM; Olson, NZ; Sunshine, A; Zighelboim, I	1
Calatroni, A; Pietta, P	1
Jasinski, DR; Johnson, RE; Kocher, TR	1
Mar, DD	1
Gever, LN	1
Romankiewicz, JA	1
Di Giacobbe, D; Duplat, JP	1
Hilleman, DE	1
Aoki, K; Ito, H; Naganawa, Y; Oda, H; Onishi, M	1
Houde, RW	1
Braun, H	1
Abe, M; Igarashi, K; Mizutani, H; Takagi, R; Takahashi, N	1
Samuel, SA	1
Ratner, SJ	1
Imazu, C; Ishii, K; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y	1
Baird, WM; Turek, D	1
Stambaugh, JE; Tejada, F; Trudnowski, RJ	1
Joy, ED; Mehlisch, DR; Moore, TE; Porter, K; Stumpf, AJ; Wolfe, SH	1
Harbert, G; Messer, RH; Vaughn, T	1
Mayer, TG; Ruoff, GE	1
Ciccone, WJ; deAndrade, JR; Honig, S; Leffall, L	1
Diamond, S	1
Bernard, A; Elbaz, JS	1
Joy, ED; Mehlisch, DR	1
Diamond, S; Medina, JL	1
McEvoy, GK	1
Honig, S; Murray, KA	1
Avery, GS; Brogden, RN; Carmine, AA; Heel, RC; Morley, PA; Speight, TM	1
Budoff, PW	1
van Thiel, D	2
Bullingham, RE; Evans, PJ; McQuay, HJ; Moore, RA; O'Sullivan, G; Rolfe, M	1
Gorder, JW	1
Smith, VT	1
Annesley, TM; Luthra, HS; Moyer, TP; Welch, CL	1
Friedman, CJ; Lesnefsky, EJ; Ross, SR	1
Blair, TJ; McCarthy, JT; Pierides, AM; Schwartz, GL; Van den Berg, CJ	1
Corre, KA; Rothstein, RJ	1
Haire, WD	1
Theron, F	1
Dingfelder, JR	1
Ellsworth, AJ; Killen, PD; Mease, PJ; Willkens, RF	1
Dettwiler, M; Jeger, A; Rippstein, S	1
Blackshear, JL	1
Kadokawa, T; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y	1
Spector, R	1
Benet, LZ; O'Neill, PJ; Renzi, NL; Williams, RL; Yorgey, KA	1
O'Neill, PJ	1
Hook, JB; Moore, GK; Noordewier, B; O'Neill, PJ; Yorgey, KA	1
McKown, LA; O'Neill, PJ; Yorgey, KA	1
Affarah, HB; Fellner, SK; Wolfe, C	1
Gottlieb, S; Nayak, RK; Ng, KT; Plostnieks, J	1
Anderson, NG; Carson, JR	1
Benet, LZ; Burlingame, AL; Ding, A; McDonagh, AF; Zia-Amirhosseini, P	1
Musa, BU	1
Spielberg, TE	1
Benet, LZ; Ojingwa, JC; Spahn-Langguth, H	1
Fortess, EE; Gurwitz, JH; Ross-Degnan, D; Soumerai, SB	1
Dickinson, RG; King, AR	1
Abraham, J	1
Liu, JH; Marquez, CD; Smith, PC; Weintraub, ST	1
Bailey, MJ; de Jersey, J; Dickinson, RG; Worrall, S	1
Bailey, MJ; Dickinson, RG	1
Dickinson, RG; Wang, M	1
Dickinson, RG; Gorrell, MD; McGaughan, GW; Wang, M	1
Klarskov, K; Naylor, S	1
Cannell, GR; Dickinson, RG; Vesey, DA	1
Abbott, CA; Dickinson, RG; Gorrell, MD; Jaggi, R; Marguet, D; Wang, M	1
Grillo, MP; Hua, F	1
Chao, SH; Chen, CJ; Chen, FA; Wang, CC; Wu, AB	1
Baillie, TA; Braun, MP; Chen, Q; Didolkar, V; Doss, GA; Evans, DC; Liu, W; Stearns, RA; Strauss, JR; Tang, W; Tang, YS; Tung, EC; Wang, RW	1
Benet, LZ; Bjørnsdottir, I; Hansen, SH; Li, C; Olsen, J; Sidenius, U	1
Stanbaugh, G	1
Atherton, J; Bauman, J; Kohl, C; Lam, W; Lou, Z; Mutlib, A; Reily, M; Walker, GS	1
Derry, S; Moore, RA; Traa, MX	1
Derry, S; McQuay, HJ; Moll, R; Moore, RA	1
Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC	1
Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y	1
Albertí, JJ; Morales-Ibanez, O; Sentellas, S; Zanuy, M	1
Aatsinki, SM; Hokkanen, J; Lassila, T; Mattila, S; Tolonen, A; Turpeinen, M	1
Akai, S; Iwamura, A; Kume, T; Nishinosono, T; Oda, S; Tsuneyama, K; Watanabe, K; Yokoi, T	1

Reviews

7 review(s) available for tolmetin and zomepirac

Article	Year
Nonsteroidal anti-inflammatory agents in relieving dental pain: a review. Journal of the American Dental Association (1939), 1983, Volume: 106, Issue:1 Topics: Analgesics; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Drug Interactions; Humans; Ibuprofen; Kinetics; Mouth; Pain, Postoperative; Tolmetin	1983
New peripherally-acting oral analgesic agents. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Diflunisal; Humans; Ibuprofen; Indoprofen; Naproxen; Pain; Pain, Postoperative; Tolmetin	1983
Review of the pharmacokinetics and metabolism of zomepirac in man and animals. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Analgesics; Animals; Biological Availability; Haplorhini; Humans; Kinetics; Mice; Protein Binding; Pyrroles; Rats; Species Specificity; Time Factors; Tolmetin	1980
Evaluation of zomepirac sodium. American journal of hospital pharmacy, 1981, Volume: 38, Issue:9 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Costs and Cost Analysis; Drug Interactions; Drug Tolerance; Humans; Kinetics; Pyrroles; Substance-Related Disorders; Tolmetin	1981
Zomepirac: a review of its pharmacological properties and analgesic efficacy. Drugs, 1982, Volume: 23, Issue:4 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Humans; Kinetics; Pain; Pyrroles; Substance-Related Disorders; Tolmetin	1982
Single dose oral fenoprofen for acute postoperative pain in adults. The Cochrane database of systematic reviews, 2011, Feb-16, Issue:2 Topics: Acute Disease; Administration, Oral; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Fenoprofen; Humans; Morphine; Pain, Postoperative; Tolmetin	2011
Single dose oral mefenamic acid for acute postoperative pain in adults. The Cochrane database of systematic reviews, 2011, Mar-16, Issue:3 Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Mefenamic Acid; Pain, Postoperative; Randomized Controlled Trials as Topic; Sulfonamides; Tolmetin	2011

Trials

40 trial(s) available for tolmetin and zomepirac

Article	Year
The analgesic efficacy of flurbiprofen compared to acetaminophen with codeine. The Journal of clinical dentistry, 1991, Volume: 2, Issue:3 Topics: Acetaminophen; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Codeine; Double-Blind Method; Drug Combinations; Female; Flurbiprofen; Humans; Male; Pain Measurement; Pain, Postoperative; Tolmetin	1991
Comparison of etodolac, zomepirac, and placebo for relief of pain after oral surgery. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1986, Volume: 44, Issue:10 Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Etodolac; Female; Humans; Male; Middle Aged; Molar, Third; Pain, Postoperative; Placebos; Pyrroles; Random Allocation; Time Factors; Tolmetin; Tooth Extraction	1986
Double-blind evaluation of etodolac (200 mg, 400 mg) compared with zomepirac (100 mg) and placebo on third molar extraction pain. Oral surgery, oral medicine, and oral pathology, 1986, Volume: 62, Issue:6 Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Etodolac; Humans; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin; Tooth Extraction	1986
Comparative study of flurbiprofen, zomepirac sodium, acetaminophen plus codeine, and acetaminophen for the relief of postsurgical dental pain. The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Flurbiprofen; Humans; Male; Pain, Postoperative; Placebos; Propionates; Pyrroles; Tolmetin; Tooth Extraction	1986
[McN-2783 for pain following the extraction of impacted wisdom tooth--clinical evaluation]. Shikai tenbo = Dental outlook, 1985, Volume: 65, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Molar, Third; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction; Tooth, Impacted	1985
A double-blind comparison of the new ibuprofen-codeine phosphate combination, zomepirac, and placebo in the relief of postepisiotomy pain. Clinical therapeutics, 1985, Volume: 7, Issue:4 Topics: Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Episiotomy; Female; Humans; Ibuprofen; Pain, Postoperative; Pyrroles; Random Allocation; Time Factors; Tolmetin	1985
Cold and performance: the effects of information load, analgesics, and the rate of cooling. Aviation, space, and environmental medicine, 1985, Volume: 56, Issue:3 Topics: Adult; Analgesics; Body Temperature; Cold Temperature; Humans; Intelligence Tests; Male; Mefenamic Acid; Reaction Time; Stress, Physiological; Task Performance and Analysis; Time Factors; Tolmetin	1985
Zomepirac, dihydrocodeine and placebo compared in postoperative pain after day-case surgery. The relationship between the effects of single and multiple doses. British journal of anaesthesia, 1985, Volume: 57, Issue:4 Topics: Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesics; Codeine; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Middle Aged; Pain, Postoperative; Pyrroles; Tolmetin	1985
A comparison of zomepirac and codeine as analgesic premedicants in short-stay surgery. Anesthesiology, 1983, Volume: 58, Issue:3 Topics: Adolescent; Adult; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Codeine; Double-Blind Method; Humans; Laparoscopy; Middle Aged; Pain, Postoperative; Preanesthetic Medication; Pyrroles; Sterilization, Reproductive; Tolmetin	1983
A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients. Current medical research and opinion, 1983, Volume: 8, Issue:6 Topics: Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Osteoarthritis; Pain; Pyrroles; Sleep; Tolmetin	1983
[Evaluation of the analgesic activity of zomepirac sodium on sciatica and lower back pain]. Bollettino chimico farmaceutico, 1984, Volume: 123, Issue:1 Topics: Adult; Aged; Analgesics; Back Pain; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Methimazole; Middle Aged; Pyrroles; Random Allocation; Sciatica; Tolmetin	1984
New peripherally-acting oral analgesic agents. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Diflunisal; Humans; Ibuprofen; Indoprofen; Naproxen; Pain; Pain, Postoperative; Tolmetin	1983
[A preliminary study on the effective dose and safety of zomepirac sodium. Pain following minor surgery and tooth extraction in the field of dentistry]. Nihon Shishubyo Gakkai kaishi, 1983, Volume: 25, Issue:2 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Mefenamic Acid; Middle Aged; Mouth; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction	1983
Measurement of pain and analgesia in cancer patients. Cancer, 1984, May-15, Volume: 53, Issue:10 Suppl Topics: Analgesia; Analgesics; Clinical Trials as Topic; Emotions; Heroin; Humans; Methods; Morphine; Neoplasms; Pain; Research Design; Surveys and Questionnaires; Tolmetin	1984
Mild analgesics and the accident and emergency department--cost and safety more important than potency? Archives of emergency medicine, 1984, Volume: 1, Issue:4 Topics: Acetaminophen; Analgesics; Clinical Trials as Topic; Costs and Cost Analysis; Emergencies; Emergency Service, Hospital; England; Fenoprofen; Humans; Mefenamic Acid; Prospective Studies; Tolmetin	1984
Comparative efficacy of fenoprofen calcium and zomepirac sodium in postsurgical dental pain. Oral surgery, oral medicine, and oral pathology, 1984, Volume: 57, Issue:5 Topics: Adult; Analgesics; Anti-Inflammatory Agents; Evaluation Studies as Topic; Female; Fenoprofen; Humans; Male; Pain, Postoperative; Phenylpropionates; Placebos; Pyrroles; Time Factors; Tolmetin; Tooth Extraction; Tooth, Impacted	1984
Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. JAMA, 1980, Nov-21, Volume: 244, Issue:20 Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Morphine; Pain, Postoperative; Pyrroles; Tolmetin	1980
Zomepirac as an analgesic premedication: a comparison of three dosage regimens. Canadian Anaesthetists' Society journal, 1983, Volume: 30, Issue:4 Topics: Adult; Analgesics; Anesthesia, General; Double-Blind Method; Drug Administration Schedule; Female; Humans; Pain, Postoperative; Premedication; Pyrroles; Random Allocation; Sterilization, Tubal; Time Factors; Tolmetin	1983
Ibuprofen, zomepirac, aspirin, and placebo in the relief of postepisiotomy pain. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:2 Topics: Adolescent; Adult; Aspirin; Episiotomy; Female; Humans; Ibuprofen; Pain, Postoperative; Placebos; Pyrroles; Tolmetin	1983
Abuse potential of zomepirac. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:3 Topics: Blood Pressure; Drug Evaluation; Euphoria; Humans; Morphine; Pupil; Pyrroles; Substance-Related Disorders; Surveys and Questionnaires; Tolmetin	1983
Proceedings of the symposium: Zomepirac: a New Non-narcotic Analgesic, held in Atlanta, Georgia on October 12 and 13, 1979. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Pt 2 Topics: Analgesics; Animals; Clinical Trials as Topic; Humans; Pyrroles; Tolmetin	1980
Efficacy of zomepirac in oral surgical pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Male; Mouth; Pain, Postoperative; Placebos; Pyrroles; Time Factors; Tolmetin	1980
Comparison of zomepirac, APC with codeine, codeine and placebo in the treatment of moderate and severe postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; Humans; Male; Pain, Postoperative; Phenacetin; Placebos; Pyrroles; Time Factors; Tolmetin	1980
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Administration, Oral; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injections, Intramuscular; Male; Morphine; Neoplasms; Pain, Postoperative; Pyrroles; Tolmetin	1980
Oral zomepirac and intramuscular morphine in postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Administration, Oral; Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Injections, Intramuscular; Morphine; Pain, Postoperative; Pyrroles; Time Factors; Tolmetin	1980
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; Male; Neoplasms; Oxycodone; Pain; Phenacetin; Pyrroles; Tolmetin	1980
Clinical comparison of zomepirac with APC/codeine combination in the treatment of pain following oral surgery. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; Humans; Male; Mouth; Pain, Postoperative; Phenacetin; Pyrroles; Tolmetin	1980
Clinical evaluation of zomepirac and APC with codeine in the treatment of postpartum episiotomy pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Episiotomy; Female; Humans; Pain, Postoperative; Phenacetin; Pyrroles; Tolmetin	1980
Clinical evaluation of zomepirac in the treatment of acute orthopedic pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; Male; Pain; Phenacetin; Pyrroles; Tolmetin; Wounds and Injuries	1980
Clinical comparison of zomepirac with pentazocine in the treatment of postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Analgesics; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Pain, Postoperative; Pentazocine; Pyrroles; Tolmetin	1980
Zomepirac in the symptomatic treatment of muscle contraction headache. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Clinical Trials as Topic; Female; Headache; Humans; Male; Middle Aged; Muscle Contraction; Pyrroles; Tolmetin	1980
A controlled repeat-dose comparison of zomepirac and clometacin in pain after plastic surgery. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adolescent; Adult; Aged; Analgesics; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indoleacetic Acids; Male; Middle Aged; Pain, Postoperative; Pyrroles; Surgery, Plastic; Time Factors; Tolmetin	1980
Zomepirac sodium -- a new oral analgesic. The Medical letter on drugs and therapeutics, 1981, Jan-09, Volume: 23, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Codeine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Pain; Placebos; Pyrroles; Tolmetin	1981
Zomepirac sodium vs APC with codeine for oral surgery pain. Journal of oral surgery (American Dental Association : 1965), 1981, Volume: 39, Issue:6 Topics: Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Humans; Mouth; Pain, Postoperative; Phenacetin; Pyrroles; Tolmetin	1981
A double-blind study of zomepirac sodium and placebo in the treatment of muscle contraction headache. Headache, 1981, Volume: 21, Issue:2 Topics: Adult; Analgesics; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans; Male; Muscle Contraction; Pyrroles; Tolmetin	1981
Postsurgical pain: zomepirac sodium, propoxyphene/-acetaminophen combination, and placebo. Journal of clinical pharmacology, 1981, Volume: 21, Issue:10 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Postoperative; Placebos; Pyrroles; Tolmetin	1981
Zomepirac sodium in the treatment of primary dysmenorrhea syndrome. The New England journal of medicine, 1982, Sep-16, Volume: 307, Issue:12 Topics: Activities of Daily Living; Adolescent; Adult; Analgesics; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Prostaglandin Antagonists; Pyrroles; Research Design; Tolmetin	1982
[An analgesic opens new therapeutic possibilities]. Therapie der Gegenwart, 1982, Volume: 121, Issue:7 Topics: Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Pain; Pyrroles; Tolmetin	1982
Zomepirac, placebo and paracetamol/dextropropoxyphene combination compared in orthopaedic postoperative pain. British journal of anaesthesia, 1982, Volume: 54, Issue:9 Topics: Acetaminophen; Adolescent; Adult; Analgesics; Bone and Bones; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Postoperative; Placebos; Pyrroles; Tolmetin	1982
The intra-uterine contraceptive device -- an attempt to prevent pain and expulsion with zomepirac sodium. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Jun-12, Volume: 61, Issue:24 Topics: Adolescent; Adult; Analgesics; Double-Blind Method; Female; Follow-Up Studies; Humans; Intrauterine Device Expulsion; Intrauterine Devices, Copper; Pain; Pyrroles; Tolmetin	1982

Other Studies

135 other study(ies) available for tolmetin and zomepirac

Article	Year
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism	2005
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies. Bioorganic & medicinal chemistry, 2011, Feb-01, Volume: 19, Issue:3 Topics: Curcumin; Drug Design; Enzyme Inhibitors; Genetic Vectors; Humans; Inhibitory Concentration 50; Lactoylglutathione Lyase; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Molecular Targeted Therapy; Plasmids; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship	2011
Structural investigation into the inhibitory mechanisms of indomethacin and its analogues towards human glyoxalase I. Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14 Topics: Binding Sites; Catalytic Domain; Humans; Indomethacin; Kinetics; Lactoylglutathione Lyase; Molecular Dynamics Simulation; Thermodynamics	2011
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach. European journal of medicinal chemistry, 2012, Volume: 53 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship	2012
Renal handling of zomepirac sodium (McN-2783-21-98) in the rat. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chlorobenzoates; Drug Interactions; Half-Life; Hydrogen-Ion Concentration; Kidney; Kinetics; Male; Metabolic Clearance Rate; Probenecid; Pyrroles; Rats; Tolmetin; Urine	1979
Clinical analgesic assay of oral zomepirac and intramuscular morphine. NIDA research monograph, 1979, Volume: 27 Topics: Administration, Oral; Affect; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Morphine; Pain; Pain, Postoperative; Pyrroles; Research Design; Tolmetin	1979
Determination of zomepirac in plasma by high-pressure liquid chromatography. Journal of chromatography, 1979, Oct-19, Volume: 178, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Pyrroles; Tolmetin	1979
Potentiation of phosphodiesterase inhibitor antithrombotic activity with alpha-2 adrenergic blockade. Life sciences, 1991, Volume: 48, Issue:7 Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Coronary Thrombosis; Dogs; Drug Synergism; Female; Fibrinolytic Agents; Hemodynamics; Male; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Pyrimidines; Random Allocation; Tolmetin; Yohimbine	1991
Court-ordered secrecy and public health. Lancet (London, England), 1990, Jul-21, Volume: 336, Issue:8708 Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Confidentiality; Female; Humans; Legislation, Drug; Male; Product Surveillance, Postmarketing; Public Health; Tolmetin; United States; United States Food and Drug Administration	1990
Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1 Topics: Anesthesia; Animals; Blood Proteins; Clofibric Acid; Esterases; Guinea Pigs; Hydrolysis; Male; Metabolic Clearance Rate; Phenylmethylsulfonyl Fluoride; Protein Binding; Rabbits; Sulfones; Tolmetin	1990
Anaphylaxis--everyone's problem. The Western journal of medicine, 1986, Volume: 144, Issue:3 Topics: Adult; Anaphylaxis; Dextrans; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Penicillin G; Tolmetin	1986
Syndrome of imperforate oropharynx with costovertebral and auricular anomalies. American journal of medical genetics, 1989, Volume: 32, Issue:2 Topics: Abnormalities, Drug-Induced; Amitriptyline; Ear, External; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Oropharynx; Ribs; Syndrome; Thoracic Vertebrae; Tolmetin	1989
7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents. Journal of medicinal chemistry, 1986, Volume: 29, Issue:6 Topics: Analgesics; Animals; Benzofurans; Cyclooxygenase Inhibitors; Gastric Mucosa; Male; Mice; Structure-Activity Relationship; Thiophenes; Tolmetin	1986
Effect of preischemia cyclooxygenase inhibition by zomepirac sodium on reflow, cerebral autoregulation, and EEG recovery in the cat after global ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:6 Topics: Animals; Brain; Cats; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Electroencephalography; Female; Homeostasis; Ischemic Attack, Transient; Male; Prostaglandins; Pyrroles; Tolmetin	1986
Time course of release in vivo of PGE2, PGF2 alpha, 6-keto-PGF1 alpha, and TxB2 into the brain extracellular space after 15 min of complete global ischemia in the presence and absence of cyclooxygenase inhibition. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1988, Volume: 8, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Brain; Brain Ischemia; Cats; Dinoprost; Dinoprostone; Extracellular Space; Female; Fibrinolytic Agents; Male; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane B2; Tolmetin	1988
Adverse drug reaction processing in the United States and its dependence on physician reporting: zomepirac (Zomax) as a case in point. Annals of emergency medicine, 1988, Volume: 17, Issue:2 Topics: Algorithms; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Drug Information Services; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Evaluation Studies as Topic; Humans; Physician's Role; Product Surveillance, Postmarketing; Pyrroles; Role; Tolmetin; United States; United States Food and Drug Administration	1988
The effect of indication on hypersensitivity reactions associated with zomepirac sodium and other nonsteroidal antiinflammatory drugs. Arthritis and rheumatism, 1987, Volume: 30, Issue:10 Topics: Adult; Aged; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Epidemiologic Methods; Female; Florida; Humans; Male; Medicaid; Middle Aged; Online Systems; Pyrroles; Risk Factors; Tolmetin	1987
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model. Pain, 1986, Volume: 24, Issue:2 Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascicularis; Male; Morphine; Naloxone; Neprilysin; Pain; Phenylalanine; Protease Inhibitors; Sensory Thresholds; Tolmetin	1986
[Drug surveillance: example of bayesian imputation of an adverse reaction]. L'union medicale du Canada, 1987, Volume: 116, Issue:2 Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Bayes Theorem; Female; Humans; Pyrroles; Tolmetin	1987
Nonsteroidal anti-inflammatory analgesics. The Compendium of continuing education in dentistry, 1985, Volume: 6, Issue:1 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diflunisal; Drug Interactions; Humans; Ibuprofen; Tolmetin	1985
Reversible renal failure and nephrotic syndrome without interstitial nephritis from zomepirac. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1985, Volume: 6, Issue:4 Topics: Acute Kidney Injury; Aged; Biopsy; Creatinine; Female; Fluorescent Antibody Technique; Humans; Kidney; Microscopy, Electron; Middle Aged; Nephrosis, Lipoid; Proteinuria; Pyrroles; Tolmetin	1985
Anaphylactic reaction during anaesthesia associated with positive intradermal skin test to fentanyl. Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:1 Topics: Adult; Analgesics; Anaphylaxis; Anesthesia, General; Female; Fentanyl; Humans; Intradermal Tests; Risk; Skin Tests; Tolmetin	1986
Irreversible binding of zomepirac to plasma protein in vitro and in vivo. The Journal of clinical investigation, 1986, Volume: 77, Issue:3 Topics: Blood Proteins; Glucuronates; Humans; Hydrogen-Ion Concentration; Isomerism; Protein Binding; Pyrroles; Serum Albumin; Tolmetin	1986
Anaphylactic reactions to zomepirac. Annals of emergency medicine, 1985, Volume: 14, Issue:2 Topics: Anaphylaxis; Anti-Inflammatory Agents; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin	1985
Continuous body fluid monitoring for zomepirac by fully automated high-performance liquid chromatography. Arzneimittel-Forschung, 1985, Volume: 35, Issue:1 Topics: Analgesics; Body Fluids; Chromatography, High Pressure Liquid; Humans; Pyrroles; Spectrophotometry, Ultraviolet; Tolmetin	1985
Zomepirac-induced anaphylactic shock: an under-reported phenomenon. The American journal of the medical sciences, 1985, Volume: 290, Issue:4 Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents; Female; Humans; Hypotension; Male; Middle Aged; Pyrroles; Tolmetin	1985
Zomepirac overdose and review of literature on acute toxicity of nonsteroidal antiinflammatory agents. Drug intelligence & clinical pharmacy, 1982, Volume: 16, Issue:4 Topics: Adult; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Bicarbonates; Charcoal; Gastrointestinal Hemorrhage; Humans; Ipecac; Kidney Function Tests; Male; Pyrroles; Tolmetin	1982
Zomepirac: preclinical narcotic abuse liability evaluation. Arzneimittel-Forschung, 1983, Volume: 33, Issue:2 Topics: Analgesics, Opioid; Animals; Discrimination, Psychological; Female; Humans; In Vitro Techniques; Macaca mulatta; Male; Mice; Morphine Dependence; Muscle, Smooth; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance-Related Disorders; Tolmetin	1983
Zomepirac and cardiovascular deaths. Lancet (London, England), 1983, Oct-15, Volume: 2, Issue:8355 Topics: Analgesics; Cardiovascular Diseases; Humans; Pyrroles; Tolmetin	1983
Government affairs. FDA Arthritis Advisory Committee Meeting. Arthritis and rheumatism, 1983, Volume: 26, Issue:11 Topics: Anaphylaxis; Drug Evaluation; Humans; Ibuprofen; Palliative Care; Pyrroles; Rheumatic Diseases; Tolmetin	1983
Zomepirac-induced renal failure. Archives of internal medicine, 1983, Volume: 143, Issue:6 Topics: Acute Kidney Injury; Adult; Aged; Arthritis; Back Pain; Body Weight; Coronary Artery Bypass; Creatinine; Female; Headache; Humans; Male; Pain; Postoperative Complications; Pyrroles; Time Factors; Tolmetin	1983
An expanded profile of cutaneous reactions to nonsteroidal anti-inflammatory drugs. Reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs. JAMA, 1984, Sep-21, Volume: 252, Issue:11 Topics: Aged; Anaphylaxis; Anti-Inflammatory Agents; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Meclofenamic Acid; Photosensitivity Disorders; Piroxicam; Propionates; Stevens-Johnson Syndrome; Sulindac; Thiazines; Tolmetin	1984
Evaluation of the analgesic properties of zomepirac. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Analgesics; Animals; Cattle; Cyclooxygenase Inhibitors; Drug Interactions; Hindlimb; Humans; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Platelet Aggregation; Pyrroles; Reaction Time; Receptors, Opioid; Substance-Related Disorders; Tolmetin	1980
The effects of nonsteroidal anti-inflammatory analgesics on pain after periodontal surgery. Journal of the American Dental Association (1939), 1984, Volume: 109, Issue:5 Topics: Adolescent; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ibuprofen; Middle Aged; Pain, Postoperative; Periodontal Diseases; Placebos; Prospective Studies; Pyrroles; Tolmetin	1984
Interstitial nephritis, proteinuria, and renal failure caused by nonsteroidal anti-inflammatory drugs. Immunologic characterization of the inflammatory infiltrate. The American journal of medicine, 1984, Volume: 76, Issue:6 Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Biopsy; Female; Fenoprofen; Fluorescent Antibody Technique; Humans; Ibuprofen; Kidney Diseases; Kidney Glomerulus; Male; Middle Aged; Nephritis, Interstitial; Phenylpropionates; Proteinuria; T-Lymphocytes, Cytotoxic; Tolmetin	1984
Drugs recently released in Belgium. Acta clinica Belgica, 1983, Volume: 38, Issue:3 Topics: Analgesics; Belgium; Drug and Narcotic Control; Ergolines; Etidronic Acid; Humans; Lisuride; Minoxidil; Pyrimidines; Pyrroles; Tolmetin	1983
Five studies on ibuprofen for postsurgical dental pain. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Codeine; Drug Combinations; Female; Humans; Ibuprofen; Male; Pain, Postoperative; Periodontal Diseases; Surgery, Oral; Tolmetin; Tooth, Impacted	1984
A new method for demonstration of central effects of analgesic agents in man. Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:8 Topics: Adult; Analgesics; Brain; Electric Stimulation; Evoked Potentials; Foot; Hand; Humans; Nerve Fibers; Nociceptors; Peripheral Nerves; Pyrroles; Sensory Thresholds; Tolmetin	1984
Zomepirac sodium (Zomax) hypersensitivity in aspirin-sensitive asthmatics. The American review of respiratory disease, 1984, Volume: 130, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Aspirin; Asthma; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Middle Aged; Pyrroles; Tolmetin	1984
Anaphylactic reaction due to zomepirac. Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:12 Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents; Humans; Male; Pyrroles; Tolmetin	1984
Central effects of zomepirac on pain evoked by intraneural stimulation in man. Journal of clinical pharmacology, 1984, Volume: 24, Issue:10 Topics: Adolescent; Adult; Double-Blind Method; Electric Stimulation; Humans; Neurons; Pain; Pyrroles; Tolmetin	1984
[Screening and detection of the analgesic zomepirac]. Arzneimittel-Forschung, 1984, Volume: 34, Issue:3 Topics: Analgesics; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Mass Spectrometry; Photometry; Pyrroles; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tolmetin	1984
Poisoning after overdose with non-steroidal anti-inflammatory drugs. Adverse drug reactions and acute poisoning reviews, 1984,Spring, Volume: 3, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Child, Preschool; Diflunisal; Female; Fenoprofen; Feprazone; Humans; Ibuprofen; Indomethacin; Ketoprofen; London; Male; Mefenamic Acid; Naproxen; Oxyphenbutazone; Phenylbutazone; Piroxicam; Thiazines; Tolmetin	1984
[Pain reduction in patients undergoing periodontal surgery treated with zomepirac sodium]. Dental Cadmos, 1983, Volume: 51, Issue:3 Topics: Adult; Analgesics; Aspirin; Female; Humans; Male; Pain, Postoperative; Periodontal Diseases; Placebos; Pyrroles; Tolmetin	1983
Arachidonic acid metabolism in inflamed gingiva and its inhibition by anti-inflammatory drugs. Journal of periodontology, 1984, Volume: 55, Issue:9 Topics: Anti-Inflammatory Agents; Arachidonic Acids; Flurbiprofen; Gingivitis; Humans; Periodontal Diseases; Prostaglandin Antagonists; Prostaglandins; Suprofen; Tolmetin	1984
[Evaluation of the analgesic and anti-inflammatory drug "Zomepirac Na" in dental surgical pain]. Nihon Shishubyo Gakkai kaishi, 1984, Volume: 26, Issue:3 Topics: Analgesics; Anti-Inflammatory Agents; Dental Care; Double-Blind Method; Drug Evaluation; Humans; Pain, Postoperative; Pyrroles; Tolmetin	1984
Non-steroidal anti-inflammatory drugs in the treatment of rheumatic disorders: pitfalls and problems with the present plethora. The Netherlands journal of medicine, 1983, Volume: 26, Issue:7 Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Humans; Propionates; Rheumatic Diseases; Tolmetin	1983
Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine. Journal of chromatography, 1984, May-11, Volume: 307, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Pyrroles; Spectrophotometry, Ultraviolet; Tolmetin	1984
Severe coronary spasm during zomepirac-induced allergic reaction. Southern medical journal, 1984, Volume: 77, Issue:7 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Coronary Vasospasm; Drug Hypersensitivity; Female; Humans; Middle Aged; Pyrroles; Tolmetin	1984
Anaphylactoid reaction to zomepirac. Annals of emergency medicine, 1983, Volume: 12, Issue:9 Topics: Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Pyrroles; Respiratory Insufficiency; Tolmetin	1983
Influence of uremia, hemodialysis, and nonesterified fatty acids on zomepirac plasma protein binding. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:5 Topics: Adult; Aged; Drug Interactions; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Protein Binding; Pyrroles; Renal Dialysis; Tolmetin; Uremia	1983
Sensitive gas chromatographic quantitation of zomepirac in plasma using an electron-capture detector. Journal of chromatography, 1983, Sep-09, Volume: 276, Issue:2 Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Pyrroles; Tolmetin	1983
Voltammetric studies of zomepirac sodium and its determination in tablets by differential-pulse polarography. The Analyst, 1983, Volume: 108, Issue:1289 Topics: Hydrogen-Ion Concentration; Polarography; Pyrroles; Tablets; Tolmetin	1983
[Nephrogenic diabetes insipidus possibly secondary to the ingestion of sodium zomepirac dihydrate]. Medicina clinica, 1983, Oct-22, Volume: 81, Issue:12 Topics: Adult; Diabetes Insipidus; Humans; Male; Pyrroles; Tolmetin	1983
Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals. Japanese journal of pharmacology, 1983, Volume: 33, Issue:4 Topics: Alprostadil; Analgesics; Animals; Ascitic Fluid; Bradykinin; Dogs; Hypertension; Injections, Intraventricular; Male; Naloxone; Pain; Prostaglandins E; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin	1983
Hypersensitivity to non-steroidal anti-inflammatory drugs--asthma precipitated by zomepirac. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1984, Feb-04, Volume: 65, Issue:5 Topics: Analgesics; Aspirin; Asthma; Humans; Male; Middle Aged; Pyrroles; Time Factors; Tolmetin	1984
Focal renal cortical necrosis associated with zomepirac. The American journal of medicine, 1984, Volume: 76, Issue:6 Topics: Analgesics; Anaphylaxis; Female; Humans; Immunoglobulin E; Kidney Cortex; Kidney Cortex Necrosis; Lymphocyte Activation; Middle Aged; Pyrroles; Tolmetin; Toothache	1984
A zomepirac reaction mimicking ectopic pregnancy. Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:6 Topics: Adult; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Hypotension; Pain; Pregnancy; Pregnancy, Ectopic; Pyrroles; Rupture, Spontaneous; Tolmetin	1984
The effect of calcium and prostaglandin inhibitors on the intestinal fluid response to heat-stable enterotoxin of Escherichia coli. The Journal of infectious diseases, 1982, Volume: 145, Issue:2 Topics: Animals; Calcium; Cromolyn Sodium; Diarrhea; Diltiazem; Dose-Response Relationship, Drug; Enterotoxins; Escherichia coli; Intestinal Secretions; Mice; Nifedipine; Prostaglandin Antagonists; Quinacrine; Tolmetin	1982
Progress report of the NIDA Addiction Research Center. NIDA research monograph, 1982, Volume: 41 Topics: Analgesics; Buprenorphine; Chlordiazepoxide; Clonidine; Diazepam; Humans; Morphine; National Institutes of Health (U.S.); Substance Withdrawal Syndrome; Substance-Related Disorders; Tobacco Use Disorder; Tolmetin; United States	1982
[Pain therapy following meniscectomy. Comparison of zomepirac and tilidine]. MMW, Munchener medizinische Wochenschrift, 1982, Jul-16, Volume: 124, Issue:28 Topics: Adult; Analgesics; Cyclohexanecarboxylic Acids; Female; Humans; Male; Menisci, Tibial; Pain, Postoperative; Pyrroles; Tilidine; Tolmetin	1982
[Treatment of postoperative pain. Zomepirac, mefenamic acid and placebo]. MMW, Munchener medizinische Wochenschrift, 1982, Oct-08, Volume: 124, Issue:40 Topics: Adult; Analgesics; Double-Blind Method; Humans; Mefenamic Acid; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin	1982
Zomepirac sodium for primary dysmenorrhea syndrome. The New England journal of medicine, 1983, Feb-17, Volume: 308, Issue:7 Topics: Analgesics; Dysmenorrhea; Female; Humans; Pyrroles; Tolmetin	1983
Zomepirac-related acute renal failure. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:1 Topics: Acute Kidney Injury; Anti-Inflammatory Agents; Female; Humans; Middle Aged; Pyrroles; Tolmetin	1983
Nonoliguric renal failure associated with zomepirac. JAMA, 1983, Apr-01, Volume: 249, Issue:13 Topics: Acute Kidney Injury; Analgesics; Humans; Male; Middle Aged; Oliguria; Pain; Pyrroles; Tolmetin	1983
Reversed-phase high-performance liquid chromatographic assay for zomepirac in urine. Journal of chromatography, 1983, Jan-14, Volume: 272, Issue:1 Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Pyrroles; Tolmetin	1983
Zomepirac-induced serum sickness. A report of two cases. JAMA, 1983, May-27, Volume: 249, Issue:20 Topics: Adult; Analgesics; Drug Hypersensitivity; Humans; Male; Middle Aged; Pain; Pyrroles; Serum Sickness; Tolmetin	1983
Anaphylactoid reactions to tolmetin and zomepirac. Annals of allergy, 1983, Volume: 50, Issue:5 Topics: Adult; Anaphylaxis; Humans; Male; Pyrroles; Respiratory Function Tests; Skin Tests; Structure-Activity Relationship; Time Factors; Tolmetin	1983
Renal failure and tubular dysfunction due to zomepirac therapy. JAMA, 1983, Jan-21, Volume: 249, Issue:3 Topics: Acidosis, Renal Tubular; Aged; Analgesics; Female; Humans; Joint Diseases; Kidney Failure, Chronic; Middle Aged; Pain; Pyrroles; Tolmetin	1983
Severe anaphylaxis and drug-induced beta-blockade. The New England journal of medicine, 1983, Jun-23, Volume: 308, Issue:25 Topics: Analgesics; Anaphylaxis; Female; Humans; Male; Middle Aged; Propranolol; Pyrroles; Tolmetin	1983
Anaphylaxis following zomepirac ingestion. The Western journal of medicine, 1983, Volume: 138, Issue:4 Topics: Analgesics; Anaphylaxis; Humans; Male; Middle Aged; Pyrroles; Tolmetin	1983
High-performance liquid chromatographic assay for zomepirac and its main metabolite in urine. Journal of chromatography, 1983, Jun-10, Volume: 275, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Pyrroles; Tolmetin	1983
The "simple" analgesics. The American journal of nursing, 1981, Volume: 81, Issue:6 Topics: Analgesics; Humans; Narcotics; Pain; Salicylates; Tolmetin	1981
Zomepirac sodium. Learn about this potent new non-narcotic analgesic. Nursing, 1981, Volume: 11, Issue:6 Topics: Adult; Analgesics; Child; Female; Humans; Male; Pain; Pyrroles; Tolmetin	1981
Nonsteroidal anti-inflammatory agents, Part IV - A new analgesic: zomepirac. The Journal of practical nursing, 1982, Volume: 32, Issue:2 Topics: Analgesics; Humans; Pyrroles; Tolmetin	1982
[Drug knowledge: zomepirac (sodium) (Zomax)]. L' Infirmiere canadienne, 1982, Volume: 24, Issue:11 Topics: Adult; Humans; Pain, Postoperative; Pyrroles; Tolmetin	1982
Summary of new drugs marketed in USA in 1980. The Journal of the Medical Society of New Jersey, 1981, Volume: 78, Issue:7 Topics: Amoxapine; Calcifediol; Daunorubicin; Drug Information Services; Epinephrine; Hydroxycholecalciferols; Meclofenamic Acid; Naproxen; Oxamniquine; Oxytetracycline; Ritodrine; Tolmetin; Trimethoprim	1981
Zomax. The Chronicle, 1982, Volume: 45, Issue:2 Topics: Analgesics; Anti-Inflammatory Agents; Pyrroles; Tolmetin	1982
[Analgesic effects of McN-2783 to post-extraction pain--preliminary test for the determination of proper dosage]. Shikai tenbo = Dental outlook, 1982, Volume: 59, Issue:1 Topics: Adolescent; Adult; Analgesics; Drug Evaluation; Female; Humans; Male; Middle Aged; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction	1982
Methods for measuring clinical pain in humans. Acta anaesthesiologica Scandinavica. Supplementum, 1982, Volume: 74 Topics: Analgesics; Humans; Morphine; Pain; Sensory Thresholds; Tolmetin	1982
[Zomax--progress in analgesia. A new, non-narcotic analgesic]. Swiss dent, 1981, Volume: 2, Issue:9 Topics: Analgesics; Humans; Kinetics; Pain; Pyrroles; Tolmetin	1981
[Analgesic effect of McN-2783 (Zomepirac sodium) for postextraction pain]. Shikai tenbo = Dental outlook, 1982, Volume: 60, Issue:4 Topics: Analgesics; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction	1982
Apparent anaphylactic reaction to zomepirac (Zomax) The New England journal of medicine, 1981, Apr-16, Volume: 304, Issue:16 Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Pyrroles; Tolmetin	1981
Zomepirac (Zomax). Drug and therapeutics bulletin, 1982, Apr-16, Volume: 20, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Pyrroles; Tolmetin	1982
Zomepirac and renal failure. Annals of internal medicine, 1982, Volume: 96, Issue:6 Pt 1 Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Humans; Male; Pyrroles; Tolmetin	1982
[Analgesic activity of a non-steroidal antiinflammatory drug, zomepirac sodium, in experimental animals]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:6 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Pressure; Bradykinin; Dogs; Edema; Female; Lethal Dose 50; Male; Mice; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Tolmetin	1982
Nonsteroidal anti-inflammatory: zomepirac sodium. Geriatrics, 1982, Volume: 37, Issue:2 Topics: Aged; Anti-Inflammatory Agents; Humans; Pain; Pyrroles; Tolmetin	1982
Anaphylactic shock, acute renal failure, and disseminated intravascular coagulation. Suspected complications of zomepirac. JAMA, 1982, Feb-26, Volume: 247, Issue:8 Topics: Acute Kidney Injury; Aged; Anaphylaxis; Disseminated Intravascular Coagulation; Humans; Male; Pain; Pyrroles; Tolmetin	1982
Liquid-chromatographic determination of zomepirac in serum and plasma. Clinical chemistry, 1982, Volume: 28, Issue:3 Topics: Adult; Analgesics; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Kinetics; Male; Pyrroles; Tolmetin	1982
Near fatal bronchospasm induced by zomepirac sodium. Annals of allergy, 1982, Volume: 48, Issue:4 Topics: Adult; Aspirin; Bronchial Spasm; Drug Hypersensitivity; Humans; Male; Pyrroles; Tolmetin	1982
Reversible nonoliguric acute renal failure associated with zomepirac therapy. Mayo Clinic proceedings, 1982, Volume: 57, Issue:6 Topics: Acute Kidney Injury; Aged; Analgesics; Creatinine; Female; Humans; Kidney Glomerulus; Pyrroles; Tolmetin	1982
Anaphylactic reaction to zomepirac. Annals of allergy, 1982, Volume: 48, Issue:5 Topics: Analgesics; Anaphylaxis; Anti-Inflammatory Agents; Blood Pressure; Epinephrine; Female; Humans; Hypersensitivity, Immediate; Middle Aged; Pruritus; Pyrroles; Rhinitis, Allergic, Seasonal; Seizures; Tolmetin	1982
Hemophilic osteoarthropathy. Archives of internal medicine, 1982, Volume: 142, Issue:5 Topics: Analgesics; Bone Diseases; Hemophilia A; Humans; Ibuprofen; Joint Diseases; Tolmetin	1982
[A drug fights pain on two levels]. Medizinische Klinik (Praxis-Ausg.), 1982, Jun-18, Volume: 77, Issue:13 Topics: Analgesics; Humans; Nociceptors; Pain; Pyrroles; Tolmetin	1982
Prostaglandin inhibitors: new treatment for an old nemesis. The New England journal of medicine, 1982, Sep-16, Volume: 307, Issue:12 Topics: Dysmenorrhea; Female; Humans; Prostaglandin Antagonists; Prostaglandins; Tolmetin	1982
Zomepirac, interstitial nephritis, and renal failure. Annals of internal medicine, 1982, Volume: 97, Issue:3 Topics: Acute Kidney Injury; Female; Humans; Male; Middle Aged; Nephritis, Interstitial; Pyrroles; Tolmetin	1982
A rapid sensitive determination of carprofen and zomepirac using thin-layer chromatography and gas chromatography--mass spectrometry. Journal of chromatography, 1982, Jul-23, Volume: 244, Issue:1 Topics: Animals; Carbazoles; Chromatography, Thin Layer; Doping in Sports; Gas Chromatography-Mass Spectrometry; Horses; Pyrroles; Tolmetin	1982
Drug-induced failure. Mayo Clinic proceedings, 1982, Volume: 57, Issue:10 Topics: Acute Kidney Injury; Humans; Pyrroles; Tolmetin	1982
[Anti-inflammatory activity of a non-steroidal anti-inflammatory agent, zomepirac sodium, in experimental animals]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:6 Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Permeability; Depression, Chemical; Edema; Guinea Pigs; In Vitro Techniques; Male; Mice; Peptic Ulcer; Prostaglandins; Protein Denaturation; Pyrroles; Rabbits; Rats; Tolmetin	1982
Zomepirac. Journal of the Iowa Medical Society, 1982, Volume: 72, Issue:10 Topics: Analgesics; Double-Blind Method; Humans; Prostaglandin Antagonists; Pyrroles; Tolmetin	1982
Disposition of zomepirac sodium in man. Journal of clinical pharmacology, 1982, Volume: 22, Issue:10 Topics: Adult; Analgesics; Glucuronates; Half-Life; Humans; Hydroxylation; Male; Pyrroles; Time Factors; Tolmetin	1982
Plasma protein binding of zomepirac sodium. Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:7 Topics: Animals; Blood Proteins; Humans; Macaca mulatta; Mice; Protein Binding; Pyrroles; Rats; Salicylates; Species Specificity; Tolmetin; Warfarin	1981
Effects of zomepirac and indomethacin on renal blood flow and electrolyte excretion in anesthetized monkeys. Life sciences, 1981, Sep-28, Volume: 29, Issue:13 Topics: Anesthesia; Animals; Electrolytes; Glomerular Filtration Rate; Indomethacin; Macaca mulatta; Male; Pyrroles; Renal Circulation; Tolmetin	1981
Dose-dependent pharmacokinetics and renal handling of zomepirac in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3 Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Female; Kidney; Kinetics; Macaca mulatta; Male; Metabolic Clearance Rate; Pyrroles; Tolmetin	1981
Acute renal failure and zomepirac. Archives of internal medicine, 1981, Volume: 141, Issue:13 Topics: Acute Kidney Injury; Adult; Analgesics; Female; Humans; Pyrroles; Tolmetin	1981
Zomepirac kinetics in healthy males. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:3 Topics: Adult; Analgesics; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Kidney; Kinetics; Male; Metabolic Clearance Rate; Pyrroles; Tolmetin	1980
Synthesis and biological activity of 5-(4-chlorobenzoyl)-4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-acetic acid, a major metabolite of zomepirac sodium. Journal of medicinal chemistry, 1980, Volume: 23, Issue:1 Topics: Analgesics; Animals; Arthritis, Experimental; Humans; In Vitro Techniques; Platelet Aggregation; Pyrroles; Rats; Stomach Ulcer; Tolmetin	1980
Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac. The Biochemical journal, 1995, Oct-15, Volume: 311 ( Pt 2) Topics: Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Protein Binding; Serum Albumin; Tolmetin	1995
Examining product risk in context: the case of zomepirac. JAMA, 1994, Oct-26, Volume: 272, Issue:16 Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Approval; Humans; Product Surveillance, Postmarketing; Tolmetin	1994
Examining product risk in context: the case of zomepirac. JAMA, 1994, Oct-26, Volume: 272, Issue:16 Topics: Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Drug Approval; Humans; Product Surveillance, Postmarketing; Tolmetin	1994
Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. Journal of pharmacokinetics and biopharmaceutics, 1994, Volume: 22, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Binding, Competitive; Blood Proteins; Chromatography, High Pressure Liquid; Female; Glucuronates; Humans; Male; Salicylates; Serum Albumin; Tolmetin; Ultrafiltration	1994
Examining product risk in context. Market withdrawal of zomepirac as a case study. JAMA, 1993, Oct-27, Volume: 270, Issue:16 Topics: Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dextropropoxyphene; Drug Approval; Drug Industry; Drug Prescriptions; Drug Utilization; Family Practice; Humans; New Jersey; Practice Patterns, Physicians'; Product Surveillance, Postmarketing; Risk Factors; Tolmetin	1993
The utility of the bile-exteriorized rat as a source of reactive acyl glucuronides: studies with zomepirac. Journal of pharmacological and toxicological methods, 1996, Volume: 36, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Glucuronates; Male; Rats; Rats, Sprague-Dawley; Tolmetin	1996
Regulating the cancer-inducing potential of non-steroidal anti-inflammatory drugs: some lessons from the 1970s and 1980s. Social science & medicine (1982), 1998, Volume: 46, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogenicity Tests; Drug and Narcotic Control; History, 20th Century; Male; Mice; Naproxen; Propionates; Rats; Suprofen; Tolmetin; United Kingdom; United States	1998
Reaction of acyl glucuronides with insulin in vitro: identification of an imine mechanism by electrospray ionization mass spectrometry. Pharmaceutical research, 1998, Volume: 15, Issue:2 Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Etodolac; Glucuronates; Humans; Imines; Insulin; Mass Spectrometry; Salicylates; Salicylic Acid; Suprofen; Tolmetin	1998
Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system. Chemico-biological interactions, 1998, Sep-04, Volume: 115, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Liver; Microtubules; Rats; Stereoisomerism; Structure-Activity Relationship; Tolmetin; Tubulin	1998
Limitations of hepatocytes and liver homogenates in modelling in vivo formation of acyl glucuronide-derived drug-protein adducts. Journal of pharmacological and toxicological methods, 1999, Volume: 41, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Glucuronates; Glycosylation; Liver; Male; Protein Binding; Rats; Rats, Wistar; Tolmetin	1999
Bile duct ligation promotes covalent drug-protein adduct formation in plasma but not in liver of rats given zomepirac. Life sciences, 2000, Dec-22, Volume: 68, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Bile Ducts; Blood Proteins; Gallbladder; Glucuronides; Isomerism; Liver; Metabolic Clearance Rate; Protein Binding; Rats; Tolmetin	2000
Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac. Life sciences, 2001, Jan-05, Volume: 68, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; CHO Cells; Cricetinae; Dipeptidyl Peptidase 4; DNA Adducts; Glucuronides; Humans; Hydrogen-Ion Concentration; Liver; Male; Precipitin Tests; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tolmetin	2001
India ink staining after sodium dodecyl sulfate polyacrylamide gel electrophoresis and in conjunction with Western blots for peptide mapping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM, 2002, Volume: 16, Issue:1 Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Blotting, Western; Carbon; Coloring Agents; Detergents; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Peptide Mapping; Povidone; Rabbits; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tolmetin	2002
Inhibition of proliferation of HT-29 colon adenocarcinoma cells by carboxylate NSAIDs and their acyl glucuronides. Life sciences, 2001, Nov-21, Volume: 70, Issue:1 Topics: Acylation; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Diclofenac; Diflunisal; Dose-Response Relationship, Drug; Glucuronides; HT29 Cells; Humans; Piroxicam; Stereoisomerism; Thymidine; Tolmetin; Valproic Acid	2001
Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. Journal of gastroenterology and hepatology, 2002, Volume: 17, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipeptidyl Peptidase 4; Glucuronides; Immunoblotting; Liver; Mice; Reverse Transcriptase Polymerase Chain Reaction; Tolmetin	2002
Identification of zomepirac-S-acyl-glutathione in vitro in incubations with rat hepatocytes and in vivo in rat bile. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:11 Topics: Animals; Bile; Glutathione; Hepatocytes; Male; Rats; Rats, Sprague-Dawley; Tolmetin	2003
Photolysis of NSAIDs. IV. Photoproducts of zomepirac determined by LC-ESI-MS. Biomedical chromatography : BMC, 2004, Volume: 18, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Decarboxylation; Ketones; Light; Oxidation-Reduction; Photolysis; Singlet Oxygen; Spectrometry, Mass, Electrospray Ionization; Tolmetin	2004
Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1 Topics: Animals; Chromatography, Liquid; Female; Glutathione; Hepatocytes; Humans; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Spectrometry, Mass, Electrospray Ionization; Tolmetin; Tritium; Troleandomycin	2006
In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chemical research in toxicology, 2005, Volume: 18, Issue:11 Topics: Acetyl Coenzyme A; Animals; Biotransformation; Carnitine; Chromatography, High Pressure Liquid; Glycine; Hepatocytes; Liver; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Taurine; Tolmetin	2005
I almost crossed over. Texas medicine, 2005, Volume: 101, Issue:10 Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Resuscitation; Death; Hallucinations; Humans; Injections, Intravenous; Male; Methylprednisolone Hemisuccinate; Tolmetin	2005
Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy. Chemical research in toxicology, 2007, Volume: 20, Issue:6 Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Chromatography, Liquid; Cyclooxygenase Inhibitors; Diclofenac; Drug Stability; Flufenamic Acid; Glucuronides; Half-Life; Ibuprofen; Indomethacin; Kinetics; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mefenamic Acid; Molecular Structure; Rats; Rats, Sprague-Dawley; Stereoisomerism; Technology, Pharmaceutical; Tolmetin	2007
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs. Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts	2012
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PloS one, 2012, Volume: 7, Issue:8 Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin	2012
GSSG/GSH ratios in cryopreserved rat and human hepatocytes as a biomarker for drug induced oxidative stress. Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:5 Topics: Aminopyrine; Animals; Biomarkers; Cells, Cultured; Cryopreservation; Cyclosporine; Flutamide; Glutathione; Glutathione Disulfide; Hepatocytes; Humans; Male; Oxidative Stress; Rats, Sprague-Dawley; Tolmetin	2014
Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated. Chemical research in toxicology, 2015, Dec-21, Volume: 28, Issue:12 Topics: Acetates; Acyl Coenzyme A; Acylation; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cyclopropanes; Gemfibrozil; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Quinolines; Sulfides; Tolmetin	2015
Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7 Topics: Acute Kidney Injury; Animals; Antioxidants; Biomarkers; Biotransformation; Blood Urea Nitrogen; Buthionine Sulfoximine; Creatinine; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Inflammation Mediators; Kidney; Mice, Inbred BALB C; Oxidative Stress; Spin Labels; Time Factors; Tolmetin; Tritolyl Phosphates	2016