tolmetin has been researched along with pyrroles in 289 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 278 (96.19) | 18.7374 |
| 1990's | 6 (2.08) | 18.2507 |
| 2000's | 2 (0.69) | 29.6817 |
| 2010's | 3 (1.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gussin, RZ; Migdalof, BH; O'Neill, PJ; Yorgey, KA | 1 |
| Cordrey, LJ | 1 |
| Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL | 2 |
| Bertelli, A; Schinetti, ML | 1 |
| Lumholtz, IB | 1 |
| Lewis, JR | 1 |
| Iwasaki, Y; Onoda, D; Shiokawa, Y; Yamamoto, M | 1 |
| Erdmann, GH; Gosling, JA; Müller, FO | 1 |
| Perrotta, P; Silvestri, N | 1 |
| Klemp, P; Meyers, OL | 1 |
| Baum, J; Brewer, E; Fink, C; Hanson, V; Levinson, JE; Schaller, J | 1 |
| Maibach, E | 3 |
| Avery, GS; Brogden, RN; Heel, RC; Speight, TM | 1 |
| Ansell, BM; Carter, ME; Gumpel, JM; Meanock, I; Rosenburg, J; Steele, CE | 1 |
| Bauer, P; Ehn, I; Schreiber, E; Stacher, G | 1 |
| Miller, JL | 1 |
| Chlud, K; Kaik, B | 1 |
| Pavelka, K; Susta, A | 3 |
| Grindel, JM; Migdalof, BH; Plostnieks, J | 1 |
| Bini, P; Giaretto, G | 1 |
| Carrabba, M; Colombo, B; Sarchi, C | 1 |
| Ryan, RE | 1 |
| Carcassi, U; Ibba, G; Passiu, G; Perpignano, G; Piras, MG | 1 |
| Ng, KT; Snyderman, T | 1 |
| Lanza, FL; Nelson, RS; Royer, GL | 1 |
| Imazu, C; Ishii, K; Motoyoshi, S; Nakamura, H; Shimizu, M; Yokoyama, Y | 1 |
| Ishii, K; Motoyoshi, S; Nakamura, H; Shimizu, M; Yokoyama, Y | 1 |
| Esteve, J; Palos, C; Rodríguez, L; Solanas, PJ | 1 |
| Brown, JR; Weir, AB | 1 |
| Ayres, JW; Hallmark, MR; Lemanowicz, EF; MacKichan, J; Sakmar, E; Wagner, JG; Weidler, DJ | 1 |
| Gilpin, RK; Janicki, CA | 1 |
| Gussin, RZ; Hook, JB; Noordewier, B; Stygles, VG | 1 |
| Scherbel, AL | 1 |
| Joseph, MW; Sakai, J | 1 |
| Paulus, HE; Restivo, C | 1 |
| Weryńska-Przybylska, J; Wróblewska-Graff, T | 1 |
| Madsen, BW; Selley, ML; Thomas, J | 1 |
| Bailie, MD; Hook, JB; Noordewier, B | 1 |
| Ng, KT | 1 |
| Aylward, M; Holly, F; Maddock, J; Parker, RJ; Thomas, SR | 1 |
| Salata, JJ; Taylor, RJ | 1 |
| Gross, D; Lobsiger, M; Rau, R | 1 |
| Ayres, JW; Hallmark, MR; Sakmar, E; Wagner, JG | 1 |
| Rainsford, KD; Whitehouse, MW | 1 |
| Ayres, JW; Sakmar, E; Wagner, JG; Weidler, DJ | 1 |
| Zarro, VJ | 2 |
| Bahous, I | 1 |
| Bain, LS; Collins, RM; el-Ghobarey, AF; Sargent, NW | 1 |
| Bachmann, F; Hartl, W; Stroescu, O | 1 |
| Cressman, WA; Lopez, B; Summer, D | 1 |
| Biland, L; Duckert, F; Nyman, D; Rüst, O; Thilo, D | 1 |
| Cressman, WA; Plostnieks, J; Wortham, GF | 1 |
| Amico-Roxas, M; Attaguile, G; Caruso, A; Cutuli, VM; De Bernardis, E | 1 |
| Arrigoni Martelli, E; Bruno, G; Cardace, G; Mancinelli, A; Marzo, A; Morabito, E | 1 |
| Bynum, L; Jung, D; Ling, TL; Mroszczak, EJ; Sevelius, H; Wu, A | 1 |
| Hunter, JR; Jick, H; Jick, SS; Walker, AM | 1 |
| Cenarruzabeitia, E; Lasheras, B; Ucelay, M | 2 |
| Hoitsma, A; Kunst, VA; Rico, PB; van Dijk, BA | 1 |
| Tietjen, DP | 1 |
| Dow, RJ; Gough, KJ; MacDonald, FC; Nicoll, RA | 1 |
| Bullingham, R; Lloyd, J; Manth, SM; Thompson, JS; Wischnik, A | 1 |
| diZerega, GS; Ellefson, D; Girgis, W; Rodgers, K; Scott, L | 1 |
| Matsuyama, K; Perrin, JH; Sen, AC | 1 |
| Arsac, M; Frileux, C | 1 |
| Campbell, RL; Giglio, JA | 1 |
| Ellis, E; Scott, R; Upton, LG | 1 |
| Flach, AJ; Lavelle, CJ; Olander, KW; Retzlaff, JA; Sorenson, LW | 1 |
| Lanza, FL | 1 |
| Anderson, RE; Hansen, RB; Stevens, MK; Yaksh, TL | 1 |
| Aspinall, RL; Davis, RE; Lanza, FL; Rack, MF; Rubin, A; Swabb, EA | 1 |
| Bovill, JG; Bravo, LJ; Burm, AG; Mattie, H; Spierdijk, J | 1 |
| Carson, J; Fisher, MC; Persico, FJ; Pritchard, JF; Wong, S; Yorgey, K | 1 |
| Stromberg, R | 1 |
| Fraser-Smith, EB; Matthews, TR | 3 |
| Corre, KA; Spielberg, TE | 1 |
| Conrad, KA; Fagan, TC; Mackie, MJ; Mayshar, PV | 1 |
| Bynum, L; Jung, D; Mroszczak, E | 1 |
| Johnstone, J; Lloyd, J; Rocha, CL; Walker, JJ | 1 |
| Greer, IA; Johnston, J; Tulloch, I; Walker, JJ | 1 |
| Bullingham, RE; Forbes, CD; Greer, IA; Lloyd, J; McLaren, M; Spowart, K | 1 |
| Davidson, GW; Ling, T; Marvin, MJ; Sanders, LM; Yu, D | 1 |
| Bullingham, RE; Gillies, GW; Kenny, GN; McArdle, CS | 1 |
| Carson, JL; Morse, ML; Soper, KA; Strom, BL; West, SL | 1 |
| Flach, AJ; Graham, J; Kruger, LP; Stegman, RC; Tanenbaum, L | 1 |
| Flach, AJ; Kraff, MC; Sanders, DR; Tanenbaum, L | 1 |
| Benet, LZ; Hyneck, ML; McDonagh, AF; Munafo, A; Smith, PC | 1 |
| Carson, JL; Morse, ML; Schinnar, R; Sim, E; Strom, BL | 1 |
| Beuerman, R; Kunysz, EA; Waterbury, L | 1 |
| Bullingham, RE; Carroll, D; McQuay, HJ; Moore, RA; Poppleton, P; Summerfield, RJ | 1 |
| Laska, EM; Marrero, I; McCormick, N; Olson, N; Sunshine, A | 1 |
| Akingbehin, T; Hung, SO; Smerdon, DL | 1 |
| Dolan, BJ; Flach, AJ; Irvine, AR | 1 |
| Biron, P | 1 |
| Fragen, RJ; Kinzer, M; O'Hara, DA; Pemberton, D | 1 |
| Combs, DL; Ling, TL | 1 |
| Cochran, DL; Janes, RL; Koren, JF | 1 |
| Benet, LZ; Hyneck, ML; Smith, PC; Unseld, E | 1 |
| Gordon, GD; Pascoe, MD; Temple-Camp, CR | 1 |
| Benet, LZ; Bosso, JA; Langendijk, PN; Smith, PC | 1 |
| Maloney, PJ; Rooks, WH; Schuler, ME; Sevelius, H; Shott, LD; Strosberg, AM; Tanenbaum, L; Tomolonis, AJ; Wallach, MB; Waterbury, D | 1 |
| Dunne, JA; Gilbert, DJ; Jacobs, N; Morrison, A | 1 |
| Hattori, T; Kawai, K; Kurita, K; Shimogo, K; Sugiura, M | 1 |
| Amadio, P; Cummings, DM | 1 |
| Cater, M; O'Brien, PM; Pickvance, NJ | 1 |
| Bander, SJ | 1 |
| Knodel, LC; Linn, WD; Wachsman, BA | 1 |
| Benet, LZ; McDonagh, AF; Smith, PC | 1 |
| Guzmán, A; Muchowski, JM; Toscano, RA; Van Horn, AR; Young, JM; Yuste, F | 1 |
| Goehrs, HR; Sagraves, R; Waller, ES | 1 |
| Sandler, RH | 1 |
| Bullingham, RE; Carroll, D; Collin, J; Evans, PJ; Lloyd, JW; McQuay, HJ; Moore, RA; O'Sullivan, G | 1 |
| Ponte, CD; Wisman, R | 1 |
| Bretza, JA; Novey, HS | 1 |
| Müller, H; Zulliger, HW | 1 |
| Alon, U; Chan, JC; Wellons, MD | 1 |
| Graman, HB; Haines, DE; Uphold, RE; Witte, GN | 1 |
| Joubert, DW | 1 |
| Aceto, MD; Harris, LS; Jacobson, AE; Medzihradsky, F; Smith, CB; Woods, JH; Young, AM | 1 |
| Inman, WH; Rawson, NS | 1 |
| Paulus, HE | 1 |
| Dunn, GL; Fargas-Babjak, AM; Goldsmith, CH; Morison, DH | 1 |
| Jefferson, WL; Steele, CE | 1 |
| Lacher, JW; Miller, FC; Schorr, WJ | 1 |
| Moretti, B; Patella, V; Pesce, V; Pipino, F | 1 |
| Gardocki, JF; Muschek, LD; Pruss, TP; Taylor, RJ | 1 |
| Gross, JI; Vogel, RI | 1 |
| Caldwell, JR; Crain, D; Hoffmeister, RT; Kantrowitz, F; Lloyd, RJ; Nussdorf, RT; Repice, MR; Schmid, FR | 1 |
| Calin, A | 1 |
| O'Brien, WM | 1 |
| Akamine, A; Aono, M; Haraga, Y; Honda, N; Kaida, H; Kishi, T; Maeda, K; Nagamine, N; Onimura, K; Yamamoto, J | 1 |
| Fellmann, N | 1 |
| Harvengt, C | 1 |
| Gumpel, JM; Prouse, PJ; Wilson, AP | 1 |
| Famaey, JP; Ginsberg, F | 1 |
| Ochoa, JL; Schady, W; Torebjörk, HE | 1 |
| Sotsky, SM; Tossell, JW | 1 |
| Affrime, MB; Lowenthal, DT; O'Neill, PJ; Pritchard, JF | 2 |
| Lumry, WR; Pleskow, WW; Simon, RA | 1 |
| Levy, DB; Vasilomanolakis, EC | 1 |
| Schady, W; Torebjörk, HE | 1 |
| Nakamura, H; Shimizu, M; Yokoyama, Y | 1 |
| Schütz, H; Suphachearabhan, S | 1 |
| Lupo, G; Mirisola, F | 1 |
| Cohn, P; Cooper, SA; Dyer, C; Gelb, S; Goldman, E | 1 |
| Hagiwara, S; Ishikawa, I; Kinoshita, S; Kowashi, Y; Miyagawa, M; Noguchi, T; Uraguchi, R; Yamazaki, M | 1 |
| Levy, J | 1 |
| Fernández, E; Rimbau, V; Sabater, J; Torralba, A | 1 |
| Benet, LZ; Hasegawa, J; Langendijk, PN; Smith, PC | 1 |
| Ahmad, S | 2 |
| Vandemark, RM | 1 |
| Kalbron, JJ; Ng, KT | 1 |
| Amankwa, L; Chatten, LG; Pons, S | 1 |
| Agulló García, M; Amador Barciela, L; Llinares Mondéjar, P; Martínez Debén, F; Sesma Sánchez, P; Suárez Sambade, D | 1 |
| Imazu, C; Ishii, K; Kadokawa, T; Nakamura, H; Shimizu, M; Yokoyama, Y | 1 |
| Chasseaud, LF; John, BA; Wood, SG | 1 |
| Botha, JJ; Weich, DJ | 1 |
| McDaniel, DH; Welton, WA | 1 |
| Cesario, T; Darwish, R; Gupta, S; Licorish, K; Novey, H; Powers, D; Spear, GS; Vaziri, ND | 1 |
| Creasy, GW; Kousen, M; Walker, WR | 1 |
| Appel, GB; Feinfeld, DA; Olesnicky, L; Pirani, CL | 1 |
| di Munno, O; Sarchi, C | 1 |
| Grindel, JM; Muschek, LD | 1 |
| Forrest, WH | 2 |
| Honig, WJ | 1 |
| Valdez, EV | 1 |
| Boike, SC; Rybak, MJ; Tintinalli, JE; Veneri, R | 1 |
| Lisker, WH | 1 |
| Grindel, JM; Hills, JF; Renzi, NL | 1 |
| Kiani, R; Kushner, M | 1 |
| Jacobs, RL; Rake, GW | 1 |
| Mosley, C; Warren, SE | 1 |
| Claypool, RG; Copley, JB; Wellborne, FR | 1 |
| Hannaway, PJ; Hopper, GD | 1 |
| Guerrero, MM | 1 |
| Dunn, GL; Fargas-Babjak, AM; Morison, DH | 1 |
| De Castro, A; De Sarrazin, C; Laska, EM; Olson, NZ; Sunshine, A; Zighelboim, I | 1 |
| Calatroni, A; Pietta, P | 1 |
| Gardocki, JF; Wong, S | 1 |
| Jasinski, DR; Johnson, RE; Kocher, TR | 1 |
| Ehrlich, GE | 1 |
| Desiraju, RK; Dromgoole, SH; Furst, DE; Paulus, HE | 1 |
| Gever, LN | 1 |
| Romankiewicz, JA | 1 |
| Di Giacobbe, D; Duplat, JP | 1 |
| Hilleman, DE | 1 |
| Aoki, K; Ito, H; Naganawa, Y; Oda, H; Onishi, M | 1 |
| Braun, H | 1 |
| Chevalier, RL; Rogol, AD | 1 |
| Abe, M; Igarashi, K; Mizutani, H; Takagi, R; Takahashi, N | 1 |
| Samuel, SA | 1 |
| Bertelletti, D; Cioffi, T; Guslandi, M; Sarchi, C | 1 |
| Ishii, K; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y | 1 |
| Ratner, SJ | 1 |
| Cenarruzabeitia, E; Fontan, JL; Lasheras, B | 1 |
| Imazu, C; Ishii, K; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y | 1 |
| Maloney, PJ; Rooks, WH; Schuler, ME; Tomolonis, AJ; Wallach, MB | 1 |
| Cooper, SA | 1 |
| Baird, WM; Turek, D | 1 |
| Stambaugh, JE; Tejada, F; Trudnowski, RJ | 1 |
| Joy, ED; Mehlisch, DR; Moore, TE; Porter, K; Stumpf, AJ; Wolfe, SH | 1 |
| Harbert, G; Messer, RH; Vaughn, T | 1 |
| Mayer, TG; Ruoff, GE | 1 |
| Ciccone, WJ; deAndrade, JR; Honig, S; Leffall, L | 1 |
| Diamond, S | 1 |
| Bernard, A; Elbaz, JS | 1 |
| Davies, J; Dixon, AS; Steele, CE | 1 |
| Berry, H; Bloom, B; Clark, RJ; Fernandes, L; Hamilton, EB | 1 |
| Balme, HW; Huskisson, EC; Wojtulewski, JA | 1 |
| Joy, ED; Mehlisch, DR | 1 |
| Bach-Andersen, R; Persson, B; Telhag, H | 1 |
| Diamond, S; Medina, JL | 1 |
| McEvoy, GK | 1 |
| Honig, S; Murray, KA | 1 |
| Shephard, NW; Steele, CE | 1 |
| Grindel, JM | 1 |
| Akingbehin, T; Cunningham, WF; Young, BJ | 1 |
| Avery, GS; Brogden, RN; Carmine, AA; Heel, RC; Morley, PA; Speight, TM | 1 |
| Budoff, PW | 1 |
| van Thiel, D | 2 |
| Bullingham, RE; Evans, PJ; McQuay, HJ; Moore, RA; O'Sullivan, G; Rolfe, M | 1 |
| Cunningham, JT | 1 |
| Gorder, JW | 1 |
| Smith, VT | 1 |
| Annesley, TM; Luthra, HS; Moyer, TP; Welch, CL | 1 |
| Gaismayer, K; Petera, P; Tausch, G | 1 |
| Friedman, CJ; Lesnefsky, EJ; Ross, SR | 1 |
| Blair, TJ; McCarthy, JT; Pierides, AM; Schwartz, GL; Van den Berg, CJ | 1 |
| Corre, KA; Rothstein, RJ | 1 |
| Theron, F | 1 |
| Knapp, DE; Rossi, AC | 1 |
| Bird, HA; Leatham, PA; Rhind, VM; Wright, V | 1 |
| Desiraju, RK; Dromgoole, SH; Furst, DE; Kirschenbaum, MA; Nayak, RK; Paulus, HE | 1 |
| Ellsworth, AJ; Killen, PD; Mease, PJ; Willkens, RF | 1 |
| Dettwiler, M; Jeger, A; Rippstein, S | 1 |
| Desiraju, RK; Pritchard, JF | 1 |
| Blackshear, JL | 1 |
| Kadokawa, T; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y | 1 |
| Desiraju, RK; Ng, KT; Sedberry, DC | 1 |
| Spector, R | 1 |
| Lockhart, JM | 1 |
| Benet, LZ; O'Neill, PJ; Renzi, NL; Williams, RL; Yorgey, KA | 1 |
| Handrich, L | 1 |
| Nassif, RI; Stefanini, M | 1 |
| Capaldo, R; DiGregorio, JG; Everts, EA; Katz, SM | 1 |
| Nakamura, H; Shimizu, M | 1 |
| O'Neill, PJ | 1 |
| Chatterjee, GP | 1 |
| Hook, JB; Moore, GK; Noordewier, B; O'Neill, PJ; Yorgey, KA | 1 |
| McKown, LA; O'Neill, PJ; Yorgey, KA | 1 |
| Reimer, GW | 1 |
| Baum, J; Gewanter, HL | 1 |
| Affarah, HB; Fellner, SK; Wolfe, C | 1 |
| Gottlieb, S; Nayak, RK; Ng, KT; Plostnieks, J | 1 |
| Daly, KF; Janicki, CA | 1 |
| Anderson, NG; Carson, JR | 1 |
| Cooper, JW; McCall, CY | 1 |
| Fellmann, N; Pavletic, B | 1 |
| Goldsmith, DP; Moore, ME | 1 |
| Clark, NR | 1 |
| Nuwer, DC | 1 |
| Barth, WF; Ruppert, GB | 1 |
| Franchimont, P; Hauwaert, C; Mailleux, E | 1 |
| Brandejský, J; Cermák, V; Fric, J; Kaucký, B; Stavinoha, V | 1 |
| Annunziato, L; di Renzo, G | 2 |
| Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP | 1 |
| Carminati, P; Coppelli, G; Coruzzi, G; Grandi, D; Lo Giudice, P; Longo, A; Morini, G; Pace, S; Pacifici, L; Pisano, C; Vesci, L | 1 |
| Cavestro, GM; Coppelli, G; Coruzzi, G; Lo Giudice, P; Okolicsanyi, L; Pisano, C; Spaggiari, S; Tepperman, BL | 1 |
| Alexandova, A; Kesiova, M; Kirkova, M; Todorov, S | 1 |
| Bharathi, DV; Chatki, P; Hotha, KK; Kumar, SS; Mullangi, R; Ravindranath, LK; Reddy, YN; Veera, KN | 1 |
| Bull, SD; Jones, MD; Taylor, JE; Williams, JM | 1 |
| Li, X; Liu, D; Rong, Z; Xiang, D; Xu, Y; Zhang, C | 1 |
6 review(s) available for tolmetin and pyrroles
| Article | Year |
|---|---|
Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Blood Platelets; Endocrine Glands; Humans; Intestinal Absorption; Intestinal Mucosa; Kinetics; Osteoarthritis; Prostaglandin Antagonists; Pyrroles; Rats; Rheumatic Diseases; Skin Tests; Spondylitis, Ankylosing; Tolmetin | 1978 |
Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Pyrroles; Spondylitis, Ankylosing; Tolmetin | 1983 |
Review of the pharmacokinetics and metabolism of zomepirac in man and animals.
Topics: Analgesics; Animals; Biological Availability; Haplorhini; Humans; Kinetics; Mice; Protein Binding; Pyrroles; Rats; Species Specificity; Time Factors; Tolmetin | 1980 |
Evaluation of zomepirac sodium.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Costs and Cost Analysis; Drug Interactions; Drug Tolerance; Humans; Kinetics; Pyrroles; Substance-Related Disorders; Tolmetin | 1981 |
The pharmacokinetic and metabolic profile of the antiinflammatory agent tolmetin in laboratory animals and man.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biological Availability; Guinea Pigs; Humans; Kinetics; Mice; Pyrroles; Rats; Species Specificity; Tissue Distribution; Tolmetin | 1981 |
Zomepirac: a review of its pharmacological properties and analgesic efficacy.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Humans; Kinetics; Pain; Pyrroles; Substance-Related Disorders; Tolmetin | 1982 |
89 trial(s) available for tolmetin and pyrroles
| Article | Year |
|---|---|
Tolmetin sodium, a new anti-arthritis drug: double-blind and long-term studies.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Pressure; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Locomotion; Male; Middle Aged; Palliative Care; Placebos; Pyrroles; Time Factors; Tolmetin | 1976 |
[Drug evaluation of McN-2559 in chronic rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1977 |
A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee.
Topics: Aspirin; Clinical Trials as Topic; Humans; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin | 1977 |
[Evaluation of the therapeutic activity of a new nonsteroid antiphlogistic drug, Tolectin in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Humans; Indomethacin; Pyrroles; Tolmetin | 1977 |
Clinical trial of tolmetin and aspirin in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1977 |
Comparison of tolmetin sodium and aspirin in the treatment of juvenile rheumatoid arthritis.
Topics: Adolescent; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Pyrroles; Tolmetin | 1977 |
[Therapy of arthroses of the hip and knee with tolectin (author's transl)].
Topics: Adult; Aged; Animals; Clinical Trials as Topic; Drug Evaluation; Female; Hip Joint; Humans; Joint Diseases; Knee Joint; Male; Middle Aged; Osteoarthritis; Pyrroles; Rats; Tolmetin | 1977 |
Clinical studies with tolmetin: open study and a double-blind cross-over comparison with aspirin in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1978 |
Effects of tolmetin, paracetamol, and of two combinations of tolmetin and paracetamol as compared to placebo on experimentally induced pain. A double blind study.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Electric Stimulation; Female; Hot Temperature; Humans; Male; Pain; Placebos; Pyrroles; Tolmetin | 1979 |
Clinical studies of the interaction between tolmetin and glibenclamide.
Topics: Adult; Aged; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Drug Interactions; Female; Glyburide; Glycosuria; Humans; Middle Aged; Pyrroles; Rheumatic Diseases; Time Factors; Tolmetin | 1977 |
[Long-term administration of tolmetin in patients with osteoarthritis. Overt controled trial].
Topics: Clinical Trials as Topic; Female; Humans; Long-Term Care; Male; Middle Aged; Osteoarthritis; Pyrroles; Tolmetin | 1978 |
Effects of ibuprofen, tolmetin and placebo on the gastric mucosa of aspirin-sensitive volunteers.
Topics: Adult; Aspirin; Gastric Mucosa; Gastritis; Gastroscopy; Humans; Ibuprofen; Placebos; Pyrroles; Tolmetin | 1979 |
[1st data related to the study of a new drug. Tolmetin, in the treatment of rheumatoid arthritis. Preliminary communication].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1975 |
Evaluation of tolmetin in the treatment of arthritis: open and controlled double-blind studies.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Pyrroles; Tolmetin | 1976 |
European experiences with tolmetin in the treatment of rheumatic diseases.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Oxyphenbutazone; Placebos; Pyrroles; Rheumatic Diseases; Tolmetin; Wounds and Injuries | 1976 |
[Treatment of severe osteoarthrosis of the knee and the hip with tolmentin. (A double-blind comparison with Indomethacin) (author's transl)].
Topics: Bone Diseases; Drug Evaluation; Hip; Humans; Indomethacin; Joint Diseases; Knee; Pyrroles; Tolmetin | 1977 |
Tolmetin: an evaluation of a new preparation in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1975 |
[Double blind and dosage studies on tolectine in rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Middle Aged; Placebos; Pyrroles; Tolmetin | 1975 |
Pharmacokinetics of ketorolac and p-hydroxyketorolac following oral and intramuscular administration of ketorolac tromethamine.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Drug Combinations; Humans; Injections, Intramuscular; Ketorolac; Ketorolac Tromethamine; Male; Pyrroles; Random Allocation; Tolmetin; Tromethamine | 1989 |
Psychomotor effects of ketorolac in comparison with buprenorphine and diclofenac.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Attention; Automobile Driving; Buprenorphine; Diclofenac; Flicker Fusion; Humans; Ketorolac; Male; Memory, Short-Term; Psychomotor Performance; Pyrroles; Reaction Time; Time Factors; Tolmetin | 1989 |
Comparative analgesic efficacy and tolerability of ketorolac tromethamine and glafenine in patients with post-operative pain.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Drug Combinations; Female; Glafenine; Humans; Ketorolac Tromethamine; Male; Middle Aged; ortho-Aminobenzoates; Pain, Postoperative; Preanesthetic Medication; Pyrroles; Random Allocation; Tolmetin; Tromethamine | 1988 |
Comparison of etodolac, zomepirac, and placebo for relief of pain after oral surgery.
Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Etodolac; Female; Humans; Male; Middle Aged; Molar, Third; Pain, Postoperative; Placebos; Pyrroles; Random Allocation; Time Factors; Tolmetin; Tooth Extraction | 1986 |
Double-blind evaluation of etodolac (200 mg, 400 mg) compared with zomepirac (100 mg) and placebo on third molar extraction pain.
Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Etodolac; Humans; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin; Tooth Extraction | 1986 |
The effect of ketorolac tromethamine solution 0.5% in reducing postoperative inflammation after cataract extraction and intraocular lens implantation.
Topics: Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Endophthalmitis; Female; Humans; Ketorolac Tromethamine; Lenses, Intraocular; Male; Middle Aged; Multicenter Studies as Topic; Placebos; Postoperative Complications; Pyrroles; Tolmetin; Tromethamine | 1988 |
A double-blind study of prophylactic effect of misoprostol on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects.
Topics: Administration, Oral; Adult; Alprostadil; Anti-Ulcer Agents; Clinical Trials as Topic; Double-Blind Method; Duodenum; Endoscopy; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Misoprostol; Pyrroles; Tolmetin | 1986 |
Double-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum.
Topics: Adult; Alprostadil; Anti-Ulcer Agents; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Duodenoscopy; Gastric Mucosa; Gastroscopy; Humans; Intestinal Mucosa; Middle Aged; Misoprostol; Pyrroles; Stomach Ulcer; Tolmetin | 1988 |
The effects on ventilation of ketorolac in comparison with morphine.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Clinical Trials as Topic; Double-Blind Method; Humans; Ketorolac; Male; Morphine; Pyrroles; Random Allocation; Respiration; Tolmetin | 1988 |
Effects of ketorolac tromethamine on hemostasis in volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Combinations; Ecchymosis; Hemostasis; Humans; Injections, Intramuscular; Ketorolac Tromethamine; Middle Aged; Pain; Pyrroles; Tolmetin; Tromethamine | 1988 |
The transfer of ketorolac tromethamine from maternal to foetal blood.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Combinations; Female; Fetal Blood; Humans; Infant, Newborn; Ketorolac Tromethamine; Maternal-Fetal Exchange; Pregnancy; Pyrroles; Spectrophotometry, Ultraviolet; Tolmetin; Tromethamine | 1988 |
Effect of maternal ketorolac administration of platelet function in the newborn.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Fetus; Humans; Infant, Newborn; Ketorolac; Maternal-Fetal Exchange; Meperidine; Obstetric Labor Complications; Platelet Aggregation; Pregnancy; Pyrroles; Random Allocation; Tolmetin | 1988 |
Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Bleeding Time; Drug Therapy, Combination; Factor Xa; Hemostatics; Heparin; Humans; Ketorolac; Partial Thromboplastin Time; Platelet Aggregation; Platelet Count; Pyrroles; Serine Proteinase Inhibitors; Thromboxane B2; Tolmetin | 1988 |
The morphine sparing effect of ketorolac tromethamine. A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery.
Topics: Abdomen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans; Infusions, Parenteral; Ketorolac Tromethamine; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin; Tromethamine | 1987 |
Quantitative assessment of postsurgical breakdown of the blood-aqueous barrier following administration of 0.5% ketorolac tromethamine solution. A double-masked, paired comparison with vehicle-placebo solution study.
Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Blood; Cataract Extraction; Double-Blind Method; Drug Combinations; Female; Fluorescein Angiography; Fluorometry; Humans; Ketorolac Tromethamine; Lenses, Intraocular; Male; Middle Aged; Pharmaceutical Vehicles; Photometry; Postoperative Complications; Pyrroles; Solutions; Tolmetin; Tromethamine | 1988 |
Ketorolac and acetaminophen for orthopedic postoperative pain.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analysis of Variance; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Ketorolac; Male; Middle Aged; Orthopedics; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin | 1986 |
Comparative study of flurbiprofen, zomepirac sodium, acetaminophen plus codeine, and acetaminophen for the relief of postsurgical dental pain.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Flurbiprofen; Humans; Male; Pain, Postoperative; Placebos; Propionates; Pyrroles; Tolmetin; Tooth Extraction | 1986 |
Double-blind controlled trial to compare anti-inflammatory effects of tolmetin 2%, prednisolone 0.5%, and placebo in post-cataract extraction eyes.
Topics: Cataract Extraction; Clinical Trials as Topic; Double-Blind Method; Endophthalmitis; Humans; Middle Aged; Postoperative Complications; Prednisolone; Pyrroles; Tolmetin | 1986 |
Effectiveness of ketorolac tromethamine 0.5% ophthalmic solution for chronic aphakic and pseudophakic cystoid macular edema.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aphakia, Postcataract; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans; Ketorolac Tromethamine; Lenses, Intraocular; Macular Edema; Ophthalmic Solutions; Pyrroles; Random Allocation; Time Factors; Tolmetin; Tromethamine; Visual Acuity | 1987 |
Ketorolac tromethamine as compared with morphine sulfate for treatment of postoperative pain.
Topics: Adult; Aged; Drug Combinations; Female; Humans; Injections, Intramuscular; Ketorolac Tromethamine; Male; Middle Aged; Morphine; Pain, Postoperative; Pyrroles; Tolmetin; Tromethamine | 1987 |
Efficacy in anterior uveitis of two known steroids and topical tolmetin.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Clinical Trials as Topic; Dexamethasone; Female; Humans; Intraocular Pressure; Male; Middle Aged; Prednisolone; Pyrroles; Tolmetin; Uveitis | 1985 |
[McN-2783 for pain following the extraction of impacted wisdom tooth--clinical evaluation].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Molar, Third; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction; Tooth, Impacted | 1985 |
The effect of tolmetin on the chronic pain and decreased functional capacity associated with degenerative joint disease.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Osteoarthritis; Pain; Pyrroles; Random Allocation; Tolmetin | 1985 |
A double-blind comparison of the new ibuprofen-codeine phosphate combination, zomepirac, and placebo in the relief of postepisiotomy pain.
Topics: Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Episiotomy; Female; Humans; Ibuprofen; Pain, Postoperative; Pyrroles; Random Allocation; Time Factors; Tolmetin | 1985 |
Zomepirac, dihydrocodeine and placebo compared in postoperative pain after day-case surgery. The relationship between the effects of single and multiple doses.
Topics: Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesics; Codeine; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Middle Aged; Pain, Postoperative; Pyrroles; Tolmetin | 1985 |
A comparison of zomepirac and codeine as analgesic premedicants in short-stay surgery.
Topics: Adolescent; Adult; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Codeine; Double-Blind Method; Humans; Laparoscopy; Middle Aged; Pain, Postoperative; Preanesthetic Medication; Pyrroles; Sterilization, Reproductive; Tolmetin | 1983 |
A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients.
Topics: Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Osteoarthritis; Pain; Pyrroles; Sleep; Tolmetin | 1983 |
[Evaluation of the analgesic activity of zomepirac sodium on sciatica and lower back pain].
Topics: Adult; Aged; Analgesics; Back Pain; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Methimazole; Middle Aged; Pyrroles; Random Allocation; Sciatica; Tolmetin | 1984 |
Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; Fenoprofen; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Osteoarthritis; Phenylpropionates; Pyrroles; Tolmetin | 1983 |
Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Pyrroles; Spondylitis, Ankylosing; Tolmetin | 1983 |
Long-term efficacy and safety of tolmetin sodium in treatment of geriatric patients with rheumatoid arthritis and osteoarthritis: a retrospective study.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Osteoarthritis; Pyrroles; Retrospective Studies; Time Factors; Tolmetin | 1983 |
[A preliminary study on the effective dose and safety of zomepirac sodium. Pain following minor surgery and tooth extraction in the field of dentistry].
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Mefenamic Acid; Middle Aged; Mouth; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction | 1983 |
[Treatment of gonarthrosis with tolectin].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Knee Joint; Male; Middle Aged; Pyrroles; Tolmetin | 1984 |
Comparative efficacy of fenoprofen calcium and zomepirac sodium in postsurgical dental pain.
Topics: Adult; Analgesics; Anti-Inflammatory Agents; Evaluation Studies as Topic; Female; Fenoprofen; Humans; Male; Pain, Postoperative; Phenylpropionates; Placebos; Pyrroles; Time Factors; Tolmetin; Tooth Extraction; Tooth, Impacted | 1984 |
Effectiveness of tolmetin in rheumatoid arthritis: evaluation by means of a new method.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1982 |
Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain.
Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Morphine; Pain, Postoperative; Pyrroles; Tolmetin | 1980 |
Zomepirac as an analgesic premedication: a comparison of three dosage regimens.
Topics: Adult; Analgesics; Anesthesia, General; Double-Blind Method; Drug Administration Schedule; Female; Humans; Pain, Postoperative; Premedication; Pyrroles; Random Allocation; Sterilization, Tubal; Time Factors; Tolmetin | 1983 |
Ibuprofen, zomepirac, aspirin, and placebo in the relief of postepisiotomy pain.
Topics: Adolescent; Adult; Aspirin; Episiotomy; Female; Humans; Ibuprofen; Pain, Postoperative; Placebos; Pyrroles; Tolmetin | 1983 |
Abuse potential of zomepirac.
Topics: Blood Pressure; Drug Evaluation; Euphoria; Humans; Morphine; Pupil; Pyrroles; Substance-Related Disorders; Surveys and Questionnaires; Tolmetin | 1983 |
Proceedings of the symposium: Zomepirac: a New Non-narcotic Analgesic, held in Atlanta, Georgia on October 12 and 13, 1979.
Topics: Analgesics; Animals; Clinical Trials as Topic; Humans; Pyrroles; Tolmetin | 1980 |
Efficacy of zomepirac in oral surgical pain.
Topics: Adult; Analgesics; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Male; Mouth; Pain, Postoperative; Placebos; Pyrroles; Time Factors; Tolmetin | 1980 |
Comparison of zomepirac, APC with codeine, codeine and placebo in the treatment of moderate and severe postoperative pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; Humans; Male; Pain, Postoperative; Phenacetin; Placebos; Pyrroles; Time Factors; Tolmetin | 1980 |
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain.
Topics: Administration, Oral; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injections, Intramuscular; Male; Morphine; Neoplasms; Pain, Postoperative; Pyrroles; Tolmetin | 1980 |
Oral zomepirac and intramuscular morphine in postoperative pain.
Topics: Administration, Oral; Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Injections, Intramuscular; Morphine; Pain, Postoperative; Pyrroles; Time Factors; Tolmetin | 1980 |
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; Male; Neoplasms; Oxycodone; Pain; Phenacetin; Pyrroles; Tolmetin | 1980 |
Clinical comparison of zomepirac with APC/codeine combination in the treatment of pain following oral surgery.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; Humans; Male; Mouth; Pain, Postoperative; Phenacetin; Pyrroles; Tolmetin | 1980 |
Clinical evaluation of zomepirac and APC with codeine in the treatment of postpartum episiotomy pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Episiotomy; Female; Humans; Pain, Postoperative; Phenacetin; Pyrroles; Tolmetin | 1980 |
Clinical evaluation of zomepirac in the treatment of acute orthopedic pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; Male; Pain; Phenacetin; Pyrroles; Tolmetin; Wounds and Injuries | 1980 |
Clinical comparison of zomepirac with pentazocine in the treatment of postoperative pain.
Topics: Analgesics; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Pain, Postoperative; Pentazocine; Pyrroles; Tolmetin | 1980 |
Zomepirac in the symptomatic treatment of muscle contraction headache.
Topics: Adult; Analgesics; Clinical Trials as Topic; Female; Headache; Humans; Male; Middle Aged; Muscle Contraction; Pyrroles; Tolmetin | 1980 |
A controlled repeat-dose comparison of zomepirac and clometacin in pain after plastic surgery.
Topics: Adolescent; Adult; Aged; Analgesics; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indoleacetic Acids; Male; Middle Aged; Pain, Postoperative; Pyrroles; Surgery, Plastic; Time Factors; Tolmetin | 1980 |
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study.
Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indomethacin; Middle Aged; Osteoarthritis; Pain; Pyrroles; Tolmetin | 1980 |
Clinical study comparing acupuncture, physiotherapy, injection and oral anti-inflammatory therapy in shoulder-cuff lesions.
Topics: Acupuncture Therapy; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Movement; Pain Management; Physical Therapy Modalities; Prednisolone; Pyrroles; Shoulder Joint; Tolmetin | 1980 |
Clinical experience with tolmetin sodium.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Fibromyalgia; Humans; Osteoarthritis; Phenylbutazone; Pyrroles; Tolmetin | 1980 |
Zomepirac sodium -- a new oral analgesic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Codeine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Pain; Placebos; Pyrroles; Tolmetin | 1981 |
Zomepirac sodium vs APC with codeine for oral surgery pain.
Topics: Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Humans; Mouth; Pain, Postoperative; Phenacetin; Pyrroles; Tolmetin | 1981 |
A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Naproxen; Osteoarthritis; Pain; Pyrroles; Tolmetin | 1981 |
A double-blind study of zomepirac sodium and placebo in the treatment of muscle contraction headache.
Topics: Adult; Analgesics; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans; Male; Muscle Contraction; Pyrroles; Tolmetin | 1981 |
Postsurgical pain: zomepirac sodium, propoxyphene/-acetaminophen combination, and placebo.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Postoperative; Placebos; Pyrroles; Tolmetin | 1981 |
Comparison of tolmetin sodium with indomethacin in osteoarthritis.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Humans; Indomethacin; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin | 1981 |
Double-masked controlled clinical trial of 5% tolmetin versus 0.5% prednisolone versus 0.9% saline in acute endogenous nongranulomatous anterior uveitis.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Prednisolone; Pyrroles; Time Factors; Tolmetin; Uveitis | 1982 |
Zomepirac sodium in the treatment of primary dysmenorrhea syndrome.
Topics: Activities of Daily Living; Adolescent; Adult; Analgesics; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Prostaglandin Antagonists; Pyrroles; Research Design; Tolmetin | 1982 |
[An analgesic opens new therapeutic possibilities].
Topics: Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Pain; Pyrroles; Tolmetin | 1982 |
Zomepirac, placebo and paracetamol/dextropropoxyphene combination compared in orthopaedic postoperative pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Bone and Bones; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Postoperative; Placebos; Pyrroles; Tolmetin | 1982 |
The intra-uterine contraceptive device -- an attempt to prevent pain and expulsion with zomepirac sodium.
Topics: Adolescent; Adult; Analgesics; Double-Blind Method; Female; Follow-Up Studies; Humans; Intrauterine Device Expulsion; Intrauterine Devices, Copper; Pain; Pyrroles; Tolmetin | 1982 |
[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; In Vitro Techniques; Indoleacetic Acids; Indomethacin; Inflammation; Male; Middle Aged; Pain; Pyrroles; Tolmetin | 1980 |
[Double-blind study with the antirheumatic tolmetin in the treatment of inpatients with osteoarthritis of hips and knees (author's transl)].
Topics: Double-Blind Method; Drug Evaluation; Female; Hip; Humans; Knee; Male; Osteoarthritis; Placebos; Pyrroles; Tolmetin | 1980 |
[A bioequivalence study of tablet and powder formulations of the nonsteroidal anti-inflammatory drug 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate].
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Glycine; Humans; Male; Powders; Pyrroles; Tablets; Therapeutic Equivalency; Time Factors; Tolmetin | 1993 |
[An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Glycine; Humans; Italy; Male; Middle Aged; Osteoarthritis; Pyrroles; Time Factors; Tolmetin | 1993 |
[A bioequivalence study in man of tablet and capsule formulations of the nonsteroidal anti-inflammatory compound 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate].
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Female; Glycine; Humans; Male; Pyrroles; Tablets; Therapeutic Equivalency; Time Factors; Tolmetin | 1993 |
Validation and clinical application of an LC-ESI-MS/MS method for simultaneous determination of tolmetin and MED5, the metabolites of amtolmetin guacil in human plasma.
Topics: Chromatography, Liquid; Drug Stability; Glycine; Humans; Linear Models; Male; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tolmetin | 2010 |
195 other study(ies) available for tolmetin and pyrroles
| Article | Year |
|---|---|
Renal handling of zomepirac sodium (McN-2783-21-98) in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chlorobenzoates; Drug Interactions; Half-Life; Hydrogen-Ion Concentration; Kidney; Kinetics; Male; Metabolic Clearance Rate; Probenecid; Pyrroles; Rats; Tolmetin; Urine | 1979 |
Clinical analgesic assay of oral zomepirac and intramuscular morphine.
Topics: Administration, Oral; Affect; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Morphine; Pain; Pain, Postoperative; Pyrroles; Research Design; Tolmetin | 1979 |
Activity of tolmetin on levels of cyclic nucleotides in experimental pleurisy.
Topics: Acetates; Animals; Cyclic AMP; Cyclic GMP; Indomethacin; Male; Pleurisy; Pyrroles; Rats; Tolmetin | 1979 |
[Drug information: therapeutic main group: current anti-inflammatory agents and weaker analgesics. Tolmetin (Tolectin)].
Topics: Analgesics; Anti-Inflammatory Agents; Humans; Pyrroles; Tolmetin | 1978 |
New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin).
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Gastrointestinal Hemorrhage; Humans; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Phenylpropionates; Pyrroles; Rheumatic Diseases; Spondylitis, Ankylosing; Tolmetin | 1977 |
Tolmetin sodium.
Topics: Arthritis, Rheumatoid; False Positive Reactions; Female; Gold Sodium Thiomalate; Humans; Middle Aged; Proteinuria; Pyrroles; Tolmetin | 1977 |
Absorption and excretion of tolmetin in arthritic patients.
Topics: Arthritis, Rheumatoid; Biotransformation; Chromatography, Thin Layer; Female; Humans; Intestinal Absorption; Kinetics; Male; Pyrroles; Tolmetin | 1979 |
[The effectiveness of tolmetin sodium in the treatment of infantile rheumatoid arthritis].
Topics: Arthritis, Juvenile; Child; Drug Evaluation; Female; Humans; Pyrroles; Tolmetin | 1979 |
[Biological availability of Tolectin after oral and rectal administration].
Topics: Administration, Oral; Adult; Biological Availability; Female; Humans; Male; Pyrroles; Suppositories; Tolmetin | 1979 |
Symptomatic treatment of tension headache.
Topics: Analgesics; Headache; Humans; Muscle Contraction; Pyrroles; Tolmetin | 1979 |
Tolmetin and G-6-PD erythrocyte deficiency: research in vitro.
Topics: Adult; Aged; Depression, Chemical; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Humans; In Vitro Techniques; Male; Middle Aged; Pyrroles; Thalassemia; Tolmetin | 1979 |
Determination of zomepirac in plasma by high-pressure liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Pyrroles; Tolmetin | 1979 |
[Analgesic activity of a non-steroidal anti-inflammatory agent, tolmetin sodium in experimental animals (author's transl)].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Blood Pressure; Bradykinin; Dogs; Female; Male; Naloxone; Pyrroles; Rats; Tolmetin | 1979 |
[Effect of a non-steroidal anti-inflammatory agent, tolmetin sodium on exudative inflammation in experimental animals (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cell Differentiation; Edema; Erythrocyte Membrane; Exudates and Transudates; Guinea Pigs; Hemolysis; Hot Temperature; In Vitro Techniques; Inflammation; Kaolin; Lymphocytes; Male; Mice; Protein Denaturation; Pyrroles; Rats; Sunburn; Tolmetin | 1979 |
[Acute toxicity and anti-inflammatory activity of tolmetin by the rectal route in the rat].
Topics: Animals; Anti-Inflammatory Agents; Lethal Dose 50; Pyrroles; Rats; Rectum; Suppositories; Tolmetin | 1979 |
[Tolmetin (Tolectin) in the long-term therapy of progressive polyarthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1978 |
Drug fever from tolmetin administration.
Topics: Arthritis, Rheumatoid; Drug Hypersensitivity; Fever; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1978 |
Pharmacokinetics of tolmetin with and without concomitant administration of antacid in man.
Topics: Adult; Antacids; Drug Interactions; Humans; Kinetics; Male; Pyrroles; Time Factors; Tolmetin | 1977 |
High-pressure liquid chromatographic method for surveying the purity of tolmetin sodium dihydrate.
Topics: Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Pyrroles; Tolmetin | 1978 |
Effect of tolmetin on renal function and prostaglandin metabolism.
Topics: Animals; Dogs; In Vitro Techniques; Indomethacin; Kidney; Male; Oxygen Consumption; Prostaglandins E; Pyrroles; Rats; Regional Blood Flow; Tolmetin | 1978 |
[Tolectin and bleeding time (author's transl)].
Topics: Acenocoumarol; Adult; Blood Coagulation; Drug Interactions; Female; Humans; Male; Middle Aged; Pyrroles; Time Factors; Tolmetin | 1978 |
Nonsteroidal antiinflammatory drugs: new alternatives for rheumatic disease.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Fenoprofen; Humans; Ibuprofen; Naproxen; Phenylpropionates; Pyrroles; Tolmetin | 1978 |
Tolmetin and agranulocytosis.
Topics: Agranulocytosis; Arthritis, Rheumatoid; Female; Humans; Middle Aged; Pyrroles; Tolmetin | 1978 |
Anaphylaxis from tolmetin.
Topics: Adult; Anaphylaxis; Arthritis, Rheumatoid; Female; Humans; Pruritus; Pyrroles; Tolmetin | 1978 |
[Clinical evaluation of Tolectin].
Topics: Adolescent; Adult; Aged; Digestive System; Drug Evaluation; Drug Tolerance; Female; Humans; Joint Diseases; Male; Middle Aged; Pyrroles; Tolmetin | 1978 |
Protein binding of tolmetin.
Topics: Adult; Aged; Arthritis, Rheumatoid; Binding Sites; Binding, Competitive; Erythrocytes; Female; Humans; In Vitro Techniques; Male; Middle Aged; Oleic Acids; Plasma; Protein Binding; Pyrroles; Serum Albumin; Tolmetin; Tryptophan | 1978 |
Effects of indomethacin and tolmetin on furosemide-induced changes in renin release.
Topics: Animals; Calcium; Dogs; Furosemide; Indomethacin; Kidney; Male; Potassium; Pyrroles; Renin; Sodium; Tolmetin | 1978 |
Micro-determination of tolmetin in plasma by electron-capture gas chromatography.
Topics: Arthritis, Juvenile; Chromatography, Gas; Humans; Microchemistry; Pyrroles; Tolmetin | 1978 |
Inhibition of prostaglandin synthetase by tolmetin (Tolectin, McN-2559), a new non-steroidal anti-inflammatory agent.
Topics: Animals; Aspirin; Cattle; Cyclooxygenase Inhibitors; Indomethacin; Kinetics; Male; Microsomes; Mixed Function Oxygenases; Prostaglandins E; Pyrroles; Seminal Vesicles; Structure-Activity Relationship; Tolmetin | 1976 |
High-pressure liquid chromatographic (HPLC) determination of tolmetin and its major metabolite in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Methods; Pyrroles; Time Factors; Tolmetin | 1977 |
Non-steroid anti-inflammatory drugs: combined assay for anti-edemic potency and gastric ulcerogenesis in the same animal.
Topics: Acacia; Adjuvants, Pharmaceutic; Animals; Aspartic Acid; Aspirin; Carrageenan; Diclofenac; Drug Evaluation, Preclinical; Edema; Female; Glucose; Glycyrrhiza; Male; Phenylacetates; Plants, Medicinal; Pyrroles; Rats; Salicylates; Stomach Ulcer; Tolmetin | 1977 |
Linear and nonlinear assessment of tolmetin pharmacokinetics.
Topics: Adult; Biological Availability; Half-Life; Humans; Kidney; Kinetics; Male; Methods; Models, Biological; Pyrroles; Time Factors; Tolmetin | 1977 |
New nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Naphthaleneacetic Acids; Naproxen; Phenylpropionates; Pyrroles; Tolmetin | 1976 |
[Clinical experiences with tolectin in rheumatic diseases (author's transl)].
Topics: Drug Evaluation; Female; Humans; Male; Middle Aged; Pyrroles; Rheumatic Diseases; Tolmetin | 1976 |
Determination of tolmetin in human plasma by GLC and spectrophotometric procedures.
Topics: Aspirin; Chromatography, Gas; Humans; Methods; Pyrroles; Salicylates; Spectrophotometry, Ultraviolet; Time Factors; Tolmetin | 1975 |
[Testing of the antirheumatic agent tolmetin for its interactions with oral anticoagulants].
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Coagulation; Drug Interactions; Female; Humans; Male; Middle Aged; Phenprocoumon; Pyrroles; Tolmetin | 1975 |
Absorption and excretion of tolemetin in man.
Topics: Aspirin; Biological Availability; Blood Proteins; Dose-Response Relationship, Drug; Half-Life; Humans; Kinetics; Male; Protein Binding; Pyrroles; Salicylates; Tablets; Tolmetin | 1976 |
Pharmacological properties and toxicology of MED-15, a prodrug of tolmetin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Glycine; Lethal Dose 50; Male; Peptic Ulcer; Prodrugs; Pyrroles; Rats; Rats, Wistar; Tolmetin | 1992 |
High-performance liquid chromatographic evaluation of Med 15 and its metabolites Med 5 and tolmetin in rat plasma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Gas; Chromatography, High Pressure Liquid; Glycine; Male; Mass Spectrometry; Pyrroles; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Tolmetin | 1991 |
Follow-up study of tolmetin users.
Topics: Adult; Aged; Aging; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peptic Ulcer; Product Surveillance, Postmarketing; Pyrroles; Sex Factors; Tolmetin | 1989 |
On the mechanism of the pharmacological activity of the new nonsteroidal antiinflammatory agent 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Carrageenan; Cell Migration Inhibition; Dinoprostone; In Vitro Techniques; Leukocytes; Lysosomes; Male; Prostaglandin Antagonists; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1989 |
Immune hemolytic anemia associated with tolmetin and suprofen.
Topics: Anemia, Hemolytic, Autoimmune; Autoantibodies; Coombs Test; Female; Humans; Middle Aged; Phenylpropionates; Pyrroles; Suprofen; Tolmetin | 1989 |
Recurrence and specificity of nephrotic syndrome due to tolmetin.
Topics: Female; Humans; Middle Aged; Nephrotic Syndrome; Pyrroles; Recurrence; Tolmetin | 1989 |
The excretion of ketorolac tromethamine into breast milk after multiple oral dosing.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female; Humans; Ketorolac Tromethamine; Milk, Human; Pyrroles; Tolmetin; Tromethamine | 1989 |
Effects of tolmetin sodium dihydrate on normal and postsurgical peritoneal cell function.
Topics: Animals; Cytotoxicity, Immunologic; Female; Injections, Intraperitoneal; Peritoneal Cavity; Peritoneum; Phagocytosis; Pyrroles; Rats; Superoxides; Time Factors; Tolmetin | 1988 |
The effects of pH, calcium and chloride ions on the binding of tolmetin to human serum albumin: circular dichroic, dialysis and fluorometric measurements.
Topics: Calcium; Chlorides; Circular Dichroism; Dialysis; Diazepam; Fluorometry; Humans; Hydrogen-Ion Concentration; Kinetics; Mathematics; Pyrroles; Serum Albumin; Tolmetin; Warfarin | 1987 |
Effect of preischemia cyclooxygenase inhibition by zomepirac sodium on reflow, cerebral autoregulation, and EEG recovery in the cat after global ischemia.
Topics: Animals; Brain; Cats; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Electroencephalography; Female; Homeostasis; Ischemic Attack, Transient; Male; Prostaglandins; Pyrroles; Tolmetin | 1986 |
Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat.
Topics: Animals; Arthritis; Arthritis, Experimental; Bone and Bones; Digestive System; Female; Indomethacin; Prodrugs; Pyrroles; Rats; Tolmetin | 1988 |
Statistical optimization of a reversed-phase ion-pair liquid chromatographic method for the analysis of tolmetin sodium in dosage forms.
Topics: Chromatography, High Pressure Liquid; Indicators and Reagents; Pyrroles; Tablets; Tolmetin | 1988 |
Effect of ketorolac on herpes simplex virus type one ocular infection in rabbits.
Topics: Administration, Topical; Animals; Conjunctivitis; Corneal Opacity; Corneal Ulcer; Dexamethasone; Drug Combinations; Iritis; Keratitis, Dendritic; Ketorolac Tromethamine; Male; Pyrroles; Rabbits; Time Factors; Tolmetin; Tromethamine | 1988 |
Adverse drug reaction processing in the United States and its dependence on physician reporting: zomepirac (Zomax) as a case in point.
Topics: Algorithms; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Drug Information Services; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Evaluation Studies as Topic; Humans; Physician's Role; Product Surveillance, Postmarketing; Pyrroles; Role; Tolmetin; United States; United States Food and Drug Administration | 1988 |
Effect of ketorolac on Pseudomonas aeruginosa ocular infection in rabbits.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Drug Therapy, Combination; Eye Diseases; Female; Ketorolac Tromethamine; Pseudomonas Infections; Pyrroles; Rabbits; Tobramycin; Tolmetin; Tromethamine | 1988 |
Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Half-Life; Humans; Injections, Intramuscular; Injections, Intravenous; Ketorolac Tromethamine; Metabolic Clearance Rate; Pyrroles; Tolmetin; Tromethamine | 1988 |
Percutaneous absorption of nicardipine and ketorolac in rhesus monkeys.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chromatography, High Pressure Liquid; Ketorolac; Ketorolac Tromethamine; Macaca mulatta; Nicardipine; Pharmaceutical Vehicles; Pyrroles; Skin Absorption; Solubility; Tolmetin; Tromethamine | 1988 |
The effect of indication on hypersensitivity reactions associated with zomepirac sodium and other nonsteroidal antiinflammatory drugs.
Topics: Adult; Aged; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Epidemiologic Methods; Female; Florida; Humans; Male; Medicaid; Middle Aged; Online Systems; Pyrroles; Risk Factors; Tolmetin | 1987 |
The quantitative effect of 0.5% ketorolac tromethamine solution and 0.1% dexamethasone sodium phosphate solution on postsurgical blood-aqueous barrier.
Topics: Adult; Aqueous Humor; Capillary Permeability; Cataract Extraction; Dexamethasone; Drug Combinations; Eye; Female; Fluorometry; Humans; Ketorolac Tromethamine; Lenses, Intraocular; Male; Middle Aged; Photometry; Postoperative Period; Pyrroles; Solutions; Tolmetin; Tromethamine | 1988 |
Disposition and irreversible plasma protein binding of tolmetin in humans.
Topics: Adult; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Female; Half-Life; Humans; Male; Pyrroles; Tolmetin | 1988 |
The effect of indication on the risk of hypersensitivity reactions associated with tolmetin sodium vs other nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Humans; Pyrroles; Regression Analysis; Retrospective Studies; Risk Factors; Tolmetin | 1988 |
Pharmacological study of the new nonsteroidal antiinflammatory agent 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Arthritis, Experimental; Carrageenan; Edema; Female; Gossypium; Guinea Pigs; Hemodynamics; Male; Mice; Platelet Aggregation; Psychomotor Performance; Pyrroles; Rats; Rats, Inbred Strains; Reaction Time; Stomach Ulcer; Tolmetin | 1988 |
Effect of ketorolac on Candida albicans ocular infection in rabbits.
Topics: Animals; Candidiasis; Dexamethasone; Endophthalmitis; Ketorolac Tromethamine; Pyrroles; Rabbits; Tolmetin; Tromethamine | 1987 |
Effects of steroidal and non-steroidal anti-inflammatory agents on corneal wound healing.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Epithelium; Ketorolac; Male; Prednisolone; Pyrroles; Rabbits; Time Factors; Tolmetin; Wound Healing | 1987 |
[Drug surveillance: example of bayesian imputation of an adverse reaction].
Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Bayes Theorem; Female; Humans; Pyrroles; Tolmetin | 1987 |
Ocular bioavailability and tissue distribution of [14C]ketorolac tromethamine in rabbits.
Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Drug Combinations; Female; Half-Life; Injections, Intravenous; Ketorolac Tromethamine; Ophthalmic Solutions; Pyrroles; Rabbits; Tissue Distribution; Tolmetin; Tromethamine | 1987 |
Tolmetin-warfarin interaction.
Topics: Drug Interactions; Humans; Male; Middle Aged; Prothrombin Time; Pyrroles; Tolmetin; Warfarin | 1987 |
High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Glucuronates; Humans; Indicators and Reagents; Isomerism; Pyrroles; Spectrophotometry, Ultraviolet; Tolmetin | 1987 |
Tolmetin-induced acute renal failure. A case report.
Topics: Acute Disease; Acute Kidney Injury; Humans; Male; Middle Aged; Nephritis, Interstitial; Peritoneal Dialysis; Pyrroles; Tolmetin | 1986 |
Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Glucuronates; Humans; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Probenecid; Pyrroles; Tolmetin | 1985 |
The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Creatine Kinase; Dogs; Drug Combinations; Eye; Guinea Pigs; Humans; Injections, Intramuscular; Irritants; Ketorolac; Ketorolac Tromethamine; Macaca mulatta; Male; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Tolmetin; Tromethamine | 1985 |
Reversible renal failure and nephrotic syndrome without interstitial nephritis from zomepirac.
Topics: Acute Kidney Injury; Aged; Biopsy; Creatinine; Female; Fluorescent Antibody Technique; Humans; Kidney; Microscopy, Electron; Middle Aged; Nephrosis, Lipoid; Proteinuria; Pyrroles; Tolmetin | 1985 |
Tolmetin-induced pseudoproteinuria.
Topics: False Positive Reactions; Humans; Male; Middle Aged; Proteinuria; Pyrroles; Tolmetin | 1986 |
Irreversible binding of zomepirac to plasma protein in vitro and in vivo.
Topics: Blood Proteins; Glucuronates; Humans; Hydrogen-Ion Concentration; Isomerism; Protein Binding; Pyrroles; Serum Albumin; Tolmetin | 1986 |
Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Ketorolac; Mice; Molecular Conformation; Pyrroles; Rats; Stereoisomerism; Tolmetin | 1986 |
Tolmetin in breast milk.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Milk, Human; Pyrroles; Tolmetin | 1985 |
Anaphylactic reactions to zomepirac.
Topics: Anaphylaxis; Anti-Inflammatory Agents; Female; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1985 |
Cost of Tolectin.
Topics: Costs and Cost Analysis; Humans; Pyrroles; Tolmetin | 1985 |
Tolmetin-induced urticaria/angioedema.
Topics: Angioedema; Humans; Pyrroles; Tolmetin; Urticaria | 1985 |
Anaphylactoid reactions to tolmetin after interrupted dosage.
Topics: Adult; Anaphylaxis; Aspirin; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pyrroles; Radioallergosorbent Test; Skin Tests; Tolmetin | 1985 |
Continuous body fluid monitoring for zomepirac by fully automated high-performance liquid chromatography.
Topics: Analgesics; Body Fluids; Chromatography, High Pressure Liquid; Humans; Pyrroles; Spectrophotometry, Ultraviolet; Tolmetin | 1985 |
Hydrochlorothiazide, amiloride and tolmetin in the treatment of diabetes insipidus of Brattleboro rats.
Topics: Amiloride; Animals; Blood; Diabetes Insipidus; Diuresis; Drug Therapy, Combination; Hydrochlorothiazide; Male; Natriuresis; Osmolar Concentration; Potassium; Pyrroles; Rats; Rats, Brattleboro; Sodium; Tolmetin; Urine | 1985 |
Zomepirac-induced anaphylactic shock: an under-reported phenomenon.
Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents; Female; Humans; Hypotension; Male; Middle Aged; Pyrroles; Tolmetin | 1985 |
Zomepirac overdose and review of literature on acute toxicity of nonsteroidal antiinflammatory agents.
Topics: Adult; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Bicarbonates; Charcoal; Gastrointestinal Hemorrhage; Humans; Ipecac; Kidney Function Tests; Male; Pyrroles; Tolmetin | 1982 |
Zomepirac: preclinical narcotic abuse liability evaluation.
Topics: Analgesics, Opioid; Animals; Discrimination, Psychological; Female; Humans; In Vitro Techniques; Macaca mulatta; Male; Mice; Morphine Dependence; Muscle, Smooth; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance-Related Disorders; Tolmetin | 1983 |
Zomepirac and cardiovascular deaths.
Topics: Analgesics; Cardiovascular Diseases; Humans; Pyrroles; Tolmetin | 1983 |
Government affairs. FDA Arthritis Advisory Committee Meeting.
Topics: Anaphylaxis; Drug Evaluation; Humans; Ibuprofen; Palliative Care; Pyrroles; Rheumatic Diseases; Tolmetin | 1983 |
Zomepirac-induced renal failure.
Topics: Acute Kidney Injury; Adult; Aged; Arthritis; Back Pain; Body Weight; Coronary Artery Bypass; Creatinine; Female; Headache; Humans; Male; Pain; Postoperative Complications; Pyrroles; Time Factors; Tolmetin | 1983 |
Evaluation of the analgesic properties of zomepirac.
Topics: Analgesics; Animals; Cattle; Cyclooxygenase Inhibitors; Drug Interactions; Hindlimb; Humans; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Platelet Aggregation; Pyrroles; Reaction Time; Receptors, Opioid; Substance-Related Disorders; Tolmetin | 1980 |
The effects of nonsteroidal anti-inflammatory analgesics on pain after periodontal surgery.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ibuprofen; Middle Aged; Pain, Postoperative; Periodontal Diseases; Placebos; Prospective Studies; Pyrroles; Tolmetin | 1984 |
Drugs recently released in Belgium.
Topics: Analgesics; Belgium; Drug and Narcotic Control; Ergolines; Etidronic Acid; Humans; Lisuride; Minoxidil; Pyrimidines; Pyrroles; Tolmetin | 1983 |
Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Auranofin; Aurothioglucose; Female; Glomerulonephritis; Gold; Humans; Middle Aged; Proteinuria; Pyrroles; Tolmetin | 1984 |
[Double-blind study of tolmetin osteoarthritis (author's transl)].
Topics: Adult; Aged; Back Pain; Double-Blind Method; Humans; Middle Aged; Naproxen; Osteoarthritis; Pyrroles; Spinal Diseases; Tolmetin | 1980 |
A new method for demonstration of central effects of analgesic agents in man.
Topics: Adult; Analgesics; Brain; Electric Stimulation; Evoked Potentials; Foot; Hand; Humans; Nerve Fibers; Nociceptors; Peripheral Nerves; Pyrroles; Sensory Thresholds; Tolmetin | 1984 |
Tolmetin induction of mania.
Topics: Arthritis; Bipolar Disorder; Female; Humans; Middle Aged; Psychoses, Substance-Induced; Pyrroles; Tolmetin | 1984 |
Influence of uremia and hemodialysis on the plasma protein binding of tolmetin.
Topics: Adult; Blood Proteins; Fatty Acids, Nonesterified; Female; Humans; Kinetics; Male; Protein Binding; Pyrroles; Renal Dialysis; Tolmetin; Uremia | 1984 |
Zomepirac sodium (Zomax) hypersensitivity in aspirin-sensitive asthmatics.
Topics: Adrenal Cortex Hormones; Adult; Aspirin; Asthma; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Middle Aged; Pyrroles; Tolmetin | 1984 |
Anaphylactic reaction due to zomepirac.
Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents; Humans; Male; Pyrroles; Tolmetin | 1984 |
Central effects of zomepirac on pain evoked by intraneural stimulation in man.
Topics: Adolescent; Adult; Double-Blind Method; Electric Stimulation; Humans; Neurons; Pain; Pyrroles; Tolmetin | 1984 |
Gastrointestinal ulcerogenic activity of tolmetin sodium in rats in comparison with those of indomethacin and aspirin.
Topics: Animals; Aspirin; Indomethacin; Male; Peptic Ulcer; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1984 |
[Screening and detection of the analgesic zomepirac].
Topics: Analgesics; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Mass Spectrometry; Photometry; Pyrroles; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tolmetin | 1984 |
[Pain reduction in patients undergoing periodontal surgery treated with zomepirac sodium].
Topics: Adult; Analgesics; Aspirin; Female; Humans; Male; Pain, Postoperative; Periodontal Diseases; Placebos; Pyrroles; Tolmetin | 1983 |
[Evaluation of the analgesic and anti-inflammatory drug "Zomepirac Na" in dental surgical pain].
Topics: Analgesics; Anti-Inflammatory Agents; Dental Care; Double-Blind Method; Drug Evaluation; Humans; Pain, Postoperative; Pyrroles; Tolmetin | 1984 |
Enhancement of deficient T-cell function in rheumatoid arthritis by tolmetin sodium.
Topics: Arthritis, Rheumatoid; Humans; In Vitro Techniques; Mitogens; Phytohemagglutinins; Pyrroles; T-Lymphocytes; Time Factors; Tolmetin | 1983 |
Comparative study of the gastrointestinal tolerability of tolmetin and 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole) acetate (AU-8001).
Topics: Animals; Feces; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Hemoglobins; Kinetics; Male; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1983 |
Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Pyrroles; Spectrophotometry, Ultraviolet; Tolmetin | 1984 |
Severe coronary spasm during zomepirac-induced allergic reaction.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Coronary Vasospasm; Drug Hypersensitivity; Female; Humans; Middle Aged; Pyrroles; Tolmetin | 1984 |
Anaphylactoid reaction to zomepirac.
Topics: Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Pyrroles; Respiratory Insufficiency; Tolmetin | 1983 |
Influence of uremia, hemodialysis, and nonesterified fatty acids on zomepirac plasma protein binding.
Topics: Adult; Aged; Drug Interactions; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Protein Binding; Pyrroles; Renal Dialysis; Tolmetin; Uremia | 1983 |
Sensitive gas chromatographic quantitation of zomepirac in plasma using an electron-capture detector.
Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Pyrroles; Tolmetin | 1983 |
Voltammetric studies of zomepirac sodium and its determination in tablets by differential-pulse polarography.
Topics: Hydrogen-Ion Concentration; Polarography; Pyrroles; Tablets; Tolmetin | 1983 |
[Nephrogenic diabetes insipidus possibly secondary to the ingestion of sodium zomepirac dihydrate].
Topics: Adult; Diabetes Insipidus; Humans; Male; Pyrroles; Tolmetin | 1983 |
Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals.
Topics: Alprostadil; Analgesics; Animals; Ascitic Fluid; Bradykinin; Dogs; Hypertension; Injections, Intraventricular; Male; Naloxone; Pain; Prostaglandins E; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1983 |
Tolmetin uptake into inflamed tissue in the rat.
Topics: Administration, Topical; Animals; Inflammation; Male; Muscles; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1983 |
Hypersensitivity to non-steroidal anti-inflammatory drugs--asthma precipitated by zomepirac. A case report.
Topics: Analgesics; Aspirin; Asthma; Humans; Male; Middle Aged; Pyrroles; Time Factors; Tolmetin | 1984 |
Furunculosis and hidradenitis suppurativa response.
Topics: Adolescent; Adult; Child; Child, Preschool; Furunculosis; Humans; Inflammation; Pyrroles; Sweat Gland Diseases; Tolmetin | 1984 |
Focal renal cortical necrosis associated with zomepirac.
Topics: Analgesics; Anaphylaxis; Female; Humans; Immunoglobulin E; Kidney Cortex; Kidney Cortex Necrosis; Lymphocyte Activation; Middle Aged; Pyrroles; Tolmetin; Toothache | 1984 |
A zomepirac reaction mimicking ectopic pregnancy.
Topics: Adult; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Hypotension; Pain; Pregnancy; Pregnancy, Ectopic; Pyrroles; Rupture, Spontaneous; Tolmetin | 1984 |
Nephrotic syndrome associated with use of the nonsteroidal anti-inflammatory drugs. Case report and review of the literature.
Topics: Aged; Anti-Inflammatory Agents; Female; Humans; Kidney Glomerulus; Nephrosis, Lipoid; Nephrotic Syndrome; Pyrroles; Tolmetin | 1984 |
[Pain therapy following meniscectomy. Comparison of zomepirac and tilidine].
Topics: Adult; Analgesics; Cyclohexanecarboxylic Acids; Female; Humans; Male; Menisci, Tibial; Pain, Postoperative; Pyrroles; Tilidine; Tolmetin | 1982 |
[Treatment of postoperative pain. Zomepirac, mefenamic acid and placebo].
Topics: Adult; Analgesics; Double-Blind Method; Humans; Mefenamic Acid; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin | 1982 |
Zomepirac sodium for primary dysmenorrhea syndrome.
Topics: Analgesics; Dysmenorrhea; Female; Humans; Pyrroles; Tolmetin | 1983 |
Zomepirac-related acute renal failure.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents; Female; Humans; Middle Aged; Pyrroles; Tolmetin | 1983 |
Nonoliguric renal failure associated with zomepirac.
Topics: Acute Kidney Injury; Analgesics; Humans; Male; Middle Aged; Oliguria; Pain; Pyrroles; Tolmetin | 1983 |
Reversed-phase high-performance liquid chromatographic assay for zomepirac in urine.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Pyrroles; Tolmetin | 1983 |
Zomepirac-induced serum sickness. A report of two cases.
Topics: Adult; Analgesics; Drug Hypersensitivity; Humans; Male; Middle Aged; Pain; Pyrroles; Serum Sickness; Tolmetin | 1983 |
Anaphylactoid reactions to tolmetin and zomepirac.
Topics: Adult; Anaphylaxis; Humans; Male; Pyrroles; Respiratory Function Tests; Skin Tests; Structure-Activity Relationship; Time Factors; Tolmetin | 1983 |
Renal failure and tubular dysfunction due to zomepirac therapy.
Topics: Acidosis, Renal Tubular; Aged; Analgesics; Female; Humans; Joint Diseases; Kidney Failure, Chronic; Middle Aged; Pain; Pyrroles; Tolmetin | 1983 |
Nephrotic range pseudoproteinuria in a tolmetin-treated patient.
Topics: False Positive Reactions; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Nephrotic Syndrome; Precipitin Tests; Proteinuria; Pyrroles; Tolmetin | 1983 |
Severe anaphylaxis and drug-induced beta-blockade.
Topics: Analgesics; Anaphylaxis; Female; Humans; Male; Middle Aged; Propranolol; Pyrroles; Tolmetin | 1983 |
Anaphylaxis following zomepirac ingestion.
Topics: Analgesics; Anaphylaxis; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1983 |
High-performance liquid chromatographic assay for zomepirac and its main metabolite in urine.
Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Pyrroles; Tolmetin | 1983 |
Anti-inflammatory and antiarthritic evaluation of acetaminophen and its potentiation of tolmetin.
Topics: Acetaminophen; Animals; Arthritis; Arthritis, Experimental; Drug Evaluation, Preclinical; Drug Therapy, Combination; Extremities; Female; Pyrroles; Radiography; Rats; Tolmetin | 1983 |
Long-term therapy with tolmetin in rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrroles; Time Factors; Tolmetin | 1983 |
Clinical pharmacology of tolmetin: comparisons in rheumatoid arthritis patients and normal volunteers.
Topics: Adult; Arthritis, Rheumatoid; Biological Availability; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Prostaglandins E; Pyrroles; Synovial Fluid; Tolmetin | 1983 |
Zomepirac sodium. Learn about this potent new non-narcotic analgesic.
Topics: Adult; Analgesics; Child; Female; Humans; Male; Pain; Pyrroles; Tolmetin | 1981 |
Nonsteroidal anti-inflammatory agents, Part IV - A new analgesic: zomepirac.
Topics: Analgesics; Humans; Pyrroles; Tolmetin | 1982 |
[Drug knowledge: zomepirac (sodium) (Zomax)].
Topics: Adult; Humans; Pain, Postoperative; Pyrroles; Tolmetin | 1982 |
Zomax.
Topics: Analgesics; Anti-Inflammatory Agents; Pyrroles; Tolmetin | 1982 |
[Analgesic effects of McN-2783 to post-extraction pain--preliminary test for the determination of proper dosage].
Topics: Adolescent; Adult; Analgesics; Drug Evaluation; Female; Humans; Male; Middle Aged; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction | 1982 |
[Zomax--progress in analgesia. A new, non-narcotic analgesic].
Topics: Analgesics; Humans; Kinetics; Pain; Pyrroles; Tolmetin | 1981 |
Tolmetin sodium in the management of nephrogenic diabetes insipidus.
Topics: Child, Preschool; Diabetes Insipidus; Dinoprostone; Humans; Kidney Tubules, Collecting; Male; Prostaglandins E; Pyrroles; Tolmetin | 1982 |
[Analgesic effect of McN-2783 (Zomepirac sodium) for postextraction pain].
Topics: Analgesics; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction | 1982 |
Apparent anaphylactic reaction to zomepirac (Zomax)
Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Pyrroles; Tolmetin | 1981 |
Tolmetin sodium in clinical practice: a survey of 32,207 treated patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Female; Humans; Male; Middle Aged; Pyrroles; Rheumatic Diseases; Tolmetin | 1981 |
[Effect of a non-steroidal anti-inflammatory drug, tolmetin sodium on arthritic pain, traumatic edema and LPS-induced fever (author's transl)].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Edema; Fever; Lipopolysaccharides; Male; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1981 |
Zomepirac (Zomax).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Pyrroles; Tolmetin | 1982 |
Zomepirac and renal failure.
Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Humans; Male; Pyrroles; Tolmetin | 1982 |
[Preliminary pharmacological studies of a new anti-inflammatory agent: 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation, Preclinical; Edema; Male; Pain; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1982 |
[Analgesic activity of a non-steroidal antiinflammatory drug, zomepirac sodium, in experimental animals].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Pressure; Bradykinin; Dogs; Edema; Female; Lethal Dose 50; Male; Mice; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Tolmetin | 1982 |
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cardiovascular System; Central Nervous System; Digestive System; Edema; Granuloma; Ketorolac; Mice; Mice, Inbred Strains; Pain; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1982 |
Induced esophageal ulceration.
Topics: Adult; Esophageal Diseases; Humans; Male; Pyrroles; Tolmetin; Ulcer | 1982 |
Nonsteroidal anti-inflammatory: zomepirac sodium.
Topics: Aged; Anti-Inflammatory Agents; Humans; Pain; Pyrroles; Tolmetin | 1982 |
Anaphylactic shock, acute renal failure, and disseminated intravascular coagulation. Suspected complications of zomepirac.
Topics: Acute Kidney Injury; Aged; Anaphylaxis; Disseminated Intravascular Coagulation; Humans; Male; Pain; Pyrroles; Tolmetin | 1982 |
Liquid-chromatographic determination of zomepirac in serum and plasma.
Topics: Adult; Analgesics; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Kinetics; Male; Pyrroles; Tolmetin | 1982 |
[Treatment of acute gout attacks with tolmetin (author's transl)].
Topics: Acute Disease; Adult; Aged; Analgesia; Gout; Humans; Male; Middle Aged; Pyrroles; Tolmetin; Uric Acid | 1982 |
Near fatal bronchospasm induced by zomepirac sodium.
Topics: Adult; Aspirin; Bronchial Spasm; Drug Hypersensitivity; Humans; Male; Pyrroles; Tolmetin | 1982 |
Reversible nonoliguric acute renal failure associated with zomepirac therapy.
Topics: Acute Kidney Injury; Aged; Analgesics; Creatinine; Female; Humans; Kidney Glomerulus; Pyrroles; Tolmetin | 1982 |
Anaphylactic reaction to zomepirac.
Topics: Analgesics; Anaphylaxis; Anti-Inflammatory Agents; Blood Pressure; Epinephrine; Female; Humans; Hypersensitivity, Immediate; Middle Aged; Pruritus; Pyrroles; Rhinitis, Allergic, Seasonal; Seizures; Tolmetin | 1982 |
Tolmetin-induced anaphylactoid reactions.
Topics: Anaphylaxis; Humans; Pyrroles; Tolmetin | 1982 |
Non-steroidals ineffective in OA.
Topics: Humans; Ibuprofen; Osteoarthritis; Placebos; Pyrroles; Tolmetin | 1982 |
Tolmetin kinetics and synovial fluid prostaglandin E levels in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Prostaglandins E; Pyrroles; Synovial Fluid; Tolmetin | 1982 |
[A drug fights pain on two levels].
Topics: Analgesics; Humans; Nociceptors; Pain; Pyrroles; Tolmetin | 1982 |
Zomepirac, interstitial nephritis, and renal failure.
Topics: Acute Kidney Injury; Female; Humans; Male; Middle Aged; Nephritis, Interstitial; Pyrroles; Tolmetin | 1982 |
A rapid sensitive determination of carprofen and zomepirac using thin-layer chromatography and gas chromatography--mass spectrometry.
Topics: Animals; Carbazoles; Chromatography, Thin Layer; Doping in Sports; Gas Chromatography-Mass Spectrometry; Horses; Pyrroles; Tolmetin | 1982 |
Effect of a major metabolite on the plasma protein binding of tolmetin.
Topics: Blood Proteins; Humans; Protein Binding; Pyrroles; Tolmetin | 1982 |
Drug-induced failure.
Topics: Acute Kidney Injury; Humans; Pyrroles; Tolmetin | 1982 |
[Anti-inflammatory activity of a non-steroidal anti-inflammatory agent, zomepirac sodium, in experimental animals].
Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Permeability; Depression, Chemical; Edema; Guinea Pigs; In Vitro Techniques; Male; Mice; Peptic Ulcer; Prostaglandins; Protein Denaturation; Pyrroles; Rabbits; Rats; Tolmetin | 1982 |
Simultaneous determination of tolmetin and its metabolite in biological fluids by high-performance liquid chromatography.
Topics: Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Humans; Pyrroles; Synovial Fluid; Tolmetin | 1982 |
Zomepirac.
Topics: Analgesics; Double-Blind Method; Humans; Prostaglandin Antagonists; Pyrroles; Tolmetin | 1982 |
Tolmetin-induced thrombocytopenia.
Topics: Child, Preschool; Female; Humans; Pyrroles; Thrombocytopenia; Tolmetin | 1982 |
Disposition of zomepirac sodium in man.
Topics: Adult; Analgesics; Glucuronates; Half-Life; Humans; Hydroxylation; Male; Pyrroles; Time Factors; Tolmetin | 1982 |
Acute thrombocytopenic purpura traced to tolmetin-related antibody.
Topics: Acute Disease; Antibody Formation; Blood Platelets; Female; Humans; Middle Aged; Platelet Count; Purpura, Thrombocytopenic; Pyrroles; Tolmetin | 1982 |
Tolmetin. Association with reversible renal failure and acute interstitial nephritis.
Topics: Acute Disease; Acute Kidney Injury; Aged; Biopsy; Female; Humans; Kidney; Nephritis, Interstitial; Osteoarthritis; Pyrroles; Tolmetin | 1981 |
Site of analgesic action of a non-steroidal, anti-inflammatory drug, tolmetin sodium, in rats.
Topics: Administration, Oral; Animals; Ascitic Fluid; Injections, Intraperitoneal; Injections, Intravenous; Male; Pain; Peritoneum; Pyrroles; Rats; Tolmetin | 1981 |
Plasma protein binding of zomepirac sodium.
Topics: Animals; Blood Proteins; Humans; Macaca mulatta; Mice; Protein Binding; Pyrroles; Rats; Salicylates; Species Specificity; Tolmetin; Warfarin | 1981 |
Nephrotic syndrome induced by tolmetin.
Topics: Arthritis, Rheumatoid; Aspirin; Female; Humans; Middle Aged; Nephritis, Interstitial; Nephrotic Syndrome; Pyrroles; Tolmetin | 1981 |
Effects of zomepirac and indomethacin on renal blood flow and electrolyte excretion in anesthetized monkeys.
Topics: Anesthesia; Animals; Electrolytes; Glomerular Filtration Rate; Indomethacin; Macaca mulatta; Male; Pyrroles; Renal Circulation; Tolmetin | 1981 |
Dose-dependent pharmacokinetics and renal handling of zomepirac in rhesus monkeys.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Female; Kidney; Kinetics; Macaca mulatta; Male; Metabolic Clearance Rate; Pyrroles; Tolmetin | 1981 |
An unusual allergic reaction.
Topics: Erythema; Female; Humans; Pruritus; Pyrroles; Tolmetin | 1981 |
The use of tolmetin sodium in systemic onset juvenile rheumatoid arthritis.
Topics: Arthritis, Juvenile; Child; Humans; Male; Pleural Effusion; Pyrroles; Radiography, Thoracic; Suction; Tolmetin | 1981 |
Acute renal failure and zomepirac.
Topics: Acute Kidney Injury; Adult; Analgesics; Female; Humans; Pyrroles; Tolmetin | 1981 |
Zomepirac kinetics in healthy males.
Topics: Adult; Analgesics; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Kidney; Kinetics; Male; Metabolic Clearance Rate; Pyrroles; Tolmetin | 1980 |
Stability-indicating assay for tolmetin sodium in solid dosage forms.
Topics: Chromatography, Thin Layer; Drug Stability; Hydrolysis; Methods; Pyrroles; Tablets; Tolmetin | 1980 |
Synthesis and biological activity of 5-(4-chlorobenzoyl)-4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-acetic acid, a major metabolite of zomepirac sodium.
Topics: Analgesics; Animals; Arthritis, Experimental; Humans; In Vitro Techniques; Platelet Aggregation; Pyrroles; Rats; Stomach Ulcer; Tolmetin | 1980 |
Tolmetin anaphylactoid reaction.
Topics: Anaphylaxis; Drug Hypersensitivity; Humans; Male; Middle Aged; Neurodermatitis; Pruritus; Pyrroles; Tolmetin; Urticaria | 1980 |
Nonsteroidal anti-inflammatory intolerance. An anaphylactic reaction to tolmetin.
Topics: Anaphylaxis; Female; Humans; Middle Aged; Pyrroles; Tolmetin | 1980 |
Reaction to tolmetin explained.
Topics: Drug Hypersensitivity; Humans; Male; Pyrroles; Tolmetin | 1980 |
Severe psoriasis and tolmetin sodium therapy.
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Male; Psoriasis; Pyrroles; Tolmetin | 1980 |
Tolmetin-induced aseptic meningitis.
Topics: Adult; Female; Fever; Humans; Ibuprofen; Knee; Lupus Erythematosus, Systemic; Meningitis; Meningitis, Aseptic; Pain; Pyrroles; Tolmetin | 1981 |
Anaphylaxis from tolmetin.
Topics: Anaphylaxis; Humans; Male; Middle Aged; Pyrroles; Tolmetin | 1980 |
[Pharmacokinetics of tolectin (tolmetin) in serum and in the synovial fluid].
Topics: Humans; Pyrroles; Synovial Fluid; Tolmetin | 1980 |
[Antirheumatics in highly demanding sports].
Topics: Athletic Injuries; Humans; Pyrroles; Sports Medicine; Tolmetin | 1980 |
Gastrosparing effect of new antiinflammatory drug amtolmetin guacyl in the rat: involvement of nitric oxide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Gastric Mucosa; Glycine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Wistar; Tolmetin | 1999 |
Gastroprotective effects of amtolmetin guacyl: a new non-steroidal anti-inflammatory drug that activates inducible gastric nitric oxide synthase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Gastric Mucosa; Glycine; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pyrroles; Rats; Rats, Wistar; Tolmetin | 2002 |
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Catalase; Celecoxib; Colon; Cyclooxygenase 2 Inhibitors; Diclofenac; Gastric Mucosa; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glycine; Lipid Peroxidation; Liver; Male; Oxyphenonium; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfhydryl Compounds; Sulfonamides; Thiobarbituric Acid Reactive Substances; Tolmetin | 2007 |
Friedel-Crafts acylation of pyrroles and indoles using 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) as a nucleophilic catalyst.
Topics: Acylation; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Crystallography, X-Ray; Indoles; Models, Molecular; Molecular Structure; Pyrroles; Tolmetin | 2010 |
Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability.
Topics: Adenosine; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Diketopiperazines; Glycine; Heterocyclic Compounds, 4 or More Rings; Intestinal Absorption; Intestinal Mucosa; Leukotriene Antagonists; Male; Mice; Mice, Knockout; Propionates; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Tolmetin; Vasodilator Agents; Verapamil | 2013 |