Page last updated: 2024-08-16

tolmetin and indomethacin

tolmetin has been researched along with indomethacin in 91 studies

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-199051 (56.04)18.7374
1990's20 (21.98)18.2507
2000's8 (8.79)29.6817
2010's12 (13.19)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bundgaard, H; Nielsen, NM1
Ariyan, ZS; Fogt, SW; Heilman, RD; Matthews, RJ; Powers, LJ; Rippin, DJ1
Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S1
Topliss, JG; Yoshida, F1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A1
Allegretti, M; Aramini, A; Aschi, M; Bertini, R; Bizzarri, C; Cesta, MC; Crucianelli, M; Di Bitondo, R; Di Giacinto, C; Gloaguen, I; Moriconi, A; Sablone, MR1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Bu, X; Cao, Y; Hu, X; Luo, M; Ren, Y; Song, Y; Wang, X; Xu, Q; Yuan, M1
Barton, P; Luker, T; Wenlock, MC1
Cheng, YK; Hu, X; Li, Z; Liu, M; Luo, HB; Yuan, M1
Kumar, M; Sinha, VR; Thareja, S1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Huskisson, EC1
Gerrard, JM; Peterson, DA; Rao, GH; White, JG1
Freeman, AM; Golding, DN; Steele, CE1
Bertelli, A; Schinetti, ML1
Brewer, EJ1
Evens, RP2
Roe, RL1
Perrotta, P; Silvestri, N1
Cohen, GN; Fisherman, EW1
Gussin, RZ; Hook, JB; Noordewier, B; Stygles, VG1
Bailie, MD; Hook, JB; Noordewier, B1
Aylward, M; Holly, F; Maddock, J; Parker, RJ; Thomas, SR1
Kaye, RL; Pemberton, RE1
Maibach, E1
Salata, JJ; Taylor, RJ1
Gross, D; Lobsiger, M; Rau, R1
Levy, JV1
Turner, R1
Janssen, PA; Niemegeers, CJ; Van Bruggen, JA1
Awouters, F; Janssen, PA; Lenaerts, PM; Niemegeers, CJ1
Janssen, PA; Lenaerts, FM; Niemegeers, CJ1
Awouters, F; Janssen, PA; Lenaerts, FM; Niemegeers, CJ1
Ehrlich, HP; Rockwell, WB1
Domer, F1
Carson, J; Fisher, MC; Persico, FJ; Pritchard, JF; Wong, S; Yorgey, K1
Alvarez, J; Blanco, A; Crespo, M; Herrero Beaumont, G; López-Linares, M; Rodríguez, A; Sánchez Villares, E; Solís, P; Taracena del Piñal, B1
Penning, TM; Smithgall, TE1
Gasparich, JP; Mayo, ME1
Hudyma, EO; Kollenberg, LO; Robbins, JM1
Macauley, D1
Anderson, R; Grabow, G; Oosthuizen, R1
Calin, A1
Faro, G; Michelotti, A; Sargiotto, A; Tarocco, RP1
Altman, RD1
Ward, JR1
Lanza, FL1
Bhalla, AK; Simon, LS1
Nakamura, H; Shimizu, M; Yokoyama, Y1
Court, H; Volans, GN1
Schlumpf, U1
Ciofalo, VB; Diamantis, W; Melton, J; Sofia, RD1
Zizic, TM1
Davies, J; Dixon, AS; Steele, CE1
Catalano, G; Gattoni, A; Manguso, L1
Shephard, NW; Steele, CE1
Handrich, L1
Lindsley, CB1
Chen, TT; Lanza, FL; Nelson, RS; Rack, MF; Royer, GL; Seckman, CE1
Hook, JB; Moore, GK; Noordewier, B; O'Neill, PJ; Yorgey, KA1
Sack, KE1
Hayes, JE; Moreden, JM; Morgan, DL; Nelson, M; Shrestha, M; Singh, R1
Atkins, DJ; Meyer zum Gottesberge, A; Nagyiványi, P; Pallapies, D; Peskar, BA; Rohleder, G; Salinger, A1
Foks, H; Kaliszan, R; Petrusewicz, J; Pilarski, B; Turowski, M1
Miranda, HF; Pinardi, G; Sierralta, F1
Cook, MJ; Morley-Forster, P; Newton, PT1
Bustamante, D; Paeile, C1
Butler, PO; El-Beheiry, H; Forse, A; Pace, RF1
Dodenhoff, RM1
Anson, N; Turner, GA; Williamson, R1
Hughes, PJ; Leake, T; Murrell, GC1
Benet, LZ; Lin, ET; Mizuma, T1
Boeckxstaens, GE; De Man, JG; De Winter, BY; Herman, AG; Moreels, TG; Pelckmans, PA1
Chatterjee, A; Frangouli, A; Kinsey, J; Morgan, PB; Shah, S1
Barragán, M; Bellosillo, B; Castaño, E; Colomer, D; Gil, J; Montserrat, E; Piqué, M; Pons, G; Villamor, N1
Corry, D; Moran, J1
Engebretsen, L; Reikeraas, O1
Dendrinou-Samara, C; Ekateriniadou, LV; Kessissoglou, DP; Kortsaris, AH; Kyriakidis, DA; Raptopoulou, CP; Terzis, A; Tsotsou, G1
Mardones, C; Ríos, A; Valcárcel, M1
Kennedy, JH; Korn, N; Thurston, RJ1
Cárdenas, S; Simonet, BM; Suárez, B; Valcárcel, M1
Atherton, J; Bauman, J; Kohl, C; Lam, W; Lou, Z; Mutlib, A; Reily, M; Walker, GS1
Cárdenas, S; Cruz-Vera, M; Lucena, R; Valcárcel, M1
Gardiner, P; Paine, SW1
Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC1
Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y1
Abdelall, EKA; Abdellatif, KRA; Fadaly, WAA; Labib, MB; Zidan, TH1

Reviews

11 review(s) available for tolmetin and indomethacin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Antiinflammatory drugs.
    Seminars in arthritis and rheumatism, 1977, Volume: 7, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Benzylidene Compounds; Child; Drug Evaluation; Female; Humans; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Mefenamic Acid; Naproxen; Phenylacetates; Phenylbutazone; Pregnancy; Pregnancy Complications; Propionates; Tolmetin

1977
Drug therapy in rheumatic diseases.
    The Medical clinics of North America, 1977, Volume: 61, Issue:2

    Topics: Acetaminophen; Adrenal Cortex Hormones; Antimalarials; Aspirin; Colchicine; Fenoprofen; Gold; Humans; Ibuprofen; Indomethacin; Levamisole; Naproxen; Penicillamine; Phenylbutazone; Rheumatic Diseases; Tolmetin

1977
Drug therapy reviews: antirheumatic agents.
    American journal of hospital pharmacy, 1979, Volume: 36, Issue:5

    Topics: Anti-Inflammatory Agents; Antimalarials; Glucocorticoids; Gold; Humans; Immunosuppressive Agents; Indomethacin; Mefenamic Acid; Penicillamine; Phenylbutazone; Phenylpropionates; Rheumatic Diseases; Salicylates; Sulindac; Tolmetin

1979
Treatment of rheumatoid arthritis: a review including newer and experimental anti-inflammatory agents.
    Archives of internal medicine, 1976, Volume: 136, Issue:9

    Topics: Activities of Daily Living; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin; Aurothioglucose; Fenoprofen; Humans; Ibuprofen; Immunosuppressive Agents; Indomethacin; Naproxen; Oxyphenbutazone; Penicillamine; Phenylbutazone; Physical Therapy Modalities; Tolmetin

1976
Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review.
    Journal of clinical pharmacology, 1983, Volume: 23, Issue:7

    Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Pyrroles; Spondylitis, Ankylosing; Tolmetin

1983
[Rheumatoid arthritis. Considerations on a rational therapeutic strategy].
    Minerva medica, 1984, Feb-28, Volume: 75, Issue:8

    Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Arthritis, Rheumatoid; Azathioprine; Gold; Humans; Indomethacin; Levamisole; Penicillamine; Phenylbutazone; Propionates; Salicylates; Sulindac; Tolmetin

1984
Review of ibuprofen for osteoarthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Meclofenamic Acid; Naproxen; Osteoarthritis; Phenylbutazone; Sulindac; Tolmetin

1984
Update on ibuprofen for rheumatoid arthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin

1984
[The introduction of non-steroidal antirheumatics: is there a rational therapy].
    Schweizerische medizinische Wochenschrift, 1982, Aug-28, Volume: 112, Issue:35

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbazoles; Chronic Disease; Diclofenac; Diflunisal; Humans; Indomethacin; ortho-Aminobenzoates; Osteoarthritis; Phenylbutazone; Piroxicam; Rheumatic Diseases; Salicylates; Thiazines; Tolmetin

1982
[Use of non-steroid anti-inflammatory agents in therapy].
    La Clinica terapeutica, 1981, Aug-31, Volume: 98, Issue:4

    Topics: Acetates; Anti-Inflammatory Agents; Central Nervous System; Digestive System; Humans; Indomethacin; Indoprofen; ortho-Aminobenzoates; Platelet Aggregation; Propionates; Pyrazoles; Salicylates; Tolmetin; Water-Electrolyte Balance

1981

Trials

20 trial(s) available for tolmetin and indomethacin

ArticleYear
A double-blind crossover study comparing tolmetin and indomethacin in the treatment of rheumatoid arthritis.
    Current medical research and opinion, 1977, Volume: 5, Issue:3

    Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Tolmetin

1977
[Evaluation of the therapeutic activity of a new nonsteroid antiphlogistic drug, Tolectin in rheumatoid arthritis].
    Il Farmaco; edizione pratica, 1977, Volume: 31, Issue:7

    Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Humans; Indomethacin; Pyrroles; Tolmetin

1977
Hypersensitivity to five non-steroidal anti-inflammatory agents: ibuprofen, fenoprofen, indomethacin, naproxen and tolmetin.
    Annals of allergy, 1978, Volume: 41, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Hypersensitivity; Fenoprofen; Humans; Ibuprofen; Indomethacin; Iodides; Naproxen; Tolmetin

1978
Evaluation of tolmetin in the treatment of arthritis: open and controlled double-blind studies.
    Current medical research and opinion, 1976, Volume: 4, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Pyrroles; Tolmetin

1976
European experiences with tolmetin in the treatment of rheumatic diseases.
    Current therapeutic research, clinical and experimental, 1976, Volume: 19, Issue:3

    Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Oxyphenbutazone; Placebos; Pyrroles; Rheumatic Diseases; Tolmetin; Wounds and Injuries

1976
[Treatment of severe osteoarthrosis of the knee and the hip with tolmentin. (A double-blind comparison with Indomethacin) (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1977, Feb-01, Volume: 66, Issue:5

    Topics: Bone Diseases; Drug Evaluation; Hip; Humans; Indomethacin; Joint Diseases; Knee; Pyrroles; Tolmetin

1977
Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review.
    Journal of clinical pharmacology, 1983, Volume: 23, Issue:7

    Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Pyrroles; Spondylitis, Ankylosing; Tolmetin

1983
Review of ibuprofen for osteoarthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Meclofenamic Acid; Naproxen; Osteoarthritis; Phenylbutazone; Sulindac; Tolmetin

1984
Update on ibuprofen for rheumatoid arthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin

1984
Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Aspirin; Buffers; Duodenum; Endoscopy; Female; Gastric Mucosa; Humans; Ibuprofen; Indomethacin; Intestinal Mucosa; Male; Middle Aged; Naproxen; Time Factors; Tolmetin

1984
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study.
    Current medical research and opinion, 1980, Volume: 7, Issue:2

    Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indomethacin; Middle Aged; Osteoarthritis; Pain; Pyrroles; Tolmetin

1980
Comparison of tolmetin sodium with indomethacin in osteoarthritis.
    The Practitioner, 1981, Volume: 225, Issue:1361

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Humans; Indomethacin; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin

1981
[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)].
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:8A

    Topics: Adult; Aged; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; In Vitro Techniques; Indoleacetic Acids; Indomethacin; Inflammation; Male; Middle Aged; Pain; Pyrroles; Tolmetin

1980
A comparative endoscopic evaluation of the damaging effects of nonsteroidal anti-inflammatory agents on the gastric and duodenal mucosa.
    The American journal of gastroenterology, 1981, Volume: 75, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Duodenum; Endoscopy; Gastric Mucosa; Humans; Ibuprofen; Indomethacin; Intestinal Mucosa; Middle Aged; Naproxen; Tolmetin

1981
Randomized double-blind comparison of the analgesic efficacy of intramuscular ketorolac and oral indomethacin in the treatment of acute gouty arthritis.
    Annals of emergency medicine, 1995, Volume: 26, Issue:6

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Double-Blind Method; Female; Gout Suppressants; Humans; Indomethacin; Injections, Intramuscular; Ketorolac Tromethamine; Male; Middle Aged; Pain Measurement; Prospective Studies; Tolmetin; Treatment Outcome; Tromethamine

1995
Ketorolac and indomethacin are equally efficacious for the relief of minor postoperative pain.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:12

    Topics: Administration, Rectal; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Fentanyl; Humans; Indomethacin; Injections, Intramuscular; Ketorolac; Middle Aged; Pain Measurement; Pain, Postoperative; Placebos; Prospective Studies; Suppositories; Time Factors; Tolmetin

1993
Indomethacin and ketorolac given preoperatively are equally effective in reducing early postoperative pain after laparoscopic cholecystectomy.
    Canadian journal of surgery. Journal canadien de chirurgie, 1996, Volume: 39, Issue:1

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cholecystectomy, Laparoscopic; Cholelithiasis; Double-Blind Method; Female; Humans; Indomethacin; Ketorolac; Male; Pain, Postoperative; Preoperative Care; Prospective Studies; Tolmetin

1996
A comparison of intramuscular ketorolac with indomethacin suppositories in the treatment of pain after oral surgery.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Injections, Intramuscular; Ketorolac; Male; Nausea; Pain Measurement; Pain, Postoperative; Single-Blind Method; Suppositories; Tolmetin; Tooth Extraction; Vomiting

1996
A comparison of the efficacy of ketorolac and indomethacin for postoperative analgesia following laparoscopic surgery in day patients.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:2

    Topics: Acute Kidney Injury; Administration, Rectal; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Indomethacin; Injections, Intramuscular; Ketorolac; Laparoscopy; Middle Aged; Pain Measurement; Pain, Postoperative; Placebos; Suppositories; Tolmetin

1996
Efficacy of topical nonsteroidal drops as pain relief after excimer laser photorefractive keratectomy.
    Journal of refractive surgery (Thorofare, N.J. : 1995), 1998, Volume: 14, Issue:2 Suppl

    Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Astigmatism; Cornea; Double-Blind Method; Humans; Indomethacin; Ketorolac; Lasers, Excimer; Myopia; Ophthalmic Solutions; Pain Measurement; Pain, Postoperative; Photorefractive Keratectomy; Safety; Tolmetin

1998

Other Studies

63 other study(ies) available for tolmetin and indomethacin

ArticleYear
Esters of N,N-disubstituted 2-hydroxyacetamides as a novel highly biolabile prodrug type for carboxylic acid agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:3

    Topics: Acetamides; Biotransformation; Carboxylic Acids; Half-Life; Humans; Indicators and Reagents; Kinetics; Structure-Activity Relationship

1987
Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemistry; Imidazoles; Lethal Dose 50; Locomotion; Male; Mice; Muscle Tonus; Nervous System; Orientation; Rats; Structure-Activity Relationship; Thiazoles

1981
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
    Molecular pharmacology, 1999, Volume: 55, Issue:5

    Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis

1999
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
    Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism

2005
Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
    Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

    Topics: Allosteric Regulation; Allosteric Site; Chemistry, Organic; Chemistry, Pharmaceutical; Chemotaxis; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Molecular Conformation; Mutagenesis; Mutation; Receptors, Interleukin-8A; Structure-Activity Relationship

2009
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies.
    Bioorganic & medicinal chemistry, 2011, Feb-01, Volume: 19, Issue:3

    Topics: Curcumin; Drug Design; Enzyme Inhibitors; Genetic Vectors; Humans; Inhibitory Concentration 50; Lactoylglutathione Lyase; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Molecular Targeted Therapy; Plasmids; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship

2011
Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Acids; Albumins; Drug Design; Humans; Hydrogen-Ion Concentration; Lipids; Molecular Structure; Pharmaceutical Preparations; Protein Binding

2011
Structural investigation into the inhibitory mechanisms of indomethacin and its analogues towards human glyoxalase I.
    Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14

    Topics: Binding Sites; Catalytic Domain; Humans; Indomethacin; Kinetics; Lactoylglutathione Lyase; Molecular Dynamics Simulation; Thermodynamics

2011
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Inhibition of ferrous iron induced oxidation of arachidonic acid by indomethacin.
    Prostaglandins and medicine, 1979, Volume: 2, Issue:2

    Topics: Arachidonic Acids; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ferrous Compounds; Ibuprofen; Indomethacin; Iron; Models, Chemical; Nitroblue Tetrazolium; Oxidation-Reduction; Tolmetin

1979
Activity of tolmetin on levels of cyclic nucleotides in experimental pleurisy.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:5

    Topics: Acetates; Animals; Cyclic AMP; Cyclic GMP; Indomethacin; Male; Pleurisy; Pyrroles; Rats; Tolmetin

1979
Nonsteroidal antiinflammatory agents.
    Arthritis and rheumatism, 1977, Volume: 20, Issue:2 Suppl

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child; Child, Preschool; Humans; Ibuprofen; Indomethacin; Infant; Phenylbutazone; Tolmetin

1977
Antirheumatic agents.
    The Journal of the Maine Medical Association, 1979, Volume: 70, Issue:4

    Topics: Adrenal Cortex Hormones; Antimalarials; Aspirin; Azathioprine; Chloroquine; Cyclophosphamide; Gold; Humans; Hydroxychloroquine; Immunosuppressive Agents; Indomethacin; Penicillamine; Phenylbutazone; Phenylpropionates; Rheumatic Diseases; Salicylates; Sulindac; Tolmetin

1979
Effect of tolmetin on renal function and prostaglandin metabolism.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:2

    Topics: Animals; Dogs; In Vitro Techniques; Indomethacin; Kidney; Male; Oxygen Consumption; Prostaglandins E; Pyrroles; Rats; Regional Blood Flow; Tolmetin

1978
Effects of indomethacin and tolmetin on furosemide-induced changes in renin release.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1978, Volume: 159, Issue:2

    Topics: Animals; Calcium; Dogs; Furosemide; Indomethacin; Kidney; Male; Potassium; Pyrroles; Renin; Sodium; Tolmetin

1978
Inhibition of prostaglandin synthetase by tolmetin (Tolectin, McN-2559), a new non-steroidal anti-inflammatory agent.
    Biochemical pharmacology, 1976, Nov-15, Volume: 25, Issue:22

    Topics: Animals; Aspirin; Cattle; Cyclooxygenase Inhibitors; Indomethacin; Kinetics; Male; Microsomes; Mixed Function Oxygenases; Prostaglandins E; Pyrroles; Seminal Vesicles; Structure-Activity Relationship; Tolmetin

1976
Changes in systolic arterial blood pressure in normal and spontaneously hypertensive rats produced by acute administration of inhibitors of prostaglandin biosynthesis.
    Prostaglandins, 1977, Volume: 13, Issue:1

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Benzothiazoles; Blood Pressure; Fenoprofen; Hypertension; Indomethacin; Meclofenamic Acid; Piperazines; Prostaglandin Antagonists; Prostaglandins; Rats; Thiazoles; Tolmetin

1977
Aspirin and newer anti-inflammatory agents in rheumatoid arthritis.
    American family physician, 1977, Volume: 16, Issue:1

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Peptic Ulcer; Phenylbutazone; Tolmetin

1977
Suprofen, a potent antagonist of acetic acid-induced writhing in rats.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Acetates; Analgesics; Animals; Arachidonic Acids; Aspirin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indomethacin; Ketoprofen; Male; Muscle Contraction; Phenylacetates; Phenylbutazone; Phenylpropionates; Prostaglandin Antagonists; Prostaglandins; Rats; Spasm; Thiophenes; Tolmetin

1975
Suprofen, a potent antagonist of ultraviolet-erythema in guinea-pigs.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythema; Guinea Pigs; Indomethacin; Ketoprofen; Male; Phenylbutazone; Phenylpropionates; Thiophenes; Time Factors; Tolmetin; Ultraviolet Rays

1975
The antipyretic effect of suprofen in rats with yeast-induced fever.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Analgesics; Animals; Aspirin; Body Temperature; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fever; Indomethacin; Male; Phenylbutazone; Phenylpropionates; Rats; Thiophenes; Time Factors; Tolmetin; Yeast, Dried

1975
The effects of suprofen in rats with Mycobacterium butyricum-induced arthritis.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Biometry; Body Weight; Bone and Bones; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Haptoglobins; Hindlimb; Indomethacin; Phenylbutazone; Phenylpropionates; Rats; Tarsal Joints; Thiophenes; Tolmetin

1975
An ibuprofen-antagonized plasmin inhibitor released by human endothelial cells.
    Experimental and molecular pathology, 1991, Volume: 54, Issue:1

    Topics: Antifibrinolytic Agents; Burns; Cells, Cultured; Cicatrix; Endothelium; Fibrinolysis; Hot Temperature; Humans; Ibuprofen; In Vitro Techniques; Indomethacin; Skin; Thrombosis; Tolmetin

1991
Characterization of the analgesic activity of ketorolac in mice.
    European journal of pharmacology, 1990, Feb-27, Volume: 177, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Ketorolac Tromethamine; Male; Mice; Morphine; Naloxone; Reaction Time; Tolmetin; Tromethamine

1990
Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Animals; Arthritis; Arthritis, Experimental; Bone and Bones; Digestive System; Female; Indomethacin; Prodrugs; Pyrroles; Rats; Tolmetin

1988
[Chronic arthritis. Round table].
    Anales espanoles de pediatria, 1987, Volume: 27 Suppl 29

    Topics: Adolescent; Adrenal Cortex Hormones; Arthritis, Juvenile; Aspirin; Autoantibodies; Child; Humans; Indomethacin; Naproxen; Penicillamine; Rheumatoid Factor; Tolmetin

1987
Inhibition of trans-dihydrodiol oxidation by the non-steroidal anti-inflammatory drugs.
    Carcinogenesis, 1986, Volume: 7, Issue:4

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Anti-Inflammatory Agents; Aspirin; Benzopyrenes; Dihydroxydihydrobenzopyrenes; Flufenamic Acid; Ibuprofen; Indomethacin; Liver; Male; Meclofenamic Acid; Mefenamic Acid; Oxidoreductases; Rats; Sulindac; Tolmetin

1986
Comparative effects of four prostaglandin synthesis inhibitors on the obstructed kidney in the dog.
    The Journal of urology, 1986, Volume: 135, Issue:5

    Topics: Animals; Blood Pressure; Dogs; Female; Ibuprofen; Indomethacin; Ketorolac; Kidney Pelvis; Naproxen; Pressure; Prostaglandin Antagonists; Tolmetin; Ureteral Obstruction

1986
Nonsteroidal anti-inflammatory agents. A review of the literature.
    Journal of the American Podiatric Medical Association, 1985, Volume: 75, Issue:10

    Topics: Absorption; Anti-Inflammatory Agents; Aspirin; Diflunisal; Drug Interactions; Female; Fenoprofen; Half-Life; Humans; Ibuprofen; Indomethacin; Kinetics; Meclofenamic Acid; Naproxen; Phenylbutazone; Piroxicam; Pregnancy; Thiazines; Tolmetin

1985
Worldwide experience with diclofenac in rheumatoid arthritis and osteoarthritis.
    Seminars in arthritis and rheumatism, 1985, Volume: 15, Issue:2 Suppl 1

    Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Humans; Indomethacin; Naproxen; Osteoarthritis; Sulindac; Tolmetin

1985
Prevention of peroxidase mediated inhibition of neutrophil motility and lymphocyte transformation by levamisole, OMPI, sodium aurothiomalate, indomethacin and tolmetin in vitro.
    International journal of immunopharmacology, 1981, Volume: 3, Issue:2

    Topics: Anti-Inflammatory Agents; Cell Migration Inhibition; Gold; Humans; Imidazoles; Imidazolidines; In Vitro Techniques; Indomethacin; Levamisole; Lymphocyte Activation; Neutrophils; Oxygen; Peroxidase; Phagocytosis; Superoxides; Tolmetin

1981
A clinical evaluation of the antiarthritic agents.
    Comprehensive therapy, 1984, Volume: 10, Issue:8

    Topics: Anti-Inflammatory Agents; Antimalarials; Arthritis; Aspirin; Diflunisal; Fenoprofen; Glucocorticoids; Gold; Humans; Ibuprofen; Immunosuppressive Agents; Indomethacin; Naproxen; ortho-Aminobenzoates; Penicillamine; Piroxicam; Prostaglandin Antagonists; Salicylates; Sulindac; Thiazines; Tolmetin

1984
Gastrointestinal ulcerogenic activity of tolmetin sodium in rats in comparison with those of indomethacin and aspirin.
    Chemical & pharmaceutical bulletin, 1984, Volume: 32, Issue:11

    Topics: Animals; Aspirin; Indomethacin; Male; Peptic Ulcer; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin

1984
Poisoning after overdose with non-steroidal anti-inflammatory drugs.
    Adverse drug reactions and acute poisoning reviews, 1984,Spring, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Child, Preschool; Diflunisal; Female; Fenoprofen; Feprazone; Humans; Ibuprofen; Indomethacin; Ketoprofen; London; Male; Mefenamic Acid; Naproxen; Oxyphenbutazone; Phenylbutazone; Piroxicam; Thiazines; Tolmetin

1984
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
    Toxicology and applied pharmacology, 1980, Mar-15, Volume: 52, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Biotransformation; Fenoprofen; Ibuprofen; Indomethacin; Male; Naproxen; Oxazines; Peptic Ulcer Hemorrhage; Phenylbutazone; Rats; Salicylates; Stomach Ulcer; Time Factors; Tolmetin

1980
Rheumatoid arthritis IV: non-steroidal anti-inflammatory agents use in treatment.
    Maryland state medical journal, 1982, Volume: 31, Issue:7

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone; Tolmetin

1982
Pharmacotherapy of juvenile rheumatoid arthritis.
    Pediatric clinics of North America, 1981, Volume: 28, Issue:1

    Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Child; Delayed-Action Preparations; Gold; Humans; Ibuprofen; Indomethacin; Penicillamine; Salicylates; Sulindac; Tolmetin

1981
Effects of zomepirac and indomethacin on renal blood flow and electrolyte excretion in anesthetized monkeys.
    Life sciences, 1981, Sep-28, Volume: 29, Issue:13

    Topics: Anesthesia; Animals; Electrolytes; Glomerular Filtration Rate; Indomethacin; Macaca mulatta; Male; Pyrroles; Renal Circulation; Tolmetin

1981
Arthritis: specifics on long-term management. Part II.
    Geriatrics, 1980, Volume: 35, Issue:11

    Topics: Anti-Inflammatory Agents; Arthritis; Gold; Humans; Immunosuppressive Agents; Indomethacin; Penicillamine; Propionates; Quinolines; Steroids; Sulindac; Tolmetin

1980
Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo.
    Life sciences, 1995, Volume: 57, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Clonixin; Cyclooxygenase Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Drug Combinations; Gastric Mucosa; Indomethacin; Isoenzymes; Ketorolac Tromethamine; Kidney; Lung; Lysine; Male; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Thromboxane B2; Tolmetin; Tromethamine

1995
Comparative studies of antiplatelet activity of nonsteroidal antiinflammatory drugs and new pyrazine CH- and NH-acids.
    Life sciences, 1995, Volume: 56, Issue:9

    Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Epinephrine; Fibrinolytic Agents; Humans; Indomethacin; Ketorolac; Male; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Pyrazines; Tolmetin

1995
Previous administration of indomethacin or naloxone did not influence ketorolac antinociception in mice.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:4

    Topics: Animals; Cecum; Cerebral Ventricles; Indomethacin; Injections, Intraperitoneal; Ketorolac; Mice; Naloxone; Time Factors; Tolmetin

1993
Ketorolac tromethamine: an experimental study of its analgesic effects in the rat.
    General pharmacology, 1993, Volume: 24, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Combinations; Electromyography; Formaldehyde; Indomethacin; Ketorolac Tromethamine; Morphine; Nociceptors; Pain Measurement; Prostaglandin Antagonists; Quinacrine; Rats; Rats, Wistar; Reflex; Tolmetin; Tromethamine

1993
Effect of ketorolac tromethamine on bleeding and on requirements for analgesia after total knee arthroplasty.
    The Journal of bone and joint surgery. American volume, 1996, Volume: 78, Issue:6

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Drug Synergism; Heparin, Low-Molecular-Weight; Humans; Indomethacin; Ketorolac Tromethamine; Knee Prosthesis; Pain, Postoperative; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Tolmetin; Tromethamine; Warfarin

1996
Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides.
    Preparative biochemistry & biotechnology, 1998, Volume: 28, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Clofibrate; Flufenamic Acid; Furosemide; Glucuronates; Glucuronidase; Indomethacin; Mass Spectrometry; Molecular Structure; Probenecid; Tolmetin

1998
Differential effect of indomethacin and ketorolac on postoperative ileus in rats.
    European journal of pharmacology, 1998, Feb-26, Volume: 344, Issue:1

    Topics: Animals; Disease Models, Animal; Indomethacin; Intestinal Obstruction; Ketorolac; Nitric Oxide; Nitroarginine; Postoperative Complications; Prostaglandin Antagonists; Rats; Tolmetin

1998
Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells.
    Blood, 1998, Aug-15, Volume: 92, Issue:4

    Topics: Aged; Amino Acid Chloromethyl Ketones; Annexins; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; B-Lymphocytes; Cell Survival; Cyclooxygenase Inhibitors; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Activation; Female; Humans; Indomethacin; Ketorolac; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Proteins; Nitrobenzenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Salicylates; Salicylic Acid; Sulfonamides; Tolmetin; Tumor Cells, Cultured

1998
Assessment of acrylic bone cement as a local delivery vehicle for the application of non-steroidal anti-inflammatory drugs.
    Biomaterials, 1998, Volume: 19, Issue:14

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Cements; Cells, Cultured; Delayed-Action Preparations; Dinoprostone; Drug Carriers; Fibroblasts; Humans; Indomethacin; Mefenamic Acid; Periodontal Ligament; Periodontitis; Polymethyl Methacrylate; Tolmetin

1998
Effects of ketoralac tromethamine and indomethacin on primary and secondary bone healing. An experimental study in rats.
    Archives of orthopaedic and trauma surgery, 1998, Volume: 118, Issue:1-2

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Femur; Indomethacin; Ketorolac Tromethamine; Male; Osteotomy; Radiography; Rats; Rats, Wistar; Time Factors; Tolmetin; Tromethamine; Wound Healing

1998
Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions.
    Journal of inorganic biochemistry, 1998, Volume: 71, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Cadmium; Cations, Divalent; Cell Division; Cell Line; Chelating Agents; Cricetinae; Crystallography, X-Ray; Drug Interactions; Humans; Ibuprofen; In Vitro Techniques; Indomethacin; Ligands; Models, Molecular; Platinum; Structure-Activity Relationship; Tolmetin; Tumor Cells, Cultured; Zinc

1998
Determination of nonsteroidal anti-inflammatory drugs in biological fluids by automatic on-line integration of solid-phase extraction and capillary electrophoresis.
    Electrophoresis, 2001, Volume: 22, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Automation; Chromatography, Micellar Electrokinetic Capillary; Humans; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutyrates; Tolmetin

2001
Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility.
    Reproductive biology and endocrinology : RB&E, 2003, Oct-09, Volume: 1

    Topics: Alprostadil; Animals; Aspirin; Cell Membrane; Cryopreservation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Resveratrol; Semen; Semen Preservation; Sperm Motility; Spermatozoa; Stilbenes; Sulfonamides; Tolmetin; Turkeys

2003
Determination of non-steroidal anti-inflammatory drugs in urine by combining an immobilized carboxylated carbon nanotubes minicolumn for solid-phase extraction with capillary electrophoresis-mass spectrometry.
    Journal of chromatography. A, 2007, Aug-03, Volume: 1159, Issue:1-2

    Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Acids; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Indomethacin; Ketoprofen; Methanol; Nanotubes, Carbon; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tolmetin; Urine

2007
Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.
    Chemical research in toxicology, 2007, Volume: 20, Issue:6

    Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Chromatography, Liquid; Cyclooxygenase Inhibitors; Diclofenac; Drug Stability; Flufenamic Acid; Glucuronides; Half-Life; Ibuprofen; Indomethacin; Kinetics; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mefenamic Acid; Molecular Structure; Rats; Rats, Sprague-Dawley; Stereoisomerism; Technology, Pharmaceutical; Tolmetin

2007
Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples.
    Journal of chromatography. A, 2008, Aug-15, Volume: 1202, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Fractionation; Flurbiprofen; Humans; Hydrogen-Ion Concentration; Indomethacin; Ionic Liquids; Ketoprofen; Molecular Structure; Naproxen; Phenylbutyrates; Reproducibility of Results; Tolmetin

2008
The impact of hepatic uptake on the pharmacokinetics of organic anions.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:10

    Topics: Animals; Anions; Benzimidazoles; Benzoates; Bile Ducts; Dogs; Hepatocytes; Humans; Indomethacin; Liver; Losartan; Male; Models, Biological; Muscles; Organic Chemicals; Pharmaceutical Preparations; Protein Binding; Rats; Rats, Sprague-Dawley; Sulfisoxazole; Telmisartan; Tolmetin

2011
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
    Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts

2012
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin

2012
Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.
    Bioorganic chemistry, 2019, Volume: 90

    Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Gastric Mucosa; Humans; Indomethacin; Inflammation; Molecular Docking Simulation; Protein Binding; Rats; Tolmetin

2019