Page last updated: 2024-08-16

tolbutamide and warfarin

tolbutamide has been researched along with warfarin in 95 studies

Research

Studies (95)

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (46.32)	18.7374
1990's	12 (12.63)	18.2507
2000's	13 (13.68)	29.6817
2010's	24 (25.26)	24.3611
2020's	2 (2.11)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Carrupt, PA; Martel, S; Ottaviani, G	1
Briand, X; Faller, B; Lázaro, E; Lowe, PJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Conradi, R; Lee, PH; Shanmugasundaram, V	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Birkett, DJ; Graham, GG; Pond, SM; Wade, DN	1
Hansen, M; Kristensen, M; Siersbaek-Nielsen, K; Skovsted, L	1
Gugler, R	1
Ryan, MP; Wosilait, WD	1
Kapoor, A; Veronich, K; White, G	1
Wosilait, WD	1
Brown, KF; Crooks, MJ	1
Ackermann, E	1
Pepper, ES; Wosilait, WD	1
Assandri, A; Perazzi, A	1
De Baere, H	1
Hansen, JM; Kampmann, J; Lumholtz, B; Siersbaek-Nielsen, K; Skovsted, L	1
Hage, DS; Noctor, TA; Wainer, IW	1
Rieth, H; Sauerbrey, N	1
Back, DJ; Stevenson, P; Tjia, JF	1
Ryan, JR	1
Chaumeil, JC; Decroix, MO; Tillement, JP; Zini, R	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y	1
Judis, J	1
Poucher, RL; Vecchio, TJ	1
Hsu, PL; Luzzi, LA; Ma, JK	1
Hüthwohl, B; Jähnchen, E	1
Heine, P; Kewitz, H; Wiegboldt, KA	1
Sellers, E; Weser, JK	1
Schlossmann, K	1
Eipe, J	1
Andreasen, PB; Vesell, ES	1
Eisenbrandt, LL; Wosilait, WD	1
Durno, D; Howie, JG; Petrie, JC	1
MacLennan, WJ	1
Iber, FL; Kater, RM; Roggin, G; Tobon, F; Zieve, P	1
Freeman, RG; Knox, JM; Murtishaw, W	1
Abrams, WB; Reich, S; Solomon, HM; Spirt, N	1
Abdel-Maguid, R; el-Dakhakhny, M; Mahfouz, M	1
Brody, BB	1
Katz, J; Levine, DA; Rosen, N	1
Schrogie, JJ; Solomon, HM; Williams, D	1
Duckert, F; Seiler, K	1
Hitzenberger, G	1
Papouchado, M; Reed, PI; Thornton, PC	1
Goldberg, DM	1
Birkett, DJ; Foenander, T; Gallus, AS; Miners, JO; Wanwimolruk, S	1
Byington, KH; Ryan, MP; Wosilait, WD	1
Chao, D; Luders, RC	1
Bradbury, A; Houston, JB; Worboys, PD	1
Gonzalez, FJ; Korzekwa, KR; Rettie, AE; Trager, WF; Wienkers, LC	1
Kunze, KL; Trager, WF	1
Dong, MS; Gillam, EM; Guengerich, FP; Johnson, WW; Shimada, T; Yamazaki, H	1
Gonzalez, FJ; Korzekwa, KR; Marra, C; Tracy, TS; Wrighton, SA	1
Shimada, T; Yamazaki, H	1
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T	1
Inoue, T; Kuroiwa, Y; Nakajima, M; Shimada, N; Tokudome, S; Yamamoto, T	1
Inoue, K; Shimada, T; Yamazaki, H	1
Birkett, DJ; Miners, JO	1
Belpaire, FM; De Vriendt, C; Hemeryck, A	1
Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P	1
Azuma, J; Fukuda, T; Funae, Y; Hanatani, T; Onishi, S	1
Horie, T; Ji, B; Masubuchi, Y	1
Feng, R; Mandula, H; Parepally, JM; Smith, QR	1
Gorman, LA; Kumar, V; Rock, DA; Tracy, TS; Wahlstrom, JL; Warren, CJ	1
Barter, ZE; Crewe, HK; Rostami-Hodjegan, A; Yeo, KR	1
Andersson, K; Ekstrand, B; Rasmussen, MK; Tomankova, J; Zamaratskaia, G	1
Lu, Y; Zhai, X	1
Hirasawa, N; Hiratsuka, M; Ito, M; Niinuma, Y; Saito, T; Takahashi, M; Tsukada, C	1
Beijnen, JH; Goey, AK; Huijbregts, TJ; Maas-Bakker, RF; Meijerman, I; Mooiman, KD; Schellens, JH	1
Inoue, T; Kawano, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H	1
Lei, D; Li, X; Liu, Y; Lu, J; Wei, J; Yan, S	1
Gong, Z; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zheng, J; Zheng, L	1
Liu, L; Liu, X; Tang, X; Wang, S; Xu, J; Yang, T; Zhang, J	1
Chen, M; Li, X; Lu, J; Wang, T; Wei, J; Xie, S	1
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N	1
Cai, JP; Chen, H; Chong, J; Dai, DP; Geng, PW; Liu, J; Lü, Y; Wang, SH; Wu, HL; Yang, JF; Zhou, Q; Zhou, S	1

Reviews

6 review(s) available for tolbutamide and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:5 Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin	1985
Drug interactions with coumarin anticoagulants. 2. The New England journal of medicine, 1971, Sep-02, Volume: 285, Issue:10 Topics: Allopurinol; Anabolic Agents; Animals; Anti-Bacterial Agents; Anticoagulants; Barbiturates; Chloral Hydrate; Chloramphenicol; Cholestyramine Resin; Clofibrate; Contraceptives, Oral; Coumarins; Dextrothyroxine; Diuretics; Drug Antagonism; Drug Synergism; Ethacrynic Acid; Ethanol; Glucagon; Glucocorticoids; Glutethimide; Humans; Oxyphenbutazone; Phenylbutazone; Quinidine; Quinine; Quinolines; Salicylates; Sulfinpyrazone; Sulfonamides; Thyroid Hormones; Tolbutamide	1971
Drugs affecting therapy with anticoagulants. The Medical clinics of North America, 1972, Volume: 56, Issue:1 Topics: Anticoagulants; Chloramphenicol; Clofibrate; Contraceptives, Oral; Coumarins; Diuretics; Drug Interactions; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Estrogens; Ethanol; Heparin; Humans; Hypnotics and Sedatives; Phenylbutazone; Phenytoin; Salicylates; Thyroxine; Tolbutamide; Vitamin K	1972
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry. Clinical chemistry, 1980, Volume: 26, Issue:6 Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; Energy Intake; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Smoking; Tolbutamide; Warfarin	1980
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. British journal of clinical pharmacology, 1998, Volume: 45, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Repression; Humans; Pharmaceutical Preparations; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfonamides; Tolbutamide; Torsemide; Warfarin	1998

Trials

4 trial(s) available for tolbutamide and warfarin

Article	Year
The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism. Acta medica Scandinavica, 1976, Volume: 199, Issue:6 Topics: Coumarins; Dicumarol; Half-Life; Humans; Phenindione; Phenprocoumon; Phenytoin; Tolbutamide; Warfarin	1976
[Interaction studies with fluconazole, a new triazole antifungal drug]. Wiener medizinische Wochenschrift (1946), 1989, Aug-31, Volume: 139, Issue:15-16 Topics: Adult; Antipyrine; Cimetidine; Clinical Trials as Topic; Contraceptives, Oral; Cyclosporins; Double-Blind Method; Drug Interactions; Female; Fluconazole; Humans; Male; Testosterone; Tolbutamide; Warfarin	1989
Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:6 Topics: Administration, Oral; Adult; Antipyrine; Clinical Trials as Topic; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Liver Cirrhosis; Male; Middle Aged; Solutions; Spectrophotometry, Ultraviolet; Time Factors; Tolbutamide; Warfarin	1974
Increased rate of clearance of drugs from the circulation of alcoholics. The American journal of the medical sciences, 1969, Volume: 258, Issue:1 Topics: Alcoholism; Clinical Trials as Topic; Ethanol; Humans; Liver; Microsomes; Phenytoin; Tolbutamide; Warfarin	1969

Other Studies

85 other study(ies) available for tolbutamide and warfarin

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption	2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Effects of tricyclic antidepressants on drug metabolism. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:2 Topics: Adult; Amitriptyline; Dicumarol; Half-Life; Humans; Kinetics; Male; Nortriptyline; Pharmaceutical Preparations; Phenytoin; Time Factors; Tolbutamide; Warfarin	1975
[Drug interactions in therapy using coumarin derivatives]. Der Internist, 1979, Volume: 20, Issue:5 Topics: Allopurinol; Anti-Inflammatory Agents; Barbiturates; Biological Availability; Cholestyramine Resin; Coumarins; Drug Interactions; Humans; Metronidazole; Phenylbutazone; Rifampin; Sulfonamides; Tolbutamide	1979
The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin. Research communications in chemical pathology and pharmacology, 1979, Volume: 25, Issue:3 Topics: Binding, Competitive; Fatty Acids; Humans; Oleic Acids; Oxyphenbutazone; Protein Binding; Serum Albumin; Tolbutamide; Warfarin	1979
Effects of phenylbutazone, tolbutamide, and clofibric acid on binding of racemic warfarin and its enantiomers to human serum albumin. Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:12 Topics: Binding, Competitive; Clofibrate; Clofibric Acid; Humans; Kinetics; Phenylbutazone; Protein Binding; Serum Albumin; Stereoisomerism; Tolbutamide; Warfarin	1979
The effect of BSP and rifamycin on the excretion of warfarin in the bile of the rate. General pharmacology, 1977, Volume: 8, Issue:5-6 Topics: Animals; Anti-Bacterial Agents; Bile; Drug Interactions; Male; Metabolic Clearance Rate; Rats; Rifamycins; Sulfobromophthalein; Tolbutamide; Warfarin	1977
Displacement of tolbutamide, glibencalmide and chlorpropamide from serum albumin by anionic drugs. Biochemical pharmacology, 1976, May-15, Volume: 25, Issue:10 Topics: Acetaminophen; Animals; Cattle; Chlorpropamide; Dialysis; Glyburide; Humans; Phenylbutazone; Protein Binding; Salicylates; Serum Albumin; Serum Albumin, Bovine; Sulfaphenazole; Tolbutamide; Warfarin	1976
[Pharmacokinetics in liver cirrhosis]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1977, Jan-01, Volume: 32, Issue:1 Topics: Aminopyrine; Biotransformation; Chloramphenicol; Coumarins; Half-Life; Humans; Kinetics; Liver Cirrhosis; Pharmaceutical Preparations; Phenylbutazone; Salicylates; Tolbutamide	1977
Multiple factors affecting excretion of warfarin in rats. Research communications in chemical pathology and pharmacology, 1977, Volume: 18, Issue:2 Topics: Animals; Bile; Binding Sites; Dialysis; Fasting; Male; Oxyphenbutazone; Rats; Temperature; Tolbutamide; Warfarin	1977
Competition between diftalone and other drugs for the binding site(s) on human serum albumin. Medical biology, 1976, Volume: 54, Issue:3 Topics: Acetaminophen; Aspirin; Binding Sites; Dexamethasone; Drug Interactions; Humans; Indomethacin; Phenobarbital; Phenylbutazone; Phthalazines; Protein Binding; Pyridazines; Serum Albumin; Temperature; Tolbutamide; Warfarin	1976
[Alcohol and drugs]. Tijdschrift voor gastro-enterologie, 1976, Volume: 19, Issue:2 Topics: Acetaldehyde; Acetyl Coenzyme A; Anesthetics; Barbiturates; Drug Interactions; Ethanol; Humans; Hypnotics and Sedatives; Intestinal Absorption; Isoniazid; Pharmaceutical Preparations; Phenytoin; Tolbutamide; Warfarin	1976
Sulfamethizole-induced inhibition of diphenlhydantoin, tolbutamide, and warfarin metabolism. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:6 Topics: Depression, Chemical; Half-Life; Humans; Kinetics; Metabolic Clearance Rate; Phenytoin; Sulfamethizole; Sulfathiazoles; Tolbutamide; Ultrafiltration; Warfarin	1975
Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. Journal of chromatography, 1992, Jun-10, Volume: 577, Issue:2 Topics: Allosteric Site; Binding, Competitive; Caprylates; Chromatography, High Pressure Liquid; Humans; Ketoprofen; Oxazepam; Pharmaceutical Preparations; Phenylbutazone; Serum Albumin; Stereoisomerism; Suprofen; Tolbutamide; Warfarin	1992
Comparative effects of two antimycotic agents, ketoconazole and terbinafine on the metabolism of tolbutamide, ethinyloestradiol, cyclosporin and ethoxycoumarin by human liver microsomes in vitro. British journal of clinical pharmacology, 1989, Volume: 28, Issue:2 Topics: Antifungal Agents; Coumarins; Cyclosporins; Cytochrome P-450 Enzyme System; Ethinyl Estradiol; Female; Humans; In Vitro Techniques; Ketoconazole; Male; Microsomes, Liver; Naphthalenes; Terbinafine; Tolbutamide	1989
Clinical pharmacology of acebutolol. American heart journal, 1985, Volume: 109, Issue:5 Pt 2 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Digoxin; Drug Interactions; Female; Humans; Hypertension; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Prothrombin Time; Tolbutamide; Warfarin	1985
Cefazolin serum protein binding and its inhibition by bilirubin, fatty acids and other drugs. Biochemical pharmacology, 1988, Jul-15, Volume: 37, Issue:14 Topics: Bilirubin; Blood Proteins; Cefazolin; Fatty Acids, Nonesterified; Furosemide; Humans; In Vitro Techniques; Protein Binding; Serum Albumin; Tolbutamide; Warfarin	1988
Displacement of sulfonylureas from human serum proteins by coumarin derivatives and cortical steroids. Journal of pharmaceutical sciences, 1973, Volume: 62, Issue:2 Topics: Acetohexamide; Adrenal Cortex Hormones; Alpha-Globulins; Chlorpropamide; Coumarins; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Phenindione; Protein Binding; Serum Albumin; Sulfonylurea Compounds; Tolbutamide	1973
Absence of tolbutamide effect on anticoagulant therapy. JAMA, 1966, Sep-26, Volume: 197, Issue:13 Topics: Anticoagulants; Blood Coagulation Tests; Diabetes Mellitus; Dicumarol; Drug Synergism; Humans; Insulin; Retrospective Studies; Tolbutamide; Warfarin	1966
Interactions of sulfonylureas with plasma proteins. Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:4 Topics: Acetohexamide; Acridines; Aniline Compounds; Animals; Binding Sites; Blood Proteins; Cattle; Chlorpropamide; Cyclohexanes; Glyburide; Humans; Hypoglycemic Agents; Naphthalenesulfonates; Protein Binding; Pyrazines; Serum Albumin; Serum Albumin, Bovine; Spectrometry, Fluorescence; Sulfonylurea Compounds; Tolbutamide; Warfarin	1974
Displacement of phenprocoumon (Marcumar) from albumin by sulfonylurea compounds, suramin, and ioglycamic acid. Naunyn-Schmiedeberg's archives of pharmacology, 1972, Volume: 273, Issue:3 Topics: Animals; Anticoagulants; Benzoates; Benzyl Compounds; Binding Sites; Carbutamide; Cattle; Chlorpropamide; Chromatography, Gel; Coumarins; Dextrans; Glycolates; In Vitro Techniques; Iodobenzoates; Protein Binding; Serum Albumin, Bovine; Sulfonylurea Compounds; Suramin; Tolbutamide	1972
Proceedings: Half-life of phenprocoumarol (Marcumar R) during treatment with insulin and sulfonylureas in diabetics. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl Topics: Benzyl Compounds; Blood Glucose; Coumarins; Diabetes Mellitus; Glyburide; Half-Life; Humans; Insulin; Prothrombin Time; Sulfonylurea Compounds; Tolbutamide	1974
[Protein binding of glisoxepide and its influence on the protein binding of phenprocoumon]. Arzneimittel-Forschung, 1974, Volume: 24, Issue:0 Topics: Animals; Anticoagulants; Azepines; Benzyl Compounds; Binding, Competitive; Carbon Radioisotopes; Cattle; Coumarins; Dialysis; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Oxazoles; Protein Binding; Serum Albumin; Serum Albumin, Bovine; Sulfonylurea Compounds; Tolbutamide; Ultracentrifugation	1974
The effect of novibiocin and tolbutamide on the excretion of warfarin in the bile of rats. Research communications in chemical pathology and pharmacology, 1973, Volume: 5, Issue:1 Topics: Animals; Bile; Carbon Isotopes; Dialysis; Male; Novobiocin; Protein Binding; Rats; Serum Albumin; Time Factors; Tolbutamide; Warfarin	1973
Awareness and experience of general practitioners of selected drug interactions. British medical journal, 1974, May-04, Volume: 2, Issue:5913 Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Cognition; Dibenzazepines; Drug Interactions; Family Practice; Humans; Hypnotics and Sedatives; Imipramine; Insulin; Monoamine Oxidase Inhibitors; Physicians; Public Opinion; Scotland; Sulfonamides; Surveys and Questionnaires; Tolbutamide; Warfarin	1974
Drug interactions. Gerontologia clinica, 1974, Volume: 16, Issue:1 Topics: 1-Propanol; Acute Kidney Injury; Aged; Albumins; Antidepressive Agents; Antihypertensive Agents; Benzyl Compounds; Cephaloridine; Coumarins; Digitoxin; Diuretics; Drug Interactions; Ethacrynic Acid; Guanethidine; Guanidines; Heart; Heart Block; Heart Conduction System; Humans; Hypoglycemia; Hypotension; Kidney; Pancreas; Phenylbutazone; Salicylates; Sympathetic Nervous System; Tolbutamide; Warfarin	1974
Tissue culture techniques in the study of cell photobiology and phototoxicity. The Journal of investigative dermatology, 1970, Volume: 54, Issue:2 Topics: Animals; Antimalarials; Carcinoma; Cell Line; Coloring Agents; Coumarins; Culture Media; Culture Techniques; Fibroblasts; Haplorhini; Humans; Kidney; Laryngeal Neoplasms; Light; Methods; Penicillins; Phenothiazines; Photosensitivity Disorders; Porphyrins; Rabbits; Sulfanilamides; Tetracycline; Thiazoles; Tolbutamide	1970
Non-equivalent preparations of the same drug. Drug and therapeutics bulletin, 1971, Aug-13, Volume: 9, Issue:17 Topics: Chloramphenicol; Dosage Forms; Humans; Nitrofurantoin; Oxytetracycline; Pharmaceutical Preparations; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Tetracycline; Therapeutic Equivalency; Tolbutamide; Warfarin	1971
Interactions between digitoxin and other drugs in vitro and in vivo. Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179 Topics: Binding Sites; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Clofibrate; Digitoxin; Digoxin; Drug Antagonism; Enzyme Induction; Erythrocytes; Humans; Microsomes, Liver; Phenobarbital; Phenylbutazone; Phenytoin; Protein Binding; Radioisotopes; Rubidium; Serum Albumin; Sulfadimethoxine; Tolbutamide; Tritium; Warfarin	1971
Potentiation of the hypoglycaemic action of tolbutamide by different drugs. Arzneimittel-Forschung, 1970, Volume: 20, Issue:1 Topics: Animals; Blood Glucose; Coumarins; Drug Synergism; Fasting; Hypoglycemic Agents; Isocarboxazid; Male; Phenylbutazone; Rabbits; Tolbutamide	1970
The effect of drugs on clinical laboratory determinations. Clinical chemistry, 1971, Volume: 17, Issue:5 Topics: 17-Ketosteroids; Chemistry, Clinical; Drug Antagonism; Drug Synergism; Drug Therapy; Hemorrhage; Humans; Nalidixic Acid; Pharmaceutical Preparations; Phenobarbital; Phenylbutazone; Steroids; Tolbutamide; Urine; Warfarin	1971
Anesthesia for patients with prosthetic heart valves. JAMA, 1967, Dec-04, Volume: 202, Issue:10 Topics: Anesthesia; Halothane; Heart Valve Prosthesis; Humans; Lidocaine; Meperidine; Middle Aged; Succinylcholine; Thiopental; Tolbutamide; Tubocurarine; Warfarin	1967
The displacement of phenylbutazone-14C and warfarin-14C from human albumin by various drugs and fatty acids. Biochemical pharmacology, 1968, Volume: 17, Issue:1 Topics: Benzene Derivatives; Binding Sites; Butyrates; Carbon Isotopes; Chlorine; Dialysis; Fatty Acids, Nonesterified; Humans; Indomethacin; Phenylbutazone; Protein Binding; Serum Albumin; Stearic Acids; Sulfamethoxypyridazine; Tolbutamide; Warfarin	1968
Properties of 3-(1-phenyl-propyl)-4-oxycoumarin (marcoumar) in the plasma when tested in normal cases and under the influence of drugs. Thrombosis et diathesis haemorrhagica, 1968, Jul-31, Volume: 19, Issue:3 Topics: Blood Proteins; Coumarins; Drug Synergism; Ethyl Biscoumacetate; Fluorometry; Phenobarbital; Phenylbutazone; Protein Binding; Spectrophotometry; Sulfadimethoxine; Sulfinpyrazone; Tolbutamide	1968
[Drug interactions as a cause for iatrogenic diseases in the aged. A tabulated presentation]. Aktuelle Gerontologie, 1983, Volume: 13, Issue:5 Topics: Aged; Alcohol Drinking; Binding, Competitive; Blood Proteins; Drug Interactions; Enzyme Induction; Ethanol; Humans; Iatrogenic Disease; Phenytoin; Protein Binding; Receptors, Drug; Tissue Distribution; Tolbutamide; Warfarin	1983
Carbenoxolone interactions in man--preliminary report. Scandinavian journal of gastroenterology. Supplement, 1980, Volume: 65 Topics: Carbenoxolone; Chlorpropamide; Drug Interactions; Glycyrrhetinic Acid; Half-Life; Humans; Phenytoin; Protein Binding; Stomach Ulcer; Tolbutamide; Warfarin	1980
The effect of sulphinpyrazone on oxidative drug metabolism in man: inhibition of tolbutamide elimination. European journal of clinical pharmacology, 1982, Volume: 22, Issue:4 Topics: Adult; Blood Proteins; Drug Interactions; Humans; In Vitro Techniques; Male; Metabolic Clearance Rate; Protein Binding; Sulfinpyrazone; Tolbutamide; Warfarin	1982
Competition between serum albumin and soluble fraction of liver for binding of warfarin and other drugs. Research communications in chemical pathology and pharmacology, 1981, Volume: 32, Issue:1 Topics: Animals; Binding, Competitive; Humans; In Vitro Techniques; Iopanoic Acid; Liver; Male; Rats; Serum Albumin; Sulfinpyrazone; Tolbutamide; Warfarin	1981
Effect of pirprofen on protein binding of warfarin and tolbutamide in human plasma. Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:12 Topics: Anti-Inflammatory Agents; Humans; In Vitro Techniques; Phenylpropionates; Protein Binding; Pyrroles; Temperature; Tolbutamide; Warfarin	1981
Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:3 Topics: Animals; Coumarins; Culture Techniques; Linear Models; Liver; Male; Metabolic Clearance Rate; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Tolbutamide	1995
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. Pharmacogenetics, 1994, Volume: 4, Issue:1 Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Recombinant Proteins; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Tolbutamide; Tumor Cells, Cultured; Warfarin	1994
Warfarin-fluconazole. III. A rational approach to management of a metabolically based drug interaction. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:4 Topics: Anticoagulants; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluconazole; Humans; Hypoglycemic Agents; Models, Biological; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide; Warfarin	1996
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. Archives of biochemistry and biophysics, 1997, Jun-15, Volume: 342, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Ethanolamines; Humans; Hydroxylation; Mixed Function Oxygenases; Mutation; NADP; Nifedipine; Oxidation-Reduction; Phospholipids; Recombinant Proteins; Testosterone; Theophylline; Tolbutamide; Warfarin	1997
Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. European journal of clinical pharmacology, 1997, Volume: 52, Issue:4 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dealkylation; Humans; In Vitro Techniques; Microsomes, Liver; Naproxen; Piroxicam; Sulfaphenazole; Tolbutamide; Transfection; Vaccinia virus; Warfarin	1997
Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers. Biochemical pharmacology, 1997, Dec-01, Volume: 54, Issue:11 Topics: Animals; Anticoagulants; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfaphenazole; Tolbutamide; Warfarin	1997
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2 Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide	1998
Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:3 Topics: Alkylation; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Gene Expression Regulation; Humans; Indomethacin; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Oxidoreductases, O-Demethylating; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Tolbutamide; Tumor Cells, Cultured; Warfarin	1998
Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1998, Volume: 28, Issue:2 Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Genotype; Humans; Hydroxylation; Japan; Kinetics; Microsomes, Liver; Polymorphism, Genetic; Recombinant Proteins; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Tolbutamide; Warfarin	1998
Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes. European journal of clinical pharmacology, 1999, Volume: 54, Issue:12 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Fluvoxamine; Humans; In Vitro Techniques; Microsomes, Liver; Middle Aged; Selective Serotonin Reuptake Inhibitors; Statistics as Topic; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Time Factors; Tolbutamide; Warfarin	1999
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:10 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Single-Blind Method; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide	2001
No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3. European journal of clinical pharmacology, 2003, Volume: 59, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Microsomes; Nicardipine; Polymorphism, Genetic; Saccharomyces cerevisiae; Tolbutamide; Warfarin	2003
The relationship between oxidative metabolism and lipid peroxidation in rat liver microsomes. Research communications in molecular pathology and pharmacology, 2003, Volume: 113-114 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Guinea Pigs; Hypoglycemic Agents; Lipid Peroxidation; Luminescent Measurements; Male; Microsomes, Liver; Naproxen; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tolbutamide	2003
Role of site-specific binding to plasma albumin in drug availability to brain. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:2 Topics: Animals; Binding, Competitive; Biological Availability; Brain; Ibuprofen; Male; Perfusion; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Serum Albumin; Tolbutamide; Ultrafiltration; Valproic Acid; Warfarin	2006
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Flurbiprofen; Genotype; In Vitro Techniques; Pharmacogenetics; Phenytoin; Piroxicam; Tolbutamide; Warfarin	2006
Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors. Biopharmaceutics & drug disposition, 2011, Volume: 32, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochromes b5; Diclofenac; Enzyme Assays; Forecasting; Humans; Hypoglycemic Agents; Liver; Microsomes, Liver; Models, Biological; Recombinant Proteins; Tolbutamide; Warfarin	2011
Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs. Vaccine, 2012, May-21, Volume: 30, Issue:24 Topics: Animals; Castration; Constitutive Androstane Receptor; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expression; Liver; Male; Pregnane X Receptor; Quinolines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Swine; Tolbutamide; Vaccines, Contraceptive	2012
Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium. Die Pharmazie, 2013, Volume: 68, Issue:1 Topics: Analgesics, Non-Narcotic; Animals; Anticoagulants; Calibration; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Culture Media; Cytochrome P-450 Enzyme System; Hypoglycemic Agents; In Vitro Techniques; Liquid-Liquid Extraction; Microsomes, Liver; Muscle Relaxants, Central; Phenacetin; Quality Control; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Testosterone; Tolbutamide	2013
Functional characterization of 32 CYP2C9 allelic variants. The pharmacogenomics journal, 2014, Volume: 14, Issue:2 Topics: Alleles; Animals; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP2C9; Genetic Variation; Humans; Precision Medicine; Recombinant Proteins; Tolbutamide; Warfarin	2014
The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity. The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:9 Topics: Aryl Hydrocarbon Hydroxylases; Camellia sinensis; Complementary Therapies; Coumarins; Herb-Drug Interactions; Humans; Microsomes, Liver; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide	2014
Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole. Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:10 Topics: Amino Acid Sequence; Animals; Callithrix; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Flurbiprofen; Humans; Macaca fascicularis; Male; Microsomes, Liver; Molecular Sequence Data; Omeprazole; Phylogeny; Species Specificity; Substrate Specificity; Tolbutamide; Warfarin	2015
Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism. Materials science & engineering. C, Materials for biological applications, 2016, Volume: 63 Topics: Animals; Cells, Cultured; Coculture Techniques; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Endothelial Cells; Fibroblasts; Hepatocytes; Male; Microscopy, Confocal; Microscopy, Electron, Scanning; Midazolam; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Tolbutamide; Warfarin	2016
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches. Molecules (Basel, Switzerland), 2017, Nov-20, Volume: 22, Issue:11 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Enzyme Activation; Herb-Drug Interactions; Isoenzymes; Midazolam; Omeprazole; Rats; Steroid 16-alpha-Hydroxylase; Tolbutamide; Warfarin	2017
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Atorvastatin; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Kinetics; Microsomes, Liver; Midazolam; Protein Isoforms; Testosterone; Tolbutamide; Verapamil; Warfarin	2019
3D spheroids generated on carbon nanotube-functionalized fibrous scaffolds for drug metabolism and toxicity screening. Biomaterials science, 2019, Dec-17, Volume: 8, Issue:1 Topics: Animals; Cell Polarity; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Hepatocytes; Maleates; Nanotubes, Carbon; Polystyrenes; Rats; Spheroids, Cellular; Tissue Engineering; Tissue Scaffolds; Tolbutamide; Warfarin	2019
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography. Scientific reports, 2020, 06-01, Volume: 10, Issue:1 Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water	2020
An identification and functional evaluation of a novel CYP2C9 variant CYP2C962. Chemico-biological interactions, 2020, Aug-25, Volume: 327* Topics: Aged, 80 and over; Alleles; Animals; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Assays; Humans; Kinetics; Losartan; Male; Microsomes; Point Mutation; Polymorphism, Genetic; Recombinant Proteins; Spodoptera; Tolbutamide; Vitamin K Epoxide Reductases; Warfarin	2020