Compounds > tolbutamide
Page last updated: 2024-08-16

tolbutamide and troglitazone

tolbutamide has been researched along with troglitazone in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (23.53)18.2507
2000's3 (17.65)29.6817
2010's10 (58.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Emoto, M; Inoue, Y; Kaku, K; Kaneko, T; Murano, K1
Azen, S; Berkowitz, K; Buchanan, TA; Dunn, ME; Goico, J; Kjos, SL; Marroquin, A; Peters, R; Xiang, A1
Boden, PR; Ibbotson, T; Lee, K; Richardson, PJ1
Boden, P; Lee, K1
Azen, SP; Berkowitz, K; Buchanan, TA; Goico, J; Kjos, SL; Marroquin, A; Ochoa, C; Peters, RK; Xiang, AH1
Asai, M; Higuchi, S; Hirano, K; Iguchi, K; Kubota, M; Usui, S1

Reviews

1 review(s) available for tolbutamide and troglitazone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for tolbutamide and troglitazone

ArticleYear
Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM.
    Diabetes, 1996, Volume: 45, Issue:11

    Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; California; Cholesterol, HDL; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Female; Glucose Intolerance; Glucose Tolerance Test; Hispanic or Latino; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Placebos; Pregnancy; Risk Assessment; Risk Factors; Thiazoles; Thiazolidinediones; Tolbutamide; Triglycerides; Troglitazone

1996
Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.
    Diabetes, 2000, Volume: 49, Issue:5

    Topics: Adult; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Glucose Intolerance; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Pregnancy; Risk Factors; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone

2000

Other Studies

14 other study(ies) available for tolbutamide and troglitazone

ArticleYear
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-bisphosphate production in rat hepatocytes.
    European journal of pharmacology, 1994, Mar-21, Volume: 254, Issue:3

    Topics: Animals; Chromans; Cyclic AMP; Dose-Response Relationship, Drug; Fructosediphosphates; Glucagon; Liver; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone

1994
Inhibition of KATP channel activity by troglitazone in CRI-G1 insulin-secreting cells.
    European journal of pharmacology, 1996, Oct-10, Volume: 313, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chromans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone

1996
Troglitazone inhibits type 2KATP channel activity and depolarises tolbutamide-sensitive neurones in the rat ventromedial hypothalamus.
    Brain research, 1997, Mar-14, Volume: 751, Issue:1

    Topics: Adenosine Triphosphate; Animals; Chromans; Hypoglycemic Agents; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone; Ventromedial Hypothalamic Nucleus

1997
Regulators for blood glucose level affect gene expression of aquaporin 3.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:5

    Topics: Actins; Androstadienes; Aquaporin 3; Biguanides; Blood Glucose; Blotting, Western; Caco-2 Cells; Chromans; Epinephrine; Gene Expression; Glucagon; Humans; Hypoglycemic Agents; Insulin; Insulin Antagonists; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazolidinediones; Tolbutamide; Troglitazone; Wortmannin

2006