tolbutamide has been researched along with theophylline in 117 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (64.10) | 18.7374 |
| 1990's | 14 (11.97) | 18.2507 |
| 2000's | 12 (10.26) | 29.6817 |
| 2010's | 16 (13.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Ismail, NA; Montague, W | 1 |
| Hoder, A; Losert, W; Scholz, Ch | 1 |
| Cerasi, E; Gutzeit, A; Kikuchi, M; Rabinovitch, A; Renold, AE | 1 |
| Adcock, K; Austin, M; Duckworth, WC; Murrell, LR; Solomon, SS | 1 |
| Garcia, SD; Jarrousse, C; Rosselin, G | 1 |
| Brown, JD; Brown, ME | 1 |
| Scarpelli, DG; Tomita, T | 1 |
| Handler, JS; Keiser, HR; Zusman, RM | 1 |
| Arends, J; Frerichs, H; Schauder, P | 1 |
| Savage, RL | 1 |
| Berde, B; Richardson, BP | 1 |
| Blumenbach, L; Gerhards, E; Gutsche, H; Klein, W; Loge, O; Losert, W; Schillinger, E; Speck, U; Vetter, H; Wendt, H | 1 |
| Sodoyez, JC; Sodoyez-Goffaux, F | 1 |
| Fujimoto, WY | 1 |
| Frerichs, H; Schauder, P | 1 |
| Ghagghazi, T; Mennear, JH | 1 |
| Curtis, GP; Lucchesi, BR; Setchfield, J | 1 |
| Davidson, MB | 1 |
| Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT | 1 |
| Houston, JB; Matthew, DE | 1 |
| Hanson, RL; Isaacson, CM | 1 |
| Cozzolino, D; Giugliano, D; Giunta, R; Salvatore, T; Torella, R | 1 |
| Diaz, VA; Zawalich, KC; Zawalich, WS | 1 |
| Gagliardino, JJ; Gronda, CM; Rossi, JP | 1 |
| Dolgaya, EV; Mironov, SL | 1 |
| Kononenko, NI; Osipenko, ON | 1 |
| Birkett, DJ; McManus, ME; Miners, JO; Robson, RA; Smith, KJ; Veronese, ME | 1 |
| Birkett, DJ; Miners, JO; Robson, RA; Whitehead, AG | 1 |
| Birkett, DJ; Miners, JO; Wing, LM | 1 |
| Jahn, P; Loge, O; Losert, W | 1 |
| Hodgins, DS; Kuo, JF; Kuo, WN | 1 |
| Addah, SA; Crockford, PM; Powell, P | 1 |
| Loubatières, A; Loubatières-Mariani, MM | 1 |
| Montague, W; Taylor, KW | 1 |
| Brown, JD; Stone, DB | 2 |
| Fink, CJ; Lacy, PE; Young, DA | 1 |
| Chesney, TM; Schofield, JG | 1 |
| Brown, JD; Steele, AA; Stone, DB | 1 |
| Coll-Garcia, E; Gill, JR | 1 |
| Ando, A; Orita, Y; Shirai, D; Takamitsu, Y; Urakabe, S | 1 |
| Cerasi, E; Luft, R | 1 |
| Ashworth, MA; Milner, RD | 1 |
| Burr, IM; Kanazawa, Y; Lambert, AE; Orci, L; Renold, AE | 1 |
| Brown, JD; Steele, AA; Steele, FA; Stone, DB | 1 |
| Fain, JN; Rosenthal, JW; Ward, WF | 1 |
| Lasseter, KC; Levey, GS; McCarthy, JS; Palmer, RF | 1 |
| Howell, SL; Montague, W | 1 |
| Bowen, V; Lazaus, NR | 1 |
| Fink, G; Gutman, RA; Penhos, JC; Recant, L; Selawry, H; Voyles, N | 1 |
| Ebert, R; Hillebrandt, O; Schwabe, U | 1 |
| Ariëns, EJ | 1 |
| Bartelt, KM; Beyer, J; Rosak, C; Schöffling, K | 1 |
| Caccamo, A; Chiumello, G; Del Guercio, MJ; Devetta, M; Di Natale, B | 1 |
| Blondel, B; Lambert, AE; Marliss, EB; Stauffacher, W | 1 |
| Fink, CJ; Klein, NJ; Lacy, PE | 1 |
| Larkins, RG | 1 |
| Carroll, KF; Nestel, PJ | 1 |
| Chapal, J; Loubatières, AL; Loubatières-Mariani, MM | 1 |
| Buchanan, K; Vance, JE | 1 |
| Löffler, G; Lohmann, E; Schweitzer, T; Trautschold, I | 1 |
| Devrim, S; Lazarus, NR; Recant, L; Tanese, T | 1 |
| Lefebvre, P; Luyckx, A | 1 |
| Fujimoto, WY; Williams, RH | 1 |
| Malaisse, WJ; Malaisse-Lagae, F | 1 |
| Bonner-Weir, S; Clore, ET; Weir, GC; Zmachinski, CJ | 1 |
| Awoke, S; Bhathena, SJ; Gazdar, AF; Oie, HK; Recant, L; Voyles, NR; Wilkins, SD | 1 |
| McEvoy, RC; Rayfield, EJ; Seto, Y; Walsh, S | 1 |
| Fujimoto, W; Metz, S; Robertson, RP | 1 |
| Henquin, JC; Tamagawa, T | 1 |
| Bailbe, D; Giroix, MH; Kergoat, M; Picon, L; Portha, B | 1 |
| Klöppel, G; Lenzen, S | 1 |
| Henquin, JC | 2 |
| Couturier, E; Kawazu, S; Malaisse, WJ; Sener, A | 1 |
| Donatsch, P; Lowe, DA; Richardson, BP; Taylor, P | 1 |
| Basilyuk, OV; Soloviev, AI | 1 |
| Krnjević, K; Zhu, PJ | 1 |
| Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N | 1 |
| Atwater, IJ; Boschero, AC; Carneiro, EM; Tombaccini, D | 1 |
| Feierman, DE; Lasker, JM | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Pisani, A | 1 |
| Dong, MS; Gillam, EM; Guengerich, FP; Johnson, WW; Shimada, T; Yamazaki, H | 1 |
| Downing, R; Heald, KA; Jay, TR | 1 |
| Back, DJ; Eagling, VA; Tjia, JF | 1 |
| Aoyagi, K; Bergsten, P; Eriksson, UJ; Hellerström, C; Persson, E | 1 |
| Kunkel, A; Wätzig, H | 2 |
| Bruce, MA; Gorski, JC; Haehner-Daniels, BD; Hall, SD | 1 |
| Aaen, K; Bock, T; Buschard, K; Hageman, I; Hansen, MW; Hansen, SV; Josefsen, K; Jørgensen, M; Kjaer, TW; Pedersen, CR | 1 |
| Fuhr, U; Jetter, A; Kirchheiner, J | 1 |
| Gao, J; Li, GQ; Shi, Z; Yan, R; Yao, M; Zhu, S | 1 |
| Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ | 1 |
| Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ | 1 |
5 review(s) available for tolbutamide and theophylline
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drugs and breast milk.
Topics: Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anticoagulants; Anticonvulsants; Cyclophosphamide; Female; Hormones; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Iodides; Male; Methotrexate; Milk, Human; Narcotics; Pharmaceutical Preparations; Propranolol; Psychotropic Drugs; Sulfonamides; Theophylline; Thiouracil; Tolbutamide | 1977 |
Diazoxide and the secretion of insulin.
Topics: Animals; Cyclic AMP; Diazoxide; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Pancreas; Perfusion; Rats; Theophylline; Tolbutamide | 1972 |
[Oral antidiabetics. Dose, plasma concentration and effect].
Topics: Acetohexamide; Adrenergic beta-Antagonists; Animals; Blood Glucose; Carbutamide; Chemical Phenomena; Chemistry; Chlorpropamide; Cyclic AMP; Diazoxide; Drug Antagonism; Drug Synergism; Glucagon; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Isoproterenol; Kidney; Liver; Sulfonamides; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1969 |
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach.
Topics: Administration, Oral; ATP-Binding Cassette Transporters; Caffeine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Pharmaceutical Preparations; Phenotype; Theophylline; Tolbutamide | 2007 |
2 trial(s) available for tolbutamide and theophylline
| Article | Year |
|---|---|
Specificity of the inhibitory effect of dextropropoxyphene on oxidative drug metabolism in man: effects on theophylline and tolbutamide disposition.
Topics: Adult; Dextropropoxyphene; Half-Life; Humans; Male; Oxidation-Reduction; Theophylline; Tolbutamide | 1987 |
In vivo effect of clarithromycin on multiple cytochrome P450s.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clarithromycin; Cross-Over Studies; Cytochrome P-450 Enzyme System; Female; Humans; Male; Theophylline; Tolbutamide | 2001 |
110 other study(ies) available for tolbutamide and theophylline
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Effects of guanosine on insulin secretion and adenylyl and guanylyl cyclase activities of isolated rat islets of Langerhans.
Topics: Adenylyl Cyclases; Animals; Female; Fluorides; Glucagon; Guanosine; Guanylate Cyclase; Insulin; Insulin Secretion; Islets of Langerhans; Prostaglandins E; Rats; Theophylline; Tolbutamide | 1977 |
[Experimental studies on mechanism of inhibition of thrombocyte aggregation caused by sulfonyl ureas. 1. Problems and methods].
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Glucose; Cyclic AMP; Depression, Chemical; In Vitro Techniques; Insulin; Liver; Male; Methods; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Protein Binding; Rats; Sulfonylurea Compounds; Temperature; Theophylline; Tolbutamide; Tritium | 1975 |
Defective early phase insulin release in perifused isolated pancreatic islets of spiny mice (Acomys cahirinus).
Topics: Age Factors; Animals; Arginine; Body Weight; Cyclic AMP; Cytochalasin B; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Obese; Perfusion; Rats; Species Specificity; Theophylline; Tolbutamide | 1975 |
Human islet cell adenoma: metabolic analysis of the patient and of tumor cells in monolayer culture.
Topics: Adenoma, Islet Cell; Adult; Cell Survival; Cells, Cultured; Culture Media; Cyclic AMP; Glucagon; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Leucine; Male; Proinsulin; Theophylline; Tolbutamide | 1975 |
Biosynthesis of proinsulin and insulin in newborn rat pancreas. Interaction of glucose, cyclic AMP, somatostatin, and sulfonylureas on the (3H) leucine incorporation into immunoreactive insulin.
Topics: Animals; Animals, Newborn; Antigens; Cyclic AMP; Glipizide; Glucose; Humans; Insulin; Islets of Langerhans; Leucine; Proinsulin; Rats; Somatostatin; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1976 |
The effect of tolbutamide on contractility and cyclic adenosine 3':5'-monophosphate concentration in the intact beating rat heart.
Topics: Albumins; Animals; Cyclic AMP; Drug Interactions; Heart; Male; Myocardial Contraction; Myocardium; Norepinephrine; Rats; Theophylline; Tolbutamide | 1977 |
Interaction of cyclic AMP and alloxan on insulin secretion in isolated rat islets perifused in vitro.
Topics: Alloxan; Animals; Bucladesine; Caffeine; Cyclic AMP; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Theophylline; Tolbutamide | 1977 |
Inhibition of vasopressin-stimulated prostaglandin E biosynthesis by chlorpropamide in the toad urinary bladder. Mechanism of enhancement of vasopressin-stimulated water flow.
Topics: Animals; Anura; Arginine Vasopressin; Chlorpropamide; Chromatography, Thin Layer; Cyclic AMP; Glyburide; Lipid Metabolism; Permeability; Prostaglandins E; Stimulation, Chemical; Structure-Activity Relationship; Theophylline; Tolbutamide; Urinary Bladder; Vasopressins; Water | 1977 |
Onset and reversibility of changes in secretory function and composition of isolated rat pancreatic islets following long-term administrationof high or low tolbutamide doses.
Topics: Animals; Blood Glucose; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Male; Rats; Theophylline; Time Factors; Tolbutamide | 1977 |
Proceedings: The effects of cyproheptadine pretreatment on insulin release from isolated pancreatic islets.
Topics: Animals; Cyproheptadine; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Rats; Theophylline; Tolbutamide | 1976 |
Gliflumide, a new oral antidiabetic of high potency and efficacy.
Topics: Administration, Oral; Animals; Blood Glucose; Cricetinae; Dogs; Fatty Acids, Nonesterified; Glucose; Glyburide; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Kinetics; Pyrimidines; Rats; Stereoisomerism; Sulfonamides; Theophylline; Tolbutamide | 1975 |
Transient diabetes mellitus in a neonate. Evaluation of insulin, glucagon, and growth hormone secretion and management with a continuous low-dose insulin infusion.
Topics: Adolescent; Antigens; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucagon; Glucose Tolerance Test; Growth Hormone; Humans; Hyperglycemia; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Parenteral; Insulin; Insulin Secretion; Pregnancy; Somatostatin; Theophylline; Time Factors; Tolbutamide | 1977 |
Somatostatin inhibition of glucose-, tolbutamide-, theophylline, cytochalasin B-, and calcium-stimulated insulin release in monolayer cultures of rat endocrine pancreas.
Topics: Animals; Calcium; Cells, Cultured; Cytochalasin B; Glucose; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Microtubules; Rats; Somatostatin; Stimulation, Chemical; Theophylline; Tolbutamide | 1975 |
Tolbutamide-induced changes of the DNA, protein and insulin content and the secretory activity of isolated rat pancreatic islets.
Topics: Animals; DNA; Glucose; Hyperplasia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Proteins; Rats; Theophylline; Tolbutamide | 1975 |
The inhibitory effect of cadmium on the secretory activity of the isolated perfused rat pancreas.
Topics: Animals; Cadmium; Depression, Chemical; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Perfusion; Potassium; Rats; Theophylline; Time Factors; Tolbutamide | 1975 |
The cardiac pharmacology of tolbutamide.
Topics: Animals; Blood Pressure; Cats; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Heart; In Vitro Techniques; Injections, Intra-Arterial; Isoproterenol; Male; Myocardial Contraction; Norepinephrine; Papillary Muscles; Purkinje Fibers; Rabbits; Species Specificity; Stimulation, Chemical; Theophylline; Tolbutamide | 1975 |
Metabolic studies in the pyelonephritic rat.
Topics: Adipose Tissue; Animals; Body Weight; Creatinine; Diet; Disease Models, Animal; Epinephrine; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose Tolerance Test; Growth Hormone; Insulin; Lipid Metabolism; Liver; Liver Glycogen; Male; Pyelonephritis; Rats; Streptococcal Infections; Theophylline; Tolbutamide | 1975 |
Characterization of metronidazole metabolism by human liver microsomes.
Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide | 1991 |
Drug metabolizing capacity in vitro and in vivo--II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antipyrine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide | 1990 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil | 1985 |
Theophylline prevents the inhibitory effect of prostaglandin E2 on glucose-induced insulin secretion in man.
Topics: Adult; Arginine; Blood Glucose; Cyclic AMP; Dinoprostone; Female; Glucose; Humans; Insulin; Insulin Secretion; Male; Prostaglandins E; Theophylline; Tolbutamide | 1988 |
Influence of cAMP and calcium on [3H]inositol efflux, inositol phosphate accumulation, and insulin release from isolated rat islets.
Topics: Animals; Calcium; Colforsin; Cyclic AMP; Glucose; Hydrolysis; Inositol; Inositol Phosphates; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Nitrendipine; Phosphatidylinositols; Rats; Rats, Inbred Strains; Sincalide; Sugar Phosphates; Theophylline; Tolbutamide | 1988 |
Effect of different insulin secretagogues and blocking agents on islet cell Ca2+-ATPase activity.
Topics: Animals; Calcium-Transporting ATPases; Caproates; Cell Membrane; Gliclazide; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Male; Rats; Somatostatin; Theophylline; Tolbutamide | 1988 |
Surface charge of mammalian neurones as revealed by microelectrophoresis.
Topics: Animals; Animals, Newborn; Bucladesine; Electrophoresis; Ethylmaleimide; Ganglia, Spinal; Kinetics; Membrane Potentials; Neurons; Rats; Theophylline; Tolbutamide | 1985 |
[Effect of application of oxytocin on neurons of Helix pomatia: depolarization effects].
Topics: Animals; Furosemide; Helix, Snails; HEPES; Imidazoles; In Vitro Techniques; Membrane Potentials; Microelectrodes; Neurons; Oxytocin; Temperature; Theophylline; Tolbutamide | 1988 |
Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations.
Topics: Cytochrome P-450 Enzyme System; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Theophylline; Tolbutamide | 1988 |
Normal metabolism of debrisoquine and theophylline in a slow tolbutamide metaboliser.
Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Hydroxylation; Isoenzymes; Isoquinolines; Male; Theophylline; Tolbutamide | 1985 |
[Comparison of the beta-cytotropic effect of glymidine sodium (glycodiazine), glucagon, and isopropylnoradrenaline in rats].
Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Animals; Barbiturates; Blood Glucose; Diazoxide; Drug Interactions; Ethers; Glucagon; Hypoglycemic Agents; Insulin; Insulin Secretion; Iodine Radioisotopes; Isoproterenol; Male; Norepinephrine; Pancreas; Phentolamine; Photometry; Pyrimidines; Rats; Stimulation, Chemical; Sulfonamides; Theophylline; Time Factors; Tolbutamide | 1973 |
Regulation by various hormones and agents of adenosine-3',5'-monophosphate levels in islets of Langerhans of rats.
Topics: Adenine; Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animals; Cresols; Cyclic AMP; Epinephrine; Glucagon; Glucose; Guanosine Triphosphate; Hormones; In Vitro Techniques; Islets of Langerhans; Isoproterenol; Leucine; Phenformin; Phenoxybenzamine; Phentolamine; Propanolamines; Propranolol; Propylamines; Prostaglandins; Rats; Receptors, Adrenergic; Secretin; Sotalol; Theophylline; Thyrotropin; Tolbutamide; Tritium | 1974 |
Effect of sulfonylureas on the secretion of pancreatic immunoreactive glucagon and enteric glucagon-like immunoreactivity.
Topics: Animals; Antibody Formation; Antigens; Arginine; Glucagon; Glucose; Glyburide; In Vitro Techniques; Insulin Antibodies; Pancreas; Radioimmunoassay; Rats; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1973 |
In vitro secretion of insulin after glucose, sulphonylureas, adrenergic and cholinergic substances studied by isolated perfused rat pancreas.
Topics: Acetylcholine; Animals; Atropine; Diazoxide; Epinephrine; Glucagon; Glucose; Glyburide; Heptoses; In Vitro Techniques; Insulin; Insulin Secretion; Isoproterenol; Ketoses; Norepinephrine; Pancreas; Parasympathomimetics; Perfusion; Phenoxybenzamine; Practolol; Propranolol; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1974 |
Islet-cell metabolism during insulin release. Effects of glucose, citrate, octanoate, tolbutamide, glucagon and theophylline.
Topics: Animals; Caprylates; Citrates; Glucagon; Gluconates; Glucose; Glycolysis; Hexosephosphates; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Oxidation-Reduction; Phosphofructokinase-1; Rats; Secretory Rate; Theophylline; Tolbutamide | 1969 |
Antilipolytic effects of sulfonylurea drugs on induced lipolysis in isolated fat cells of the rat.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Antimetabolites; Dexamethasone; Fatty Acids; Fatty Acids, Nonesterified; Glucagon; Glycerol; Hypoglycemic Agents; In Vitro Techniques; Insulin Antibodies; Male; Norepinephrine; Rats; Theophylline; Tolazamide; Tolbutamide | 1967 |
The mechanism of action antilipolytic agents: a comparison of the effects of PGE1, insulin, tolbutamide, and phenformin on lipolysis induced by dibutryl cyclic AMP.
Topics: Adenine Nucleotides; Adipose Tissue; Animals; Cyclic AMP; In Vitro Techniques; Insulin; Lipase; Lipid Metabolism; Phenformin; Phosphoric Monoester Hydrolases; Prostaglandins; Rats; Theophylline; Tolbutamide | 1968 |
Studies on insulin secretion in vitro from isolated islets of the rat pancreas.
Topics: Animals; Cyclic AMP; Endopeptidases; Glucagon; Glucose; Heptoses; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mannose; Microbial Collagenase; Rats; Stimulation, Chemical; Theophylline; Tolbutamide | 1968 |
Studies on the secretion of pancreatic glucagon.
Topics: Amino Acids; Animals; Cattle; Cyclic AMP; Glucagon; Glucose; Guinea Pigs; Immune Sera; Iodine Isotopes; Islets of Langerhans; Ouabain; Radioimmunoassay; Secretory Rate; Swine; Sympathomimetics; Theophylline; Tolbutamide | 1969 |
Mechanism of action of antilipolytic agents: comparison of the effects of insulin, tolbutamide, and phenformin on lipolysis induced by dibutyryl cyclic AMP plus theophylline.
Topics: Adenine Nucleotides; Adipose Tissue; Animals; Cyclic AMP; Epididymis; In Vitro Techniques; Insulin; Lipid Metabolism; Male; Phenformin; Rats; Theophylline; Tolbutamide | 1969 |
Insulin release by isolated pancreatic islets of the mouse incubated in vitro.
Topics: Animals; Culture Techniques; Epinephrine; Glucagon; Glucose; Heptoses; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Microbial Collagenase; Phentolamine; Secretory Rate; Theophylline; Tolbutamide | 1969 |
Effect of sulfonylureas on the permeability to water and electrical properties of the urinary bladder of the toad.
Topics: Acetohexamide; Animals; Anura; Biguanides; Biological Transport; Calcium; Carbutamide; Cell Membrane Permeability; Chlorpropamide; Cyclic AMP; Depression, Chemical; Dinitrophenols; Electrophysiology; Epinephrine; Glutathione; Pyrimidines; Stimulation, Chemical; Sulfonic Acids; Temperature; Theophylline; Tolbutamide; Urinary Bladder; Vasopressins; Water | 1970 |
[Mechanism of insulin secretion with special regard to prediabetes].
Topics: Adenylyl Cyclases; Cyclic AMP; Glucose; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Pancreas; Prediabetic State; Propranolol; Theophylline; Tolbutamide | 1971 |
Insulin release from human fetal pancreas in vitro.
Topics: Arginine; Barium; Body Weight; Cyclic AMP; Female; Fetus; Gestational Age; Glucagon; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Leucine; Ouabain; Pancreas; Potassium; Pregnancy; Theophylline; Tolbutamide | 1971 |
On the role of cyclic AMP in insulin release: I. Overall effects in cultured fetal rat pancreas.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Caffeine; Calcium; Cyclic AMP; Fetus; Glucose; Hexoses; Insulin; Insulin Secretion; Islets of Langerhans; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Pyruvates; Rats; Theophylline; Tolbutamide | 1971 |
The effect of tolbutamide on lipolysis and cyclic AMP concentration in white fat cells.
Topics: Adipose Tissue; Animals; Cyclic AMP; Depression, Chemical; Epididymis; Fasting; Glucose; Glycerol; Lipid Metabolism; Male; Norepinephrine; Rats; Stimulation, Chemical; Theophylline; Tolbutamide | 1972 |
Anti-lipolytic action of tolbutamide on brown fat cells.
Topics: Adenosine Triphosphate; Adipose Tissue, Brown; Animals; Brain; Cyclic AMP; Depression, Chemical; Epinephrine; Female; Lipid Metabolism; Oxygen Consumption; Phosphoric Monoester Hydrolases; Phosphorus; Phosphorus Isotopes; Rats; Theophylline; Tolbutamide | 1972 |
The effect of sulfonylurea drugs on rabbit myocardial contractility, canine purkinje fiber automaticity, and adenyl cyclase activity from rabbit and human hearts.
Topics: Acetohexamide; Adenylyl Cyclases; Animals; Chlorpropamide; Culture Techniques; Cyclic AMP; Dogs; Heart; Heart Atria; Heart Conduction System; Humans; Membrane Potentials; Microelectrodes; Myocardium; Phenformin; Propranolol; Rabbits; Stimulation, Chemical; Sulfonylurea Compounds; Theophylline; Tolazamide; Tolbutamide | 1972 |
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.
Topics: Animals; Arginine; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucagon; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Phosphorus Isotopes; Phosphotransferases; Protein Kinases; Rats; Theophylline; Time Factors; Tolbutamide; Xanthines; Xylitol | 1973 |
Glucose-mediated insulin release: 3',5' cAMP phosphodiesterase.
Topics: Animals; Chloromercuribenzoates; Chromatography; Cyclic AMP; Glucose; Hydrogen-Ion Concentration; Insulin; Insulin Secretion; Islets of Langerhans; Magnesium; Mice; Phosphoric Diester Hydrolases; Proteins; Theophylline; Tolbutamide; Ultracentrifugation; Ultraviolet Rays | 1973 |
Interaction of various stimulators and inhibitors on insulin secretion in vitro.
Topics: Animals; Bucladesine; Cyclic GMP; Diazoxide; Drug Interactions; Epinephrine; Inosine Nucleotides; Insulin; Insulin Antagonists; Insulin Secretion; Male; Nucleotides, Cyclic; Pancreas; Rats; Starvation; Stimulation, Chemical; Theophylline; Thymine Nucleotides; Time Factors; Tolbutamide | 1973 |
Role of calcium and cyclic adenosine 3',5'-monophosphate in the antilipolytic effect of tolbutamide and glibenclamide.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Bucladesine; Calcium; Carboxylic Acids; Cyclic AMP; Epinephrine; Glucagon; Glyburide; Isoproterenol; Lipid Metabolism; Male; Norepinephrine; Rats; Theophylline; Tolbutamide | 1974 |
Studies on the site of action of tolbutamide in the lipolytic system.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cyclic AMP; In Vitro Techniques; Lipid Metabolism; Male; Norepinephrine; Phentolamine; Rats; Theophylline; Tolbutamide | 1972 |
B-pancreatic function in obese and diabetic children.
Topics: Arginine; Blood Glucose; Child; Diabetes Mellitus, Type 1; Ethylenediamines; Female; Glucagon; Glucose Tolerance Test; Humans; Injections, Intravenous; Insulin; Islets of Langerhans; Male; Obesity; Theophylline; Tolbutamide | 1972 |
Insulin release from monolayer cultures of rat pancreatic cells: a preliminary characterization.
Topics: Amines; Amino Acids; Animals; Calcium; Cells, Cultured; Depression, Chemical; Epinephrine; Glucose; Heptoses; Hexoses; Histological Techniques; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Mannose; Ouabain; Pancreas; Potassium; Pyruvates; Rats; Stimulation, Chemical; Theophylline; Tolbutamide | 1972 |
Effect of cytochalasin B on the biphasic release of insulin in perifused rat islets.
Topics: Animals; Cytochalasin B; Glucagon; Glucose; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Iodine Isotopes; Islets of Langerhans; Mitosporic Fungi; Perfusion; Rats; Secretory Rate; Theophylline; Tolbutamide; Vinblastine | 1973 |
Defective insulin secretion in the N.Z.O. mouse: in vitro studies.
Topics: Animals; Arginine; Blood; Blood Glucose; Epinephrine; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Theophylline; Tolbutamide | 1973 |
Diurnal variation in glucose tolerance and in insulin secretion in man.
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glucose; Glucose Tolerance Test; Growth Hormone; Humans; Injections, Intravenous; Insulin; Male; Phentolamine; Theophylline; Tolbutamide | 1973 |
[Interaction between tolbutamide and theophylline, as studied on insulin secretion by the isolated, perfused rat pancreas].
Topics: Animals; Drug Synergism; Insulin; Insulin Secretion; Organ Culture Techniques; Pancreas; Rats; Theophylline; Time Factors; Tolbutamide | 1973 |
Interrelationship between glucagon and insulin release from isolated islets of Langerhans.
Topics: Animals; Glucagon; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Rats; Theophylline; Tolbutamide | 1968 |
[Effect of HB 419 and tolbutamide on isolated islands of Langerhans in rats].
Topics: Animals; Carbon Isotopes; Diazoxide; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Rats; Theophylline; Tolbutamide | 1969 |
Synthesis and release of proinsulin and insulin by isolated rat islets of Langerhans.
Topics: Adenine Nucleotides; Animals; Electrophoresis; Glucose; Immunoassay; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Theophylline; Tolbutamide | 1970 |
[Factors influencing the secretion of pancreatic and extrapancreatic glucagon].
Topics: Animals; Blood Glucose; Dogs; Fatty Acids; Glucagon; Glucose; Intestinal Mucosa; Islets of Langerhans; Jejunum; Nicotinic Acids; Pancreas; Theophylline; Tolbutamide | 1970 |
Insulin release from cultured fetal human pancreas.
Topics: Arginine; Culture Media; Drug Synergism; Fetus; Gestational Age; Glucose; Humans; Insulin; Insulin Secretion; Organ Culture Techniques; Pancreas; Radioimmunoassay; Stimulation, Chemical; Theophylline; Tolbutamide | 1972 |
Stimulation of insulin secretion by noncarbohydrate metabolites.
Topics: Amino Acids; Animals; Caprylates; Fatty Acids; Glucose; Hydroxybutyrates; Insulin; Insulin Secretion; Keto Acids; Methods; Palmitic Acids; Pancreas; Phosphatidylcholines; Rats; Theophylline; Tolbutamide | 1968 |
Islet secretion in a new experimental model for non-insulin-dependent diabetes.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Male; Pregnancy; Rats; Somatostatin; Theophylline; Tolbutamide | 1981 |
Insulin, glucagon, and somatostatin secretion by cultured rat islet cell tumor and its clones.
Topics: Adenoma, Islet Cell; Animals; Arginine; Calcium; Clone Cells; Glucagon; Glucose; Insulin; Potassium; Rats; Somatostatin; Theophylline; Tolbutamide | 1984 |
Virus-induced alterations in insulin release in hamster islets of Langerhans.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cricetinae; Cyclic AMP; DNA; Encephalitis Viruses; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mesocricetus; Theophylline; Tolbutamide | 1981 |
Modulation of insulin secretion by cyclic AMP and prostaglandin E: the effects of theophylline, sodium salicylate and tolbutamide.
Topics: Animals; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucose; Ibuprofen; Insulin; Insulin Secretion; Islets of Langerhans; Prostaglandins E; Rats; Rats, Inbred Strains; Sodium Salicylate; Theophylline; Tolbutamide | 1982 |
Chloride modulation of insulin release, 86Rb+ efflux, and 45Ca2+ fluxes in rat islets stimulated by various secretagogues.
Topics: Animals; Arginine; Calcium; Chlorides; Exocytosis; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Rats; Rats, Inbred Strains; Rubidium; Theophylline; Tolbutamide | 1983 |
Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas.
Topics: Acetylcholine; Amino Acids; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Keto Acids; Leucine; Mannose; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide | 1983 |
Intracellular localization of calcium in pancreatic B-cells in relation to insulin secretion by the perfused ob/ob mouse pancreas.
Topics: Animals; Antimycin A; Calcium; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mice; Mice, Obese; Microscopy, Electron; Perfusion; Theophylline; Tolbutamide | 1984 |
Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets.
Topics: Animals; Biological Transport, Active; Calcium; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Potassium; Rats; Rubidium; Theophylline; Tolbutamide | 1980 |
Metabolic, cationic and secretory effects of hypoglycemic sulfonylureas in pancreatic islets.
Topics: Animals; Calcium; Female; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; NAD; NADP; Rats; Rubidium; Sodium; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1980 |
Mechanisms of tolbutamide-stimulation of pancreatic B cells--a reply.
Topics: Animals; Biological Transport; Calcium; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Rubidium; Theophylline; Tolbutamide | 1980 |
Mechanism by which cyproheptadine inhibits insulin secretion.
Topics: Animals; Calcium; Cyproheptadine; Depression, Chemical; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Sodium; Theophylline; Time Factors; Tolbutamide; Veratridine | 1980 |
Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats.
Topics: Actin Cytoskeleton; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Chlorides; Cyclic AMP; Dose-Response Relationship, Drug; Hypoxia; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Rats; Rats, Inbred WKY; Sodium Fluoride; Theophylline; Tolbutamide | 1993 |
Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices.
Topics: Action Potentials; Adenosine; Animals; Caffeine; Cell Hypoxia; Energy Metabolism; Evoked Potentials; Glucose; Glyburide; Hippocampus; Hypoglycemia; Neural Inhibition; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline; Tolbutamide | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured | 1993 |
Differences in K+ permeability between cultured adult and neonatal rat islets of Langerhans in response to glucose, tolbutamide, diazoxide, and theophylline.
Topics: Animals; Animals, Newborn; Diazoxide; Glucose; In Vitro Techniques; Islets of Langerhans; Permeability; Potassium; Rats; Rats, Wistar; Theophylline; Tolbutamide | 1993 |
Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tolbutamide | 1996 |
Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses.
Topics: Adenosine; Animals; Caffeine; Cerebral Cortex; Corpus Striatum; Evoked Potentials; Glipizide; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Theophylline; Tolbutamide; Xanthines | 1997 |
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Ethanolamines; Humans; Hydroxylation; Mixed Function Oxygenases; Mutation; NADP; Nifedipine; Oxidation-Reduction; Phospholipids; Recombinant Proteins; Testosterone; Theophylline; Tolbutamide; Warfarin | 1997 |
Effect of donor age on porcine insulin secretion.
Topics: Aging; Animals; Carbachol; Cells, Cultured; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Swine; Theophylline; Tolbutamide | 1997 |
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Substrate Specificity; Sulfaphenazole; Testosterone; Theophylline; Tolbutamide | 1998 |
Appearance of glucose-induced insulin release in fetal rat beta-cells.
Topics: Animals; Cells, Cultured; Diazoxide; Diuretics; Gestational Age; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mannoheptulose; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Sodium Chloride Symporter Inhibitors; Theophylline; Tolbutamide | 1998 |
Pharmacokinetic investigations with direct injection of plasma samples: possible savings using capillary electrophoresis (CE).
Topics: Acetaminophen; Blood Proteins; Drug Monitoring; Electrophoresis, Capillary; Humans; Reproducibility of Results; Salicylic Acid; Sulfamethoxazole; Theophylline; Tolbutamide; Trimethoprim | 1999 |
Micellar electrokinetic capillary chromatography as a powerful tool for pharmacological investigations without sample pretreatment: a precise technique providing cost advantages and limits of detection to the low nanomolar range.
Topics: Acetaminophen; Chromatography, Micellar Electrokinetic Capillary; Costs and Cost Analysis; Humans; Reproducibility of Results; Salicylic Acid; Sulfamethoxazole; Theophylline; Time Factors; Tolbutamide; Trimethoprim | 1999 |
Neonatal treatment with beta-cell stimulatory agents reduces the incidence of diabetes in BB rats.
Topics: Animals; Animals, Newborn; Arginine; Diabetes Mellitus, Type 1; Drug Combinations; Female; Glucagon; Glucose; Incidence; Islets of Langerhans; Male; Protamines; Rats; Rats, Inbred BB; Theophylline; Time Factors; Tolbutamide | 2000 |
Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches.
Topics: Adamantane; Animals; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Enzyme Activators; Enzyme Inhibitors; Herb-Drug Interactions; Isoenzymes; Male; Plant Extracts; Rats; Rats, Wistar; Rheum; Theophylline; Tolbutamide; Wine | 2013 |
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress].
Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide | 2015 |
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency].
Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency | 2017 |