tolbutamide has been researched along with potassium chloride in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (7.55) | 18.7374 |
| 1990's | 22 (41.51) | 18.2507 |
| 2000's | 23 (43.40) | 29.6817 |
| 2010's | 2 (3.77) | 24.3611 |
| 2020's | 2 (3.77) | 2.80 |
| Authors | Studies |
|---|---|
| Hayakawa, T; Kanamori, T; Nagatsu, T | 1 |
| Barnett, DW; Falke, LC; Gillis, KD; Misler, S; Pressel, DM; Scharp, DW | 1 |
| Bosco, D; Chanson, M; Giordano, E; Meda, P; Soria, B | 1 |
| Angus, JA; Cocks, TM; King, SJ | 1 |
| Wilson, C | 1 |
| Anselmi, E; D'Ocon, MP; Ivorra, MD; Villar, A | 1 |
| Deng, LY; Li, JS; Schiffrin, EL | 1 |
| Fukunaga, K; Matsumoto, K; Miyamoto, E; Miyazaki, J; Shichiri, M | 1 |
| Ashcroft, FM; Gray, DW; Leow, K; Shimizu, S; Smith, PA; Williams, BA | 1 |
| Biden, TJ; Davison, AG; Prugue, ML | 1 |
| Fontela, T; Garcia-Hermida, O; Marco, J; Rodriguez-Gallardo, J; Salas, M; Silvestre, RA | 1 |
| Abe, H; Akabane, A; Kato, I; Nata, K; Suzuki, Y; Takamura, T; Takasawa, S; Tanaka, O; Yonekura, H; Yoshimoto, T | 1 |
| Misler, S; Zhou, Z | 1 |
| Gagliardino, JJ; Gronda, CM; Rossi, JP | 1 |
| Gross, R; Hillaire-Buys, D; Manteghetti, M; Ribes, G; Roye, M | 1 |
| Capito, K; Hansen, SE; Thams, P | 1 |
| Fujimura, N; Higashi, H; Shigemori, M; Tanaka, E; Yamamoto, S | 1 |
| Asano, T; Inukai, K; Ishihara, H; Kakei, M; Kikuchi, M; Miyazaki, JI; Nakazaki, M; Oka, Y; Tanaka, H; Yada, T | 1 |
| Nakata, M; Tanaka, H; Yada, T; Yaekura, K | 1 |
| Bell, GI; Dukes, ID; Levisetti, M; Ostrega, D; Philipson, L; Polonsky, KS; Pontoglio, M; Roe, MW; Sreenan, S; Yaniv, M; Zhou, YP | 1 |
| Albuquerque-Silva, J; Herchuelz, A; Lebeau, C; Van Eylen, F | 1 |
| Yada, T; Yaekura, K; Yanagida, K | 1 |
| Brismar, T; Hyllienmark, L | 1 |
| An, J; Becker, GW; Churgay, LM; Gold, G; Hale, JE; Osborne, JJ; Shi, Y; Stramm, LE; Zhao, G | 1 |
| Aynsley-Green, A; Barnes, PD; Chapman, JC; Cosgrove, KE; Docherty, HM; Docherty, K; Dunne, MJ; Hart, AW; Hashmi, MN; James, RF; Kamimura, N; Lindley, KJ; MacFarlane, WM; O'Brien, RE; Shepherd, RM | 1 |
| Harris, TE; Jones, PM; Persaud, SJ; Squires, PE | 1 |
| Ball, AJ; Flatt, PR; McClenaghan, NH; McCluskey, JT | 1 |
| Ball, AJ; Flatt, PR; McClenaghan, NH | 2 |
| Bernal-Mizrachi, E; Inoue, H; Permutt, MA; Wice, B | 1 |
| Schermerhorn, T; Sharp, GW | 1 |
| Gong, Q; Ichinari, K; Kakei, M; Koriyama, N; Morimitsu, S; Nakazaki, M; Tei, C; Yada, T; Yaekura, K | 1 |
| Ainscow, EK; Rutter, GA | 1 |
| Bertrand, G; Henquin, JC; Ishiyama, N; Nenquin, M; Ravier, MA | 1 |
| ALDEN, JS; BEARDWOOD, DM; BEARDWOOD, JT; GRAHAM, CA; MARBLE, A | 1 |
| Chaffard, G; Maechler, P; Merglen, A; Rubi, B; Theander, S; Wollheim, CB | 1 |
| Bancila, V; Bloc, A; Dunant, Y; Nikonenko, I | 1 |
| Eliasson, L; Krutzfeldt, J; Kuwajima, S; Ma, X; Macdonald, PE; Pfeffer, S; Poy, MN; Rajewsky, N; Rorsman, P; Stoffel, M; Tuschl, T | 1 |
| Sharp, GW; Straub, SG | 1 |
| Burns, CJ; Evans, ND; Jones, PM; Milne, HM; Persaud, SJ; Pickup, J; Squires, PE | 1 |
| Churamani, D; Jones, PM; Pararajasingam, R; Persaud, SJ; Squires, PE | 1 |
| Chepurny, O; Graf, O; Harbeck, M; Holz, GG; Kaihara, K; Kitiphongspattana, K; Landa, LR; Lohse, MJ; Nikolaev, VO; Roe, MW | 1 |
| Abdel-Wahab, YH; Ali, L; Flatt, PR; Hannan, JM; Marenah, L; Rokeya, B | 1 |
| Brennan, L; Flatt, PR; McClenaghan, NH; Newsholme, P; Patterson, S | 1 |
| Flatt, PR; McClenaghan, NH; Patterson, S | 1 |
| Barbosa, HC; Borelli, MI; Boschero, AC; Bosqueiro, JR; Carneiro, EM; Del Zotto, H; Gagliardino, JJ; Rafacho, A; Silva, KE; Stoppiglia, LF | 1 |
| Mayer, SI; Thiel, G | 1 |
| Baltrusch, S; Barrientos, R; Belcourt, A; Legeay, G; Lenzen, S; Sigrist, S | 1 |
| Hatlapatka, K; Rustenbeck, I; Willenborg, M | 1 |
| Bonfleur, ML; Boschero, AC; Carneiro, EM; de Oliveira, CA; Ribeiro, RA; Rodrigues, FB; Souza, KL; Vanzela, EC | 1 |
| Rustenbeck, I; Seemann, N; Welling, A | 1 |
| Bertram, R; Corbin, KL; Law, NC; Marinelli, I; Nunemaker, CS; Schildmeyer, C | 1 |
| Eggert, F; Elgert, C; Früh, E; Rustenbeck, I; Scherneck, S | 1 |
53 other study(ies) available for tolbutamide and potassium chloride
| Article | Year |
|---|---|
Characterization of protein kinases from bovine parotid glands. The effect of tolbutamide and its derivative on these partially purified enzymes.
Topics: Adenosine Triphosphate; Animals; Cattle; Cyclic AMP; Cyclic GMP; Enzyme Activation; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Parotid Gland; Potassium Chloride; Protein Kinases; Sodium Chloride; Tolbutamide | 1976 |
Stimulus-secretion coupling in beta-cells of transplantable human islets of Langerhans. Evidence for a critical role for Ca2+ entry.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Azides; Calcium; Cytosol; Electrophysiology; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Kinetics; Membrane Potentials; Nifedipine; Potassium Chloride; Sodium Azide; Time Factors; Tolbutamide | 1992 |
Ion channels of glucose-responsive and -unresponsive beta-cells.
Topics: Animals; Cobalt; Electrophysiology; Glucose; Glyburide; Hemolytic Plaque Technique; In Vitro Techniques; Ion Channels; Islets of Langerhans; Male; Membrane Potentials; Potassium Channels; Potassium Chloride; Rats; Rats, Inbred Strains; Sodium Channels; Tolbutamide | 1991 |
Glibenclamide is a competitive antagonist of the thromboxane A2 receptor in dog coronary artery in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vessels; Dogs; Endothelins; Endothelium, Vascular; Female; Glyburide; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptides; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Tolbutamide | 1990 |
Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guanidines; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Sulfonylurea Compounds; Tolbutamide; Vasodilator Agents | 1989 |
[Importance of calcium in the interaction between prostaglandins E and sulfonylureas in utero].
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Muscle Relaxation; Oxytocin; Potassium Chloride; Pregnancy; Prostaglandins E; Rats; Rats, Inbred Strains; Tolbutamide; Uterine Contraction | 1986 |
Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats.
Topics: Acetylcholine; Adult; Animals; Apamin; Arginine; Arterioles; Charybdotoxin; Endothelium, Vascular; Humans; Hypertension; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Middle Aged; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Ouabain; Potassium Chloride; Rats; Rats, Inbred SHR; Scorpion Venoms; Tolbutamide; Vasoconstriction | 1995 |
Ca2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells.
Topics: Animals; Autoradiography; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Insulin; Insulin Secretion; Insulinoma; Ionomycin; Mice; Mice, Transgenic; Pancreatic Neoplasms; Phosphorylation; Potassium Chloride; Substrate Specificity; Synapsins; Time Factors; Tolbutamide; Tumor Cells, Cultured | 1995 |
Two types of potassium channel regulated by ATP in pancreatic B cells isolated from a type-2 diabetic human.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Diabetes Mellitus, Type 2; Electric Conductivity; Electrophysiology; Humans; Islets of Langerhans; Kinetics; Male; Potassium Channels; Potassium Chloride; Tetraethylammonium; Tetraethylammonium Compounds; Tolbutamide | 1993 |
Regulation by membrane potential of phosphatidylinositol hydrolysis in pancreatic islets.
Topics: Animals; Carbachol; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucose; Hydrolysis; Inositol Phosphates; Islets of Langerhans; Kinetics; Membrane Potentials; Ouabain; Phosphatidylinositols; Potassium Chloride; Rats; Tolbutamide | 1993 |
Inhibitory effect of amylin (islet amyloid polypeptide) on insulin response to non-glucose stimuli. Study in perfused rat pancreas.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amyloid; Animals; Calcium Channel Agonists; Glucose; Hypoglycemic Agents; In Vitro Techniques; Islet Amyloid Polypeptide; Islets of Langerhans; Kinetics; Male; Perfusion; Phospholipids; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Wistar; Sincalide; Time Factors; Tolbutamide | 1995 |
Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Cyclic ADP-Ribose; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Membrane Glycoproteins; Mice; Mice, Transgenic; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Potassium Chloride; Promoter Regions, Genetic; Rats; Reference Values; Subcellular Fractions; Tolbutamide | 1995 |
Amperometric detection of quantal secretion from patch-clamped rat pancreatic beta-cells.
Topics: Animals; Colforsin; Hypoglycemic Agents; Islets of Langerhans; Male; Membrane Potentials; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Serotonin; Tolbutamide | 1996 |
Effect of pH upon Ca(2+)-ATPase activity of rat pancreatic islets: its possible contribution to the inhibitory effect of different insulin secretagogues.
Topics: Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Glucose; Hydrogen-Ion Concentration; Insulin; Insulin Secretion; Islets of Langerhans; Male; Potassium Chloride; Propionates; Rats; Rats, Wistar; Tolbutamide | 1995 |
Alterations of insulin response to different beta cell secretagogues and pancreatic vascular resistance induced by N omega-nitro-L-arginine methyl ester.
Topics: Analysis of Variance; Animals; Arginine; Drug Interactions; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Pancreas; Potassium Chloride; Rats; Rats, Wistar; Stereoisomerism; Tolbutamide; Vascular Resistance; Vasoconstriction; Vasodilator Agents | 1995 |
Production of [3H]choline-labelled metabolites from endogenously 3H-labelled phosphatidylcholine in mouse pancreatic islets.
Topics: Animals; Carbachol; Cells, Cultured; Choline; Cyclohexanones; Diazoxide; Glucose; Glycerylphosphorylcholine; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Kinetics; Lysophosphatidylcholines; Male; Mice; Mice, Inbred Strains; Phosphatidylcholines; Potassium Chloride; Radioisotope Dilution Technique; Rats; Sodium Fluoride; Succinates; Tetradecanoylphorbol Acetate; Tolbutamide; Tritium | 1996 |
Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; Calcium; Electrophysiology; Hippocampus; Hypoglycemic Agents; Hypoxia, Brain; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 1997 |
Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6.
Topics: Adenosine Triphosphate; Aequorin; Animals; Calcium; Calcium Channels; Cell Line; Chelating Agents; Cytosol; DNA Probes; Dose-Response Relationship, Drug; Fluorescent Dyes; Fura-2; Glucose; Hypoglycemic Agents; Islets of Langerhans; Mitochondria; Potassium Chloride; Signal Transduction; Tolbutamide | 1998 |
Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 1997 |
Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.
Topics: Adenosine Triphosphate; Animals; Calcium; DNA-Binding Proteins; Glucose; Glyceraldehyde; Glycolysis; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Mice, Knockout; Nuclear Proteins; Patch-Clamp Techniques; Potassium Channels; Potassium Chloride; Signal Transduction; Tolbutamide; Transcription Factors | 1998 |
Contribution of Na/Ca exchange to Ca2+ outflow and entry in the rat pancreatic beta-cell: studies with antisense oligonucleotides.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Adhesion; Glucose; Hypoglycemic Agents; Ion Transport; Islets of Langerhans; Nifedipine; Oligonucleotides, Antisense; Potassium Chloride; Rats; Rats, Wistar; RNA, Messenger; Sodium; Sodium-Calcium Exchanger; Tolbutamide | 1998 |
PACAP and GLP-1 protect islet beta-cells against Ca2+ toxicity induced by high K+.
Topics: Animals; Arginine; Calcium; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Neuropeptides; Nifedipine; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium Chloride; Protein Precursors; Rats; Rats, Wistar; Tolbutamide | 1998 |
Effect of hypoxia on membrane potential and resting conductance in rat hippocampal neurons.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Dantrolene; Dizocilpine Maleate; Electric Conductivity; Glyburide; Hippocampus; Hypoglycemia; In Vitro Techniques; Membrane Potentials; Potassium Chloride; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors; Tolbutamide | 1999 |
Threonine phosphorylations induced by RX-871024 and insulin secretagogues in betaTC6-F7 cells.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cytosol; Diazoxide; Exocytosis; Humans; Hypoglycemic Agents; Imidazoles; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isomerism; Membrane Potentials; Membrane Proteins; Myosin Heavy Chains; Nifedipine; Phosphorylation; Potassium Chloride; Protein Kinase C; Subcellular Fractions; Threonine; Tolbutamide | 1999 |
Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Calcium; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; Genetic Engineering; Glucose; Homeodomain Proteins; Humans; Hyperinsulinism; Hypoglycemia; Infant; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Potassium Channels, Inwardly Rectifying; Potassium Chloride; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors; Tolbutamide; Trans-Activators; Transfection; Tumor Cells, Cultured | 1999 |
Depolarizing stimuli reduce Ca(2+)/calmodulin-dependent protein kinase II activity in islets of Langerhans.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Electrophysiology; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Potassium Chloride; Rats; Tolbutamide | 2000 |
Drug-induced desensitization of insulinotropic actions of sulfonylureas.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cell Line; Dose-Response Relationship, Drug; Glucose; Guanidines; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Channels; Potassium Chloride; Rats; Tolbutamide | 2000 |
Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide.
Topics: Animals; Bodily Secretions; Carbachol; Cells, Cultured; Colforsin; Down-Regulation; Drug Interactions; Glucose; Guanidines; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Chloride; Rats; Tetradecanoylphorbol Acetate; Time Factors; Tolbutamide | 2000 |
Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells.
Topics: Animals; Calcium; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diazoxide; Diuretics; DNA-Binding Proteins; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Egtazic Acid; Enzyme Inhibitors; Gene Deletion; Glucose; Hypoglycemic Agents; Imidazoles; Immediate-Early Proteins; Islets of Langerhans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Chloride; Promoter Regions, Genetic; Rats; RNA, Messenger; Serum Response Factor; Signal Transduction; Sodium Chloride Symporter Inhibitors; Time Factors; Tolbutamide; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2000 |
Norepinephrine acts on the KATP channel and produces different effects on [Ca2+]i in oscillating and non-oscillating HIT-T15 cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Cricetinae; Cytophotometry; Diazoxide; Glucose; Hypoglycemic Agents; Islets of Langerhans; Norepinephrine; Potassium Channels; Potassium Chloride; Tolbutamide; Tumor Cells, Cultured; Vasodilator Agents | 2000 |
PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.
Topics: 2,4-Dinitrophenol; Actins; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cytochalasin D; Cytosol; Diazoxide; Electric Conductivity; Islets of Langerhans; Patch-Clamp Techniques; Phalloidine; Phosphatidylinositol 4,5-Diphosphate; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 2000 |
Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide.
Topics: Adenosine Triphosphate; Alanine; Animals; Arginine; Cell Line; Culture Media; Dose-Response Relationship, Drug; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Potassium Channels; Potassium Chloride; Sulfonylurea Compounds; Tolbutamide | 2000 |
Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets.
Topics: Adenosine Triphosphate; Aequorin; Animals; Calcium; Cell Line; Cells, Cultured; Cytomegalovirus; Glucose; Hypoglycemic Agents; Insulin; Islets of Langerhans; Luciferases; Luminescent Measurements; Male; Mitochondria; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 2001 |
The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related.
Topics: Allosteric Site; Amino Acids, Cyclic; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Exocytosis; Female; Glucose; Glutamic Acid; Hydrogen-Ion Concentration; Insulin; Insulin Secretion; Male; Mice; Pancreas; Potassium; Potassium Chloride; Protein Binding; Rats; Rats, Wistar; Time Factors; Tolbutamide | 2002 |
EVIDENCE FOR A PERIPHERAL ACTION OF CHLOROTHIAZIDE IN NORMAL MAN.
Topics: Biomedical Research; Blood Glucose; Cell Membrane Permeability; Chlorothiazide; Humans; Pharmacology; Phosphorus; Potassium; Potassium Chloride; Tolbutamide | 1965 |
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Differentiation; Cell Division; Cytosol; Diazoxide; Electric Conductivity; Electrophysiology; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Membrane Potentials; Mitochondria; NADP; Pancreatic Neoplasms; Patch-Clamp Techniques; Potassium Chloride; Rats; Tolbutamide; Tumor Cells, Cultured | 2004 |
Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Brain Ischemia; Chelating Agents; Chlorocebus aethiops; COS Cells; Drug Interactions; Edetic Acid; Glutamic Acid; Gramicidin; Hippocampus; Ionophores; Luminescent Measurements; Male; Membrane Proteins; Microscopy, Electron; Mossy Fibers, Hippocampal; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Wistar; Synaptosomes; Time Factors; Tolbutamide; Transfection; Valinomycin; Zinc | 2004 |
A pancreatic islet-specific microRNA regulates insulin secretion.
Topics: Animals; Calcium Signaling; Cell Line; Cloning, Molecular; Diabetes Mellitus; Exocytosis; Gene Expression; Gene Silencing; Genetic Therapy; Glucose; Insulin; Insulin Secretion; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Mice; MicroRNAs; Organ Specificity; Potassium Chloride; Substrate Specificity; Tolbutamide | 2004 |
Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets.
Topics: Animals; Diazoxide; Enzyme Inhibitors; Indoles; Insulin; Islets of Langerhans; Male; Norepinephrine; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Tolbutamide | 2004 |
Uncoupling of nutrient metabolism from insulin secretion by overexpression of cytosolic phospholipase A(2).
Topics: Animals; Calcium; Cell Line; Glucose; Insulin; Insulin Secretion; Ion Channels; Islets of Langerhans; Membrane Transport Proteins; Mitochondrial Proteins; NAD; NADP; Phospholipases A; Potassium Chloride; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tolbutamide; Transfection; Uncoupling Protein 2 | 2005 |
Similarities of K+ATP channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium; Cell Line; Glucose; Hypoglycemic Agents; Insulin-Secreting Cells; Mice; Mice, Inbred Strains; Multidrug Resistance-Associated Proteins; Neurons; Potassium Channels, Inwardly Rectifying; Potassium Chloride; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors; Tolbutamide; Ventromedial Hypothalamic Nucleus | 2005 |
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.
Topics: Animals; Calcium; Cell Line; Cyclic AMP; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Glucose; Guanine Nucleotide Exchange Factors; Hypoglycemic Agents; Insulin; Islets of Langerhans; Mice; Potassium Chloride; Recombinant Fusion Proteins; Second Messenger Systems; Tetraethylammonium; Tolbutamide | 2005 |
Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Animals; Butanols; Cell Line; Diazoxide; Ethanol; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Ocimum; Pancreas; Perfusion; Plant Extracts; Plant Leaves; Potassium Chloride; Rats; Rats, Long-Evans; Tissue Culture Techniques; Tolbutamide; Verapamil | 2006 |
Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.
Topics: Alanine; Arginine; Calcium; Carbachol; Clone Cells; Colforsin; Culture Media; Dose-Response Relationship, Drug; Gastrointestinal Hormones; Glucose; Homocysteine; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Keto Acids; Metabolic Syndrome; Potassium Chloride; Tetradecanoylphorbol Acetate; Tolbutamide | 2006 |
Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase.
Topics: Amino Acids; Animals; Calcium; Carcinogens; Catalase; Cell Line; Clone Cells; Colforsin; Dose-Response Relationship, Drug; Glucose; Homocysteine; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Keto Acids; Oxidation-Reduction; Potassium Chloride; Rats; Tetradecanoylphorbol Acetate; Tolbutamide | 2007 |
INGAP-PP up-regulates the expression of genes and proteins related to K+ ATP channels and ameliorates Ca2+ handling in cultured adult rat islets.
Topics: Animals; Blotting, Western; Calcium; Cytokines; Gene Expression; Glucose; Hepatocyte Nuclear Factor 3-beta; Insulin; Islets of Langerhans; KATP Channels; Pancreatitis-Associated Proteins; Peptide Fragments; Potassium Channels, Inwardly Rectifying; Potassium Chloride; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tissue Culture Techniques; Tolbutamide | 2008 |
Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB.
Topics: Animals; Calcium; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein; Dual Specificity Phosphatase 1; Early Growth Response Protein 1; Enzyme Activation; Epigenesis, Genetic; ErbB Receptors; ets-Domain Protein Elk-1; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Glucose; Hypoglycemic Agents; Insulinoma; Mice; Potassium Chloride; Protein Kinase C; PTEN Phosphohydrolase; Signal Transduction; Ternary Complex Factors; Tolbutamide; Transcriptional Activation; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2009 |
Kinetics of insulin secretion from MIN6 pseudoislets after encapsulation in a prototype device of a bioartificial pancreas.
Topics: Animals; Cell Culture Techniques; Cell Line; Feasibility Studies; Glucose; Green Fluorescent Proteins; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Kinetics; Mice; Pancreas, Artificial; Potassium Chloride; Tolbutamide | 2009 |
Plasma membrane depolarization as a determinant of the first phase of insulin secretion.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; KATP Channels; Membrane Potentials; Mice; Potassium Chloride; Time Factors; Tolbutamide | 2009 |
Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats.
Topics: Animals; Blood Glucose; Body Weight; Calcium; Calcium Channels; Diet; DNA; Female; Gene Expression; Glucose Tolerance Test; Homeostasis; Hypoglycemic Agents; Insulin; Islets of Langerhans; Lipids; Obesity; Organ Size; Oxidation-Reduction; Potassium Chloride; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tolbutamide | 2010 |
The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Connexins; Dihydropyridines; Gap Junction delta-2 Protein; Glucose; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Mefloquine; Mice; Nisoldipine; Potassium Chloride; Tolbutamide | 2018 |
Chronic stimulation induces adaptive potassium channel activity that restores calcium oscillations in pancreatic islets in vitro.
Topics: Adaptation, Physiological; Animals; Calcium Signaling; Cell Membrane; Congenital Hyperinsulinism; Humans; Insulin-Secreting Cells; Islets of Langerhans; KATP Channels; Male; Mice; Models, Theoretical; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Potassium Chloride; Stimulation, Chemical; Tolbutamide | 2020 |
Glucagonotropic and Glucagonostatic Effects of KATP Channel Closure and Potassium Depolarization.
Topics: Animals; Arginine; Calcium; Cell Membrane; Female; Gliclazide; Glucagon; Glucagon-Secreting Cells; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Membrane Potentials; Mice; Potassium; Potassium Chloride; Tolbutamide | 2021 |