tolbutamide has been researched along with phenylalanine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Curzon, G; Fernando, JC | 1 |
| Nishikawa, M; Sato, Y; Shinkai, H; Sukegawa, E | 1 |
| Hauswaldt, C; Klinge, O; Stöcker, E | 1 |
| Korner, A; Morris, GE | 1 |
| Göttinger, E | 1 |
| DeChatelet, LR; McDonald, HJ | 1 |
| Christensen, HN; Cullen, AM | 1 |
| Akiyoshi, M; Kakei, M; Nakazaki, M; Tanaka, H | 1 |
| Fujitani, S; Okazaki, K; Yada, T | 1 |
| Kikuchi, M; Niki, I; Oka, Y; Sakurada, M; Tsukuda, K | 1 |
| Hashimoto, Y; Inui, K; Saito, H; Uwai, Y | 1 |
| Lenzen, S; Peckmann, T | 1 |
| Gonoi, T; Ichikawa, K; Kusama, H; Seino, S; Shibasaki, T; Sunaga, Y; Yano, H | 1 |
| Ashcroft, FM; Carr, RD; Christensen, IT; Hansen, AM; Hansen, JB; Wahl, P | 1 |
| CARNEVALI, R; POLI, E; RAINERI, P | 1 |
| Iida, M; Iwase, M; Nakamura, U; Nohara, S; Sasaki, N; Sonoki, K; Uchizono, Y | 1 |
| Abdelmoneim, AS; Brocks, DR; Hasenbank, SE; Light, PE; Seubert, JM; Simpson, SH | 1 |
| Fatehi, M; Lang, VY; Light, PE | 1 |
1 review(s) available for tolbutamide and phenylalanine
| Article | Year |
|---|---|
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Cardiovascular Diseases; Cricetinae; Cyclohexanes; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Isoindoles; Mice; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nateglinide; Phenylalanine; Piperidines; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Risk Factors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
17 other study(ies) available for tolbutamide and phenylalanine
| Article | Year |
|---|---|
Drugs altering insulin secretion: effects on plasma and brain concentrations of aromatic amino acids and on brain 5-hydroxytryptamine turnover.
Topics: Amino Acids; Animals; Brain Chemistry; Fatty Acids, Nonesterified; Hydroxyindoleacetic Acid; Insulin; Insulin Secretion; Male; Phentolamine; Phenylalanine; Propranolol; Rats; Serotonin; Streptozocin; Tolbutamide; Tryptophan; Tyrosine | 1977 |
Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Dogs; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Mice; Mice, Mutant Strains; Nateglinide; Phenylalanine; Rats; Rats, Inbred Strains; Tolbutamide | 1991 |
[Autoradiographic studies on nucleic acid and protein metabolism in the islet cells of the rat under normal and pathological conditions].
Topics: Alloxan; Animals; Autoradiography; DNA; Glucagon; Insulin; Islets of Langerhans; Karyometry; Nucleosides; Phenylalanine; Protein Biosynthesis; Rats; RNA; Thymidine; Tolbutamide; Tritium | 1966 |
The effect of glucose on insulin biosynthesis by isolated islets of Langerhans of the rat.
Topics: Animals; Ascites; Carbon Isotopes; Chromatography, Gel; Cycloheximide; Electrophoresis; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Liver; Male; Metabolism; Mice; Phenylalanine; Protein Biosynthesis; Tolbutamide | 1970 |
[Toxicology of chemical sweetening agents].
Topics: Abnormalities, Drug-Induced; Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chromosome Aberrations; Chromosome Disorders; Cyclamates; Cyclohexylamines; Depression, Chemical; Esters; Guinea Pigs; Humans; Kidney Diseases; Mice; Pancreatic Diseases; Peptides; Phenylalanine; Photosensitivity Disorders; Rats; Saccharin; Sweetening Agents; Tolbutamide; Triazoles; Urinary Bladder Neoplasms | 1971 |
The inhibition in vitro of hepatic protein biosynthesis by various oral hypoglycemic agents--site of action.
Topics: Animals; Carbon Isotopes; Chlorpropamide; Female; Hypoglycemic Agents; In Vitro Techniques; Leucine; Liver; Lysine; Microsomes; Phenformin; Phenylalanine; Protein Biosynthesis; Rats; RNA, Transfer; Time Factors; Tolbutamide | 1969 |
Behavior in the rat of a transport-specific, bicyclic amino acid. Hypoglycemic action.
Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Animals; Blood Glucose; Bridged-Ring Compounds; Carbon Isotopes; Diaphragm; Drug Synergism; Leucine; Male; Pancreas; Phenylalanine; Rats; Stereoisomerism; Tolbutamide | 1969 |
A new hypoglycemic agent, A-4166, inhibits ATP-sensitive potassium channels in rat pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Calcium Channels; Cyclohexanes; Dose-Response Relationship, Drug; Electrophysiology; Hydrogen-Ion Concentration; Hypoglycemic Agents; Islets of Langerhans; Male; Membrane Potentials; Nateglinide; Phenylalanine; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 1995 |
The ability of a new hypoglycaemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition.
Topics: Animals; Calcium; Cyclohexanes; Cytosol; Electron Transport; Enzyme Inhibitors; Gliclazide; Glucokinase; Glucose; Hypoglycemic Agents; Islets of Langerhans; Mitochondria; Nateglinide; Oxidative Phosphorylation; Phenylalanine; Rats; Rats, Wistar; Sulfonylurea Compounds; Tolbutamide | 1997 |
Insulin secretion from isolated rat islets induced by the novel hypoglycemic agent A-4166, a derivative of D-phenylalanine.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Calcium; Cell Line; Cyclohexanes; Diazoxide; Epinephrine; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rubidium; Somatostatin; Stereoisomerism; Sulfonylurea Receptors; Tolbutamide | 1998 |
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.
Topics: Animals; Anion Transport Proteins; Binding, Competitive; Carbon Radioisotopes; Carrier Proteins; Chlorpropamide; Cyclohexanes; Dose-Response Relationship, Drug; Female; Glyburide; Hypoglycemic Agents; Kinetics; Nateglinide; Oocytes; p-Aminohippuric Acid; Phenylalanine; Rats; RNA, Complementary; Sulfonylurea Compounds; Tolbutamide; Xenopus | 2000 |
Effects of tolbutamide and N-benzoyl-D-phenylalanine (NBDP) on the regulation of [Ca2+]i oscillations in mouse pancreatic islets.
Topics: Animals; Calcium; Cells, Cultured; Drug Synergism; Female; Glucose; Hypoglycemic Agents; Islets of Langerhans; Membrane Proteins; Mice; Phenylalanine; Photoaffinity Labels; Potassium Channels; Tolbutamide | 2001 |
The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Line; COS Cells; Cyclohexanes; Glyburide; Hypoglycemic Agents; Indoles; Insulin; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transfection | 2001 |
Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1.
Topics: ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cell Line; Cyclohexanes; Drug Interactions; Electrophysiology; Humans; Islets of Langerhans; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 2002 |
[HYPOGLYCEMIC REACTION TO LEUCINE, VALINE AND PHENYLALANINE IN A CASE OF DIFFUSE HYPERPLASIA OF THE BETA CELLS].
Topics: Glucose Tolerance Test; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Hypoglycemic Agents; Insulin-Secreting Cells; Islands; Islets of Langerhans; Leucine; Pathology; Pharmacology; Phenylalanine; Tolbutamide; Valine | 1963 |
Nateglinide, a non-sulfonylurea rapid insulin secretagogue, increases pancreatic islet blood flow in rats.
Topics: 3-O-Methylglucose; Administration, Oral; Anesthesia; Animals; Blood Glucose; Blood Pressure; Consciousness; Cyclohexanes; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Gastrointestinal Tract; Glucose; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylalanine; Rats; Rats, Inbred OLETF; Rats, Sprague-Dawley; Regional Blood Flow; Time Factors; Tolbutamide | 2005 |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Topics: ATP-Binding Cassette Transporters; Chlorpropamide; Cyclohexanes; Diabetes Mellitus, Type 2; Gene Expression Regulation; Gliclazide; Glyburide; Haplotypes; Homozygote; Humans; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Polymorphism, Single Nucleotide; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |