Page last updated: 2024-08-16

tolbutamide and phenacetin

tolbutamide has been researched along with phenacetin in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (14.81)	18.7374
1990's	5 (9.26)	18.2507
2000's	6 (11.11)	29.6817
2010's	29 (53.70)	24.3611
2020's	6 (11.11)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J	1
Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C	1
Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT	1
Döring, G; Lackner, H	1
Bird, GW; Eeles, GH; Litchfield, JA; Rahman, M; Wingham, J	1
Bacci, MC; Bianchi, C; Bonardi, G; Coppi, G; Molino, C; Tomasi, L; Vidi, A	1
Nimmo, J; Prescott, LF	1
Walder, HR	1
Dibbern, HW	2
Eichelbaum, M	1
Chiba, K; Echizen, H; Ishizaki, T; Tani, M; Yoshimoto, K	1
Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D	1
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T	1
Back, DJ; Eagling, VA; Tjia, JF	1
Desta, Z; Flockhart, DA; Ko, JW; Soukhova, NV; Tracy, T	1
Fan, H; Li, Q; Liu, C; Song, N; Zhang, S	1
Jurica, J; Kyr, M; McCaskey Hadasova, E; Tomandl, J	1
Jurica, J; Konecný, J; Tomandl, J; Zahradníková, LZ	1
Castell, JV; Donato, MT; Gomez-Lechón, MJ; Hallifax, D; Houston, JB; Lahoz, A; Picazo, L	1
Furue, MK; Hayakawa, T; Higuchi, M; Inamura, M; Kawabata, K; Kikuchi, K; Mizuguchi, H; Nagamoto, Y; Sakurai, F; Sugawara, M; Takayama, K; Tashiro, K; Watanabe, H	1
Che, CT; Feng, R; Fu, J; Ma, C; Ma, JY; Or, PM; Shi, JG; Tan, XS; Wang, Y; Yeung, JH; Zhou, X	1
Hoi, PM; Hu, T; Kwan, YW; Lai, PB; Or, PM; Wan, DC; Wang, Y; Wong, J; Yeung, JH; Zhou, X	1
Lu, Y; Zhai, X	1
Chen, JL; Cui, HM; Dong, Y; Gong, JY; Zhang, YL	1
Chen, M; Chen, X; Hu, G; Hu, L; Lin, G; Ma, J; Pan, J; Wang, X	1
Hou, Y; Huang, Y; Xu, ZS; Zheng, SL	1
Ge, RS; Xu, RA; Xu, ZS	1
Liang, DL; Zheng, SL	1
Guo, YJ; Zheng, SL	1
Chen, WH; Chen, ZB; Hu, LF; Li, D; Lin, FY; Yu, XG; Zhi, AY	1
Chen, GL; Feng, XS; Gao, SG; Hu, XC; Kong, GQ; Liang, S; Ren, J; Sun, JC; Wang, XS; Yang, RN; Yuan, X	1
Lin, C; Lin, G; Ma, J; Wang, S; Wang, X; Zhang, M; Zhang, Q; Zhou, Y	1
Hu, L; Lin, F; Tang, M; Zheng, Y; Zhuang, Z	1
Lin, K; Lin, Y; Liu, Z; Wen, C; Yang, S; Zhang, Q; Zheng, Y	1
Chen, RJ; Ge, NY; Hao, C; Zhang, DF; Zhang, Y; Zhang, YT; Zhu, GH	1
Casteleyn, C; Jacobs, F; Pijpers, I; Snoeys, J; Van Cruchten, S; Van Ginneken, C; Van Houdt, J; Van Peer, E	1
Kharkar, P; Pandita, N; Sahu, N; Vaghela, M	1
Du, HJ; Lin, YP; Tan, WZ; Tang, BE; Wei, YL; Wu, ML; Ying, XQ	1
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N	1
Chen, LJ; Chen, XP; Chen, Y; Guo, J; Liou, YL; Tan, ZR; Xu, Y; Zhang, SX; Zhang, W; Zhou, HH	1
Dong, YY; Huang, CK; Lang, LP; Li, QQ; Qian, JC; Sun, W; Wang, Z; Zhang, XD	1

Other Studies

54 other study(ies) available for tolbutamide and phenacetin

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. Journal of medicinal chemistry, 2020, 07-09, Volume: 63, Issue:13 Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays	2020
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase. European journal of medicinal chemistry, 2022, Aug-05, Volume: 238 Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship	2022
Characterization of metronidazole metabolism by human liver microsomes. Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8 Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide	1991
Nmr spectroscopic identification of sulfonamides from urine. Forensic science, 1974, Volume: 4, Issue:3 Topics: Magnetic Resonance Spectroscopy; Phenacetin; Sulfonamides; Tolbutamide	1974
Haemolytic anaemia associated with antibodies to tolbutamide and phenacetin. British medical journal, 1972, Mar-18, Volume: 1, Issue:5802 Topics: Anemia, Hemolytic; Antibodies; Chlorpropamide; Coombs Test; Cross Reactions; Female; Glyburide; Humans; Middle Aged; Phenacetin; Tolbutamide	1972
Experimental models for the in vivo evaluation of enzyme induction properties of drugs. Arzneimittel-Forschung, 1973, Volume: 23, Issue:12 Topics: Acetanilides; Amides; Aminopyrine; Amphetamine; Aniline Compounds; Animals; Central Nervous System; Codeine; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Hexobarbital; Male; Meperidine; Mice; Oxotremorine; Pentobarbital; Phenacetin; Phenytoin; Rabbits; Rats; Strychnine; Tolbutamide; Tremorine; Zoxazolamine	1973
Generic inequivalence--clinical observations. Acta pharmacologica et toxicologica, 1971, Volume: 29 Suppl 3 Topics: Absorption; Acetaminophen; Administration, Oral; Adult; Aspirin; Biopharmaceutics; Capsules; Chloramphenicol; Delayed-Action Preparations; Drug Compounding; Female; Humans; Hydrochlorothiazide; Phenacetin; Prednisone; Tablets; Tablets, Enteric-Coated; Tetracycline; Therapeutic Equivalency; Time Factors; Tolbutamide; Triamterene	1971
[Idiopathic and drug-induced acquired aplastic anemia. 2]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1970, Nov-10, Volume: 59, Issue:45 Topics: Adult; Anemia, Aplastic; Aspirin; Bone Marrow Examination; Chloramphenicol; Chlorpheniramine; Chlorpromazine; Gold; Hemoglobins; Humans; Hydantoins; Middle Aged; Penicillins; Phenacetin; Prognosis; Sulfisoxazole; Switzerland; Tetracycline; Tolbutamide	1970
[Experiments with an in vitro model for the determination of gastroenteric absorption quota]. Arzneimittel-Forschung, 1966, Volume: 16, Issue:2 Topics: Aminopyrine; Aspirin; Caffeine; Digestive System Physiological Phenomena; Furosemide; Intestinal Absorption; Lipids; Models, Biological; Phenacetin; Spectrophotometry; Tolbutamide	1966
[On the resportion profile of drugs. 2. On studies with the resorption model]. Arzneimittel-Forschung, 1966, Volume: 16, Issue:10 Topics: Absorption; Antipyrine; Aspirin; Codeine; Hydrogen-Ion Concentration; Models, Biological; Phenacetin; Phenobarbital; Tolbutamide	1966
Polymorphic drug oxidation in humans. Federation proceedings, 1984, May-15, Volume: 43, Issue:8 Topics: Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Debrisoquin; Humans; Mephenytoin; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenytoin; Polymorphism, Genetic; Sparteine; Tolbutamide	1984
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. British journal of clinical pharmacology, 1995, Volume: 39, Issue:4 Topics: Aged; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Ditiocarb; Female; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazines; Phenacetin; Propranolol; Quinidine; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Sulfaphenazole; Tolbutamide; Troleandomycin	1995
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide	1997
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2 Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide	1998
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. British journal of clinical pharmacology, 1998, Volume: 45, Issue:2 Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Substrate Specificity; Sulfaphenazole; Testosterone; Theophylline; Tolbutamide	1998
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. British journal of clinical pharmacology, 2000, Volume: 49, Issue:4 Topics: Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Humans; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Muscle Relaxants, Central; Phenacetin; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tolbutamide	2000
Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Aug-01, Volume: 871, Issue:1 Topics: Animals; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Male; Mephenytoin; Midazolam; Phenacetin; Phenotype; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tolbutamide	2008
Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. Neuro endocrinology letters, 2009, Volume: 30 Suppl 1 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Liver; Male; Phenacetin; Rats; Rats, Wistar; Time Factors; Tolbutamide	2009
Simultaneous HPLC determination of tolbutamide, phenacetin and their metabolites as markers of cytochromes 1A2 and 2C6/11 in rat liver perfusate. Journal of pharmaceutical and biomedical analysis, 2010, Aug-01, Volume: 52, Issue:4 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P450 Family 2; Drug Interactions; Liver; Male; Models, Biological; Perfusion; Phenacetin; Rats; Rats, Wistar; Steroid 16-alpha-Hydroxylase; Steroid 21-Hydroxylase; Tolbutamide	2010
Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:9 Topics: Adenoviridae; Alprazolam; Base Sequence; Cell Line; Cytochrome P-450 Enzyme System; DNA Primers; Hepatocytes; Humans; Midazolam; Phenacetin; Tolbutamide	2010
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. Journal of hepatology, 2012, Volume: 57, Issue:3 Topics: Bupropion; Cell Differentiation; Cell Line; Embryonic Stem Cells; Ethanolamines; Gene Transfer Techniques; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 3-beta; Hepatocytes; Humans; Induced Pluripotent Stem Cells; Midazolam; Paclitaxel; Phenacetin; Testosterone; Tolbutamide; Transduction, Genetic	2012
Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, Sep-15, Volume: 19, Issue:12 Topics: Cytochrome P-450 Enzyme System; Gentianaceae; Herb-Drug Interactions; Humans; Phenacetin; Plant Extracts; Testosterone; Tolbutamide; Xanthones	2012
Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Feb-15, Volume: 20, Issue:3-4 Topics: Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Phenacetin; Phenanthrenes; Salvia miltiorrhiza; Testosterone; Tolbutamide	2013
Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium. Die Pharmazie, 2013, Volume: 68, Issue:1 Topics: Analgesics, Non-Narcotic; Animals; Anticoagulants; Calibration; Chlorzoxazone; Chromatography, High Pressure Liquid; Coumarins; Culture Media; Cytochrome P-450 Enzyme System; Hypoglycemic Agents; In Vitro Techniques; Liquid-Liquid Extraction; Microsomes, Liver; Muscle Relaxants, Central; Phenacetin; Quality Control; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Testosterone; Tolbutamide	2013
[CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:12 Topics: Berberine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Microsomes, Liver; Midazolam; Phenacetin; Tolbutamide	2013
Assessment of effects of chronic hydrogen sulfide poisoning on cytochrome P450 isoforms activity of rats by cocktail approach. Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:10 Topics: Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bupropion; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Hydrogen Sulfide; Male; Phenacetin; Protein Isoforms; Random Allocation; Rats; Rats, Sprague-Dawley; Tolbutamide	2013
Effects of unprocessed vs. cooked-processed Gastrodia elata on cytochrome P450 enzymes in rats. Drug research, 2014, Volume: 64, Issue:8 Topics: Analgesics, Non-Narcotic; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Compounding; Drug Interactions; Gastrodia; Hypoglycemic Agents; Isoenzymes; Male; Phenacetin; Plant Extracts; Rats; Rats, Sprague-Dawley; Tolbutamide	2014
Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats. Journal of ethnopharmacology, 2014, Feb-12, Volume: 151, Issue:3 Topics: Animals; Chalcone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Quinones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide	2014
Effects of icaritin on cytochrome P450 enzymes in rats. Die Pharmazie, 2014, Volume: 69, Issue:4 Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Flavonoids; Half-Life; Indicators and Reagents; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tolbutamide; Xenobiotics	2014
Effect of myricetin on cytochrome P450 isoforms CYP1A2, CYP2C9 and CYP3A4 in rats. Die Pharmazie, 2014, Volume: 69, Issue:4 Topics: Animals; Area Under Curve; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Flavonoids; Half-Life; Indicators and Reagents; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; Tolbutamide	2014
Pharmacokinetic of four probe drugs in adriamycin-induced nephropathy rat. European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:10 Topics: Animals; Bupropion; Cytochrome P-450 Enzyme System; Doxorubicin; Male; Nephrotic Syndrome; Omeprazole; Phenacetin; Rats, Sprague-Dawley; Tolbutamide	2014
Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. Phytotherapy research : PTR, 2015, Volume: 29, Issue:3 Topics: Animals; Apigenin; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Cytochromes; Herb-Drug Interactions; Liver; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Tolbutamide	2015
Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats. Biomedical chromatography : BMC, 2015, Volume: 29, Issue:8 Topics: Adjuvants, Anesthesia; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erlotinib Hydrochloride; Hypoglycemic Agents; Limit of Detection; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Phenacetin; Protein Kinase Inhibitors; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tolbutamide	2015
Effect of Dimethoate on the Activity of Hepatic CYP450 Based on Pharmacokinetics of Probe Drugs. Pharmacology, 2015, Volume: 95, Issue:5-6 Topics: Animals; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Dimethoate; Gene Expression; Insecticides; Liver; Male; Metoprolol; Midazolam; Phenacetin; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide	2015
Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:5 Topics: Administration, Oral; Animals; Bupropion; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2B6 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochromes; Drug Interactions; Edema; Enzyme Induction; Histone Deacetylase Inhibitors; Hydroxamic Acids; Liver; Male; Metoprolol; Omeprazole; Phenacetin; Rats, Sprague-Dawley; Substrate Specificity; Tandem Mass Spectrometry; Tolbutamide; Vorinostat	2015
Effect of Evodiamine on CYP Enzymes in Rats by a Cocktail Method. Pharmacology, 2016, Volume: 97, Issue:5-6 Topics: Administration, Oral; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Liver; Male; Metoprolol; Midazolam; Omeprazole; Phenacetin; Quinazolines; Rats, Sprague-Dawley; Tolbutamide	2016
In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs. Pharmaceutical research, 2017, Volume: 34, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Fetus; Glucuronosyltransferase; Humans; Male; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Microsomes, Liver; Midazolam; Phenacetin; Swine; Swine, Miniature; Tolbutamide	2017
In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats. Chemico-biological interactions, 2017, Dec-25, Volume: 278 Topics: Administration, Oral; Amlodipine; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Ethanol; Gas Chromatography-Mass Spectrometry; Gymnema sylvestre; Half-Life; Male; Mass Spectrometry; Phenacetin; Plant Extracts; Rats; Rats, Wistar; Tolbutamide	2017
Calycosin Influences the Metabolism of Five Probe Drugs in Rats. Drug design, development and therapy, 2020, Volume: 14 Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Isoflavones; Medicine, Chinese Traditional; Metoprolol; Midazolam; Omeprazole; Phenacetin; Rats; Tolbutamide	2020
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography. Scientific reports, 2020, 06-01, Volume: 10, Issue:1 Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water	2020
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug. Journal of advanced research, 2022, Volume: 39 Topics: Animals; Chlorzoxazone; Gastrointestinal Microbiome; Metoprolol; Mice; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Pharmaceutical Preparations; Phenacetin; Tolbutamide	2022
Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method. Journal of pharmaceutical and biomedical analysis, 2023, Feb-05, Volume: 224 Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Metoprolol; Midazolam; Phenacetin; Rats; Tandem Mass Spectrometry; Tolbutamide	2023