Page last updated: 2024-08-16

tolbutamide and midazolam

tolbutamide has been researched along with midazolam in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	22 (28.57)	29.6817
2010's	43 (55.84)	24.3611
2020's	12 (15.58)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J	1
Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C	1
Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P	1
Gorski, JC; Hall, SD; Hamman, MA; Huang, SM; Lesko, LJ; Wang, Z	1
Kokue, E; Kuroha, M; Kuze, Y; Shimoda, M	1
Aherne, Z; Blakey, GE; Lockton, JA; Norwood, P; Perrett, J; Plume, J; Russell, M	1
Desai, M; Gorski, JC; Hall, SD; Hamman, MA; Hilligoss, JK; Huang, SM; Miller, M; Pinto, A; Zaheer, NA	1
Blum, RA; Bradstreet, TE; Evans, JK; Gargano, C; Lee, Y; Majumdar, AK; Petty, KJ; Shadle, CR	1
Adams, M; Ahdieh, H; Gammaitoni, AR; Pieniaszek, HJ	1
Dostalek, M; Hadasova, E; Jurica, J; Linhart, I; Pistovcakova, J; Sulcová, A; Tomandl, J	1
Kokue, E; Kuroha, M; Shibata, Y; Shimoda, M; Zhang, K	1
Li, XD; Maruyama, S; Ohashi, K; Ohmori, Y; Oki, T; Uchida, S; Umegaki, K; Watanabe, H; Yamada, H; Yamada, S	1
Brown, HS; Chadwick, A; Houston, JB	1
Regmi, NL; Sanda, S; Sasaki, K; Shah, SS; Shimoda, M	1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J	1
Fan, H; Li, Q; Liu, C; Song, N; Zhang, S	1
Higashi, R; Matsumoto, I; Miyata, Y; Nakade, S; Nunoya, K; Ogawa, M; Sutoh, F; Yoneda, K	1
Bertelsen, K; Guo, P; Han, F; Huang, MQ; Lin, ZJ; Weng, N; Zhang, W; Zhao, H	1
Castell, JV; Donato, MT; Gomez-Lechón, MJ; Hallifax, D; Houston, JB; Lahoz, A; Picazo, L	1
Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M	1
Auwärter, V; Dresen, S; Lutz-Bonengel, S; Naue, J; Wohlfarth, A	1
Guo, C; Han, YL; Jing, GP; Li, D; Li, Y; Meng, XL; Ren, B; Wan, LL; Yu, Q; Zhou, ZY	1
Bekersky, I; Blum, RA; Tolbert, D; Walzer, M	1
Furue, MK; Hayakawa, T; Higuchi, M; Inamura, M; Kawabata, K; Kikuchi, K; Mizuguchi, H; Nagamoto, Y; Sakurai, F; Sugawara, M; Takayama, K; Tashiro, K; Watanabe, H	1
Takayanagi, R; Teramoto, S; Uotsu, N; Yamada, M; Yamada, Y; Yamasaki, I	1
Chalasani, N; Hall, SD; Jones, DR; Mattar, S; Tandra, S; Vuppalanchi, R	1
Jiao, J; Li, Q; Liu, Y; Lou, J; Zhang, C	1
Srinivas, NR	1
Chen, JL; Cui, HM; Dong, Y; Gong, JY; Zhang, YL	1
Huang, Y; Xu, RA; Xu, ZS; Zheng, SL; Zhu, HY	1
Chen, M; Chen, X; Han, A; Lin, G; Ma, J; Wang, X; Wen, C; Yang, X	1
Ge, RS; Xu, RA; Xu, ZS	1
Liang, DL; Zheng, SL	1
Guo, YJ; Zheng, SL	1
Bernstein, HJ; Brinda, BJ; Chavin, KD; Frye, RF; Kawaguchi-Suzuki, M; Markowitz, JS; Zhu, HJ	1
Cao, X; Huang, Y; Lan, YY; Li, YJ; Liao, SG; Liu, Y; Lu, Y; Tang, L; Wang, AM; Wang, YL; Zheng, L	1
Chen, GL; Feng, XS; Gao, SG; Hu, XC; Kong, GQ; Liang, S; Ren, J; Sun, JC; Wang, XS; Yang, RN; Yuan, X	1
Lin, C; Lin, G; Ma, J; Wang, S; Wang, X; Zhang, M; Zhang, Q; Zhou, Y	1
Gurley, BJ; Markowitz, JS; Munoz, J; Wang, X; Zhu, HJ	1
Hu, L; Lin, F; Tang, M; Zheng, Y; Zhuang, Z	1
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ	1
Cannady, EA; Friedrich, S; Krueger, KA; Nicholls, SJ; Rehmel, JR; Suico, JG; Wang, MD	1
Bénech, H; Lenuzza, N; Nguyen, TT; Pruvost, A	1
Chen, RJ; Ge, NY; Hao, C; Zhang, DF; Zhang, Y; Zhang, YT; Zhu, GH	1
Lei, D; Li, X; Liu, Y; Lu, J; Wei, J; Yan, S	1
Casteleyn, C; Jacobs, F; Pijpers, I; Snoeys, J; Van Cruchten, S; Van Ginneken, C; Van Houdt, J; Van Peer, E	1
Gong, Z; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zheng, J; Zheng, L	1
Liu, L; Liu, X; Tang, X; Wang, S; Xu, J; Yang, T; Zhang, J	1
Gaudette, F; Huguet, J; Michaud, V; Turgeon, J	1
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ	1
Cho, SA; Kim, WY; Lee, SJ; Lee, SS; Shin, JG; Yi, M; Yoo, SE	1
Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J	1
Du, HJ; Lin, YP; Tan, WZ; Tang, BE; Wei, YL; Wu, ML; Ying, XQ	1
Ohtsuki, S; Otagiri, M; Sakai, H; Taguchi, K; Tokuno, M; Yamasaki, K	2
Custodio, JM; Donaldson, KM; Hunt, HJ	1
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH	1
Chen, LJ; Chen, XP; Chen, Y; Guo, J; Liou, YL; Tan, ZR; Xu, Y; Zhang, SX; Zhang, W; Zhou, HH	1
Abdulrasool, LI; Endres, CJ; Lee, A; Mayor, JG; Rustia, EL; Sun, H; Topletz-Erickson, A; Walker, L	1
Dong, YY; Huang, CK; Lang, LP; Li, QQ; Qian, JC; Sun, W; Wang, Z; Zhang, XD	1
Chen, SY; Chen, Y; Gong, ZP; Huang, J; Huang, Y; Li, Y; Li, YT; Wang, YL; Yang, HL; Zheng, L	1
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW	1

Reviews

1 review(s) available for tolbutamide and midazolam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

13 trial(s) available for tolbutamide and midazolam

Article	Year
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological Availability; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Drug Interactions; Enzyme Induction; Female; Humans; Hypericum; Injections, Intravenous; Isoenzymes; Male; Midazolam; Oxidoreductases, N-Demethylating; Plant Extracts; Tolbutamide	2001
Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1. British journal of clinical pharmacology, 2004, Volume: 57, Issue:2 Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Combinations; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Plasma; Tolbutamide	2004
Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity. Journal of clinical pharmacology, 2004, Volume: 44, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Antiemetics; Aprepitant; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Enzyme Induction; Female; Half-Life; Humans; Injections, Intravenous; Male; Midazolam; Morpholines; Neurokinin-1 Receptor Antagonists; Tolbutamide	2004
Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways. Journal of clinical pharmacology, 2005, Volume: 45, Issue:3 Topics: Adolescent; Adult; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Delayed-Action Preparations; Drug Interactions; Erythromycin; Female; Humans; Male; Midazolam; Middle Aged; Naltrexone; Oxymorphone; Rifampin; Tolbutamide	2005
Effect of oral administration of clinically relevant doses of dexamethasone on regulation of cytochrome P450 subfamilies in hepatic microsomes from dogs and rats. American journal of veterinary research, 2006, Volume: 67, Issue:2 Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Cytochrome P-450 Enzyme System; Dexamethasone; Dogs; Ethanolamines; Hypnotics and Sedatives; Hypoglycemic Agents; Male; Microsomes, Liver; Midazolam; Oxazines; Rats; Rats, Wistar; Tolbutamide	2006
Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. Journal of clinical pharmacology, 2006, Volume: 46, Issue:11 Topics: Adult; Anti-Anxiety Agents; Area Under Curve; Drug Interactions; Ginkgo biloba; Half-Life; Humans; Hypoglycemic Agents; Male; Midazolam; Plant Extracts; Tolbutamide	2006
Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy, 2012, Volume: 32, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Clinical Trials, Phase I as Topic; Clobazam; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Isoenzymes; Lamotrigine; Male; Midazolam; Middle Aged; Models, Statistical; Pharmacokinetics; Prospective Studies; Tolbutamide; Triazines; Valproic Acid; Young Adult	2012
Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients. Annals of surgery, 2013, Volume: 258, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Biotransformation; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dextromethorphan; Diuretics; Excitatory Amino Acid Antagonists; Female; Furosemide; GABA Modulators; Gastric Bypass; Humans; Hypoglycemic Agents; Male; Midazolam; Middle Aged; Omeprazole; Pharmacokinetics; Tandem Mass Spectrometry; Tolbutamide; Young Adult	2013
The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10 Topics: Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Female; Herb-Drug Interactions; Humans; Male; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult	2014
CYP-mediated drug-drug interactions with evacetrapib, an investigational CETP inhibitor: in vitro prediction and clinical outcome. British journal of clinical pharmacology, 2015, Volume: 80, Issue:6 Topics: Anticholesteremic Agents; Benzodiazepines; Cells, Cultured; Cholesterol Ester Transfer Proteins; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Drug Interactions; Humans; Microsomes, Liver; Midazolam; Simvastatin; Tolbutamide	2015
A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail. European journal of clinical pharmacology, 2016, Volume: 72, Issue:1 Topics: Bayes Theorem; Caffeine; Computer Simulation; Dextromethorphan; Drug Interactions; Humans; Midazolam; Models, Biological; Omeprazole; Phenotype; Pilot Projects; Tolbutamide	2016
An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes. Journal of clinical pharmacology, 2021, Volume: 61, Issue:2 Topics: Area Under Curve; Cross-Over Studies; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Humans; Isoquinolines; Midazolam; Pioglitazone; Pyrazoles; Pyridines; Tolbutamide	2021
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers. Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:7 Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide	2022

Other Studies

63 other study(ies) available for tolbutamide and midazolam

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. Journal of medicinal chemistry, 2020, 07-09, Volume: 63, Issue:13 Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays	2020
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase. European journal of medicinal chemistry, 2022, Aug-05, Volume: 238 Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship	2022
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:10 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Single-Blind Method; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide	2001
In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes. American journal of veterinary research, 2002, Volume: 63, Issue:6 Topics: Animals; Antifungal Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Ethanolamines; Isoenzymes; Ketoconazole; Kinetics; Male; Microsomes, Liver; Midazolam; Oxazines; Tolbutamide	2002
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clinical pharmacology and therapeutics, 2004, Volume: 75, Issue:1 Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Echinacea; Female; Herb-Drug Interactions; Humans; Infusions, Intravenous; Male; Midazolam; Phytotherapy; Plant Extracts; Plant Roots; Reference Values; Tolbutamide	2004
Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver. Life sciences, 2005, Dec-05, Volume: 78, Issue:3 Topics: Animals; Antidepressive Agents; Area Under Curve; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Hypericum; Injections, Intraperitoneal; Liver; Male; Midazolam; Perfusion; Plant Extracts; Rats; Rats, Wistar; Tolbutamide	2005
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11 Topics: Animals; Catalysis; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluconazole; Fluoxetine; Fluvoxamine; Hepatocytes; Ketoconazole; Kinetics; Male; Miconazole; Microsomes, Liver; Midazolam; Phenytoin; Quinine; Rats; Rats, Sprague-Dawley; Tolbutamide	2007
Characterization of cytochrome P450-mediated drug metabolism in cats. Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30, Issue:5 Topics: Adrenergic beta-Antagonists; Animals; Cats; Cytochrome P-450 Enzyme System; Ethanolamines; Female; Hypnotics and Sedatives; Hypoglycemic Agents; Male; Microsomes, Liver; Midazolam; Oxazines; Tolbutamide	2007
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide	2007
Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Aug-01, Volume: 871, Issue:1 Topics: Animals; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Male; Mephenytoin; Midazolam; Phenacetin; Phenotype; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tolbutamide	2008
In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:4 Topics: Anti-Asthmatic Agents; Antibodies, Blocking; Antifungal Agents; Cell Line, Tumor; Chromones; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Ketoconazole; Leukotriene Antagonists; Microsomes, Liver; Midazolam; Oxygenases; Terfenadine; Tolbutamide	2009
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, May-01, Volume: 878, Issue:15-16 Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Discovery; Drug Interactions; Drug Stability; High-Throughput Screening Assays; Humans; Midazolam; Omeprazole; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Temperature; Tolbutamide	2010
Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:9 Topics: Adenoviridae; Alprazolam; Base Sequence; Cell Line; Cytochrome P-450 Enzyme System; DNA Primers; Hepatocytes; Humans; Midazolam; Phenacetin; Tolbutamide	2010
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	2011
Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping. Journal of clinical pharmacology, 2012, Volume: 52, Issue:8 Topics: Adult; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Genotype; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Phenotype; Pilot Projects; Tandem Mass Spectrometry; Tolbutamide; Young Adult	2012
Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs. Journal of ethnopharmacology, 2012, Jan-06, Volume: 139, Issue:1 Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Enzyme Inhibitors; Erigeron; Herb-Drug Interactions; Metoprolol; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide	2012
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. Journal of hepatology, 2012, Volume: 57, Issue:3 Topics: Bupropion; Cell Differentiation; Cell Line; Embryonic Stem Cells; Ethanolamines; Gene Transfer Techniques; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 3-beta; Hepatocytes; Humans; Induced Pluripotent Stem Cells; Midazolam; Paclitaxel; Phenacetin; Testosterone; Tolbutamide; Transduction, Genetic	2012
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats. Biomedical research (Tokyo, Japan), 2012, Volume: 33, Issue:4 Topics: Administration, Oral; Animals; Area Under Curve; Brassica; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dextromethorphan; Enzyme Inhibitors; Herb-Drug Interactions; Liver; Metabolic Clearance Rate; Midazolam; Omeprazole; Rats; RNA, Messenger; Tolbutamide	2012
Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach. Drug development and industrial pharmacy, 2014, Volume: 40, Issue:2 Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Enzyme Activation; Female; Ischemic Preconditioning; Isoenzymes; Liver; Male; Metoprolol; Midazolam; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Tolbutamide	2014
Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence. European journal of drug metabolism and pharmacokinetics, 2013, Volume: 38, Issue:4 Topics: Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Beverages; Buspirone; Caco-2 Cells; Calcium Channel Blockers; Carbamazepine; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Flurbiprofen; Food-Drug Interactions; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Lythraceae; Midazolam; Nitrendipine; Tolbutamide; Triazolam	2013
[CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:12 Topics: Berberine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Microsomes, Liver; Midazolam; Phenacetin; Tolbutamide	2013
Effects of aescin on cytochrome P450 enzymes in rats. Journal of ethnopharmacology, 2014, Volume: 151, Issue:1 Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 Enzyme System; Escin; Gene Expression Regulation, Enzymologic; Half-Life; Herb-Drug Interactions; Hypnotics and Sedatives; Hypoglycemic Agents; Liver; Male; Midazolam; Muscle Relaxants, Central; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide	2014
The effects of H2S on the activities of CYP2B6, CYP2D6, CYP3A4, CYP2C19 and CYP2C9 in vivo in rat. International journal of molecular sciences, 2013, Dec-10, Volume: 14, Issue:12 Topics: Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; Half-Life; Hydrogen Sulfide; Male; Mass Spectrometry; Midazolam; Omeprazole; Rats; Rats, Sprague-Dawley; Tolbutamide	2013
Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats. Journal of ethnopharmacology, 2014, Feb-12, Volume: 151, Issue:3 Topics: Animals; Chalcone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Quinones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide	2014
Effects of icaritin on cytochrome P450 enzymes in rats. Die Pharmazie, 2014, Volume: 69, Issue:4 Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Flavonoids; Half-Life; Indicators and Reagents; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tolbutamide; Xenobiotics	2014
Effect of myricetin on cytochrome P450 isoforms CYP1A2, CYP2C9 and CYP3A4 in rats. Die Pharmazie, 2014, Volume: 69, Issue:4 Topics: Animals; Area Under Curve; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Flavonoids; Half-Life; Indicators and Reagents; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; Tolbutamide	2014
Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs. Journal of ethnopharmacology, 2014, Dec-02, Volume: 158 Pt A Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Midazolam; Omeprazole; Plant Extracts; Polygonum; Rats; Rats, Sprague-Dawley; Tolbutamide	2014
Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. Phytotherapy research : PTR, 2015, Volume: 29, Issue:3 Topics: Animals; Apigenin; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Cytochromes; Herb-Drug Interactions; Liver; Male; Midazolam; Phenacetin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Tolbutamide	2015
Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats. Biomedical chromatography : BMC, 2015, Volume: 29, Issue:8 Topics: Adjuvants, Anesthesia; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erlotinib Hydrochloride; Hypoglycemic Agents; Limit of Detection; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Phenacetin; Protein Kinase Inhibitors; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tolbutamide	2015
An ex vivo approach to botanical-drug interactions: a proof of concept study. Journal of ethnopharmacology, 2015, Apr-02, Volume: 163 Topics: Adult; Benzylisoquinolines; Berberine; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Herb-Drug Interactions; Humans; Hydrastis; Male; Microsomes, Liver; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult	2015
Effect of Dimethoate on the Activity of Hepatic CYP450 Based on Pharmacokinetics of Probe Drugs. Pharmacology, 2015, Volume: 95, Issue:5-6 Topics: Animals; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Dimethoate; Gene Expression; Insecticides; Liver; Male; Metoprolol; Midazolam; Phenacetin; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide	2015
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress]. Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:3 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide	2015
Effect of Evodiamine on CYP Enzymes in Rats by a Cocktail Method. Pharmacology, 2016, Volume: 97, Issue:5-6 Topics: Administration, Oral; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Liver; Male; Metoprolol; Midazolam; Omeprazole; Phenacetin; Quinazolines; Rats, Sprague-Dawley; Tolbutamide	2016
Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism. Materials science & engineering. C, Materials for biological applications, 2016, Volume: 63 Topics: Animals; Cells, Cultured; Coculture Techniques; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Endothelial Cells; Fibroblasts; Hepatocytes; Male; Microscopy, Confocal; Microscopy, Electron, Scanning; Midazolam; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Tolbutamide; Warfarin	2016
In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs. Pharmaceutical research, 2017, Volume: 34, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Fetus; Glucuronosyltransferase; Humans; Male; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Microsomes, Liver; Midazolam; Phenacetin; Swine; Swine, Miniature; Tolbutamide	2017
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches. Molecules (Basel, Switzerland), 2017, Nov-20, Volume: 22, Issue:11 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Enzyme Activation; Herb-Drug Interactions; Isoenzymes; Midazolam; Omeprazole; Rats; Steroid 16-alpha-Hydroxylase; Tolbutamide; Warfarin	2017
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Atorvastatin; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Kinetics; Microsomes, Liver; Midazolam; Protein Isoforms; Testosterone; Tolbutamide; Verapamil; Warfarin	2019
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Bupropion; Butyrophenones; Carbamates; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Ethanolamines; Humans; Lauric Acids; Microsomes; Midazolam; Myocardium; Oxazines; Piperidines; Tolbutamide	2019
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency]. Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency	2017
Influences of cytochrome b5 expression and its genetic variant on the activity of CYP2C9, CYP2C19 and CYP3A4. Drug metabolism and pharmacokinetics, 2019, Volume: 34, Issue:3 Topics: Alternative Splicing; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochromes b5; Genetic Variation; Humans; In Vitro Techniques; Liver; Midazolam; Omeprazole; Tolbutamide	2019
Modulation of CYP450 Activities in Patients With Type 2 Diabetes. Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6 Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha	2019
Calycosin Influences the Metabolism of Five Probe Drugs in Rats. Drug design, development and therapy, 2020, Volume: 14 Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Isoflavones; Medicine, Chinese Traditional; Metoprolol; Midazolam; Omeprazole; Phenacetin; Rats; Tolbutamide	2020
Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:5 Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide	2020
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:5 Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tolbutamide	2020
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug. Journal of advanced research, 2022, Volume: 39 Topics: Animals; Chlorzoxazone; Gastrointestinal Microbiome; Metoprolol; Mice; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Pharmaceutical Preparations; Phenacetin; Tolbutamide	2022
Evaluation of Safety and Clinically Relevant Drug-Drug Interactions with Tucatinib in Healthy Volunteers. Clinical pharmacokinetics, 2022, Volume: 61, Issue:10 Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Digoxin; Drug Interactions; Gemfibrozil; Healthy Volunteers; Humans; Itraconazole; Midazolam; Oxazoles; Pyridines; Quinazolines; Rifampin; Tolbutamide	2022
Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method. Journal of pharmaceutical and biomedical analysis, 2023, Feb-05, Volume: 224 Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Metoprolol; Midazolam; Phenacetin; Rats; Tandem Mass Spectrometry; Tolbutamide	2023
[Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:23 Topics: Animals; Caffeine; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Metoprolol; Midazolam; Omeprazole; Plant Extracts; Rats; Tandem Mass Spectrometry; Tolbutamide	2022
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis. Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10 Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary	2023