tolbutamide has been researched along with mephenytoin in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.76) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 7 (20.59) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J | 1 |
| Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C | 1 |
| Beaune, PH; Ged, C; Guengerich, FP; Srivastava, PK; Yun, CH | 1 |
| Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT | 1 |
| Birkett, DJ; Doecke, CJ; McManus, ME; Miners, JO; Pond, SM; Sansom, LN; Veronese, ME | 1 |
| Breckenridge, AM; Helsby, NA; Howells, RE; Ward, SA | 1 |
| Aoyama, T; Gonzalez, FJ; Meyer, UA; Relling, MV | 1 |
| Brian, WR; Guengerich, FP; Lloyd, RS; Srivastava, PK; Umbenhauer, DR | 1 |
| Birkett, DJ; McManus, ME; Miners, JO; Robson, RA; Smith, KJ; Veronese, ME | 1 |
| Guengerich, FP; Hall, SD; Knodell, RG; Wilkinson, GR | 1 |
| Eichelbaum, M | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Tani, M; Yoshimoto, K | 1 |
| Burke, MD; Dickins, M; Weaver, RJ | 1 |
| Faletto, MB; Ghanayem, BI; Goldstein, JA; Kitareewan, S; Lasker, JM; Raucy, JL; Romkes-Sparks, M; Sullivan, T | 1 |
| Desager, JP; Horsmans, Y; Kanyinda, JM | 1 |
| Akasaka, S; Guengerich, FP; Imiya, K; Inoue, K; Shimada, T; Yamazaki, H | 1 |
| Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D | 1 |
| Aramsombatdee, E; Lasker, JM; Raucy, JL; Wester, MR | 1 |
| Johnson, EF; Lasker, JM; Raucy, JL; Wester, MR | 1 |
| Desta, Z; Flockhart, DA; Ko, JW; Soukhova, NV; Tracy, T | 1 |
| Ishibashi, F; Kageyama, A; Katagiri, M; Kishimoto, K; Niwa, T; Yabusaki, Y | 1 |
| Baker, GB; Holt, A; Salsali, M | 1 |
| Asahi, S; Iwasaki, M; Mitsuda, M | 1 |
| Fujino, H; Kamataki, T; Kito, G; Kumano, T; Nagata, R; Uno, Y | 1 |
| Fan, H; Li, Q; Liu, C; Song, N; Zhang, S | 1 |
| Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M | 1 |
| Burmistrova, OA; Poloznikov, AA; Sakharov, DA; Shkurnikov, MY; Zakhariants, AA | 1 |
| Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N | 1 |
1 review(s) available for tolbutamide and mephenytoin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
33 other study(ies) available for tolbutamide and mephenytoin
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays | 2020 |
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2022 |
Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.
Topics: Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; DNA; Humans; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid; Tolbutamide; Tritium | 1991 |
Characterization of metronidazole metabolism by human liver microsomes.
Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide | 1991 |
Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.
Topics: Binding, Competitive; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Immunoglobulin G; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Sulfaphenazole; Tolbutamide | 1991 |
In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.
Topics: Antimalarials; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Proguanil; Sparteine; Tolbutamide | 1990 |
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.
Topics: Cell Line; Cytochrome P-450 Enzyme System; DNA; Humans; Hydantoins; Hydroxylation; In Vitro Techniques; Mephenytoin; Microsomes, Liver; Polymorphism, Genetic; Tolbutamide; Vaccinia virus | 1990 |
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
Topics: Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Electrophoresis; Gene Expression Regulation; Genetic Vectors; Hexobarbital; Humans; Liver; Mephenytoin; Mixed Function Oxygenases; Oxidation-Reduction; Plasmids; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Sulfaphenazole; Tolbutamide | 1989 |
Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations.
Topics: Cytochrome P-450 Enzyme System; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Theophylline; Tolbutamide | 1988 |
Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition.
Topics: Adult; Aged; Binding, Competitive; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Tolbutamide | 1987 |
Polymorphic drug oxidation in humans.
Topics: Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Debrisoquin; Humans; Mephenytoin; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenytoin; Polymorphism, Genetic; Sparteine; Tolbutamide | 1984 |
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
Topics: Aged; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Ditiocarb; Female; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazines; Phenacetin; Propranolol; Quinidine; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Sulfaphenazole; Tolbutamide; Troleandomycin | 1995 |
Hydroxylation of the antimalarial drug 58C80 by CYP2C9 in human liver microsomes: comparison with mephenytoin and tolbutamide hydroxylations.
Topics: Antimalarials; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Naphthoquinones; Steroid 16-alpha-Hydroxylase; Tolbutamide | 1995 |
Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.
Topics: Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Gene Expression; Humans; Hydroxylation; Immunoblotting; Liver; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger; Saccharomyces cerevisiae; Sequence Analysis, RNA; Stereoisomerism; Substrate Specificity; Tolbutamide | 1994 |
Relationship between mephenytoin, phenytoin and tolbutamide hydroxylations in healthy African subjects.
Topics: Adult; Democratic Republic of the Congo; Female; Humans; Hydroxylation; Male; Mephenytoin; Phenytoin; Tolbutamide | 1996 |
Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations.
Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Genotype; Humans; Hydroxylation; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide; White People | 1997 |
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide | 1997 |
Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Humans; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide; Ultrafiltration | 1998 |
CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes.
Topics: Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cross Reactions; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Hydroxylation; Male; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Rabbits; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 2000 |
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
Topics: Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Humans; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Muscle Relaxants, Central; Phenacetin; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tolbutamide | 2000 |
Amino acid residues affecting the activities of human cytochrome P450 2C9 and 2C19.
Topics: Amino Acid Substitution; Aminopyrine; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Diclofenac; Humans; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes; Mixed Function Oxygenases; Point Mutation; Recombinant Fusion Proteins; Stereoisomerism; Substrate Specificity; Testosterone; Tolbutamide | 2002 |
Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Mephenytoin; Mitochondria; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Tolbutamide; Tranylcypromine | 2004 |
Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cloning, Molecular; Cricetinae; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Guinea Pigs; Humans; Kinetics; Macaca fascicularis; Mephenytoin; Mice; Microsomes, Liver; Mixed Function Oxygenases; Progesterone; Rabbits; Rats; Recombinant Proteins; Substrate Specificity; Testosterone; Tolbutamide | 2006 |
CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans.
Topics: Animals; Antibodies; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Haplorhini; Humans; Kinetics; Male; Mephenytoin; Microsomes, Liver; Paclitaxel; Quinolines; Recombinant Proteins; Species Specificity; Testosterone; Tolbutamide | 2007 |
Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.
Topics: Animals; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Male; Mephenytoin; Midazolam; Phenacetin; Phenotype; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tolbutamide | 2008 |
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 2011 |
Development of a Specific Substrate-Inhibitor Panel (Liver-on-a-Chip) for Evaluation of Cytochrome P450 Activity.
Topics: Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; Ketoconazole; Lab-On-A-Chip Devices; Liver; Mass Spectrometry; Mephenytoin; Microsomes, Liver; Omeprazole; Phencyclidine; Substrate Specificity; Sulfaphenazole; Testosterone; Tolbutamide | 2016 |
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography.
Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water | 2020 |