Page last updated: 2024-08-16

tolbutamide and losartan

tolbutamide has been researched along with losartan in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (30.77)	29.6817
2010's	7 (53.85)	24.3611
2020's	2 (15.38)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Blaisdell, JA; Frye, RF; Goldstein, JA; Hinderliter, AL; Lee, CR; Pieper, JA	1
Maciążek-Jurczyk, M; Pentak, D; Ploch, A; Pożycka, J; Szkudlarek, A	1
Cai, JP; Chen, H; Chong, J; Dai, DP; Geng, PW; Liu, J; Lü, Y; Wang, SH; Wu, HL; Yang, JF; Zhou, Q; Zhou, S	1
Cai, JP; Chen, H; Dai, DP; Geng, PW; Liu, J; Shi, HF; Wang, F; Wang, SH; Wu, HL; Yang, JF; Zhou, Q; Zhou, YF	1

Reviews

1 review(s) available for tolbutamide and losartan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for tolbutamide and losartan

Article	Year
Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans. Journal of clinical pharmacology, 2003, Volume: 43, Issue:1 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2C9; Female; Flurbiprofen; Genotype; Humans; Losartan; Male; Phenotype; Tolbutamide	2003

Other Studies

11 other study(ies) available for tolbutamide and losartan

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States. Molecules (Basel, Switzerland), 2017, Dec-17, Volume: 22, Issue:12 Topics: Antihypertensive Agents; Glucose; Glycation End Products, Advanced; Humans; Hyperglycemia; Hypoglycemic Agents; Losartan; Protein Conformation, alpha-Helical; Protein Structure, Tertiary; Serum Albumin, Human; Tolbutamide	2017
An identification and functional evaluation of a novel CYP2C9 variant CYP2C962. Chemico-biological interactions, 2020, Aug-25, Volume: 327* Topics: Aged, 80 and over; Alleles; Animals; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Assays; Humans; Kinetics; Losartan; Male; Microsomes; Point Mutation; Polymorphism, Genetic; Recombinant Proteins; Spodoptera; Tolbutamide; Vitamin K Epoxide Reductases; Warfarin	2020
Functional characterization of the defective CYP2C9 variant CYP2C918. Pharmacology research & perspectives, 2021, Volume: 9, Issue:1* Topics: Amino Acid Substitution; Animals; Asian People; Baculoviridae; Catalysis; Cell Line; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Insecta; Losartan; Models, Molecular; Polymorphism, Genetic; Protein Conformation; Recombinant Proteins; Tolbutamide	2021