Page last updated: 2024-08-16

tolbutamide and diclofenac

tolbutamide has been researched along with diclofenac in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (3.64)	18.7374
1990's	4 (7.27)	18.2507
2000's	25 (45.45)	29.6817
2010's	21 (38.18)	24.3611
2020's	3 (5.45)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A	1
Carrupt, PA; Martel, S; Ottaviani, G	1
Briand, X; Faller, B; Lázaro, E; Lowe, PJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Schlumpf, U	1
Fowler, PD	1
Appel, S; Hitzenberger, G; Kalafsky, G; Kallay, Z; Kutz, K; Rüfenacht, T; Tetzloff, W	1
Feron, VJ; Groene, EM; Horbach, GJ; Kappers, WA; Kleij, LA; Witkamp, RF; Zweers-Zeilmaker, WM	1
Horbach, GJ; Witkamp, RF; Zweers-Zeilmaker, WM	1
Ghanayem, BI; Goldstein, JA; Hall, SD; Ibeanu, GC; Klose, TS; Li, L; Pedersen, LG	1
Johnson, EF; Lasker, JM; Raucy, JL; Wester, MR	1
Rodrigues, AD; Shou, M; Tang, C	1
Gelboin, HV; Goldfarb, I; Gonzalez, FJ; Krausz, KW; Yang, TJ	1
Horie, T; Masubuchi, Y; Ose, A	1
Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI; Rosas, R; Torres-López, JE; Vidal-Cantú, GC	2
Ishibashi, F; Kageyama, A; Katagiri, M; Kishimoto, K; Niwa, T; Yabusaki, Y	1
Flanagan, JU; McLaughlin, LA; Paine, MJ; Roberts, GC; Sutcliffe, MJ; Wolf, CR	1
Azuma, J; Fukuda, T; Funae, Y; Hanatani, T; Onishi, S	1
Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA	1
Andersson, TB; Bredberg, E; Ericsson, H; Sjöberg, H	1
Fawcett, PJ; Guo, Y; Si, D; Wang, Y; Zhong, D; Zhou, H	1
Asahi, S; Iwasaki, M; Mitsuda, M	1
Gorman, LA; Kumar, V; Rock, DA; Tracy, TS; Wahlstrom, JL; Warren, CJ	1
Huang, HH; Lin, LH; Zhang, P; Zhong, DF	1
Ariyoshi, N; Ishii, I; Kitada, M; Kobayashi, Y; Nakamura, H; Nakasa, H; Nakazawa, K; Shimizu, Y	1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J	1
Iwasaki, K; Matsuno, K; Matsushita, A; Nakamura, C; Nakanishi, Y; Uno, Y; Utoh, M	1
Barter, ZE; Crewe, HK; Rostami-Hodjegan, A; Yeo, KR	1
Pickova, J; Vestergren, AS; Zamaratskaia, G; Zlabek, V	1
Di Nardo, G; Gilardi, G; Goyal, A; Sideri, A; Tsotsou, GE	1
Agrawal, V; Miller, WL; Sandee, D; Subramanian, M; Tam, HK; Tracy, TS	1
Drolet, B; Hasibu, I; Patoine, D; Pilote, S; Simard, C	1
Catucci, G; Dell'Angelo, V; Di Nardo, G; Gilardi, G; Sadeghi, SJ	1
Liu, L; Liu, X; Tang, X; Wang, S; Xu, J; Yang, T; Zhang, J	1
Endo, S; Ikari, A; Matsunaga, T; Miyagi, N	1
Cai, JP; Chen, H; Chong, J; Dai, DP; Geng, PW; Liu, J; Lü, Y; Wang, SH; Wu, HL; Yang, JF; Zhou, Q; Zhou, S	1
Glatz, Z; Michalcová, L; Nevídalová, H	1
Cai, JP; Chen, H; Dai, DP; Geng, PW; Liu, J; Shi, HF; Wang, F; Wang, SH; Wu, HL; Yang, JF; Zhou, Q; Zhou, YF	1

Reviews

1 review(s) available for tolbutamide and diclofenac

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for tolbutamide and diclofenac

Article	Year
Lack of interaction between fluvastatin and oral hypoglycemic agents in healthy subjects and in patients with non-insulin-dependent diabetes mellitus. The American journal of cardiology, 1995, Jul-13, Volume: 76, Issue:2 Topics: Administration, Oral; Anticholesteremic Agents; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Diclofenac; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Glyburide; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Insulin; Lovastatin; Placebos; Simvastatin; Tolbutamide	1995
An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:7 Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C9; Diclofenac; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Ibuprofen; In Vitro Techniques; Indoles; Male; Mass Spectrometry; Microsomes, Liver; Middle Aged; Tolbutamide	2004

Article

Year

Lack of interaction between fluvastatin and oral hypoglycemic agents in healthy subjects and in patients with non-insulin-dependent diabetes mellitus.

The American journal of cardiology, 1995, Jul-13, Volume: 76, Issue:2

Topics: Administration, Oral; Anticholesteremic Agents; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Diclofenac; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Glyburide; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Insulin; Lovastatin; Placebos; Simvastatin; Tolbutamide

1995

An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates.

Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:7

Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C9; Diclofenac; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Ibuprofen; In Vitro Techniques; Indoles; Male; Mass Spectrometry; Microsomes, Liver; Middle Aged; Tolbutamide

2004

Other Studies

52 other study(ies) available for tolbutamide and diclofenac

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism	2005
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
[The effect of diclofenac sodium on the metabolism of diabetics in qualitative diet therapy with an without tolbuamide. A clinically oriented study in aged diabetics with rheumatic disease]. Schweizerische medizinische Wochenschrift, 1978, Jan-07, Volume: 108, Issue:1 Topics: Adult; Aged; Diabetes Mellitus; Diclofenac; Drug Interactions; Female; Humans; Male; Middle Aged; Phenylacetates; Rheumatic Diseases; Sulfonylurea Compounds; Tolbutamide	1978
Diclofenac sodium (Voltarol): drug interactions and special studies. Rheumatology and rehabilitation, 1979, Volume: Suppl 2 Topics: Adult; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Blood Coagulation Factors; Blood Glucose; Diabetes Mellitus; Diclofenac; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Hypoglycemic Agents; Insulin; Male; Partial Thromboplastin Time; Phenylacetates; Platelet Aggregation; Prothrombin Time; Rheumatic Diseases; Time Factors; Tolbutamide	1979
Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Drug Interactions; Enzyme Inhibitors; Flurbiprofen; Gene Expression; Humans; Hydroxylation; Ketoprofen; Lung; Methylation; Mixed Function Oxygenases; Phenylbutazone; Sulfaphenazole; Tolbutamide; Transfection	1996
Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus). Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:8 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Female; Goats; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Phenylbutazone; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Sulfonamides; Tolbutamide	1997
Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen. Archives of biochemistry and biophysics, 1998, Sep-15, Volume: 357, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Activation; Escherichia coli; Humans; Hydroxylation; Ibuprofen; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Protein Binding; Recombinant Fusion Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide	1998
CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:3 Topics: Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cross Reactions; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Hydroxylation; Male; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Rabbits; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	2000
Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:5 Topics: Acetonitriles; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Celecoxib; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Humans; Hypoglycemic Agents; In Vitro Techniques; Microsomes, Liver; Phenotype; Phenytoin; Pyrazoles; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfonamides; Tolbutamide	2000
An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:6 Topics: Alleles; Amino Acid Substitution; Antibodies, Monoclonal; Antibody Specificity; Arginine; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme-Linked Immunosorbent Assay; Genetic Variation; Humans; Hybridomas; Isoenzymes; Phenanthrenes; Polymorphism, Genetic; Protein Binding; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	2000
Mechanism-based inactivation of CYP2C11 by diclofenac. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 2; Diclofenac; Enzyme Inhibitors; Glutathione; Humans; Hydroxylation; Male; Microsomes, Liver; Rats; Rats, Wistar; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone; Tolbutamide	2001
Pharmacological evidence for the activation of K(+) channels by diclofenac. European journal of pharmacology, 2002, Mar-01, Volume: 438, Issue:1-2 Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Female; Formaldehyde; Glyburide; Hindlimb; Morphine; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tolbutamide	2002
Amino acid residues affecting the activities of human cytochrome P450 2C9 and 2C19. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:8 Topics: Amino Acid Substitution; Aminopyrine; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Diclofenac; Humans; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes; Mixed Function Oxygenases; Point Mutation; Recombinant Fusion Proteins; Stereoisomerism; Substrate Specificity; Testosterone; Tolbutamide	2002
Role of the nitric oxide-cyclic GMP-K+ channel pathway in the antinociception induced by atrial natriuretic peptide (ANP) and diclofenac. Proceedings of the Western Pharmacology Society, 2002, Volume: 45 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrial Natriuretic Factor; Charybdotoxin; Cyclic GMP; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain Measurement; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Tolbutamide	2002
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. The Biochemical journal, 2003, Mar-15, Volume: 370, Issue:Pt 3 Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Aspartic Acid; Cytochrome P-450 CYP2C9; Dextromethorphan; Diclofenac; Humans; Hypoglycemic Agents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; NADPH-Ferrihemoprotein Reductase; Protein Binding; Protein Structure, Secondary; Rabbits; Sequence Alignment; Substrate Specificity; Tolbutamide	2003
No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3. European journal of clinical pharmacology, 2003, Volume: 59, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Microsomes; Nicardipine; Polymorphism, Genetic; Saccharomyces cerevisiae; Tolbutamide; Warfarin	2003
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation. Life sciences, 2004, Apr-02, Volume: 74, Issue:20 Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indomethacin; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide	2004
Catalytic activities of human cytochrome P450 2C91, 2C93 and 2C913. Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:9* Topics: Amino Acid Substitution; Animals; Aryl Hydrocarbon Hydroxylases; Chlorocebus aethiops; COS Cells; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Hypoglycemic Agents; Kinetics; Point Mutation; Substrate Specificity; Tolbutamide	2005
Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization. Journal of biochemistry, 2006, Volume: 139, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cloning, Molecular; Cricetinae; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Guinea Pigs; Humans; Kinetics; Macaca fascicularis; Mephenytoin; Mice; Microsomes, Liver; Mixed Function Oxygenases; Progesterone; Rabbits; Rats; Recombinant Proteins; Substrate Specificity; Testosterone; Tolbutamide	2006
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Flurbiprofen; Genotype; In Vitro Techniques; Pharmacogenetics; Phenytoin; Piroxicam; Tolbutamide; Warfarin	2006
[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:10 Topics: Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cunninghamella; Cytochrome P-450 CYP2C9; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Fungal Proteins; Indomethacin; Isoenzymes; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfaphenazole; Tolbutamide; Valproic Acid	2006
Identification and partial characterization of a novel CYP2C9 splicing variant encoding a protein lacking eight amino acid residues. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:3 Topics: Adolescent; Adult; Alternative Splicing; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cell Line; Cloning, Molecular; Cytochrome P-450 CYP2C9; Diclofenac; Gene Deletion; Humans; Isoenzymes; Liver; Male; Middle Aged; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; RNA, Messenger; Sequence Homology, Nucleic Acid; Spectrophotometry; Spodoptera; Tolbutamide	2007
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide	2007
Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diclofenac; Duodenum; Ileum; Intestine, Small; Jejunum; Kinetics; Liver; Macaca fascicularis; Male; Mephenytoin; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Paclitaxel; Pharmaceutical Preparations; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	2011
Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors. Biopharmaceutics & drug disposition, 2011, Volume: 32, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochromes b5; Diclofenac; Enzyme Assays; Forecasting; Humans; Hypoglycemic Agents; Liver; Microsomes, Liver; Models, Biological; Recombinant Proteins; Tolbutamide; Warfarin	2011
Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.). Molecular biology reports, 2012, Volume: 39, Issue:6 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diclofenac; Dioxoles; Ellipticines; Fish Proteins; Fluconazole; Hydroxylation; Ketoconazole; Kinetics; Lignans; Microsomes, Liver; Oxazines; Salmo salar; Sulfaphenazole; Tolbutamide	2012
Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide. Chemistry (Weinheim an der Bergstrasse, Germany), 2012, Mar-19, Volume: 18, Issue:12 Topics: Asparagine; Bacillus megaterium; Catalysis; Cytochrome P-450 Enzyme System; Diclofenac; Drug Discovery; Escherichia coli; Glutamine; Glycine; Histidine; Humans; Hydroxylation; Ibuprofen; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Tolbutamide	2012
Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3. Pharmacogenetics and genomics, 2012, Volume: 22, Issue:8 Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2C9; Diclofenac; Flurbiprofen; Humans; Kinetics; NADPH-Ferrihemoprotein Reductase; Polymorphism, Genetic; Recombinant Proteins; Tolbutamide	2012
The guinea-pig expresses functional CYP2C and P-glycoprotein: further validation of its usefulness in drug biotransformation/transport studies. Biopharmaceutics & drug disposition, 2015, Volume: 36, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biotransformation; Cytochrome P-450 Enzyme System; Diclofenac; Guinea Pigs; HEK293 Cells; Humans; Hydroxylation; Intestine, Small; Liver; Male; Microsomes, Liver; Tolbutamide	2015
Subtle structural changes in the Asp251Gly/Gln307His P450 BM3 mutant responsible for new activity toward diclofenac, tolbutamide and ibuprofen. Archives of biochemistry and biophysics, 2016, Jul-15, Volume: 602 Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Computer Simulation; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Activation; Ibuprofen; Molecular Docking Simulation; Molecular Sequence Data; Mutation; NADPH-Ferrihemoprotein Reductase; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tolbutamide	2016
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2 Topics: Atorvastatin; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Kinetics; Microsomes, Liver; Midazolam; Protein Isoforms; Testosterone; Tolbutamide; Verapamil; Warfarin	2019
Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions, 2019, May-25, Volume: 305 Topics: 17-Hydroxysteroid Dehydrogenases; Acetohexamide; Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Catalytic Domain; Diclofenac; Humans; Kinetics; Male; Mutagenesis; Myocardium; Phenobarbital; Rabbits; Recombinant Proteins; Sequence Alignment; Substrate Specificity; Tolbutamide	2019
An identification and functional evaluation of a novel CYP2C9 variant CYP2C962. Chemico-biological interactions, 2020, Aug-25, Volume: 327* Topics: Aged, 80 and over; Alleles; Animals; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Assays; Humans; Kinetics; Losartan; Male; Microsomes; Point Mutation; Polymorphism, Genetic; Recombinant Proteins; Spodoptera; Tolbutamide; Vitamin K Epoxide Reductases; Warfarin	2020
Applicability of capillary electrophoresis-frontal analysis for displacement studies: Effect of several drugs on l-tryptophan and lidocaine binding to human serum albumin. Journal of separation science, 2020, Volume: 43, Issue:22 Topics: Binding Sites; Chlorpropamide; Diclofenac; Electrophoresis, Capillary; Flurbiprofen; Humans; Ibuprofen; Lidocaine; Phenylbutazone; Serum Albumin, Human; Tolbutamide; Tryptophan	2020
Functional characterization of the defective CYP2C9 variant CYP2C918. Pharmacology research & perspectives, 2021, Volume: 9, Issue:1* Topics: Amino Acid Substitution; Animals; Asian People; Baculoviridae; Catalysis; Cell Line; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Insecta; Losartan; Models, Molecular; Polymorphism, Genetic; Protein Conformation; Recombinant Proteins; Tolbutamide	2021