tolbutamide has been researched along with diazoxide in 232 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 104 (44.83) | 18.7374 |
| 1990's | 55 (23.71) | 18.2507 |
| 2000's | 50 (21.55) | 29.6817 |
| 2010's | 23 (9.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aguilar-Bryan, L; Bryan, J; Clement, JP; Gonoi, T; Gonzalez, G; Inagaki, N; Inazawa, J; Namba, N; Seino, S | 1 |
| Higashiguchi, O; Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Matsuzawa, Y; Yamada, M | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Greenwood, RH; Hales, CN; Mahler, RF | 1 |
| Berger, H | 1 |
| Davis, B; Lazarus, NR | 1 |
| Come, SE; Eastman, RC; Gorden, P; Kahn, CR; Strewler, GJ | 1 |
| Andreani, D; Natoli, C; Tamburrano, G; Tamburrano, S | 1 |
| Prandota, J; Pruitt, AW | 1 |
| Chertow, BS; Fariss, BL; Schikman, CH | 1 |
| Day, JA; Patel, YC; Ramseur, R; Samols, E; Weir, GC | 1 |
| Alberti, KG; Marks, V | 1 |
| Alric, R; Lignon, F; Loubatières, A; Manteghetti, M; Puech, R | 1 |
| Bierwolf, B; Blech, W | 1 |
| Crestani, B; Dodi, G; Lise, M; Militello, C; Pedrazzoli, S | 1 |
| Levy, J; Malaisse, WJ | 1 |
| Blackard, WG; Kikuchi, M; Rabinovitch, A; Renold, AE | 1 |
| Sumi, T; Ui, M | 1 |
| Koene, R; Wijdeveld, P | 1 |
| Krämer, K; Sailer, FX | 1 |
| Kozlowski, RZ; Nye, PC; Robertson, BE | 1 |
| Gilon, P; Henquin, JC | 1 |
| Dickel, C; Ebers, I; Lins, S; Panten, U; Schwanstecher, C; Zünkler, BJ | 1 |
| Ohno-Shosaku, T; Yamamoto, C | 2 |
| Krnjević, K | 1 |
| Dunne, MJ; Gallacher, DV; Petersen, OH; Yule, DI | 1 |
| Grill, VE; Sako, Y | 1 |
| Henquin, JC; Plant, TD | 1 |
| Ohno-Shosaku, T; Rorsman, P; Trube, G | 1 |
| Arkhammar, P; Berggren, PO; Nilsson, T; Rorsman, P | 1 |
| Henquin, JC | 2 |
| Dunne, MJ; Illot, MC; Peterson, OH | 1 |
| Lenzen, S; Männer, K; Panten, U; Trube, G; Zünkler, BJ | 1 |
| Falke, LC; Gillis, KD; Misler, S; Pressel, DM | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Faivre, JF; Findlay, I | 1 |
| Devreux, V; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Falke, LC; Gee, WM; Gillis, KD; Hammoud, A; McDaniel, ML; Misler, S | 1 |
| Desbuquois, B; López, S | 1 |
| Bergsten, P; Hellman, B; Wesslén, N | 1 |
| Ali, L; Hellman, B; Wesslén, N | 1 |
| Ashford, ML; Carrington, CA; Hales, CN; Kozlowski, RZ; Sturgess, NC | 1 |
| Hellman, B; Rorsman, F | 1 |
| Henquin, JC; Hermans, MP; Schmeer, W | 2 |
| Wolff, G | 1 |
| Bower, RH; Cohen, MS; Fidler, SM; Johnsonbaugh, RE; Sode, J | 1 |
| Jahn, P; Loge, O; Losert, W | 1 |
| Howell, SL; Taylor, KW | 1 |
| Grant, AM; Wales, JK; Wolff, FW | 2 |
| Hellman, B; Sehlin, J; Täljedal, IB | 1 |
| Loubatières, A; Loubatières-Mariani, MM | 1 |
| Loubatiéres, A; Mariani, MM | 1 |
| Alric, R; Houareau, MH; Loubatières, A; Mariani, MM | 1 |
| Etheridge, JE | 1 |
| Conn, JW; Fajans, SS; Floyd, JC; Harrison, TS; Knopf, RF; Thiffault, CA | 1 |
| Dorner, M; Fontaine, R; Haarscher, A; Hasselmann, JL; Levy-Silagy, J; Schneegans, E | 1 |
| Dulin, WE; Wyse, BM | 1 |
| Creutzfelt, W | 1 |
| Mondorf, W; Rios, MS | 1 |
| Schwartz, JF; Zwiren, GT | 1 |
| Anderson, JH; Blackard, WG; Byrd, GW | 1 |
| Gorden, P; Roth, J; Sherman, B | 1 |
| Creutzfeldt, C; Creutzfeldt, W; Frerichs, H; Perings, E; Sicklinger, K | 1 |
| Baker, L; Balsam, MJ; Bishop, HC; Hummeler, K; Kaye, R; Yakovac, WC | 1 |
| Kavlie, H; White, TT | 1 |
| Howell, SL; Montague, W | 1 |
| Fink, G; Gutman, RA; Penhos, JC; Recant, L; Selawry, H; Voyles, N | 1 |
| Lefebvre, P; Luyckx, A | 1 |
| Ariëns, EJ | 1 |
| Buchanan, KD; Hollander, D; Kitabchi, AE; Stoll, RW; Vance, JE; Williams, RH | 1 |
| Finnerty, FA | 1 |
| Blondel, B; Lambert, AE; Like, AA; Marliss, EB; Orci, L; Renold, AE; Stauffacher, W; Wollheim, CB | 1 |
| Miller, M; Moses, AM | 1 |
| Klöppel, G; Schäfer, HJ | 1 |
| Chapal, J; Loubatiéres, AL; Loubatiéres-Mariani, MM; Ribes, G | 1 |
| Colle, E; Schiff, D; Stern, L; Wells, D | 1 |
| Chapal, J; Loubatières, AL; Loubatières-Mariani, MM | 1 |
| Castro, A; Grettie, DP | 1 |
| Romanoff, NE | 1 |
| Alric, R; Loubatières, A; Mariani, MM | 2 |
| Crout, JR; Seltzer, HS | 1 |
| Isshiki, G; Ogawa, S; Okuno, G; Ueda, T; Yoshinaga, T | 1 |
| Buchanan, KD; Vance, JE; Williams, RH | 1 |
| Serrano Ríos, M | 1 |
| Alric, R; Chapal, J; de Malbosc, H; Loubatières, A; Mariani, MM; Ribes, G | 1 |
| Löffler, G; Lohmann, E; Schweitzer, T; Trautschold, I | 1 |
| Creutzfeldt, W; Frerichs, H; Gerber, R | 1 |
| Loubatières, A | 1 |
| Chapal, J; de Malbosc, H; Loubatières, A; Mariani, MM; Ribes, G | 1 |
| Loubatières, AL | 1 |
| Ashcroft, SJ; Hedeskov, CJ; Randle, PJ | 1 |
| Brisson, GR; Malaisse, WJ | 1 |
| Wüstenberg, PW | 1 |
| Basabe, JC; Grant, AM; Krees, SV; Lopez, NL; Wolff, FW | 1 |
| Grant, A; Wolff, F | 1 |
| Gulbenkian, A; Ornstein, L; Tabachnick, II | 1 |
| Davis, D; Morgan, MY; Pohl, JE; Thurston, H | 1 |
| Pohl, JE; Thurston, H | 1 |
| Danforth, E | 1 |
| Mariani, MM | 1 |
| Mahler, RJ; Szabo, O | 1 |
| Basabe, J; Grant, A; Krees, S; Lopez, N; Terry, M; Viktora, J; Wolff, F | 1 |
| Basabe, JC; Lopez, NL; Viktora, JK; Wolff, FW | 1 |
| Ehrlich, RM; Martin, JM | 1 |
| Hales, CN; Milner, RD | 1 |
| Anjaneyulu, K; Anjaneyulu, R; Couturier, E; Malaisse, WJ | 1 |
| Henquin, JC; Meissner, HP | 1 |
| Martin, F; Soria, B | 2 |
| Dubinsky, WP; Mayorga-Wark, O; Schultz, SG | 1 |
| Henderson, G; Hicks, GA; Watts, AE | 1 |
| Angel, I; Henquin, JC; Jonas, JC; Langer, SZ; Plant, TD | 1 |
| Ballanyi, K; Richter, DW; Trapp, S | 1 |
| Panten, U; Schwanstecher, C | 2 |
| Greer, MA; Greer, SE; Sato, N; Wang, X | 1 |
| Dunne, MJ; Finch, A; Harding, EA | 1 |
| Baró, I; Berthon, B; Escande, D; Hongre, AS | 1 |
| Gilon, P; Henquin, JC; Shepherd, RM | 1 |
| Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P | 1 |
| Ashcroft, SJ; Niki, I | 1 |
| Beales, PE; Gale, EA; Krug, J; Pozzilli, P; Procaccini, E; Signore, A; Williams, AJ; Xu, S | 1 |
| Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N | 1 |
| Atwater, IJ; Boschero, AC; Carneiro, EM; Tombaccini, D | 1 |
| Martin, F; Reig, JA; Soria, B | 1 |
| Ammälä, C; Ashcroft, FM; Moorhouse, A | 1 |
| Ballanyi, K; Brockhaus, J; Doutheil, J | 1 |
| Capito, K; Hansen, SE; Thams, P | 1 |
| Ashcroft, FM; Gribble, FM; Trapp, S; Tucker, SJ; Zhao, C | 1 |
| Francini, F; Gagliardino, JJ; Pirotte, B | 1 |
| Berggren, PO; Bränström, R; Höög, A; Larsson, O; Wahl, MA | 1 |
| Kikuchi, M; Niki, I; Oka, Y; Sakurada, M; Tsukuda, K | 1 |
| Gomis, A; Valdeolmillos, M | 1 |
| Gilon, P; Henquin, JC; Mariot, P; Nenquin, M | 1 |
| Haller, M; Langohr, K; Mironov, SL; Richter, DW | 1 |
| Dixon, AK; Freeman, TC; Lee, K; Richardson, PJ | 1 |
| Aoyagi, K; Bergsten, P; Eriksson, UJ; Hellerström, C; Persson, E | 1 |
| Ashford, ML; Harvey, J | 1 |
| Aguilar-Bryan, L; Babenko, AP; Bryan, J; Gonzalez, G | 1 |
| Konnerth, A; Neumcke, B; Plant, TD; Schirra, C; Zawar, C | 1 |
| Chagneau, C; De Gottardi, A; Fléjou, JF; Fouassier, L; Housset, C; Lahaye, P; Lebrec, D; Moreau, R; Reichen, J; Rona, JP; Tazi, KA | 1 |
| Illes, P; Krauss, GJ; Pissarek, M; Reichelt, C | 1 |
| Anello, M; Henquin, JC; Sato, Y | 1 |
| Ashcroft, FM; Proks, P; Reimann, F; Tucker, SJ | 1 |
| Koster, JC; Nichols, CG; Sha, Q | 1 |
| Franke, H; Garcia de Arriba, S; Illes, P; Nieber, K; Pissarek, M | 1 |
| An, J; Becker, GW; Churgay, LM; Gold, G; Hale, JE; Osborne, JJ; Shi, Y; Stramm, LE; Zhao, G | 1 |
| Kirchgessner, AL; Liu, M; Seino, S | 1 |
| Ammälä, C; Chapman, JC; Cosgrove, KE; Dunne, MJ; Flatt, PR; Giesberts, AN; Hashmi, MN; McClenaghan, NH; Shepherd, RM; White, SJ | 1 |
| Nadal, A; Quesada, I; Soria, B | 1 |
| Ashcroft, FM; Liss, B; Sakura, H; Trapp, S | 1 |
| Dallaporta, M; Orsini, JC; Perrin, J | 1 |
| Brioni, JD; Gopalakrishnan, M; Molinari, EJ; Monteggia, LM; Roch, JM; Scott, VE; Shieh, CC; Sullivan, JP; Whiteaker, KL | 1 |
| Börger, J; Brabant, G; Mader, T; Schöfl, C; von zur Mühlen, A; Waring, M | 1 |
| Bernal-Mizrachi, E; Inoue, H; Permutt, MA; Wice, B | 1 |
| Baertschi, AJ; Baron, A; Baumann, P; Jiao, JH; Pence, RA; Roatti, A | 1 |
| Mohan, RM; Paterson, DJ | 1 |
| Barg, S; Eliasson, L; Galvanovskis, J; Göpel, SO; Rorsman, P | 1 |
| Schermerhorn, T; Sharp, GW | 1 |
| Ashcroft, F; Ashfield, R; Huopio, H; Kere, J; Komulainen, J; Laakso, M; Lenko, HL; Otonkoski, T; Rahier, J; Reimann, F; Vauhkonen, I | 1 |
| Almond, SC; Paterson, DJ | 1 |
| Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS | 1 |
| Gong, Q; Ichinari, K; Kakei, M; Koriyama, N; Morimitsu, S; Nakazaki, M; Tei, C; Yada, T; Yaekura, K | 1 |
| Brockhaus, J; Deitmer, JW | 1 |
| Bae, YH; Kim, SW; Park, KH | 1 |
| Bielfeld-Ackermann, A; Konstas, AA; Korbmacher, C | 1 |
| Barez, A; Flatt, PR; Herchuelz, A; Horta, OD; Kamagate, A; Macianskiene, R; Mubagwa, K; Van Eylen, F | 1 |
| Illes, P; Manaenko, A; Pissarek, M; Reinhardt, R; Wagner, A | 1 |
| Greger, R; Herbst, M; Hescheler, J; Sasse, P; Ullrich, S; Yu, H | 1 |
| Gribble, FM; Reimann, F | 1 |
| Griesemer, D; Neumcke, B; Zawar, C | 1 |
| Giblin, JP; Quinn, K; Tinker, A | 1 |
| Benomar, Y; Crochet, S; Derouet, M; Rideau, N; Taouis, M | 1 |
| Chen, M; Dong, Y; Simard, JM | 1 |
| WOLFF, F | 1 |
| LANGDON, RG; WOLFF, FW | 1 |
| Chaffard, G; Maechler, P; Merglen, A; Rubi, B; Theander, S; Wollheim, CB | 1 |
| Aguilar-Bryan, L; Bryan, J; Henquin, JC; Nenquin, M; Szollosi, A | 1 |
| Arkhammar, PO; Donath, MY; Maedler, K; Mandrup-Poulsen, T; Spinas, GA; Sturis, J; Størling, J; Zuellig, RA | 1 |
| Sharp, GW; Straub, SG | 1 |
| Carr, RD; Chen, YJ; Davies, GC; Hansen, JB; Jenner, TJ; Randall, VA; Thornton, MJ | 1 |
| Acevedo, JJ; Darszon, A; de la Vega-Beltrán, JL; Felix, R; Mendoza-Lujambio, I; Treviño, CL | 1 |
| Conte Camerino, D; Desai, RR; George, AL; Lundquist, AL; Mele, A; Tricarico, D | 1 |
| Huang, L; Li, B; Li, W; Zou, F | 1 |
| Hoe, FM; Simmons, RA; Stanley, CA; Steinkrauss, L; Thornton, PS; Wanner, LA | 1 |
| Abdel-Wahab, YH; Ali, L; Flatt, PR; Hannan, JM; Marenah, L; Rokeya, B | 1 |
| Ahnert-Hilger, G; Beyer, A; Brune, A; Jöns, T; Meier, C; Thomzig, A; Veh, RW; Wittschieber, D | 1 |
| Kaku, K; Katsura, M; Matsuda, M; Ohkuma, S; Shigeto, M | 1 |
| Bleck, C; Lackmann, TG; Rustenbeck, I; Wienbergen, A | 1 |
| Coetzee, WA; Ghiu, I; Gutstein, DE; Hendricks-Munoz, KD; Kontogeorgis, A; Malester, B; Tong, X; Xu, J | 1 |
| Chang, Y; Li, GH; Lin, YF; Liu, Q; Mao, X; Misaki, N; Suga, S; Wakui, M; Wang, H; Wu, J | 1 |
| Acosta-Martínez, M; Huang, W; Levine, JE | 1 |
| Carreño, FR; Cunningham, JT; Mifflin, SW; Zhang, W | 1 |
| Beauvois, MC; Cheng-Xue, R; Gilon, P; Guiot, Y; Henquin, JC; Mattart, L; Quoix, N; Zeinoun, Z | 1 |
| Bertholet, AM; Betourne, A; Feng, ZP; Frances, B; French, RJ; Halley, H; Labroue, E; Lassalle, JM; Lorsignol, A; Penicaud, L; Sun, HS | 1 |
| Davison, AS; Hine, TJ; Holmes, E; Roberts, NB; Sodi, R | 1 |
| Amisten, S; Bengtsson, M; Braun, M; Johnson, PR; Moritoh, Y; Ramracheya, R; Rorsman, P; Zhang, Q | 1 |
| Henquin, JC; Nenquin, M; Szollosi, A | 1 |
| Carter, JD; Cole, BK; Crim, WS; Kunsch, C; Mirmira, RG; Nadler, JL; Nunemaker, CS; Trace, AP; Wu, R | 1 |
| Huang, LY; Li, BX; Li, WJ; Zou, F | 1 |
| Drews, G; Düfer, M; Günther, E; Haspel, D; Kraushaar, U; Krippeit-Drews, P; Pfeiffer, T; Schönecker, S | 1 |
| Bellanné-Chantelot, C; de Lonlay, P; Guiot, Y; Henquin, JC; Nenquin, M; Nihoul-Fékété, C; Otonkoski, T; Rahier, J; Sempoux, C | 1 |
| Godecharles, S; Guiot, Y; Henquin, JC; Marchandise, J; Nenquin, M; Rahier, J; Sempoux, C | 1 |
| Antoine, N; Chae, HY; Cheng-Xue, R; Chimienti, F; Gilon, P; Gómez-Ruiz, A; Noël, LA; Ravier, MA; Schuit, FC | 1 |
| Björklund, A; Catrina, SB; Grill, V; Hals, I; Ma, Z; Moruzzi, N; Oberholzer, J | 1 |
| Abdel-Wahab, YH; Flatt, PR; McKillop, AM; Ng, MT | 1 |
| Folkow, LP; Geiseler, SJ; Ludvigsen, S | 1 |
| Harada, K; Kitaguchi, T; Kojima, M; Numano, R; Oya, M; Sato, T; Tsuboi, T | 1 |
| Guiot, Y; Henquin, JC; Nenquin, M; Rahier, J; Sempoux, C | 1 |
| Bai, JZ; Freestone, PS; Lipski, J; Yee, AG | 1 |
| Henquin, JC; Nenquin, M | 1 |
| Peña-Ortega, F; Prado-Alcalá, RA; Rodríguez-Colorado, J; Salgado-Puga, K | 1 |
13 review(s) available for tolbutamide and diazoxide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Selected tests of carbohydrate metabolism.
Topics: Adolescent; Adult; Blood Glucose; Carbohydrate Metabolism; Child; Clinical Laboratory Techniques; Diazoxide; Fasting; Female; Fructose; Galactose; Glucagon; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Inulin; Lactose; Leucine; Male; Middle Aged; Proinsulin; Time Factors; Tolbutamide | 1976 |
Regulation of insulin release by ionic and electrical events in B cells.
Topics: Amino Acids; Animals; Calcium; Diazoxide; Glucose; Insulin; Ion Channels; Islets of Langerhans; Membrane Potentials; Permeability; Potassium; Sulfonylurea Compounds; Tolbutamide | 1987 |
[Hypoglycemia. 3].
Topics: Animals; Arginine; Biguanides; Diazoxide; Dicumarol; Drug Synergism; Ethanol; Glucagon; Glucocorticoids; Glucose; Guinea Pigs; Humans; Hypoglycemia; Hypoglycemic Agents; Leucine; Mice; Rabbits; Rats; Sympatholytics; Tolbutamide; Xylitol | 1970 |
Hypoglycemia and the central nervous system.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Diazoxide; Diet Therapy; Epinephrine; Fasting; Glucagon; Glucose; Glucose Tolerance Test; Humans; Hypoglycemia; Hypoxia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Insulin; Leucine; Oxygen Consumption; Seizures; Tolbutamide; Zinc | 1967 |
[Recent studies on insulin with special reference to Spanish publications 1951-69].
Topics: Adrenocorticotropic Hormone; Biological Transport, Active; Cell Membrane Permeability; Diazoxide; Diet; Epinephrine; Glucagon; Growth Hormone; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Protein Biosynthesis; Radioimmunoassay; Thyrotropin; Tolbutamide | 1970 |
Diazoxide and the secretion of insulin.
Topics: Animals; Cyclic AMP; Diazoxide; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Pancreas; Perfusion; Rats; Theophylline; Tolbutamide | 1972 |
[Oral antidiabetics. Dose, plasma concentration and effect].
Topics: Acetohexamide; Adrenergic beta-Antagonists; Animals; Blood Glucose; Carbutamide; Chemical Phenomena; Chemistry; Chlorpropamide; Cyclic AMP; Diazoxide; Drug Antagonism; Drug Synergism; Glucagon; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Isoproterenol; Kidney; Liver; Sulfonamides; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1969 |
Drug-induced dilutional hyponatremia.
Topics: Acetaminophen; Amitriptyline; Animals; Anura; Body Fluids; Carbamazepine; Chlorpropamide; Clofibrate; Cyclophosphamide; Diabetes Insipidus; Diabetes Mellitus; Diazoxide; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycemic Agents; Hyponatremia; Kidney; Rats; Sodium; Sulfonylurea Compounds; Tolbutamide; Urinary Bladder; Vasopressins; Vincristine; Water Intoxication; Water-Electrolyte Balance | 1974 |
Factors controlling release of insulin from beta cell in relation to diabetes mellitus.
Topics: Amino Acids; Animals; Catecholamines; Diabetes Mellitus; Diazoxide; Glucagon; Glucose; Hexoses; Humans; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Proteins; Secretin; Tolbutamide | 1968 |
[Spanish contribution to our knowledge on insulin].
Topics: Carbohydrate Metabolism; Cell Membrane Permeability; Diazoxide; Glucocorticoids; Humans; Insulin; Insulin Secretion; Pancreas; Spain; Tolbutamide | 1969 |
[Physiological and pharmacological aspects of the central role of the pancreas in the mode of action of hypoglycemic sulfonamides].
Topics: Action Potentials; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Drug Antagonism; Drug Synergism; Glucose; Glucose Tolerance Test; Growth Hormone; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Organ Size; Pancreas; Pancreatectomy; Perfusion; Rats; Sulfonamides; Tolbutamide | 1969 |
[The hypoglycemia syndrome].
Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide; Diet Therapy; Epinephrine; Gastrointestinal Diseases; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Metabolic Diseases; Neoplasms; Pancreatic Neoplasms; Prednisone; Tolbutamide | 1970 |
1 trial(s) available for tolbutamide and diazoxide
| Article | Year |
|---|---|
Improvement in insulin secretion in diabetes after diazoxide.
Topics: Administration, Oral; Blood Glucose; Diabetes Mellitus; Diazoxide; Glucagon; Humans; Injections, Intravenous; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Placebos; Tolbutamide | 1976 |
218 other study(ies) available for tolbutamide and diazoxide
| Article | Year |
|---|---|
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Cricetinae; Diazoxide; Humans; Islets of Langerhans; KATP Channels; Mice; Molecular Sequence Data; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Rubidium; Sulfonylurea Compounds; Sulfonylurea Receptors | 1995 |
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Cloning, Molecular; DNA, Complementary; Humans; Mice; Molecular Sequence Data; Muscle, Smooth; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Hypoglycemia: a perspective.
Topics: Adenoma, Islet Cell; Citric Acid Cycle; Diabetes Complications; Diazoxide; Female; Glucose; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Leucine; Liver; Liver Diseases; Middle Aged; Muscles; Pancreatic Neoplasms; Streptozocin; Tolbutamide | 1975 |
An in Vitro system for studying insulin release caused by secretory granules-plasma membrane interaction: definition of the system.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Calcium; Carbohydrates; Cell Membrane; Cyclic AMP; Cytoplasmic Granules; Diazoxide; Epinephrine; Fishes; Glucose; Growth Hormone; Humans; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Mice; Nucleotides; Rats; Sugar Phosphates; Temperature; Tolbutamide | 1976 |
Adriamycin therapy for advanced insulinoma.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Diazoxide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Glucagon; Humans; Insulin; Leucine; Male; Middle Aged; Prednisone; Streptozocin; Tolbutamide | 1977 |
[The insulinomas].
Topics: Adenoma, Islet Cell; Diazoxide; Glucagon; Humans; Hyperplasia; Insulin; Insulin Secretion; Pancreatic Diseases; Pancreatic Neoplasms; Tolbutamide | 1979 |
Furosemide binding to human albumin and plasma of nephrotic children.
Topics: Acetazolamide; Aspirin; Child; Diazoxide; Dose-Response Relationship, Drug; Female; Furosemide; Humans; Hydrogen-Ion Concentration; Male; Nephrotic Syndrome; Phenylbutazone; Phosphates; Protein Binding; Renal Dialysis; Serum Albumin; Sulfisoxazole; Temperature; Time Factors; Tolbutamide | 1975 |
Paradoxical enhancement of tolbutamide-induced insulin release by diazoxide in a patient with islet cell hyperplasia.
Topics: Blood Glucose; Child; Diazoxide; Glucagon; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreatic Diseases; Propranolol; Tolbutamide | 1978 |
Modulation of pancreatic somatostatin by adrenergic and cholinergic agonism and by hyper- and hypoglycemic sulfonamides.
Topics: Acetylcholine; Animals; Diazoxide; Dogs; Epinephrine; Glucagon; Insulin; Insulin Secretion; Isoproterenol; Male; Pancreas; Phentolamine; Propranolol; Somatostatin; Sulfonamides; Tolbutamide | 1978 |
[Non-saturable cooperative binding of tolbutamide to rat endocrine pancreas. Criteria of specificity].
Topics: Animals; Diazoxide; Drug Interactions; Glipizide; Glucose; Glyburide; Islets of Langerhans; Kinetics; Rats; Tolbutamide | 1976 |
[Modification of insulin-secretion, induced by glucose, of the isolation-perfused rat pancreas using tolbutamide, glucosamine, diazoxide, glucagon and endogenous insulin].
Topics: Animals; Diazoxide; Glucagon; Glucosamine; Insulin; Insulin Secretion; Pancreas; Perfusion; Rats; Tolbutamide | 1976 |
Action of insulin inhibitors on exocrine pancreatic secretion of the rat with chronic pancreatic fistula.
Topics: Animals; Bicarbonates; Cholecystokinin; Deoxyglucose; Diazoxide; Epinephrine; Insulin Antagonists; Pancreas; Rats; Secretin; Tolbutamide | 1976 |
The stimulus-secretion coupling of glucose-induced insulin release-XVII. Effects of sulfonylureas and diazoxide on insular biosynthetic activity.
Topics: Animals; Cyclohexanes; Cyclopentanes; Diazoxide; Glucose; Hormones; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Oxidation-Reduction; Peptide Biosynthesis; Proinsulin; Pyrazines; Pyrroles; Rats; Sulfonylurea Compounds; Tolbutamide | 1975 |
An effect of hyposmolarity on insulin release in vitro.
Topics: Amiloride; Amylases; Animals; Atropine; Calcium; Choline; Colchicine; Diazoxide; Epinephrine; Glucagon; Glucose; Hypotonic Solutions; Imidazoles; In Vitro Techniques; Insulin; Insulin Secretion; Male; Osmolar Concentration; Ouabain; Pancreas; Phentolamine; Phenytoin; Propranolol; Rats; Sorbitol; Tolbutamide; Trypsin Inhibitors; Vinblastine | 1975 |
Potentiation of the adrenergic beta-receptor-mediated insulin secretion in pertussis-sensitized rats.
Topics: Animals; Blood Glucose; Diazoxide; Epinephrine; Glucagon; Glucose; Hydrocortisone; Insulin; Insulin Antibodies; Isoproterenol; Male; Norepinephrine; Pertussis Vaccine; Phentolamine; Phenylephrine; Rats; Receptors, Adrenergic; Time Factors; Tolbutamide; Whooping Cough | 1975 |
[Diazoxide: new way in treatment of hypertension].
Topics: Adult; Chlorthalidone; Diazoxide; Diet, Sodium-Restricted; Female; Humans; Hydralazine; Hypertension; Male; Methyldopa; Middle Aged; Propranolol; Tolbutamide; Water-Electrolyte Balance | 1975 |
[Diagnosis of organic hyperinsulinism].
Topics: Diagnosis, Differential; Diazoxide; Fasting; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Radiography; Radionuclide Imaging; Tolbutamide | 1975 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction | 1992 |
Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell.
Topics: Animals; Arginine; Azides; Calcium; Cytosol; Diazoxide; Female; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Mannoheptulose; Membrane Potentials; Mice; Mice, Inbred Strains; NAD; NADP; Oscillometry; Potassium; Spectrometry, Fluorescence; Tolbutamide | 1992 |
Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Binding Sites; Diazoxide; Electric Conductivity; In Vitro Techniques; Islets of Langerhans; Magnesium; Male; Mice; Models, Biological; Potassium Channels; Tolbutamide | 1992 |
Identification of an ATP-sensitive K+ channel in rat cultured cortical neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Diazoxide; Electric Conductivity; Hippocampus; Membrane Potentials; Neurons; Potassium Channels; Rats; Tolbutamide | 1992 |
Adenosine triphosphate-sensitive potassium channels in anoxia.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Glyburide; Hippocampus; Hypoxia; Neurons; Potassium Channels; Tolbutamide | 1990 |
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cell Line; Cromakalim; Diazoxide; Glucose; Islets of Langerhans; Kinetics; Membrane Potentials; Potassium Channels; Pyrroles; Tolbutamide | 1990 |
Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats.
Topics: Animals; Blood Glucose; Diazoxide; Glucose; Hyperglycemia; Infusions, Intravenous; Insulin; Islets of Langerhans; Male; Pancreas; Rats; Rats, Inbred Strains; Sodium Chloride; Tolbutamide | 1990 |
Phentolamine and yohimbine inhibit ATP-sensitive K+ channels in mouse pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; In Vitro Techniques; Islets of Langerhans; Mice; Phentolamine; Potassium Channels; Rubidium Radioisotopes; Tolbutamide; Yohimbine | 1990 |
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Glucose; Glyburide; Ion Channels; Islets of Langerhans; Mice; Potassium; Tolbutamide | 1986 |
Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Diazoxide; Female; Glucose; Hyperglycemia; In Vitro Techniques; Ion Channels; Islets of Langerhans; Male; Membrane Potentials; Mice; Mice, Obese; Potassium; Tolbutamide | 1987 |
Interaction of diazoxide, tolbutamide and ATP4- on nucleotide-dependent K+ channels in an insulin-secreting cell line.
Topics: Adenosine Triphosphate; Animals; Cell Line; Diazoxide; Insulin; Insulin Secretion; Ion Channels; Islets of Langerhans; Magnesium; Membrane Potentials; Potassium; Rats; Saponins; Tolbutamide | 1987 |
Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Benzamides; Diazoxide; Glipizide; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Ion Channels; Islets of Langerhans; Mice; Mice, Inbred Strains; Potassium; Sulfonylurea Compounds; Tolbutamide | 1988 |
'Perforated patch recording' allows long-term monitoring of metabolite-induced electrical activity and voltage-dependent Ca2+ currents in pancreatic islet B cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Azides; Calcium Channels; Diazoxide; Electric Conductivity; Glucose; Humans; Islets of Langerhans; Membrane Potentials; Nifedipine; Rats; Sodium Azide; Tolbutamide | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diazoxide; Glyburide; Heart; In Vitro Techniques; Male; Potassium Channels; Rats; Rats, Inbred Strains; Tolbutamide | 1989 |
Similarities between the effects of pinacidil and diazoxide on ionic and secretory events in rat pancreatic islets.
Topics: Animals; Calcimycin; Calcium; Cell Membrane Permeability; Diazoxide; Glucose; Guanidines; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Pinacidil; Potassium; Rats; Rubidium; Secretory Rate; Tolbutamide | 1989 |
Effects of sulfonamides on a metabolite-regulated ATPi-sensitive K+ channel in rat pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Electric Conductivity; Glucose; Glyburide; Islets of Langerhans; Kinetics; Mathematics; Membrane Potentials; Models, Biological; Potassium Channels; Rats; Tolbutamide | 1989 |
Insulin-related changes in the subcellular distribution of insulin receptors in intact rat liver: effects of acute hypoinsulinemia induced by diazoxide, somatostatin, and xylazine.
Topics: Animals; Cell Membrane; Diazoxide; Golgi Apparatus; Insulin; Liver; Male; Rats; Rats, Inbred Strains; Receptor, Insulin; Somatostatin; Thiazines; Tolbutamide; Xylazine | 1987 |
ATP-sensitive K+ channels may control glucose-induced electrical activity in pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Radioisotopes; Cell Membrane Permeability; Diazoxide; Electrophysiology; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Rubidium Radioisotopes; Tolbutamide | 1988 |
Influence of glucose on the sodium content of beta-cell-rich pancreatic islets exposed to sulphonamides and amiloride.
Topics: Adenosine Triphosphate; Amiloride; Animals; Diazoxide; Glucose; Islets of Langerhans; Mice; Potassium Channels; Sodium; Sulfonamides; Tolbutamide | 1988 |
Sulphonamide modulation of sodium content in rat pancreatic islets.
Topics: Animals; Calcium; Diazoxide; Glipizide; Glucose; Islets of Langerhans; Male; Potassium; Rats; Rats, Inbred Strains; Sodium; Sulfonamides; Tolbutamide | 1988 |
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line.
Topics: Adenosine Triphosphate; Animals; Cell Line; Diazoxide; Electrophysiology; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Nucleotides; Potassium Channels; Rats; Sulfonylurea Compounds; Tolbutamide | 1988 |
Glucose-induced increase of potassium in pancreatic beta-cells associated with reduced mobilization of the ion.
Topics: Animals; Cell Membrane Permeability; Diazoxide; Glucose; In Vitro Techniques; Islets of Langerhans; Mice; Mice, Inbred Strains; Potassium; Quinine; Tetraethylammonium Compounds; Tolbutamide | 1988 |
The permissive effect of glucose, tolbutamide and high K+ on arginine stimulation of insulin release in isolated mouse islets.
Topics: Animals; Arginine; Culture Techniques; Diazoxide; Female; Glucose; Glucose Solution, Hypertonic; Insulin; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Potassium; Rats; Tolbutamide | 1987 |
Modulation of the effect of acetylcholine on insulin release by the membrane potential of B cells.
Topics: Acetylcholine; Animals; Arginine; Calcium Radioisotopes; Cell Membrane; Diazoxide; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Membrane Potentials; Mice; Potassium; Radioisotopes; Rubidium; Tolbutamide | 1987 |
Inhibition of insulin release by diphenylhydantoin and diazoxide in a patient with benign insulinoma.
Topics: Adenoma, Islet Cell; Aged; Depression, Chemical; Diazoxide; Glucose; Humans; Insulin; Insulin Secretion; Male; Pancreatic Neoplasms; Phenytoin; Tolbutamide | 1973 |
[Comparison of the beta-cytotropic effect of glymidine sodium (glycodiazine), glucagon, and isopropylnoradrenaline in rats].
Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Animals; Barbiturates; Blood Glucose; Diazoxide; Drug Interactions; Ethers; Glucagon; Hypoglycemic Agents; Insulin; Insulin Secretion; Iodine Radioisotopes; Isoproterenol; Male; Norepinephrine; Pancreas; Phentolamine; Photometry; Pyrimidines; Rats; Stimulation, Chemical; Sulfonamides; Theophylline; Time Factors; Tolbutamide | 1973 |
Effects of diazoxide on insulin secretion in vitro.
Topics: Alloxan; Animals; Antihypertensive Agents; Diazoxide; Glucose; In Vitro Techniques; Insulin; Pancreas; Rabbits; Tolbutamide | 1966 |
Reversal of diazoxide effects by tolbutamide.
Topics: Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Ethacrynic Acid; Hyperglycemia; Hypotension; Injections, Intravenous; Rats; Tolbutamide | 1967 |
The pancreatic -cell recognition of insulin secretagogues. IV. Islet uptake of sulfonylureas.
Topics: Animals; Antimycin A; Carbon Isotopes; Chlorpromazine; Diazoxide; Glucose; Glyburide; In Vitro Techniques; Islets of Langerhans; Leucine; Male; Mice; Serum Albumin; Sulfur Isotopes; Tolbutamide | 1973 |
In vitro secretion of insulin after glucose, sulphonylureas, adrenergic and cholinergic substances studied by isolated perfused rat pancreas.
Topics: Acetylcholine; Animals; Atropine; Diazoxide; Epinephrine; Glucagon; Glucose; Glyburide; Heptoses; In Vitro Techniques; Insulin; Insulin Secretion; Isoproterenol; Ketoses; Norepinephrine; Pancreas; Parasympathomimetics; Perfusion; Phenoxybenzamine; Practolol; Propranolol; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1974 |
[Recent pharmacologic aspects of sulfamides modifying insulin secretion (hypoglycemic and hyperglycemic sulfamides)].
Topics: Animals; Catecholamines; Diazoxide; Dogs; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Pancreas; Pancreatectomy; Phenoxybenzamine; Propranolol; Rats; Tolbutamide | 1973 |
[Study in rats of the development of the islands of Langerhans under the effect of the chronic administration, separate or combined, of tolbutamide and diazoxide].
Topics: Animals; Diabetes Mellitus; Diazoxide; Drug Antagonism; Female; Islets of Langerhans; Rats; Tolbutamide | 1968 |
Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.
Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Catecholamines; Depression, Chemical; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Tolbutamide; Trichlormethiazide | 1968 |
[Apropos of a case of severe hypoglycemia. Present possibilities of diagnosis and treatment].
Topics: Adenoma, Islet Cell; Blood Glucose; Diagnosis, Differential; Diazoxide; Glucocorticoids; Glucose; Glucose Tolerance Test; Humans; Hypoglycemia; Infant; Insulin; Leucine; Male; Pancreatectomy; Tolbutamide | 1968 |
Studies on the ability of compounds to block the diabetogenic activity of streptozotocin.
Topics: Amino Acids; Animals; Diabetes Mellitus; Diaphragm; Diazoxide; Epinephrine; Ethanol; Glucosamine; Glucose; Hyperglycemia; Hypoglycemic Agents; Male; NAD; Niacinamide; Nitroso Compounds; Pyrazinamide; Pyrazines; Pyrazoles; Rats; Tolbutamide | 1969 |
[Morphology and histochemistry of insulin secretion].
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Diazoxide; Histocytochemistry; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Microscopy, Electron; Rats; Tolbutamide | 1968 |
The effect of tolbutamide on blood pressure.
Topics: Angiotensin II; Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Hydralazine; Insulin; Norepinephrine; Pentolinium Tartrate; Phentolamine; Tolbutamide | 1971 |
Islet cell adenomatosis and adenoma in an infant.
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Diazoxide; Glucose; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Intellectual Disability; Leucine; Male; Pancreatectomy; Pancreatic Neoplasms; Prednisone; Tolbutamide | 1971 |
Hyperresponsiveness to tolbutamide of dogs pretreated with diazoxide.
Topics: Animals; Cyclic AMP; Depression, Chemical; Diazoxide; Dogs; Epinephrine; Insulin; Insulin Secretion; Propranolol; Radioimmunoassay; Secretory Rate; Stimulation, Chemical; Time Factors; Tolbutamide | 1971 |
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.
Topics: Acromegaly; Adenoma, Islet Cell; Adolescent; Adult; Animals; Child; Chromatography, Gel; Cricetinae; Cushing Syndrome; Diazoxide; Disease Models, Animal; Female; Glucagon; Glucose Tolerance Test; Half-Life; Humans; Hypoglycemia; Hypokalemia; Insulin; Iodine Isotopes; Leucine; Male; Middle Aged; Myotonic Dystrophy; Neoplasms, Experimental; Obesity; Proinsulin; Radioimmunoassay; Stimulation, Chemical; Tolbutamide | 1971 |
Surgical grand rounds from the University of Mississippi Medical Center. Management of hyperinsulinism.
Topics: Adenoma, Islet Cell; Diagnosis, Differential; Diazoxide; Dietary Carbohydrates; Female; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia; Male; Middle Aged; Neoplasm Metastasis; Pancreas; Pancreatectomy; Pancreatic Neoplasms; Splenectomy; Stomach Neoplasms; Tolbutamide | 1971 |
The morphological substrate of the inhibition of insulin secretion by diazoxide.
Topics: Animals; Blood Glucose; Cells; Diazoxide; Diet; Inclusion Bodies; Insulin; Insulin Antibodies; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Microscopy, Electron; Models, Biological; Rats; Rats, Inbred Strains; Tolbutamide | 1969 |
Beta cell adenoma in a child with hypoglycemia controlled with diazoxide.
Topics: Adenoma, Islet Cell; Blood Glucose; Child, Preschool; Diazoxide; Female; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Leucine; Microscopy, Electron; Pancreatectomy; Pancreatic Neoplasms; Splenectomy; Tolbutamide | 1972 |
Pancreatic islet beta cell tumors and hyperplasia: experience in 14 Seattle hospitals.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Male; Middle Aged; Pancreatectomy; Pancreatic Neoplasms; Tolbutamide | 1972 |
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.
Topics: Animals; Arginine; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucagon; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Phosphorus Isotopes; Phosphotransferases; Protein Kinases; Rats; Theophylline; Time Factors; Tolbutamide; Xanthines; Xylitol | 1973 |
Interaction of various stimulators and inhibitors on insulin secretion in vitro.
Topics: Animals; Bucladesine; Cyclic GMP; Diazoxide; Drug Interactions; Epinephrine; Inosine Nucleotides; Insulin; Insulin Antagonists; Insulin Secretion; Male; Nucleotides, Cyclic; Pancreas; Rats; Starvation; Stimulation, Chemical; Theophylline; Thymine Nucleotides; Time Factors; Tolbutamide | 1973 |
[Exploration of hypoglycemia].
Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Diazoxide; Diet; Fasting; Glucagon; Hormones, Ectopic; Humans; Hypoglycemia; Insulin; Insulin Secretion; Leucine; Medical History Taking; Pancreatic Neoplasms; Physical Examination; Time Factors; Tolbutamide | 1974 |
Familial nesidioblastosis as the predominant manifestation of multiple endocrine adenomatosis.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Diazoxide; Female; Gastric Mucosa; Gastrins; Glucagon; Glucose Tolerance Test; Humans; Hypercalcemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Multiple Endocrine Neoplasia; Pedigree; Tolbutamide; Zollinger-Ellison Syndrome | 1972 |
Hypertensive crisis.
Topics: Acute Disease; Cerebrovascular Circulation; Cerebrovascular Disorders; Diagnosis, Differential; Diazoxide; Ferricyanides; Furosemide; Humans; Hypertension; Nitric Oxide; Tolbutamide; Trimethaphan; Vasodilator Agents | 1974 |
Insulin and glucagon release from monolayer cell cultures of pancreas from newborn rats.
Topics: Alanine; Animals; Animals, Newborn; Arginine; Calcium; Cells, Cultured; Diazoxide; Epinephrine; Glucagon; Glucose; Heptoses; Insulin; Islets of Langerhans; Mannose; Ouabain; Pancreas; Potassium; Rats; Tolbutamide | 1973 |
[Proceedings: Cellular calcium and insulin secretion. Morphologic studies of B-cells in the mouse following tolbutamide and diazoxide administration].
Topics: Animals; Calcium; Depression, Chemical; Diazoxide; Hypoglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Tolbutamide | 1974 |
[Antagonistic effect of diazoxide and tolbutamide on the cardiovascular system].
Topics: Animals; Blood Pressure; Diazoxide; Dogs; Heart; Heart Atria; In Vitro Techniques; Perfusion; Rabbits; Tolbutamide | 1972 |
Metabolic aspects of the Beckwith-Wiedemann syndrome.
Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epinephrine; Glucagon; Glucose; Glucose Tolerance Test; Growth Hormone; Hernia, Umbilical; Humans; Hydrocortisone; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Insulin; Kidney Diseases; Leucine; Male; Tolbutamide; Tongue; Umbilicus | 1973 |
Analysis of the stimulating action of tolbutamide on the secretion of insulin using mannoheptulose and diazoxide.
Topics: Animals; Diazoxide; Drug Interactions; Glucose; Heptoses; In Vitro Techniques; Insulin; Insulin Secretion; Pancreas; Perfusion; Rats; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide | 1973 |
Effect of diazoxide in plasma glucose and insulin concentrations after acute glycemic stimulation and intravenous tolbutamide.
Topics: Adult; Blood Glucose; Body Height; Body Weight; Diazoxide; Fasting; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Injections, Intravenous; Insulin; Male; Time Factors; Tolbutamide | 1974 |
[Sulfonamides modifying insulin secretion and the development of the islands of Langerhans. Actions and antagonisms of actions. Some experimental studies of their clinical applications].
Topics: Animals; Diazoxide; Drug Antagonism; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Tolbutamide | 1967 |
The action of diazoxide on insulin secretion, medullo-adrenal secretion, and the liberation of catecholamines.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Catecholamines; Diazoxide; Dogs; Epinephrine; Female; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Tolbutamide | 1968 |
Insulin secretory blockade by benzothiadiazines and catecholamines: reversal by sulfonylureas.
Topics: Adrenal Glands; Adrenalectomy; Animals; Benzothiadiazines; Catecholamines; Chlorothiazide; Diazoxide; Dogs; Epinephrine; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Norepinephrine; Pancreas; Tolbutamide; Veins | 1968 |
A-cell deficiency and B-cell hyperplasia of Langerhans' islet as a cause of leucine sensitive hypoglycemia.
Topics: Blood Glucose; Diazoxide; Epinephrine; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia; Infant; Insulin; Islets of Langerhans; Leucine; Male; Pancreatectomy; Pancreatic Diseases; Seizures; Tolbutamide | 1968 |
Insulin and glucagon release from isolated islets of Langerhans. Effect of enteric factors.
Topics: Animals; Cholecystokinin; Diazoxide; Gastrins; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Secretin; Tolbutamide | 1969 |
[Pharmacological studies of a new highly effective blood sugar decreasing sulfonamide, glibenclamide (HB 419)].
Topics: Animals; Blood Glucose; Depression, Chemical; Diazoxide; Dogs; Drug Synergism; Female; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Pancreas; Pancreatectomy; Rats; Stimulation, Chemical; Tolbutamide; Urea | 1969 |
[Effect of HB 419 and tolbutamide on isolated islands of Langerhans in rats].
Topics: Animals; Carbon Isotopes; Diazoxide; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Rats; Theophylline; Tolbutamide | 1969 |
[Insulin secretion in vitro. II. Inhibition of glucose induced insulin release by diazoxide].
Topics: Animals; Culture Techniques; Diazoxide; Diuretics; Epinephrine; Glucose; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rabbits; Rats; Swine; Tolbutamide | 1966 |
[Experimental study of a new especially active hypoglycemic sulfonamide, HB-419 or Glibenclamide].
Topics: Animals; Blood Glucose; Catheterization; Diazoxide; Dogs; Drug Synergism; Female; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Rats; Tolbutamide | 1969 |
Complementary arguments in favor of the betacytotrophic action of the hypglycemic sulfonamides.
Topics: Animals; Diabetes Mellitus; Diazoxide; Dogs; Glucose; Hyperplasia; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Pancreatectomy; Rats; Tolbutamide | 1970 |
Glucose metabolism in mouse pancreatic islets.
Topics: Animals; Arginine; Cycloheximide; Diazoxide; Epinephrine; Fructose; Glucagon; Glucosamine; Glucose; Hexosephosphates; Hexoses; In Vitro Techniques; Islets of Langerhans; Lactates; Mannose; Mice; Monosaccharides; Phlorhizin; Tolbutamide | 1970 |
Insulinotropic effect and possible mode of action of a new potent sulfonylurea (BS-4231).
Topics: Animals; Carbutamide; Depression, Chemical; Diazoxide; Epinephrine; Glucose; Heptoses; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Stimulation, Chemical; Tolbutamide | 1971 |
Mode of action of a diazoxide analog (A025). Its effects on insulin secretion.
Topics: Adrenal Glands; Animals; Autoanalysis; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Catecholamines; Diazoxide; Dogs; Female; Glucose Tolerance Test; Haplorhini; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Liver Glycogen; Male; Mice; Pancreas; Rats; Time Factors; Tolbutamide | 1970 |
Effect of tolbutamide on blood pressure.
Topics: Animals; Blood Pressure; Diazoxide; Dogs; Epinephrine; Haplorhini; In Vitro Techniques; Norepinephrine; Rats; Renal Artery; Tolbutamide | 1971 |
The use of diazoxide inhibition of insulin secretion as a tool to investigate insulin stimulation by other agents.
Topics: Animals; Antigens; Chlorpropamide; Depression, Chemical; Diazoxide; Drug Antagonism; Immunoassay; Insulin; Insulin Secretion; Kinetics; Male; Mice; Mice, Inbred Strains; Stimulation, Chemical; Tolbutamide | 1972 |
Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy.
Topics: Acute Disease; Administration, Oral; Adult; Albuminuria; Blood Glucose; Diazoxide; Female; Furosemide; Humans; Hyperglycemia; Hypertension; Infant; Infant, Newborn; Kidney Failure, Chronic; Pre-Eclampsia; Pregnancy; Pregnancy in Diabetics; Tolbutamide | 1972 |
Use of diazoxide in hypertension with renal failure.
Topics: Adolescent; Adult; Blood Glucose; Creatine; Diazoxide; Dietary Proteins; Female; Humans; Hyperglycemia; Hypertension; Hypertension, Malignant; Injections, Intravenous; Insulin; Kidney Failure, Chronic; Male; Middle Aged; Posture; Tolbutamide; Urea | 1971 |
Hyperglycemia after diazoxide.
Topics: Coma; Diazoxide; Furosemide; Humans; Hyperglycemia; Injections, Intravenous; Tolbutamide | 1971 |
[The action of sulfonylureas on the insulin secretion of the perfused rat pancreas].
Topics: Animals; Diazoxide; Drug Antagonism; Drug Synergism; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Pancreas; Perfusion; Rats; Sulfonamides; Tolbutamide | 1969 |
The effects of epinephrine, amino acids and albumin on the measurement of insulin by radioimmunoassay.
Topics: Animals; Antigen-Antibody Reactions; Antigens; Arginine; Binding Sites; Chemical Phenomena; Chemistry; Diazoxide; Epinephrine; Evaluation Studies as Topic; Glucose; Glucose Tolerance Test; Guinea Pigs; Humans; Immune Sera; Insulin; Insulin Antibodies; Iodine Isotopes; Leucine; Methods; Protein Binding; Radioimmunoassay; Serum Albumin; Swine; Tolbutamide | 1970 |
AO44: an improved hyperglycemic agent.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Epinephrine; Female; Hyperglycemia; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intravenous; Insulin; Insulin Antagonists; Insulin Secretion; Male; Norepinephrine; Pancreas; Rats; Tolbutamide | 1971 |
Insulin secretion studied in the perfused rat pancreas. I. Effect of tolbutamide, leucine and arginine; their interaction with diazoxide, and relation to glucose.
Topics: Animals; Arginine; Buffers; Diazoxide; Glucose; Insulin; Insulin Secretion; Leucine; Male; Pancreas; Perfusion; Radioimmunoassay; Rats; Stimulation, Chemical; Tolbutamide | 1971 |
Diazoxide in the management of hypoglycemia in infancy and childhood.
Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucose; Glucose Tolerance Test; Growth Hormone; Humans; Hypoglycemia; Infant; Insulin; Insulin Secretion; Leucine; Male; Tolbutamide | 1969 |
The interaction of various inhibitors and stimuli of insulin release studied with rabbit pancreas in vitro.
Topics: Animals; Barium; Diazoxide; Dibucaine; Dinitrophenols; Epinephrine; Glucose; Heptoses; Hypoxia; In Vitro Techniques; Insulin; Insulin Secretion; Leucine; Ouabain; Pancreas; Potassium; Rabbits; Tetrodotoxin; Tolbutamide | 1969 |
Opposite effects of hypoglycemic and hyperglycemic sulfonamides upon ionophore-mediated calcium transport.
Topics: Anti-Bacterial Agents; Blood Glucose; Calcimycin; Calcium; Diazoxide; Gliclazide; Hypoglycemic Agents; Lithium; Sodium; Sulfonamides; Tolbutamide | 1980 |
Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells.
Topics: Animals; Calcium; Diazoxide; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Potentials; Mice; Potassium; Radioisotopes; Rats; Rats, Inbred Strains; Rubidium; Tolbutamide | 1982 |
Amino acid-induced [Ca2+]i oscillations in single mouse pancreatic islets of Langerhans.
Topics: Amino Acids; Animals; Blood Glucose; Calcium; Cytosol; Diazoxide; Glucose; Glyceraldehyde; In Vitro Techniques; Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Osmolar Concentration; Tolbutamide | 1995 |
Reconstitution of a KATP channel from basolateral membranes of Necturus enterocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Glyburide; Intestine, Small; Membranes; Necturus; Potassium Channels; Tolbutamide | 1995 |
Putative pre- and postsynaptic ATP-sensitive potassium channels in the rat substantia nigra in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazoxide; GABA-A Receptor Antagonists; Glucose; In Vitro Techniques; Kinetics; Male; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channels; Propanolamines; Rats; Rats, Wistar; Receptors, GABA-A; Substantia Nigra; Synapses; Synaptic Transmission; Time Factors; Tolbutamide | 1995 |
In vitro stimulation of insulin release by SL 84.0418, a new alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Diazoxide; Dioxanes; Electrophysiology; Female; Glucose; Idazoxan; In Vitro Techniques; Indoles; Insulin; Islets of Langerhans; Mice; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Tolbutamide | 1994 |
Spontaneous activation of KATP current in rat dorsal vagal neurones.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Diffusion; Female; Glyburide; Male; Membrane Potentials; Neurons; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium Compounds; Tolbutamide; Vagus Nerve | 1994 |
Identification of an ATP-sensitive K+ channel in spiny neurons of rat caudate nucleus.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Caudate Nucleus; Cyanides; Diazoxide; Electrophysiology; Female; Male; Neurons; Potassium Channel Blockers; Potassium Channels; Rats; Tolbutamide | 1994 |
Evidence that tolbutamide induces prolactin secretion by a mechanism which does not involve blocking ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Nifedipine; Pituitary Gland, Anterior; Potassium Channels; Prolactin; Rats; Rats, Sprague-Dawley; Tolbutamide | 1994 |
Blockade of K+ channels in insulin-secreting cells by the 'potassium channel opener' SDZ PCO 400.
Topics: Animals; Benzopyrans; Cell Membrane; Cyclopentanes; Diazoxide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Phentolamine; Potassium Channel Blockers; Potassium Channels; Rats; Tolbutamide | 1993 |
Effects of sulphonylureas on cAMP-stimulated Cl- transport via the cystic fibrosis gene product in human epithelial cells.
Topics: Adenosine Triphosphate; Blood Proteins; Cell Line; Chloride Channels; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Electrophysiology; Glyburide; Humans; Sulfonylurea Compounds; Tolbutamide | 1994 |
Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets.
Topics: Acetylcholine; Animals; Calcium; Cells, Cultured; Cytoplasm; Diazoxide; Epinephrine; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mice; Oscillometry; Time Factors; Tolbutamide | 1993 |
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagonoma; Glyburide; Insulinoma; Kinetics; Membrane Potentials; Mice; Pancreatic Neoplasms; Potassium Channels; Tolbutamide; Tritium; Tumor Cells, Cultured | 1993 |
Characterization and solubilization of the sulphonylurea receptor in rat brain.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Animals; ATP-Binding Cassette Transporters; Benzamides; Binding, Competitive; Brain Chemistry; Ca(2+) Mg(2+)-ATPase; Diazoxide; Glyburide; Guanine Nucleotides; Hypoglycemic Agents; In Vitro Techniques; Membranes; Microsomes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 1993 |
Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse.
Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diazoxide; Female; Insulin; Islets of Langerhans; Mice; Mice, Inbred NOD; Pancreatic Diseases; Tolbutamide | 1993 |
Tolbutamide- and diazoxide-sensitive K+ channel in neurons of substantia nigra pars reticulata.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; In Vitro Techniques; Male; Potassium Channels; Rats; Substantia Nigra; Tolbutamide | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured | 1993 |
Differences in K+ permeability between cultured adult and neonatal rat islets of Langerhans in response to glucose, tolbutamide, diazoxide, and theophylline.
Topics: Animals; Animals, Newborn; Diazoxide; Glucose; In Vitro Techniques; Islets of Langerhans; Permeability; Potassium; Rats; Rats, Wistar; Theophylline; Tolbutamide | 1993 |
Secretagogue-induced [Ca2+]i changes in single rat pancreatic islets and correlation with simultaneously measured insulin release.
Topics: Animals; Calcium; Carbachol; Cells, Cultured; Cytosol; Diazoxide; Fluorescent Dyes; Fura-2; Glucose; Glutamine; Indoles; Inulin; Islets of Langerhans; Kinetics; Leucine; Male; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Time Factors; Tolbutamide | 1995 |
The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells.
Topics: Adenosine Triphosphate; Diazoxide; Humans; Kidney; Patch-Clamp Techniques; Potassium Channels; Tolbutamide | 1996 |
Membrane potentials and microenvironment of rat dorsal vagal cells in vitro during energy depletion.
Topics: Animals; Brain Stem; Cell Hypoxia; Diazoxide; Electric Stimulation; Glucose; Glyburide; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Neuroglia; Neurons; Oxygen Consumption; Potassium; Rats; Synaptic Transmission; Tolbutamide; Vagus Nerve | 1996 |
Production of [3H]choline-labelled metabolites from endogenously 3H-labelled phosphatidylcholine in mouse pancreatic islets.
Topics: Animals; Carbachol; Cells, Cultured; Choline; Cyclohexanones; Diazoxide; Glucose; Glycerylphosphorylcholine; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Kinetics; Lysophosphatidylcholines; Male; Mice; Mice, Inbred Strains; Phosphatidylcholines; Potassium Chloride; Radioisotope Dilution Technique; Rats; Sodium Fluoride; Succinates; Tetradecanoylphorbol Acetate; Tolbutamide; Tritium | 1996 |
Glucose-induced [Ca2+]i oscillations in single human pancreatic islets.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biological Transport; Calcium; Cells, Cultured; Diazoxide; Fluorescent Dyes; Fura-2; Glucose; Humans; Hypoglycemic Agents; Islets of Langerhans; Male; Pancreatic Neoplasms; Pancreatitis; Potassium Channels; Tolbutamide | 1996 |
Single-channel recordings of an ATP-sensitive K channel in rat cultured cortical neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Diazoxide; Neurons; Potassium Channels; Rats; Tolbutamide | 1993 |
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Cell Membrane; Diazoxide; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sequence Deletion; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Xenopus | 1997 |
Effect of activators and inhibitors of K+ channels on insulin secretion in the amphibian pancreas.
Topics: Animals; Antihypertensive Agents; Bufo arenarum; Calcium Channels; Clonidine; Diazoxide; Galactose; Glucose; Glyceraldehyde; Hormone Antagonists; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Potassium Channel Blockers; Potassium Channels; Pyridines; Radioimmunoassay; Somatostatin; Tetraethylammonium; Tetraethylammonium Compounds; Thiadiazines; Tolbutamide | 1997 |
RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Patch-Clamp Techniques; Potassium Channels; Rats; Somatostatin; Tolbutamide; Tumor Cells, Cultured | 1997 |
Insulin secretion from isolated rat islets induced by the novel hypoglycemic agent A-4166, a derivative of D-phenylalanine.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Calcium; Cell Line; Cyclohexanes; Diazoxide; Epinephrine; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rubidium; Somatostatin; Stereoisomerism; Sulfonylurea Receptors; Tolbutamide | 1998 |
Regulation by tolbutamide and diazoxide of the electrical activity in mouse pancreatic beta-cells recorded in vivo.
Topics: Animals; Blood Glucose; Diazoxide; Dose-Response Relationship, Drug; Islets of Langerhans; Membrane Potentials; Mice; Tolbutamide | 1998 |
Tolbutamide and diazoxide influence insulin secretion by changing the concentration but not the action of cytoplasmic Ca2+ in beta-cells.
Topics: Animals; Calcium; Calcium Channels; Cyclic AMP; Diazoxide; Evoked Potentials; Exocytosis; Female; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Patch-Clamp Techniques; Perfusion; Tolbutamide | 1998 |
Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Diazoxide; Electric Stimulation; Glyburide; Hypoglycemic Agents; Hypoxia; Hypoxia, Brain; Ion Channel Gating; Medulla Oblongata; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Potassium Channels; Respiration; Tolbutamide; Vasodilator Agents | 1998 |
Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Diuretics; Electric Stimulation; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Neostriatum; Parasympathetic Nervous System; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride Symporter Inhibitors; Tolbutamide | 1998 |
Appearance of glucose-induced insulin release in fetal rat beta-cells.
Topics: Animals; Cells, Cultured; Diazoxide; Diuretics; Gestational Age; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mannoheptulose; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Sodium Chloride Symporter Inhibitors; Theophylline; Tolbutamide | 1998 |
Insulin occludes leptin activation of ATP-sensitive K+ channels in rat CRI-G1 insulin secreting cells.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Binding, Competitive; Chromones; Diabetes Mellitus, Type 2; Diazoxide; Drug Interactions; Electric Conductivity; Enzyme Inhibitors; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Like Growth Factor I; Ion Channel Gating; Leptin; Membrane Potentials; Morpholines; Patch-Clamp Techniques; Potassium Channels; Proteins; Rats; Tolbutamide; Vasodilator Agents; Wortmannin | 1998 |
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cromakalim; Diazoxide; DNA, Complementary; Gene Library; Glyburide; Heart Ventricles; Humans; Magnesium; Middle Aged; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors; Tolbutamide; Transfection | 1998 |
Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Diazoxide; Hippocampus; In Vitro Techniques; Interneurons; Neuroglia; Neurons; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transcription, Genetic | 1999 |
Endothelium-dependent blunted membrane potential responses to ATP-sensitive K+ channel modulators in aortae from rats with cirrhosis.
Topics: Adenosine Triphosphate; Animals; Aorta; Bosentan; Cromakalim; Diazoxide; Endothelin-1; Endothelium, Vascular; Glyburide; Liver Cirrhosis, Experimental; Male; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides; Tolbutamide | 1999 |
Tolbutamide attenuates diazoxide-induced aggravation of hypoxic cell injury.
Topics: Animals; Brain; Cell Hypoxia; Diazoxide; In Vitro Techniques; Male; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Rats, Wistar; Tolbutamide | 1998 |
Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Diazoxide; Exocytosis; Female; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Mice; Potassium Channels; Sulfonylurea Compounds; Tolbutamide | 1999 |
Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Diazoxide; Diuretics; Electrophysiology; Fungal Proteins; Glycosyltransferases; Hypoglycemic Agents; Ion Channel Gating; Membrane Potentials; Membrane Proteins; Mice; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sequence Deletion; Sodium Chloride Symporter Inhibitors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Xenopus laevis | 1999 |
Sulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunits.
Topics: Adenosine Diphosphate; Animals; ATP-Binding Cassette Transporters; Chlorocebus aethiops; COS Cells; Diazoxide; Diuretics; Electric Stimulation; Electrophysiology; Glycosyltransferases; Hypoglycemic Agents; Ion Channel Gating; KATP Channels; Membrane Potentials; Membrane Proteins; Mutagenesis; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Polylysine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Sodium Chloride Symporter Inhibitors; Sulfonylurea Compounds; Tolbutamide | 1999 |
Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia.
Topics: Animals; ATP-Binding Cassette Transporters; Diazoxide; Hypoglycemic Agents; Hypoxia, Brain; Ion Channel Gating; KATP Channels; Male; Neocortex; Neurons; Parietal Lobe; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyramidal Cells; Rats; Rats, Wistar; Somatosensory Cortex; Tolbutamide; Vasodilator Agents | 1999 |
Threonine phosphorylations induced by RX-871024 and insulin secretagogues in betaTC6-F7 cells.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cytosol; Diazoxide; Exocytosis; Humans; Hypoglycemic Agents; Imidazoles; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isomerism; Membrane Potentials; Membrane Proteins; Myosin Heavy Chains; Nifedipine; Phosphorylation; Potassium Chloride; Protein Kinase C; Subcellular Fractions; Threonine; Tolbutamide | 1999 |
Identification and characterization of glucoresponsive neurons in the enteric nervous system.
Topics: Adenosine Triphosphate; Animals; Colon; Diazoxide; Electrophysiology; Enteric Nervous System; Gastrointestinal Motility; Glucose; Guinea Pigs; Leptin; Male; Myenteric Plexus; Neurons; Potassium Channels; Synaptic Transmission; Tolbutamide | 1999 |
ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cell Fusion; Cell Line; Diazoxide; Glucose; Imidazoles; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Membrane Potentials; Pancreatic Neoplasms; Phentolamine; Pinacidil; Potassium Channels; Tolbutamide; Tumor Cells, Cultured | 1999 |
Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans.
Topics: Animals; Boron Compounds; Calcium; Diazoxide; Fluorescent Dyes; Glucose; Glyburide; In Vitro Techniques; Islets of Langerhans; Kinetics; Mice; Mice, Inbred Strains; Potassium Channels; Receptors, Drug; Signal Transduction; Tolbutamide | 1999 |
Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alternative Splicing; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Azides; Base Sequence; Brain Chemistry; Cloning, Molecular; Diazoxide; Gene Deletion; Hypoglycemic Agents; Ion Channel Gating; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; Oocytes; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Vasodilator Agents; Xenopus | 1999 |
Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diazoxide; Glyburide; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Male; Nerve Tissue Proteins; Neurons; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Solitary Nucleus; Tolbutamide | 2000 |
Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells.
Topics: ATP-Binding Cassette Transporters; Binding, Competitive; Cations; Cell Line; Deoxyglucose; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Fluorescence; Gene Expression; Glipizide; Glyburide; Humans; Membrane Potentials; Oligomycins; Potassium Channels; Potassium Channels, Inwardly Rectifying; Radioligand Assay; Receptors, Drug; Recombinant Fusion Proteins; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolazamide; Tolbutamide; Tritium | 2000 |
Tolbutamide and diazoxide modulate phospholipase C-linked Ca(2+) signaling and insulin secretion in beta-cells.
Topics: Animals; Calcium Channels; Calcium Signaling; Carbachol; Cell Line; Diazoxide; Diuretics; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Muscarinic Agonists; Sodium Chloride Symporter Inhibitors; Tolbutamide; Type C Phospholipases | 2000 |
Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells.
Topics: Animals; Calcium; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diazoxide; Diuretics; DNA-Binding Proteins; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Egtazic Acid; Enzyme Inhibitors; Gene Deletion; Glucose; Hypoglycemic Agents; Imidazoles; Immediate-Early Proteins; Islets of Langerhans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Chloride; Promoter Regions, Genetic; Rats; RNA, Messenger; Serum Response Factor; Signal Transduction; Sodium Chloride Symporter Inhibitors; Time Factors; Tolbutamide; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2000 |
Sulfonylurea receptor ligands modulate stretch-induced ANF secretion in rat atrial myocyte culture.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Atrial Natriuretic Factor; Cells, Cultured; Deoxyglucose; Diazoxide; Electric Conductivity; Heart Atria; Ligands; Myocardium; Physical Stimulation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 2000 |
Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.
Topics: Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Enzyme Inhibitors; Glyburide; Guinea Pigs; Heart Atria; Heart Rate; Hypoxia; In Vitro Techniques; Male; Nitric Oxide; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Stellate Ganglion; Sympathetic Nervous System; Tolbutamide | 2000 |
Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
Topics: Animals; Cells, Cultured; Cytoplasmic Granules; Diazoxide; Exocytosis; Glucagon; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Sodium Channels; Tetrodotoxin; Tolbutamide | 2000 |
Norepinephrine acts on the KATP channel and produces different effects on [Ca2+]i in oscillating and non-oscillating HIT-T15 cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Cricetinae; Cytophotometry; Diazoxide; Glucose; Hypoglycemic Agents; Islets of Langerhans; Norepinephrine; Potassium Channels; Potassium Chloride; Tolbutamide; Tumor Cells, Cultured; Vasodilator Agents | 2000 |
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; ATP-Binding Cassette Transporters; Binding Sites; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Finland; Genes, Dominant; Humans; Hyperinsulinism; Male; Mutation, Missense; Pancreas; Pedigree; Polymorphism, Single-Stranded Conformational; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 2000 |
Sulphonylurea-sensitive channels and NO-cGMP pathway modulate the heart rate response to vagal nerve stimulation in vitro.
Topics: Acetylcholine; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Glyburide; Guinea Pigs; Heart Conduction System; Heart Rate; Ion Transport; Male; Muscle Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Potassium; Potassium Channels; Signal Transduction; Sulfonylurea Compounds; Tolbutamide; Vagus Nerve | 2000 |
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Ion Channel Gating; Kinetics; Male; Mammals; Membrane Potentials; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tolbutamide | 2000 |
PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.
Topics: 2,4-Dinitrophenol; Actins; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cytochalasin D; Cytosol; Diazoxide; Electric Conductivity; Islets of Langerhans; Patch-Clamp Techniques; Phalloidine; Phosphatidylinositol 4,5-Diphosphate; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 2000 |
Developmental downregulation of ATP-sensitive potassium conductance in astrocytes in situ.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cellular Senescence; Cerebellum; Cyclic AMP; Diazoxide; Down-Regulation; Electric Conductivity; Glucose; Hippocampus; Hypoglycemic Agents; Hypoxia-Ischemia, Brain; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rats; Sulfonylurea Compounds; Tolbutamide; Vagus Nerve; Vasodilator Agents | 2000 |
Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.
Topics: Acrylic Resins; Animals; Biocompatible Materials; Culture Media, Conditioned; Diazoxide; Glucose; Glyburide; Insulin; Insulin Secretion; Insulinoma; Kinetics; Magnetic Resonance Spectroscopy; Materials Testing; Molecular Structure; Pancreatic Neoplasms; Povidone; Sulfonylurea Compounds; Tolbutamide; Tumor Cells, Cultured | 2001 |
Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression.
Topics: Animals; ATP-Binding Cassette Transporters; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Diuretics; Epithelial Sodium Channels; Glyburide; Hypoglycemic Agents; Oocytes; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sodium Channel Blockers; Sodium Channels; Sodium Chloride Symporter Inhibitors; Sulfonylurea Receptors; Time Factors; Tolbutamide; Vasodilator Agents; Xenopus laevis | 2001 |
Overexpression of the Na/Ca exchanger shapes stimulus-induced cytosolic Ca(2+) oscillations in insulin-producing BRIN-BD11 cells.
Topics: Animals; Calcium; Cell Fusion; Cells, Cultured; Cytosol; Diazoxide; Electric Conductivity; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Oscillometry; Potassium; Rats; Sodium-Calcium Exchanger; Tolbutamide; Transfection | 2002 |
Alterations of purine and pyrimidine nucleotide contents in rat corticoencephalic cell cultures following metabolic damage and treatment with openers and blockers of ATP-sensitive potassium channels.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Diazoxide; Diphosphates; Embryo, Mammalian; Female; Glucose; Nucleosides; Potassium Channel Blockers; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Rats, Wistar; Tolbutamide | 2002 |
Membrane potential dependent modulations of calcium oscillations in insulin-secreting INS-1 cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Signaling; Cell Line; Clonidine; Colforsin; Diazoxide; Enzyme Inhibitors; Epinephrine; Fluorescent Dyes; Fura-2; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Patch-Clamp Techniques; Potassium Channels; Prazosin; Receptors, Adrenergic, alpha-2; Thapsigargin; Tolbutamide | 2002 |
Glucose-sensing in glucagon-like peptide-1-secreting cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Diazoxide; Electric Conductivity; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glucose; Glycosyltransferases; Hypoglycemic Agents; Membrane Proteins; Peptide Fragments; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Precursors; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Tolbutamide | 2002 |
Cell-type specific depression of neuronal excitability in rat hippocampus by activation of ATP-sensitive potassium channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diazoxide; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Pyramidal Cells; Rats; Rats, Inbred WF; Reference Values; Sensitivity and Specificity; Tolbutamide | 2002 |
The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Biotinylation; Cell Line; Cell Membrane; Cricetinae; Diazoxide; Fluorescent Antibody Technique; Glyburide; Humans; Kidney; Macromolecular Substances; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Structure, Tertiary; Protein Transport; Receptors, Drug; Sequence Deletion; Structure-Activity Relationship; Sulfonylurea Receptors; Tolbutamide | 2002 |
Leptin fully suppresses acetylcholine-induced insulin secretion and is reversed by tolbutamide in isolated perfused chicken pancreas.
Topics: Acetylcholine; Animals; Base Sequence; Chickens; Cholinergic Antagonists; Diazoxide; DNA Primers; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leptin; Perfusion; Receptors, Cell Surface; Receptors, Leptin; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tolbutamide | 2003 |
Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain.
Topics: Adenosine Triphosphate; Animals; Antibodies; Astrocytes; ATP-Binding Cassette Transporters; Binding, Competitive; Brain; Brain Injuries; Cell Size; Cells, Cultured; Diazoxide; Gliosis; Glyburide; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Sodium Azide; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Trypsin | 2003 |
DIAZOXIDE HYPERGLYCAEMIA AND ITS CONTINUED RELIEF BY TOLBUTAMIDE.
Topics: Antihypertensive Agents; Diazoxide; Hyperglycemia; Pharmacology; Rats; Research; Tolbutamide | 1964 |
CONJOINT CLINIC ON DRUGS AND DIABETES.
Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose; Body Weight; Chlorothiazide; Chlorpropamide; Diabetes Mellitus; Diazoxide; Diuretics; Dogs; Hydrochlorothiazide; Hypertension; Hypophysectomy; Nitrogen; Pharmacology; Placebos; Polythiazide; Potassium; Rats; Research; Tolbutamide; Toxicology; Trichlormethiazide; Urea | 1964 |
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Differentiation; Cell Division; Cytosol; Diazoxide; Electric Conductivity; Electrophysiology; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Membrane Potentials; Mitochondria; NADP; Pancreatic Neoplasms; Patch-Clamp Techniques; Potassium Chloride; Rats; Tolbutamide; Tumor Cells, Cultured | 2004 |
Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; ATP-Binding Cassette Transporters; Calcium; Cytosol; Diazoxide; Exocytosis; Female; Glucose; Glutamine; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Signal Transduction; Sulfonylurea Receptors; Time Factors; Tolbutamide | 2004 |
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassiu
Topics: Aged; Apoptosis; ATP-Binding Cassette Transporters; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channels, L-Type; Cells, Cultured; Cyclic S-Oxides; Diazoxide; Drug Synergism; Enzyme Activation; Glucose; Humans; Interleukin-1; Islets of Langerhans; Middle Aged; Mitogen-Activated Protein Kinases; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 2004 |
Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets.
Topics: Animals; Diazoxide; Enzyme Inhibitors; Indoles; Insulin; Islets of Langerhans; Male; Norepinephrine; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Tolbutamide | 2004 |
Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles.
Topics: Animals; Coloring Agents; Deer; Diazoxide; Hair Follicle; Hydrogen-Ion Concentration; Hypoglycemic Agents; Ion Channel Gating; Male; Minoxidil; Organ Culture Techniques; Phenolsulfonphthalein; Potassium Channels; Tolbutamide; Vasodilator Agents | 2005 |
KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Barium; Diazoxide; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Membrane Potentials; Mice; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; RNA, Messenger; Sperm Capacitation; Spermatogenesis; Spermatozoa; Sulfonylurea Receptors; Time Factors; Tolbutamide | 2006 |
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; ATP-Binding Cassette Transporters; Biophysics; Cromakalim; Diazoxide; DNA Primers; Dose-Response Relationship, Drug; Gene Expression Regulation; Glyburide; Hypoglycemic Agents; KATP Channels; Kinetics; Male; Models, Statistical; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscles; Patch-Clamp Techniques; Phenotype; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors; Tolbutamide | 2006 |
Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Cell Hypoxia; Cells, Cultured; Diazoxide; Hippocampus; Neurons; Oxidative Stress; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide; Tumor Suppressor Protein p53 | 2006 |
Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.
Topics: Antihypertensive Agents; Calcium; Case-Control Studies; Diazoxide; Enteral Nutrition; Fasting; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Hypoglycemic Agents; Infant; Infant, Newborn; Infusions, Intravenous; Insulin; Insulin Secretion; Leucine; Male; Prospective Studies; Risk Factors; Sweetening Agents; Tolbutamide | 2006 |
Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Animals; Butanols; Cell Line; Diazoxide; Ethanol; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Ocimum; Pancreas; Perfusion; Plant Extracts; Plant Leaves; Potassium Chloride; Rats; Rats, Long-Evans; Tissue Culture Techniques; Tolbutamide; Verapamil | 2006 |
K+-ATP-channel-related protein complexes: potential transducers in the regulation of epithelial tight junction permeability.
Topics: Animals; Antihypertensive Agents; ATP-Binding Cassette Transporters; Diazoxide; Eating; Epithelial Cells; Gastrointestinal Tract; Humans; Hypoglycemic Agents; KATP Channels; Kidney Tubules, Collecting; Membrane Proteins; Multiprotein Complexes; Occludin; Permeability; Phosphoproteins; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Signal Transduction; Sulfonylurea Receptors; Swine; Tight Junctions; Tolbutamide; Urothelium; Zonula Occludens-1 Protein | 2006 |
First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx.
Topics: Animals; Calcium; Calcium Isotopes; Cell Line, Tumor; Cell Survival; Dantrolene; Diazoxide; Dose-Response Relationship, Drug; Extracellular Fluid; Glucose; Glyburide; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Secreting Cells; L-Lactate Dehydrogenase; Male; Mice; Potassium Channels; Sodium Channels; Tetrodotoxin; Tolbutamide; Verapamil | 2006 |
Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels.
Topics: Animals; Calcium; Diazoxide; Imidazolines; Insulin; Insulin Secretion; Membrane Potentials; Mice; Potassium Channels; Tolbutamide | 2007 |
Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Coronary Circulation; Diazoxide; Electrocardiography; Endothelin-1; Endothelium, Vascular; Ergonovine; Exocytosis; Gene Expression Regulation; Genes, Synthetic; Glyburide; KATP Channels; Mice; Mice, Transgenic; Point Mutation; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pressure; Rats; Rats, Sprague-Dawley; Tolbutamide; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Diazoxide; Dose-Response Relationship, Drug; Female; Glucose; Humans; Insulin; Insulin-Secreting Cells; Ion Channel Gating; KATP Channels; Membrane Potentials; Nifedipine; Oocytes; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Propylamines; Rats; Tolbutamide; Xenopus laevis | 2007 |
Ovarian steroids stimulate adenosine triphosphate-sensitive potassium (KATP) channel subunit gene expression and confer responsiveness of the gonadotropin-releasing hormone pulse generator to KATP channel modulation.
Topics: Animals; ATP-Binding Cassette Transporters; Diazoxide; Feedback, Physiological; Female; Gene Expression Regulation; Gonadal Steroid Hormones; Gonadotropin-Releasing Hormone; KATP Channels; Luteinizing Hormone; Ovariectomy; Ovary; Potassium Channels; Potassium Channels, Inwardly Rectifying; Preoptic Area; Protein Subunits; Pulsatile Flow; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors; Tolbutamide | 2008 |
Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Carotid Body; Chronic Disease; Diazoxide; Electrophysiology; Hypoglycemic Agents; Hypoxia; In Vitro Techniques; KATP Channels; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Tolbutamide | 2008 |
Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.
Topics: Animals; Azides; Calcium; Diazoxide; gamma-Aminobutyric Acid; Glucagon-Secreting Cells; Glucose; Insulin-Secreting Cells; KATP Channels; Mice; Mice, Inbred Strains; NADP; Nimodipine; Tolbutamide | 2009 |
Involvement of hippocampal CA3 K(ATP) channels in contextual memory.
Topics: Animals; Diazoxide; Fear; Hippocampus; KATP Channels; Locomotion; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Potassium Channels, Inwardly Rectifying; Tolbutamide | 2009 |
The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase.
Topics: Blood Glucose; Diazoxide; Enzyme Activation; Humans; Hypokalemia; Membrane Transport Modulators; Pinacidil; Potassium; Sodium-Potassium-Exchanging ATPase; Temperature; Tolbutamide | 2009 |
Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.
Topics: Diazoxide; Exocytosis; Glucose; Humans; Islets of Langerhans; Membrane Potentials; Patch-Clamp Techniques; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Somatostatin; Somatostatin-Secreting Cells; Tolbutamide | 2009 |
Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels.
Topics: Animals; Benzofurans; Calcium; Cytosol; Diazoxide; Female; Imidazoles; Imidazolines; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Mice; Mice, Knockout; Phentolamine; Pinacidil; Potassium Channels; Tolbutamide | 2010 |
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Calcium; Cell Death; Cytokines; Diazoxide; Gene Expression; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Potassium Channels; Probucol; Tolbutamide | 2010 |
[Protection mechanisms of ATP-sensitive K channels on hippocampal CA1 neurons during chronic severe hypoxia].
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Hypoxia; Cell Survival; Diazoxide; Genes, p53; Hippocampus; KATP Channels; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tolbutamide | 2007 |
Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays.
Topics: Action Potentials; Animals; Antihypertensive Agents; Calcium; Diazoxide; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Membrane Potentials; Mice; Mice, Inbred C57BL; Microelectrodes; Patch-Clamp Techniques; Tolbutamide | 2011 |
In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions.
Topics: ATP-Binding Cassette Transporters; Congenital Hyperinsulinism; Cyclin-Dependent Kinase Inhibitor p57; Diazoxide; Drug Resistance; Humans; In Vitro Techniques; Infant; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; Mutation; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 2011 |
Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.
Topics: Amino Acid Substitution; Diazoxide; Glucokinase; Hexokinase; Humans; Hyperinsulinism; Hypoglycemic Agents; Infant, Newborn; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mutation; Tolbutamide | 2013 |
Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells.
Topics: Animals; ATP-Binding Cassette Transporters; Cation Transport Proteins; Crosses, Genetic; Diazoxide; Glucagon; Glucose; Hypoglycemic Agents; Insulin-Secreting Cells; Islets of Langerhans; KATP Channels; Membrane Transport Modulators; Mice; Mice, Knockout; Osmolar Concentration; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Somatostatin; Somatostatin-Secreting Cells; Sulfonylurea Receptors; Tissue Culture Techniques; Tolbutamide; Zinc Transporter 8 | 2013 |
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells.
Topics: AMP-Activated Protein Kinases; Animals; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Diabetes Mellitus, Experimental; Diazoxide; Electron Transport Chain Complex Proteins; Humans; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Insulin-Secreting Cells; Male; Mice; Nifedipine; Oxygen; Phosphorylation; Potassium; Proinsulin; Rats; Streptozocin; Tolbutamide | 2013 |
Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic β-cell function and insulin secretion.
Topics: Animals; C-Peptide; Cell Line; Diazoxide; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Rats; Tolbutamide | 2014 |
KATP-channels play a minor role in the protective hypoxic shut-down of cerebellar activity in eider ducks (Somateria mollissima).
Topics: Animals; Avian Proteins; Cerebellum; Diazoxide; Ducks; Female; Hypoxia, Brain; KATP Channels; Male; Membrane Transport Modulators; Microelectrodes; Neurons; Neuroprotective Agents; Tissue Culture Techniques; Tolbutamide | 2015 |
Low glucose-induced ghrelin secretion is mediated by an ATP-sensitive potassium channel.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Line; Diazoxide; Exocytosis; Gastric Mucosa; Ghrelin; Glucose; KATP Channels; Mice; Mutant Proteins; Potassium Channels, Inwardly Rectifying; Tolbutamide | 2015 |
Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro.
Topics: Adult; Aged, 80 and over; Calcium Chloride; Diazoxide; Female; Gene Expression Regulation; Glucose; Hexokinase; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Retrospective Studies; Tissue Culture Techniques; Tolbutamide | 2015 |
Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone.
Topics: Action Potentials; Animals; Animals, Newborn; Antihypertensive Agents; Calcium; Diazoxide; Hydrogen Peroxide; Hypoglycemic Agents; In Vitro Techniques; Insecticides; Locus Coeruleus; Membrane Potential, Mitochondrial; Neurons; Pars Compacta; Patch-Clamp Techniques; Rats; Rats, Wistar; Reactive Oxygen Species; Rotenone; Tolbutamide; TRPM Cation Channels | 2017 |
Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children.
Topics: Amino Acids; Calcium Chloride; Child, Preschool; Colforsin; Diazoxide; Female; Glucose; Humans; Infant; Insulin; Insulin Secretion; Islets of Langerhans; Male; Tolbutamide | 2016 |
Subclinical Doses of ATP-Sensitive Potassium Channel Modulators Prevent Alterations in Memory and Synaptic Plasticity Induced by Amyloid-β.
Topics: Amyloid beta-Peptides; Animals; Diazoxide; Hippocampus; KATP Channels; Male; Membrane Transport Modulators; Memory Disorders; Motor Activity; Neuronal Plasticity; Nootropic Agents; Peptide Fragments; Rats, Wistar; Synaptic Transmission; Tissue Culture Techniques; Tolbutamide | 2017 |