Page last updated: 2024-08-16

tolbutamide and dextromethorphan

tolbutamide has been researched along with dextromethorphan in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.63)	18.2507
2000's	11 (28.95)	29.6817
2010's	21 (55.26)	24.3611
2020's	5 (13.16)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J	1
Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C	1
Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D	1
Desta, Z; Flockhart, DA; Ko, JW; Soukhova, NV; Tracy, T	1
Miller, JL; Trepanier, LA	1
Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P	1
Gorski, JC; Hall, SD; Hamman, MA; Huang, SM; Lesko, LJ; Wang, Z	1
Flanagan, JU; McLaughlin, LA; Paine, MJ; Roberts, GC; Sutcliffe, MJ; Wolf, CR	1
Desai, M; Gorski, JC; Hall, SD; Hamman, MA; Hilligoss, JK; Huang, SM; Miller, M; Pinto, A; Zaheer, NA	1
Baker, GB; Holt, A; Salsali, M	1
Dostalek, M; Hadasova, E; Jurica, J; Linhart, I; Pistovcakova, J; Sulcová, A; Tomandl, J	1
Brown, HS; Chadwick, A; Houston, JB	1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J	1
D'Esposito, F; Edwards, RJ; Murray, M; Ramzan, I; Zhang, WV	1
Bertelsen, K; Guo, P; Han, F; Huang, MQ; Lin, ZJ; Weng, N; Zhang, W; Zhao, H	1
Abd-Rashid, BA; Er, HM; Ismail, R; Ismail, Z; Mak, JW; Ong, CE; Pan, Y; Pook, PC	1
Auwärter, V; Dresen, S; Lutz-Bonengel, S; Naue, J; Wohlfarth, A	1
Bekersky, I; Blum, RA; Tolbert, D; Walzer, M	1
Takayanagi, R; Teramoto, S; Uotsu, N; Yamada, M; Yamada, Y; Yamasaki, I	1
Hoi, PM; Hu, T; Kwan, YW; Lai, PB; Or, PM; Wan, DC; Wang, Y; Wong, J; Yeung, JH; Zhou, X	1
Chalasani, N; Hall, SD; Jones, DR; Mattar, S; Tandra, S; Vuppalanchi, R	1
Chen, JL; Cui, HM; Dong, Y; Gong, JY; Zhang, YL	1
Ge, RS; Xu, RA; Xu, ZS	1
Guo, S; Lin, Z; Liu, G; Liu, Y; Tai, S; Yin, S	1
Bernstein, HJ; Brinda, BJ; Chavin, KD; Frye, RF; Kawaguchi-Suzuki, M; Markowitz, JS; Zhu, HJ	1
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ	1
Bénech, H; Lenuzza, N; Nguyen, TT; Pruvost, A	1
Bhateria, M; Bhatta, RS; Ramakrishna, R; Singh, R	1
Casteleyn, C; Jacobs, F; Pijpers, I; Snoeys, J; Van Cruchten, S; Van Ginneken, C; Van Houdt, J; Van Peer, E	1
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ	1
Kansra, V; Lu, S; Powers, D; Wang, J; Wang, X; Zhang, ZY	1
Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J	1
Chen, L; van Breemen, RB	1
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH	1
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW	1

Reviews

1 review(s) available for tolbutamide and dextromethorphan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

7 trial(s) available for tolbutamide and dextromethorphan

Article	Year
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological Availability; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Drug Interactions; Enzyme Induction; Female; Humans; Hypericum; Injections, Intravenous; Isoenzymes; Male; Midazolam; Oxidoreductases, N-Demethylating; Plant Extracts; Tolbutamide	2001
Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy, 2012, Volume: 32, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Clinical Trials, Phase I as Topic; Clobazam; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Isoenzymes; Lamotrigine; Male; Midazolam; Middle Aged; Models, Statistical; Pharmacokinetics; Prospective Studies; Tolbutamide; Triazines; Valproic Acid; Young Adult	2012
Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients. Annals of surgery, 2013, Volume: 258, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Biotransformation; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dextromethorphan; Diuretics; Excitatory Amino Acid Antagonists; Female; Furosemide; GABA Modulators; Gastric Bypass; Humans; Hypoglycemic Agents; Male; Midazolam; Middle Aged; Omeprazole; Pharmacokinetics; Tandem Mass Spectrometry; Tolbutamide; Young Adult	2013
The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10 Topics: Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Female; Herb-Drug Interactions; Humans; Male; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult	2014
A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail. European journal of clinical pharmacology, 2016, Volume: 72, Issue:1 Topics: Bayes Theorem; Caffeine; Computer Simulation; Dextromethorphan; Drug Interactions; Humans; Midazolam; Models, Biological; Omeprazole; Phenotype; Pilot Projects; Tolbutamide	2016
Effects of rolapitant administered orally on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019, Volume: 27, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Alkynes; Antiemetics; Benzoxazines; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Middle Aged; Molecular Probes; Neurokinin-1 Receptor Antagonists; Omeprazole; Piperidines; Spiro Compounds; Tolbutamide; Young Adult	2019
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers. Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:7 Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide	2022

Other Studies

30 other study(ies) available for tolbutamide and dextromethorphan

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. Journal of medicinal chemistry, 2020, 07-09, Volume: 63, Issue:13 Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays	2020
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase. European journal of medicinal chemistry, 2022, Aug-05, Volume: 238 Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship	2022
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide	1997
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. British journal of clinical pharmacology, 2000, Volume: 49, Issue:4 Topics: Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Humans; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Muscle Relaxants, Central; Phenacetin; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tolbutamide	2000
NADH-dependent reduction of sulphamethoxazole hydroxylamine in dog and human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:12 Topics: Adult; Animals; Anti-Infective Agents; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Erythromycin; Female; Humans; Inactivation, Metabolic; Kinetics; Male; Microsomes, Liver; Middle Aged; NAD; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Protein Synthesis Inhibitors; Species Specificity; Sulfamethoxazole; Tolbutamide	2000
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:10 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Single-Blind Method; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide	2001
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. The Biochemical journal, 2003, Mar-15, Volume: 370, Issue:Pt 3 Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Aspartic Acid; Cytochrome P-450 CYP2C9; Dextromethorphan; Diclofenac; Humans; Hypoglycemic Agents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; NADPH-Ferrihemoprotein Reductase; Protein Binding; Protein Structure, Secondary; Rabbits; Sequence Alignment; Substrate Specificity; Tolbutamide	2003
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clinical pharmacology and therapeutics, 2004, Volume: 75, Issue:1 Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Echinacea; Female; Herb-Drug Interactions; Humans; Infusions, Intravenous; Male; Midazolam; Phytotherapy; Plant Extracts; Plant Roots; Reference Values; Tolbutamide	2004
Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6. Cellular and molecular neurobiology, 2004, Volume: 24, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Mephenytoin; Mitochondria; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Tolbutamide; Tranylcypromine	2004
Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver. Life sciences, 2005, Dec-05, Volume: 78, Issue:3 Topics: Animals; Antidepressive Agents; Area Under Curve; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Hypericum; Injections, Intraperitoneal; Liver; Male; Midazolam; Perfusion; Plant Extracts; Rats; Rats, Wistar; Tolbutamide	2005
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11 Topics: Animals; Catalysis; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluconazole; Fluoxetine; Fluvoxamine; Hepatocytes; Ketoconazole; Kinetics; Male; Miconazole; Microsomes, Liver; Midazolam; Phenytoin; Quinine; Rats; Rats, Sprague-Dawley; Tolbutamide	2007
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide	2007
Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12 Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Biotransformation; Catalysis; Clozapine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluvoxamine; Humans; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Oxygenases; Recombinant Proteins; Testosterone; Tolbutamide	2008
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, May-01, Volume: 878, Issue:15-16 Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Discovery; Drug Interactions; Drug Stability; High-Throughput Screening Assays; Humans; Midazolam; Omeprazole; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Temperature; Tolbutamide	2010
In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. Journal of ethnopharmacology, 2010, Jul-20, Volume: 130, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Centella; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dealkylation; Dextromethorphan; Dose-Response Relationship, Drug; Enzyme Inhibitors; Herb-Drug Interactions; Humans; Hydroxylation; Kinetics; Methylation; Pentacyclic Triterpenes; Plant Extracts; Recombinant Proteins; Substrate Specificity; Testosterone; Tolbutamide; Triterpenes	2010
Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping. Journal of clinical pharmacology, 2012, Volume: 52, Issue:8 Topics: Adult; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Genotype; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Phenotype; Pilot Projects; Tandem Mass Spectrometry; Tolbutamide; Young Adult	2012
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats. Biomedical research (Tokyo, Japan), 2012, Volume: 33, Issue:4 Topics: Administration, Oral; Animals; Area Under Curve; Brassica; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dextromethorphan; Enzyme Inhibitors; Herb-Drug Interactions; Liver; Metabolic Clearance Rate; Midazolam; Omeprazole; Rats; RNA, Messenger; Tolbutamide	2012
Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Feb-15, Volume: 20, Issue:3-4 Topics: Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Phenacetin; Phenanthrenes; Salvia miltiorrhiza; Testosterone; Tolbutamide	2013
[CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:12 Topics: Berberine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Microsomes, Liver; Midazolam; Phenacetin; Tolbutamide	2013
Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats. Journal of ethnopharmacology, 2014, Feb-12, Volume: 151, Issue:3 Topics: Animals; Chalcone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Quinones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide	2014
Effects of eleutheroside B and eleutheroside E on activity of cytochrome P450 in rat liver microsomes. BMC complementary and alternative medicine, 2014, Jan-02, Volume: 14 Topics: Animals; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dextromethorphan; Glucosides; Inhibitory Concentration 50; Kinetics; Lignans; Male; Microsomes, Liver; Phenylpropionates; Phytotherapy; Rats; Rats, Wistar; Testosterone; Tolbutamide	2014
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress]. Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:3 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide	2015
Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes. The Journal of steroid biochemistry and molecular biology, 2016, Volume: 163 Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Dapsone; Dextromethorphan; Gene Expression Regulation; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Tolbutamide	2016
In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs. Pharmaceutical research, 2017, Volume: 34, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Fetus; Glucuronosyltransferase; Humans; Male; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Microsomes, Liver; Midazolam; Phenacetin; Swine; Swine, Miniature; Tolbutamide	2017
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency]. Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2 Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency	2017
Modulation of CYP450 Activities in Patients With Type 2 Diabetes. Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6 Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha	2019
Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research. Journal of pharmaceutical and biomedical analysis, 2020, Feb-05, Volume: 179 Topics: Alprazolam; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Drug Contamination; Herb-Drug Interactions; Humans; Serum; Tandem Mass Spectrometry; Tolbutamide	2020
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis. Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10 Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary	2023