tolbutamide has been researched along with clonidine in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Ammälä, C; Arkhammar, P; Berggren, PO; Bokvist, K; Larsson, O; Rorsman, P; Wåhlander, K | 1 |
| Altiere, RJ; Kiritsy-Roy, JA; Lee, KC; Randall, DC; Wilson, RA | 1 |
| Chafetz, MD; Diaz, S; Leibowitz, SF; Parko, K | 1 |
| Hasselblatt, A; Schulz, A | 1 |
| Abiko, Y; Kameda, K; Koyama, I; Ono, S | 1 |
| Altszuler, N; Cherksey, B | 1 |
| Hellman, B; Saha, S | 1 |
| Angel, I; Henquin, JC; Jonas, JC; Langer, SZ; Plant, TD | 1 |
| Francini, F; Gagliardino, JJ; Pirotte, B | 1 |
| Dunne, MJ; James, RF; Sharp, GW; Straub, SG | 1 |
| Ho, JW; Leung, YK | 1 |
| Greger, R; Herbst, M; Hescheler, J; Sasse, P; Ullrich, S; Yu, H | 1 |
| Dansk, H; Grapengiesser, E; Hellman, B | 1 |
1 review(s) available for tolbutamide and clonidine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
24 other study(ies) available for tolbutamide and clonidine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.
Topics: Animals; Clonidine; Epinephrine; Glucose; Glyburide; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Tolbutamide; Yohimbine | 1991 |
An analysis of the haemodynamic effects of tolbutamide in conscious dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Catecholamines; Clonidine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hemodynamics; Norepinephrine; Phentolamine; Tolbutamide | 1988 |
Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose.
Topics: Animals; Blood Glucose; Clonidine; Female; Food Deprivation; Hypothalamus, Middle; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tolbutamide | 1986 |
Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release.
Topics: Animals; Clonidine; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Phentolamine; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Tolbutamide; Yohimbine | 1988 |
Insulin releasing action of 2-[2-(4,5-dihydro-1H-imadazol-2-yl)-1-phenylethyl] pyridine dihydrochloride sesquihydrate (DG-5128), a new, orally effective hypoglycaemic agent.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Blood Glucose; Clonidine; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Tolbutamide | 1982 |
Tolbutamide and glyburide differ in effectiveness to displace alpha- and beta-adrenergic radioligands in pancreatic islet cells and membranes.
Topics: Alprenolol; Animals; Cell Membrane; Clonidine; Dihydroalprenolol; Epinephrine; Glyburide; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tolbutamide | 1984 |
Alpha 2-adrenergic stimulation counteracts glucose-induced rise of sodium in pancreatic islets exposed to ouabain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bucladesine; Calcium Channel Blockers; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Gallopamil; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Mice; Mice, Obese; Sodium; Tolbutamide; Yohimbine | 1995 |
In vitro stimulation of insulin release by SL 84.0418, a new alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Diazoxide; Dioxanes; Electrophysiology; Female; Glucose; Idazoxan; In Vitro Techniques; Indoles; Insulin; Islets of Langerhans; Mice; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Tolbutamide | 1994 |
Effect of activators and inhibitors of K+ channels on insulin secretion in the amphibian pancreas.
Topics: Animals; Antihypertensive Agents; Bufo arenarum; Calcium Channels; Clonidine; Diazoxide; Galactose; Glucose; Glyceraldehyde; Hormone Antagonists; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Potassium Channel Blockers; Potassium Channels; Pyridines; Radioimmunoassay; Somatostatin; Tetraethylammonium; Tetraethylammonium Compounds; Thiadiazines; Tolbutamide | 1997 |
Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adult; Clonidine; Dinoprostone; Female; Galanin; Glucose; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Potassium Channels; Secretory Rate; Signal Transduction; Somatostatin; Tolbutamide | 1998 |
Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes.
Topics: Adrenergic alpha-Agonists; Animals; Antioxidants; Atropine; Carcinogens; Cimetidine; Clonidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hypoglycemic Agents; Male; Microsomes, Liver; Muscarinic Antagonists; Nitrosamines; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tolbutamide; Vitamins | 2001 |
Membrane potential dependent modulations of calcium oscillations in insulin-secreting INS-1 cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Signaling; Cell Line; Clonidine; Colforsin; Diazoxide; Enzyme Inhibitors; Epinephrine; Fluorescent Dyes; Fura-2; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Patch-Clamp Techniques; Potassium Channels; Prazosin; Receptors, Adrenergic, alpha-2; Thapsigargin; Tolbutamide | 2002 |
Sulfonylurea Blockade of KATP Channels Unmasks a Distinct Type of Glucose-Induced Ca2+ Decrease in Pancreatic β-Cells.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Calcium; Cells, Cultured; Clonidine; Female; Gliclazide; Glucose; Hypoglycemic Agents; Insulin-Secreting Cells; KATP Channels; Mice, Inbred C57BL; Receptors, Adrenergic, alpha-2; Sulfonylurea Compounds; Time Factors; Tolbutamide | 2017 |