tolbutamide has been researched along with carboxytolbutamide in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boutagy, JS; Page, MA; Shenfield, GM | 1 |
| Birkett, DJ; Gregov, D; Miners, JO; Randles, D; Veronese, ME | 1 |
| Adir, J; Miller, AK; Vestal, RE | 1 |
| Belanger, PM; St-Hilaire, S | 1 |
| Vesely, DL | 1 |
| Berg, M; Boyd, AE; Gaines, KL; Nelson, TY; Rajan, AS | 1 |
| Cook, GA | 1 |
| Keal, J; Somogyi, A; Stockley, C | 1 |
| Kanatsuka, A; Kumagai, A; Makino, H; Osegawa, M | 1 |
| Albasini, A; Manenti, F; Melegari, M; Pecorari, P; Vampa, G | 1 |
| Meyer, MC; Raghow, G | 1 |
| Makaya, O; Nakamura, J; Nishida, K; Sasaki, H; Shibasaki, J; Washio, K | 1 |
| Birkett, DJ; Miners, JO; Rees, DL; Veronese, ME | 1 |
| Bridge, S; Gross, AS; Shenfield, GM | 1 |
| Brøsen, K; Hansen, LL | 1 |
| Hasnain, S; Krupa, JC; Ménard, R; Mort, JS; Nägler, DK | 1 |
| CHULSKI, T; NELSON, E; O'REILLY, I | 1 |
| NELSON, E; O'REILLY, I | 1 |
| Brockmöller, J; Fuhr, U; Hering, U; Jabrane, W; Jakob, V; Jetter, A; Kasel, D; Kinzig-Schippers, M; Kirchheiner, J; Lazar, A; Rodamer, M; Skott, A; Sörgel, F; Tomalik-Scharte, D; Walchner-Bonjean, M | 1 |
| Fan, H; Li, Q; Liu, C; Song, N; Zhang, S | 1 |
1 trial(s) available for tolbutamide and carboxytolbutamide
| Article | Year |
|---|---|
Pharmacokinetics of tolbutamide in ethnic Chinese.
Topics: Adult; Asian People; Chromatography, High Pressure Liquid; Female; Humans; Male; Tolbutamide; White People | 1999 |
19 other study(ies) available for tolbutamide and carboxytolbutamide
| Article | Year |
|---|---|
A screening test for slow metabolisers of tolbutamide.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Male; Middle Aged; Pilot Projects; Polymorphism, Genetic; Reference Values; Tolbutamide | 1991 |
Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers.
Topics: Administration, Oral; Adult; Chromatography; Female; Half-Life; Humans; Hydroxylation; Male; Phenotype; Random Allocation; Sulfaphenazole; Tolbutamide | 1990 |
Excretion of tolbutamide metabolites in young and old subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Humans; Male; Middle Aged; Tolbutamide | 1990 |
Simultaneous determinations of tolbutamide and its hydroxy and carboxy metabolites in serum and urine: application to pharmacokinetic studies of tolbutamide in the rat.
Topics: Animals; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Rats; Rats, Inbred Strains; Tolbutamide | 1989 |
The comparative effects of tolbutamide and the non-hypoglycemic analog carboxytolbutamide on guanylate cyclase activity.
Topics: Animals; Butylated Hydroxytoluene; Colon; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Kidney Cortex; Liver; Lung; Male; Myocardium; Oxidation-Reduction; Pancreas; Rats; Rats, Inbred Strains; Spleen; Tolbutamide | 1986 |
Increased cytosolic calcium. A signal for sulfonylurea-stimulated insulin release from beta cells.
Topics: Animals; Calcium; Cells, Cultured; Colforsin; Cricetinae; Cyclic AMP; Glyburide; Insulin; Islets of Langerhans; Tolbutamide; Verapamil | 1987 |
The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase.
Topics: Acyltransferases; Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Experimental; Fatty Acids; Glyburide; Male; Malonyl Coenzyme A; Mitochondria, Liver; Muscles; Myocardium; Rats; Rats, Inbred Strains; Tolbutamide | 1987 |
Simultaneous determination of tolbutamide and its hydroxy and carboxy metabolites in plasma and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Tolbutamide | 1986 |
Effects of sulfonylureas on membrane-bound low Km cyclic AMP phosphodiesterase in rat fat cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetohexamide; Adipose Tissue; Animals; Buformin; Glyburide; Isoproterenol; Kinetics; Male; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1982 |
An HPLC method for the simultaneous determination of tolbutamide and its metabolites in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Tolbutamide | 1981 |
High-performance liquid chromatographic assay of tolbutamide and carboxytolbutamide in human plasma.
Topics: Chlorpropamide; Chromatography, High Pressure Liquid; Drug Stability; Humans; Spectrophotometry, Ultraviolet; Tolbutamide | 1981 |
A new aspect of tolbutamide metabolism in the rabbit: the role of 1-butyl-3-(p-formylphenyl)sulphonylurea.
Topics: Animals; Chromatography, High Pressure Liquid; Disulfiram; Male; Oxidation-Reduction; Rabbits; Tolbutamide | 1993 |
Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects.
Topics: Adolescent; Adult; Female; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Middle Aged; Tolbutamide | 1993 |
Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection.
Topics: Chromatography, High Pressure Liquid; Humans; Hypoglycemic Agents; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tolbutamide | 1999 |
S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B.
Topics: Amidohydrolases; Aspartic Acid; Binding Sites; Cathepsin B; Exopeptidases; Glutamic Acid; Histidine; Humans; Ions; Kinetics; Lysosomes; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Substrate Specificity; Tolbutamide | 2002 |
Determination of carboxytolbutamide in urine.
Topics: Body Fluids; Humans; Tolbutamide | 1960 |
Kinetics of carboxytolbutamide excretion following tolbutamide and carboxytolbutamide administration.
Topics: Biological Transport; Body Fluids; Humans; Kinetics; Tolbutamide | 1961 |
Cytochrome P450 2C9 phenotyping using low-dose tolbutamide.
Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Exons; Genotype; Humans; Male; Mass Spectrometry; Metabolic Clearance Rate; Middle Aged; Pharmacogenetics; Phenotype; Pilot Projects; Sequence Analysis, DNA; Time Factors; Tolbutamide | 2004 |
Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.
Topics: Animals; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Male; Mephenytoin; Midazolam; Phenacetin; Phenotype; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tolbutamide | 2008 |