Page last updated: 2024-08-16

tolbutamide and caffeine

tolbutamide has been researched along with caffeine in 79 studies

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-199017 (21.52)18.7374
1990's7 (8.86)18.2507
2000's19 (24.05)29.6817
2010's30 (37.97)24.3611
2020's6 (7.59)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Carrupt, PA; Martel, S; Ottaviani, G1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Conradi, R; Lee, PH; Shanmugasundaram, V1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN1
Ashcroft, SJ1
Scarpelli, DG; Tomita, T1
Hayashi, M; Ikeuchi, M; Kanazawa, Y; Kawazu, S; Kosaka, K1
Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT1
Krnjevic, K; Leblond, J1
Jeanrenaud, B; Lambert, AE; Renold, AE1
Kanazawa, Y; Lambert, A; Orci, L; Renold, AE1
Brooker, G; Fichman, M1
Burr, IM; Kanazawa, Y; Lambert, AE; Orci, L; Renold, AE1
Jeanrenaud, B; Kanazawa, Y; Lambert, AE; Orci, L; Renold, AE1
Karl, IE; Kipnis, DB; Pagliara, AS1
Howell, SL; Montague, W1
Kanazawa, Y; Lambert, AE; Orci, L1
Kanazawa, Y; Lambert, AE; Orci, L; Renold, AE; Rouiller, C1
Junod, A; Lambert, AE; Letarte, J; Stauffacher, W1
Jeanrenaud, B; Junod, A; Lambert, AE; Renold, AE1
Dibbern, HW1
Krnjević, K; Zhu, PJ1
Bradbury, A; Houston, JB; Worboys, PD1
Bernardi, G; Calabresi, P; Centonze, D; Pisani, A1
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T1
Hoya, A; Venosa, RA1
Carpenter, E; Peers, C; Roberts, ML; Taylor, SC1
Brixius, K; Fässler, R; Fleischmann, B; Herr, C; Hescheler, J; Lasek, K; Noegel, AA; Sasse, P; Schröder, R; Schwinger, RH; Smyth, N; Ullrich, S; Yun, F1
Bruce, MA; Gorski, JC; Haehner-Daniels, BD; Hall, SD1
Gorski, JC; Hall, SD; Hamman, MA; Huang, SM; Lesko, LJ; Wang, Z1
Mano, Y; Miyamoto, K; Nomura, M; Takeshita, H; Watanabe, M; Yokogawa, K1
Aherne, Z; Blakey, GE; Lockton, JA; Norwood, P; Perrett, J; Plume, J; Russell, M1
Desai, M; Gorski, JC; Hall, SD; Hamman, MA; Hilligoss, JK; Huang, SM; Miller, M; Pinto, A; Zaheer, NA1
Arsenault, M; Bélanger, PM; Hamelin, BA; Pilote, S; Sharma, A1
Arold, G; Bauer, S; Diefenbach, K; Donath, F; Friede, M; Henneicke-von Zepelin, HH; Maurer, A; Roots, I1
Fuhr, U; Jetter, A; Kirchheiner, J1
Auwärter, V; Dresen, S; Lutz-Bonengel, S; Naue, J; Wohlfarth, A1
Guo, C; Han, YL; Jing, GP; Li, D; Li, Y; Meng, XL; Ren, B; Wan, LL; Yu, Q; Zhou, ZY1
Hang, P; Liu, G; Liu, R; Liu, Y; Qin, M; Zhang, Z1
Bekersky, I; Blum, RA; Tolbert, D; Walzer, M1
Li, X; Liu, G; Liu, Y; Tai, S; Yang, C; Zhang, X1
Takayanagi, R; Teramoto, S; Uotsu, N; Yamada, M; Yamada, Y; Yamasaki, I1
Chalasani, N; Hall, SD; Jones, DR; Mattar, S; Tandra, S; Vuppalanchi, R1
Jiao, J; Li, Q; Liu, Y; Lou, J; Zhang, C1
Bernstein, HJ; Brinda, BJ; Chavin, KD; Frye, RF; Kawaguchi-Suzuki, M; Markowitz, JS; Zhu, HJ1
Cao, X; Huang, Y; Lan, YY; Li, YJ; Liao, SG; Liu, Y; Lu, Y; Tang, L; Wang, AM; Wang, YL; Zheng, L1
Bénech, H; Lenuzza, N; Nguyen, TT; Pruvost, A1
Bhateria, M; Bhatta, RS; Ramakrishna, R; Singh, R1
Gong, Z; Huang, J; Li, Y; Liu, C; Liu, T; Lu, Y; Pan, J; Sun, J; Wang, Y; Zheng, J; Zheng, L1
Dong, M; Liu, D; Liu, G; Qiao, Y; Qin, M; Shi, Y; Xu, J; Zhang, W1
Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J1
Chen, L; van Breemen, RB1
Ohtsuki, S; Otagiri, M; Sakai, H; Taguchi, K; Tokuno, M; Yamasaki, K2
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH1
Chen, SY; Chen, Y; Gong, ZP; Huang, J; Huang, Y; Li, Y; Li, YT; Wang, YL; Yang, HL; Zheng, L1
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW1

Reviews

4 review(s) available for tolbutamide and caffeine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The control of insulin release by sugars.
    Ciba Foundation symposium, 1976, Volume: 41

    Topics: Acetylglucosamine; Animals; Caffeine; Calcium; Carbohydrates; Cyclic AMP; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Mice; Perfusion; Potassium; Rats; Receptors, Drug; Starvation; Tolbutamide

1976
Alcohol: another intoxicating instalment.
    Food and cosmetics toxicology, 1970, Volume: 8, Issue:4

    Topics: Alcohol Oxidoreductases; Animals; Barbiturates; Caffeine; Drug Incompatibility; Ethanol; Fatty Liver; Female; Gluconeogenesis; Glycols; Humans; Liver; Male; Microsomes, Liver; Pancreatitis; Pregnancy; Rats; Tolbutamide

1970
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach.
    Clinical pharmacology and therapeutics, 2007, Volume: 81, Issue:2

    Topics: Administration, Oral; ATP-Binding Cassette Transporters; Caffeine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Pharmaceutical Preparations; Phenotype; Theophylline; Tolbutamide

2007

Trials

9 trial(s) available for tolbutamide and caffeine

ArticleYear
In vivo effect of clarithromycin on multiple cytochrome P450s.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:7

    Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clarithromycin; Cross-Over Studies; Cytochrome P-450 Enzyme System; Female; Humans; Male; Theophylline; Tolbutamide

2001
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity.
    Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4

    Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological Availability; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Drug Interactions; Enzyme Induction; Female; Humans; Hypericum; Injections, Intravenous; Isoenzymes; Male; Midazolam; Oxidoreductases, N-Demethylating; Plant Extracts; Tolbutamide

2001
Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.
    British journal of clinical pharmacology, 2004, Volume: 57, Issue:2

    Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Combinations; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Plasma; Tolbutamide

2004
No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract.
    Planta medica, 2005, Volume: 71, Issue:4

    Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Caffeine; Cardiotonic Agents; Central Nervous System Stimulants; Digoxin; Double-Blind Method; Drug Interactions; Female; Humans; Hypericum; Hypoglycemic Agents; Male; Middle Aged; Phytotherapy; Plant Extracts; Tolbutamide; Treatment Outcome

2005
Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes.
    Pharmacotherapy, 2012, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Clinical Trials, Phase I as Topic; Clobazam; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Isoenzymes; Lamotrigine; Male; Midazolam; Middle Aged; Models, Statistical; Pharmacokinetics; Prospective Studies; Tolbutamide; Triazines; Valproic Acid; Young Adult

2012
Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients.
    Annals of surgery, 2013, Volume: 258, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Biotransformation; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dextromethorphan; Diuretics; Excitatory Amino Acid Antagonists; Female; Furosemide; GABA Modulators; Gastric Bypass; Humans; Hypoglycemic Agents; Male; Midazolam; Middle Aged; Omeprazole; Pharmacokinetics; Tandem Mass Spectrometry; Tolbutamide; Young Adult

2013
The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10

    Topics: Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Female; Herb-Drug Interactions; Humans; Male; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult

2014
A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail.
    European journal of clinical pharmacology, 2016, Volume: 72, Issue:1

    Topics: Bayes Theorem; Caffeine; Computer Simulation; Dextromethorphan; Drug Interactions; Humans; Midazolam; Models, Biological; Omeprazole; Phenotype; Pilot Projects; Tolbutamide

2016
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers.
    Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:7

    Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide

2022

Other Studies

66 other study(ies) available for tolbutamide and caffeine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water

2007
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
    Chemical biology & drug design, 2016, Volume: 88, Issue:6

    Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain

2016
Interaction of cyclic AMP and alloxan on insulin secretion in isolated rat islets perifused in vitro.
    Endocrinology, 1977, Volume: 100, Issue:5

    Topics: Alloxan; Animals; Bucladesine; Caffeine; Cyclic AMP; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Theophylline; Tolbutamide

1977
The dynamics of insulin release from monolayer-cultured pancreatic cells in a new perifusion system.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1977, Volume: 156, Issue:2

    Topics: Caffeine; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Secretory Rate; Time Factors; Tolbutamide

1977
Characterization of metronidazole metabolism by human liver microsomes.
    Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8

    Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide

1991
Hypoxic changes in hippocampal neurons.
    Journal of neurophysiology, 1989, Volume: 62, Issue:1

    Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Apamin; Caffeine; Calcium; Egtazic Acid; Electric Stimulation; Hippocampus; Hypoxia; Membrane Potentials; Neuroglia; Neuromuscular Depolarizing Agents; Neurons; Nitrogen; Quinine; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tolbutamide

1989
Enhancement by caffeine of glucagon-induced and tolbutamide-induced insulin release from isolated foetal pancreatic tissue.
    Lancet (London, England), 1967, Apr-15, Volume: 1, Issue:7494

    Topics: Animals; Caffeine; Glucagon; Insulin; Pancreas; Rats; Tolbutamide

1967
[Biosynthesis and release of insulin in organ cultures of fetal rat pancreas].
    Acta diabetologica latina, 1969, Volume: 6 Suppl 1

    Topics: Animals; Caffeine; Culture Techniques; Cyclic AMP; Drug Antagonism; Drug Synergism; Energy Transfer; Fetus; Glucagon; Glucose; Hexoses; Hypoglycemic Agents; Insulin; Islets of Langerhans; Microscopy, Electron; Pancreas; Pyruvates; Rats; Sulfonamides; Tolbutamide

1969
Chlorpropamide and tolbutamide inhibition of adenosine 3'5' cyclic monophosphate phosphodiesterase.
    Biochemical and biophysical research communications, 1971, Mar-05, Volume: 42, Issue:5

    Topics: Animals; Arteriosclerosis; Caffeine; Chlorpropamide; Cyclic AMP; Kidney; Phosphoric Monoester Hydrolases; Rats; Tolbutamide; Tritium

1971
On the role of cyclic AMP in insulin release: I. Overall effects in cultured fetal rat pancreas.
    Annals of the New York Academy of Sciences, 1971, Dec-30, Volume: 185

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Caffeine; Calcium; Cyclic AMP; Fetus; Glucose; Hexoses; Insulin; Insulin Secretion; Islets of Langerhans; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Pyruvates; Rats; Theophylline; Tolbutamide

1971
Biochemical and morphological events associated with the development of fetal rat pancreas "in vivo" and "in vitro": effect of glucagon and of other agents.
    Acta isotopica, 1970, Volume: 10, Issue:3

    Topics: Animals; Caffeine; Cell Differentiation; Culture Techniques; Cyclic AMP; Glucagon; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Pyruvates; Rats; Sulfonylurea Compounds; Tolbutamide

1970
Transient neonatal diabetes: delayed maturation of the pancreatic beta cell.
    The Journal of pediatrics, 1973, Volume: 82, Issue:1

    Topics: Adenylyl Cyclases; Blood Glucose; Caffeine; Cyclic AMP; Diabetes Mellitus, Type 1; Female; Glucose Tolerance Test; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Insulin; Islets of Langerhans; Phosphoric Diester Hydrolases; Tolbutamide

1973
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.
    The Biochemical journal, 1973, Volume: 134, Issue:1

    Topics: Animals; Arginine; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucagon; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Phosphorus Isotopes; Phosphotransferases; Protein Kinases; Rats; Theophylline; Time Factors; Tolbutamide; Xanthines; Xylitol

1973
Organ culture of fetal rat pancreas. IV. Effects of metabolic inhibitors on insulin release.
    Endocrinology, 1971, Volume: 89, Issue:2

    Topics: Animals; Binding Sites; Biological Transport, Active; Caffeine; Citrates; Female; Glucose; Heptoses; Hexoses; Insulin; Insulin Secretion; Iodoacetates; Islets of Langerhans; Oligomycins; Organ Culture Techniques; Pancreas; Pregnancy; Pyruvates; Rats; Stimulation, Chemical; Tolbutamide; Xylitol

1971
Organ culture of fetal-rat pancreas. 3. Ultrastructural changes occurring in B cells during stimulation of insulin release.
    Chemico-biological interactions, 1970, Volume: 1, Issue:4

    Topics: Animals; Caffeine; Drug Synergism; Fetus; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Microscopy, Electron; Models, Biological; Nitrosourea Compounds; Organ Culture Techniques; Pancreas; Potassium; Radioimmunoassay; Rats; Tolbutamide

1970
Studies in spiny mice (Acomys cahirinus): metabolic state and pancreatic insulin release in vitro.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1969, Volume: 1, Issue:2

    Topics: Age Factors; Animals; Antigens; Arginine; Blood Glucose; Caffeine; Calcium; Diabetes Mellitus; Glucagon; Glycosuria; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Leucine; Mice; Mice, Inbred Strains; Obesity; Pancreas; Tolbutamide

1969
Organ culture of fetal rat pancreas. II. Insulin release induced by amino and organic acids, by hormonal peptides, by cationic alterations of the medium and by other agents.
    Biochimica et biophysica acta, 1969, Sep-02, Volume: 184, Issue:3

    Topics: Acids; Adenylyl Cyclases; Amino Acids; Animals; Caffeine; Calcium; Culture Media; Culture Techniques; Depression, Chemical; Dicarboxylic Acids; Fatty Acids; Female; Glucagon; Glucose; Hormones; Insulin; Intestinal Mucosa; Magnesium; Metals; Ouabain; Pancreas; Peptides; Potassium; Pregnancy; Rats; Sodium; Stimulation, Chemical; Tolbutamide

1969
[Experiments with an in vitro model for the determination of gastroenteric absorption quota].
    Arzneimittel-Forschung, 1966, Volume: 16, Issue:2

    Topics: Aminopyrine; Aspirin; Caffeine; Digestive System Physiological Phenomena; Furosemide; Intestinal Absorption; Lipids; Models, Biological; Phenacetin; Spectrophotometry; Tolbutamide

1966
Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices.
    Neuroscience letters, 1993, Jun-11, Volume: 155, Issue:2

    Topics: Action Potentials; Adenosine; Animals; Caffeine; Cell Hypoxia; Energy Metabolism; Evoked Potentials; Glucose; Glyburide; Hippocampus; Hypoglycemia; Neural Inhibition; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline; Tolbutamide

1993
Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:4

    Topics: Animals; Caffeine; Diazepam; In Vitro Techniques; Liver; Male; Ondansetron; Pharmacokinetics; Phenytoin; Rats; Rats, Sprague-Dawley; Tolbutamide

1997
Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jun-15, Volume: 17, Issue:12

    Topics: Adenosine; Animals; Caffeine; Cerebral Cortex; Corpus Striatum; Evoked Potentials; Glipizide; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Theophylline; Tolbutamide; Xanthines

1997
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide

1998
Effect of caffeine on K+ efflux in frog skeletal muscle.
    Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:3

    Topics: Amiloride; Animals; Anura; Apamin; Biological Transport; Caffeine; Calcium; Charybdotoxin; Cytosol; Ionomycin; Muscle, Skeletal; Potassium; Potassium Channel Blockers; Potassium Channels; Sarcoplasmic Reticulum; Tetracaine; Tolbutamide

1999
Potentiation of quantal catecholamine secretion by glibenclamide: evidence for a novel role of sulphonylurea receptors in regulating the Ca(2+) sensitivity of exocytosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Jul-15, Volume: 19, Issue:14

    Topics: Animals; ATP-Binding Cassette Transporters; Caffeine; Calcium; Catecholamines; Cromakalim; Egtazic Acid; Electrochemistry; Exocytosis; Glyburide; Kinetics; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quantum Theory; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide

1999
Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes.
    Molecular and cellular biology, 2001, Volume: 21, Issue:13

    Topics: Animals; Annexin A7; Caffeine; Calcium; Cardiotonic Agents; Central Nervous System Stimulants; Colforsin; Embryo, Mammalian; Female; Gene Targeting; Glucose; Homeostasis; Hypoglycemic Agents; Immunoblotting; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Contraction; Myocardium; Patch-Clamp Techniques; Tolbutamide

2001
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
    International journal of pharmaceutics, 2004, Jan-28, Volume: 269, Issue:2

    Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 Enzyme System; Half-Life; Isoenzymes; Lidocaine; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats; Rats, Wistar; Tolbutamide; Transaminases

2004
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo.
    Clinical pharmacology and therapeutics, 2004, Volume: 75, Issue:1

    Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Echinacea; Female; Herb-Drug Interactions; Humans; Infusions, Intravenous; Male; Midazolam; Phytotherapy; Plant Extracts; Plant Roots; Reference Values; Tolbutamide

2004
A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study.
    British journal of clinical pharmacology, 2004, Volume: 58, Issue:3

    Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Drug Combinations; Humans; Male; Metoprolol; Phenformin; Pilot Projects; Tolbutamide

2004
Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:8

    Topics: Adult; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Genotype; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Phenotype; Pilot Projects; Tandem Mass Spectrometry; Tolbutamide; Young Adult

2012
Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs.
    Journal of ethnopharmacology, 2012, Jan-06, Volume: 139, Issue:1

    Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Enzyme Inhibitors; Erigeron; Herb-Drug Interactions; Metoprolol; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide

2012
Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:8

    Topics: Animals; Blotting, Western; Caffeine; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Dapsone; Enzyme Activation; Injections, Intraperitoneal; Liver; Male; Metoprolol; Panax notoginseng; Protein Biosynthesis; Rats; Rats, Wistar; Saponins; Tandem Mass Spectrometry; Time Factors; Tolbutamide

2012
UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats.
    Journal of chromatographic science, 2013, Volume: 51, Issue:1

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dapsone; Drug Stability; Linear Models; Male; Metoprolol; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tolbutamide

2013
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats.
    Biomedical research (Tokyo, Japan), 2012, Volume: 33, Issue:4

    Topics: Administration, Oral; Animals; Area Under Curve; Brassica; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dextromethorphan; Enzyme Inhibitors; Herb-Drug Interactions; Liver; Metabolic Clearance Rate; Midazolam; Omeprazole; Rats; RNA, Messenger; Tolbutamide

2012
Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach.
    Drug development and industrial pharmacy, 2014, Volume: 40, Issue:2

    Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Enzyme Activation; Female; Ischemic Preconditioning; Isoenzymes; Liver; Male; Metoprolol; Midazolam; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Tolbutamide

2014
Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs.
    Journal of ethnopharmacology, 2014, Dec-02, Volume: 158 Pt A

    Topics: Animals; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Midazolam; Omeprazole; Plant Extracts; Polygonum; Rats; Rats, Sprague-Dawley; Tolbutamide

2014
Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes.
    The Journal of steroid biochemistry and molecular biology, 2016, Volume: 163

    Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Dapsone; Dextromethorphan; Gene Expression Regulation; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Tolbutamide

2016
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches.
    Molecules (Basel, Switzerland), 2017, Nov-20, Volume: 22, Issue:11

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Enzyme Activation; Herb-Drug Interactions; Isoenzymes; Midazolam; Omeprazole; Rats; Steroid 16-alpha-Hydroxylase; Tolbutamide; Warfarin

2017
Effects of shuanghuanglian injection on the activities of CYP1A2, 2C11, 2D1 and 3A1/2 in rats in vivo and in vitro.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:8

    Topics: Animals; Caffeine; Calibration; Cytochrome P-450 Enzyme System; Dapsone; Drugs, Chinese Herbal; Injections; Limit of Detection; Male; Metabolome; Metoprolol; Rats, Wistar; Reproducibility of Results; Time Factors; Tolbutamide

2019
Modulation of CYP450 Activities in Patients With Type 2 Diabetes.
    Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6

    Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha

2019
Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research.
    Journal of pharmaceutical and biomedical analysis, 2020, Feb-05, Volume: 179

    Topics: Alprazolam; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Drug Contamination; Herb-Drug Interactions; Humans; Serum; Tandem Mass Spectrometry; Tolbutamide

2020
Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats.
    Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:5

    Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Tolbutamide

2020
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles.
    Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:5

    Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Liposomes; Male; Midazolam; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tolbutamide

2020
[Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:23

    Topics: Animals; Caffeine; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Metoprolol; Midazolam; Omeprazole; Plant Extracts; Rats; Tandem Mass Spectrometry; Tolbutamide

2022
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis.
    Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10

    Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary

2023