Page last updated: 2024-08-16

tolbutamide and antipyrine

tolbutamide has been researched along with antipyrine in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (57.50)	18.7374
1990's	4 (10.00)	18.2507
2000's	5 (12.50)	29.6817
2010's	8 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Carrupt, PA; Martel, S; Ottaviani, G	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Conradi, R; Lee, PH; Shanmugasundaram, V	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bending, MR; Dollery, CT; Kahn, GC; Mucklow, JC	1
Gachályi, B; Káldor, A; Szeberényi, S	2
Adjepon-Yamoah, KK; Finlayson, ND; Forrest, JA; Prescott, LF	1
Eichelbaum, M	1
Reidenberg, MM	2
Reidenberg, MM; Vesell, ES	1
Daintith, H; O'Malley, K; Stevenson, IH	1
Houston, JB; Matthew, DE	1
Rieth, H; Sauerbrey, N	1
Back, DJ; Mihaly, GW; Tjia, JF; Ward, SA	1
Back, DJ; Mönig, H; Ohnhaus, EE; Park, BK; Tjia, J	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y	1
Welch, RM	1
Ikeda, M; Imamura, T; Otsuji, H	1
Andreasen, PB; Vesell, ES	1
Andritsch, F; Gundert-Remy, U; Marquardt, R; Weber, E	1
Burns, JJ; Harrison, YE; Welch, RM	1
Dibbern, HW	1
Gachályi, B; Káldor, A; Tornyossy, M; Vas, A	1
Biltz, H; Pentz, R; Siegers, CP	1
Goldberg, DM	1
Krishna, DM; Krishnaiah, YS; Satyanarayana, S; Visweswaram, D	1
Elliott, BD; Johnson, R; Langer, O; Prihoda, T; Schenker, S	1
Back, DJ; Brockmann, B; Heidemann, HT; Mönig, H; Ohnhaus, EE; Schulte, HM	1
GLOBUS, M; MCCOLL, JD; ROBINSON, S	1

Reviews

5 review(s) available for tolbutamide and antipyrine

Article	Year
Drug metabolism in liver disease. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; Half-Life; Humans; Isoniazid; Lidocaine; Liver; Liver Diseases; Pharmaceutical Preparations; Tolbutamide	1975
Drug metabolism in thyroid disease. Clinical pharmacokinetics, 1976, Volume: 1, Issue:5 Topics: Administration, Oral; Aminopyrine; Anticoagulants; Antipyrine; Digitalis Glycosides; Hormones; Humans; Kinetics; Methimazole; Pharmaceutical Preparations; Propylthiouracil; Riboflavin; Steroids; Thyroid Diseases; Tolbutamide	1976
Drug metabolism in uremia. Clinical nephrology, 1975, Volume: 4, Issue:3 Topics: Acetohexamide; Animals; Antipyrine; Humans; Hydrolysis; Lipid Metabolism; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Procainamide; Rats; Tolbutamide; Uremia; Vitamin D	1975
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:5 Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin	1985
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry. Clinical chemistry, 1980, Volume: 26, Issue:6 Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; Energy Intake; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Smoking; Tolbutamide; Warfarin	1980

Trials

2 trial(s) available for tolbutamide and antipyrine

Article	Year
[Interaction studies with fluconazole, a new triazole antifungal drug]. Wiener medizinische Wochenschrift (1946), 1989, Aug-31, Volume: 139, Issue:15-16 Topics: Adult; Antipyrine; Cimetidine; Clinical Trials as Topic; Contraceptives, Oral; Cyclosporins; Double-Blind Method; Drug Interactions; Female; Fluconazole; Humans; Male; Testosterone; Tolbutamide; Warfarin	1989
Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:6 Topics: Administration, Oral; Adult; Antipyrine; Clinical Trials as Topic; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Liver Cirrhosis; Male; Middle Aged; Solutions; Spectrophotometry, Ultraviolet; Time Factors; Tolbutamide; Warfarin	1974

Article

Year

[Interaction studies with fluconazole, a new triazole antifungal drug].

Wiener medizinische Wochenschrift (1946), 1989, Aug-31, Volume: 139, Issue:15-16

Topics: Adult; Antipyrine; Cimetidine; Clinical Trials as Topic; Contraceptives, Oral; Cyclosporins; Double-Blind Method; Drug Interactions; Female; Fluconazole; Humans; Male; Testosterone; Tolbutamide; Warfarin

1989

Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration.

Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:6

Topics: Administration, Oral; Adult; Antipyrine; Clinical Trials as Topic; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Liver Cirrhosis; Male; Middle Aged; Solutions; Spectrophotometry, Ultraviolet; Time Factors; Tolbutamide; Warfarin

1974

Other Studies

33 other study(ies) available for tolbutamide and antipyrine

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Drug concentration in saliva. Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:5 Topics: Adolescent; Adult; Aged; Antipyrine; Chlorpropamide; Humans; Hydrogen-Ion Concentration; Male; Meperidine; Middle Aged; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Saliva; Tolbutamide	1978
m-Trifluoromethyl-alpha-ethylbenzhydrol: a new enzyme inducer. European journal of clinical pharmacology, 1978, Jun-19, Volume: 13, Issue:4 Topics: Adult; Animals; Antipyrine; Benzhydryl Compounds; Enzyme Induction; Female; Glucaric Acid; Half-Life; Humans; Male; Mice; Mice, Inbred Strains; Middle Aged; Rats; Rats, Inbred Strains; Species Specificity; Tolbutamide	1978
[The effect of a new compound (m-trifluormethyl-alpha-ethylbenxhydrol) on the mixed oxygenase function system of the liver]. Orvosi hetilap, 1979, Jan-07, Volume: 120, Issue:1 Topics: Animals; Antipyrine; Benzhydryl Compounds; Enzyme Induction; Humans; Liver; Mice; Oxygenases; Rats; Tolbutamide	1979
Obesity and fasting--effects on drug metabolism and drug action in man. Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:5 Pt 2 Topics: Adult; Animals; Antipyrine; Atropine; Blood Proteins; Fasting; Female; Humans; Isoniazid; Obesity; Pharmaceutical Preparations; Procaine; Protein Binding; Sulfisoxazole; Tolbutamide	1977
Unaltered metabolism of antipyrine and tolbutamide in fasting man. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:6 Topics: Administration, Oral; Adult; Antipyrine; Fasting; Female; Half-Life; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Obesity; Tolbutamide	1975
Influence of diabetes mellitus on drug metabolism in man. International journal of clinical pharmacology and biopharmacy, 1976, Volume: 13, Issue:1 Topics: Antipyrine; Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Female; Half-Life; Humans; Insulin; Kinetics; Male; Middle Aged; Pharmaceutical Preparations; Tolbutamide	1976
Drug metabolizing capacity in vitro and in vivo--II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats. Biochemical pharmacology, 1990, Aug-15, Volume: 40, Issue:4 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antipyrine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide	1990
The effect of some benzimidazoles on the disposition of antipyrine and tolbutamide from the rat isolated perfused liver. The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:1 Topics: Animals; Antipyrine; Benzimidazoles; Drug Interactions; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Tolbutamide	1985
Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide. European journal of clinical pharmacology, 1988, Volume: 34, Issue:2 Topics: Adult; Antipyrine; Cimetidine; Female; Half-Life; Humans; Male; Oxidation-Reduction; Pharmaceutical Preparations; Primaquine; Sulfaphenazole; Tolbutamide	1988
Drug-protein binding: a method for studying the interactions of drugs with bishydroxycoumarin (dicoumarol) in dogs. Annals of the New York Academy of Sciences, 1973, Nov-26, Volume: 226 Topics: Allopurinol; Animals; Antipyrine; Blood Coagulation; Dicumarol; Dogs; Drug Interactions; Drug Synergism; Enzyme Induction; Half-Life; Liver; Methods; Oxidoreductases; Phenobarbital; Phenylbutazone; Protein Binding; Prothrombin Time; Time Factors; Tolbutamide	1973
Comparative studies on hepatic N- and O-demethylation. Japanese journal of pharmacology, 1972, Volume: 22, Issue:4 Topics: Aniline Compounds; Animals; Anisoles; Antipyrine; Benzene; Biotransformation; Depression, Chemical; Ethylamines; Female; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Pyridines; Rats; Stimulation, Chemical; Tolbutamide	1972
[Induction of drug-catabolizing enzymes in chronic alcoholics]. Archives of biochemistry and biophysics, 1974, Volume: 160, Issue:1 Topics: Alcoholism; Antipyrine; Chronic Disease; Enzyme Induction; Humans; Microsomes, Liver; Pharmaceutical Preparations; Tolbutamide	1974
Implications of enzyme induction in drug toxicity studies. Toxicology and applied pharmacology, 1967, Volume: 10, Issue:2 Topics: Animals; Antipyrine; Diphenhydramine; Dogs; Enzyme Induction; Female; Haplorhini; Liver; Male; Microsomes; Peptic Ulcer; Phenylbutazone; Probenecid; Rats; Tolbutamide	1967
[On the resportion profile of drugs. 2. On studies with the resorption model]. Arzneimittel-Forschung, 1966, Volume: 16, Issue:10 Topics: Absorption; Antipyrine; Aspirin; Codeine; Hydrogen-Ion Concentration; Models, Biological; Phenacetin; Phenobarbital; Tolbutamide	1966
Effect of alphamethyldopa on the half-lives of antipyrine, tolbutamide and D-glucaric acid excretion in man. International journal of clinical pharmacology, therapy, and toxicology, 1980, Volume: 18, Issue:3 Topics: Adult; Antipyrine; Drug Interactions; Female; gamma-Glutamyltransferase; Glucaric Acid; Half-Life; Humans; Male; Methyldopa; Middle Aged; Sugar Acids; Tolbutamide	1980
Effect of diethyldithiocarbamate on the metabolic elimination of hexobarbital, phenazone, tolbutamide and four halogenated hydrocarbons. European journal of drug metabolism and pharmacokinetics, 1981, Volume: 6, Issue:2 Topics: Animals; Antipyrine; Ditiocarb; Hexobarbital; Hydrocarbons, Halogenated; Kinetics; Male; Mice; Mixed Function Oxygenases; Thiocarbamates; Tolbutamide	1981
Interaction of pargyline with tolbutamide in rabbits. Indian journal of physiology and pharmacology, 1995, Volume: 39, Issue:1 Topics: Animals; Antipyrine; Blood Glucose; Drug Interactions; Female; Half-Life; Hypoglycemia; Injections, Intraperitoneal; Male; Microsomes, Liver; Pargyline; Rabbits; Tolbutamide	1995
Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer. American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:3 Topics: Administration, Oral; Analysis of Variance; Antipyrine; Biological Transport; Chlorpropamide; Chromatography, High Pressure Liquid; Female; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Maternal-Fetal Exchange; Models, Biological; Molecular Weight; Placenta; Pregnancy; Regression Analysis; Tolbutamide	1994
Effect of chlormethiazole on hepatic monooxygenases activity in vivo. European journal of clinical pharmacology, 1993, Volume: 44, Issue:2 Topics: Antipyrine; Chlormethiazole; Half-Life; Humans; Liver; Male; Mixed Function Oxygenases; Tolbutamide	1993
EFFECT OF SOME THERAPEUTIC AGENTS ON THE DEVELOPING RAT FETUS. Toxicology and applied pharmacology, 1965, Volume: 7 Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Aspirin; Chloral Hydrate; Dimenhydrinate; Female; Fetal Development; Fetus; Humans; Pathology; Pharmacology; Pregnancy; Pregnancy, Animal; Rats; Research; Thalidomide; Tolbutamide; Toxicology	1965