tolbutamide has been researched along with 2-keto-4-methylvalerate in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 11 (52.38) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arroyo, JA; Cervera, T; Ortiz, MA; Perez, A; Pou, JM | 1 |
| Bhathena, S; Powell, AM; Recant, L; Solomon, D; Timmers, KI; Voyles, NR; Wilkins, SD | 1 |
| Bedoya, FJ; Jeanrenaud, B | 1 |
| Zawalich, WS | 1 |
| Malaisse, WJ; Malaisse-Lagae, F; Mathias, PC; Sener, A | 1 |
| Bailbe, D; Giroix, MH; Kergoat, M; Picon, L; Portha, B | 1 |
| Francini, F; Gagliardino, JJ | 1 |
| Abe, H; Akabane, A; Kato, I; Nata, K; Suzuki, Y; Takamura, T; Takasawa, S; Tanaka, O; Yonekura, H; Yoshimoto, T | 1 |
| Best, L | 2 |
| Abrunhosa, AJ; Antunes, CM; Barbosa, RM; Pereira, FC; Rosário, LM; Salgado, AP; Santos, RM; Seiça, RM; Silva, AM | 1 |
| Ashcroft, FM; Ashcroft, SJ; Kadowaki, T; Sakura, H; Terauchi, Y | 1 |
| Eberhardson, M; Grapengiesser, E | 1 |
| Clark, A; de Koning, EJ; MacArthur, DL; Morris, JF; Verbeek, JS | 1 |
| Dickel, C; Grimmsmann, T; Herrmann, C; Rustenbeck, I | 1 |
| Ball, AJ; Flatt, PR; McClenaghan, NH | 1 |
| Bergsten, P; Fakhrai-Rad, H; Galli, J; Lin, JM; Luthman, H; Ortsäter, H | 1 |
| Brennan, L; Flatt, PR; McClenaghan, NH; Newsholme, P; Patterson, S | 1 |
| Ashcroft, SJ; Lovrencić, MV; Poje, M; Rocić, B | 1 |
| Antunes, CM; Baldeiras, IE; Barbosa, RM; Rosário, LM; Santos, RM; Silva, AM; Tomé, AR | 1 |
| Carter, JD; Cole, BK; Crim, WS; Kunsch, C; Mirmira, RG; Nadler, JL; Nunemaker, CS; Trace, AP; Wu, R | 1 |
21 other study(ies) available for tolbutamide and 2-keto-4-methylvalerate
| Article | Year |
|---|---|
Effect of L-asparaginase on insulin secretion from isolated rat islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Asparaginase; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Male; Rats; Rats, Inbred Strains; Tolbutamide | 1991 |
Multiple alterations in insulin responses to glucose in islets from 48-h glucose-infused nondiabetic rats.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drug Hypersensitivity; Glucagon; Glucose; Glyceraldehyde; Glycerides; Infusions, Intravenous; Insulin; Islets of Langerhans; Keto Acids; Male; Mannoheptulose; Rats; Rats, Inbred Strains; Somatostatin; Temperature; Tetradecanoylphorbol Acetate; Tolbutamide; Verapamil | 1990 |
Insulin secretory response to secretagogues by perifused islets from chronically glucose-infused rats.
Topics: Animals; Colforsin; Glucose; In Vitro Techniques; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Leucine; Male; Perfusion; Rats; Rats, Mutant Strains; Tetradecanoylphorbol Acetate; Thinness; Tolbutamide | 1991 |
Phosphoinositide hydrolysis and insulin secretion in response to glucose stimulation are impaired in isolated rat islets by prolonged exposure to the sulfonylurea tolbutamide.
Topics: Animals; Glucose; Glycerides; Hydrolysis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Male; Nitrendipine; Phosphatidylinositols; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1989 |
Suppression by 2-ketoisocaproate of the insulinotropic action of hypoglycemic sulfonylureas.
Topics: Animals; Calcium; Gliclazide; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Ionophores; Keto Acids; Oxidation-Reduction; Rats; Sulfonylurea Compounds; Tolbutamide | 1985 |
Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas.
Topics: Acetylcholine; Amino Acids; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Keto Acids; Leucine; Mannose; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide | 1983 |
An in vitro model suitable for studying insulin secretion in amphibians.
Topics: Acetylcholine; Amphibians; Animals; Arginine; Bufo arenarum; Caproates; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Keto Acids; Male; Nifedipine; Pancreatin; Potassium; Radioimmunoassay; Somatostatin; Swine; Tolbutamide | 1995 |
Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Cyclic ADP-Ribose; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Membrane Glycoproteins; Mice; Mice, Transgenic; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Potassium Chloride; Promoter Regions, Genetic; Rats; Reference Values; Subcellular Fractions; Tolbutamide | 1995 |
Glucose and alpha-ketoisocaproate induce transient inward currents in rat pancreatic beta cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Action Potentials; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Female; Glucose; Hypoglycemic Agents; Insulin; Ion Channels; Islets of Langerhans; Keto Acids; Male; Membrane Potentials; Nitrobenzoates; Patch-Clamp Techniques; Potassium; Rats; Tolbutamide | 1997 |
Bursting electrical activity generated in the presence of KATP channel blockers. Pharmacology, sensitivity to intracellular pH and modulation by glucose metabolism.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium; Calcium Channel Blockers; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Iodoacetic Acid; Islets of Langerhans; KATP Channels; Keto Acids; Membrane Potentials; Mice; ortho-Aminobenzoates; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Tolbutamide | 1997 |
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Diabetes Mellitus, Type 2; Eukaryotic Cells; Glucokinase; Glucose; Heterozygote; Homozygote; Hypoglycemic Agents; Islets of Langerhans; Keto Acids; Membrane Potentials; Mice; Mice, Knockout; Mutation; Potassium Channels; Tolbutamide | 1998 |
Role of voltage-dependent Na+ channels for rhythmic Ca2+ signalling in glucose-stimulated mouse pancreatic beta-cells.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Signaling; Cells, Cultured; Electric Conductivity; Glucose; Islets of Langerhans; Keto Acids; Mice; Sodium Channel Agonists; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Tolbutamide; Veratridine | 1999 |
Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets.
Topics: Amyloid; Animals; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Extracellular Space; Female; Glucose; Glutamine; Humans; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Islets of Langerhans; Keto Acids; Leucine; Male; Mice; Mice, Transgenic; Time Factors; Tolbutamide | 1999 |
Mitochondria present in excised patches from pancreatic B-cells may form microcompartments with ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Aldehydes; Animals; Antimycin A; Ascorbic Acid; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Compartmentation; Cell Membrane; Enzyme Inhibitors; Fluorescent Dyes; Hemiterpenes; Islets of Langerhans; Keto Acids; Mice; Mitochondria; Oligomycins; Potassium Channels; Rhodamines; Rotenone; Sodium Azide; Succinic Acid; Tetramethylphenylenediamine; Tolbutamide | 1999 |
Glucose-sensitive conductances in rat pancreatic beta-cells: contribution to electrical activity.
Topics: Animals; Dose-Response Relationship, Drug; Electric Conductivity; Glucose; In Vitro Techniques; Islets of Langerhans; Keto Acids; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rats; Tolbutamide | 2000 |
Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide.
Topics: Adenosine Triphosphate; Alanine; Animals; Arginine; Cell Line; Culture Media; Dose-Response Relationship, Drug; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Potassium Channels; Potassium Chloride; Sulfonylurea Compounds; Tolbutamide | 2000 |
Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats.
Topics: Alleles; Animals; Crosses, Genetic; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Oxygen; Periodicity; Phenotype; Rats; Rats, Inbred F344; Tolbutamide | 2001 |
Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.
Topics: Alanine; Arginine; Calcium; Carbachol; Clone Cells; Colforsin; Culture Media; Dose-Response Relationship, Drug; Gastrointestinal Hormones; Glucose; Homocysteine; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Keto Acids; Metabolic Syndrome; Potassium Chloride; Tetradecanoylphorbol Acetate; Tolbutamide | 2006 |
Effect of creatine on the pancreatic beta-cell.
Topics: Adenosine Triphosphate; Animals; Creatine; Dose-Response Relationship, Drug; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Keto Acids; Tolbutamide | 2007 |
Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in absence of functional K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Glucose; Glyburide; Insulin; Insulin Secretion; Insulin-Secreting Cells; Keto Acids; Membrane Potentials; Mice; Patch-Clamp Techniques; Potassium Channels; Serotonin; Tolbutamide | 2008 |
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Calcium; Cell Death; Cytokines; Diazoxide; Gene Expression; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Potassium Channels; Probucol; Tolbutamide | 2010 |