tocotrienol--delta and xanthone

Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents.

Topics: Animals; Anthracenes; Anthraquinones; Benzophenones; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Humans; Indonesia; KB Cells; Leukemia P388; Mice; Mice, Inbred DBA; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Bark; Plant Leaves; Plant Stems; Plants, Medicinal; Tumor Cells, Cultured; Vitamin E; Xanthenes; Xanthones