Page last updated: 2024-08-23

tocainide and mexiletine

tocainide has been researched along with mexiletine in 87 studies

Research

Studies (87)

Timeframe	Studies, this research(%)	All Research%
pre-1990	65 (74.71)	18.7374
1990's	9 (10.34)	18.2507
2000's	11 (12.64)	29.6817
2010's	2 (2.30)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bódi, I; Frank, L; Hankovszky, OH; Hideg, K	1
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Coumel, P; Krikler, D; Rosen, MR; Wellens, HJ; Zipes, DP	1
Jung, W; Lüderitz, B; Manz, M	1
Kwieciński, H; Ostrzycki, A; Ryniewicz, B	1
Annesley, T; vasBinder, E	1
Desai, DM; Gal, J; Meyer-Lehnert, S	1
Roden, DM	2
Podrid, PJ	2
Lüderitz, B; Manz, M; Wagner, WL	1
Graboys, TB; Grossbard, CL; Lown, B; Patt, MV	1
Martinez, R; Swerdlow, CD	1
Grauer, K; Gums, J; Skluth, H	1
Barbey, JT; Echt, DS; Kopelman, HA; Murray, KT; Roden, DM; Siddoway, LA; Woosley, RL	1
Snyder, DW	1
Lampert, S; Lown, B; Podrid, PJ; Ravid, S	1
Burchiel, KJ; Chabal, C; Russell, LC	1
Somberg, J	1
Roden, DM; Siddoway, LA; Woosley, RL	1
Roy, D	1
Blum, R; Hession, M; Lampert, S; Lown, B; Podrid, PJ; Stein, J	1
Andersson, KE; Wettrell, G	1
Morganroth, J; Nestico, PF	2
Huang, SK; Marcus, FI	1
Bernard, R; de Hemptinne, J; Gillet, JM; Lewinson, H; Liebens, I; Renard, M; Shita, A; Waterschoot, P	1
Bauman, JL; Deal, BJ; Gallastegui, JL; Hariman, RJ; Martinez, JJ; Miller, SM; Scagliotti, D	1
Horowitz, LN; Morganroth, J	1
Di Biase, M; Favale, S; Rizzon, P; Visani, L	1
Eigenberg, MC	1
Easley, AR; Mann, DE; Reiter, MJ	1
Hattori, Y; Ishihara, T; Kodama, I; Kusunoki, T; Toyama, J; Yamada, K	1
Woosley, RL	1
Hammill, SC; Kreeger, RW	1
Linderer, EM; Tippe, A	1
Hirosawa, K; Kasanuki, H; Onishi, S	1
Collignon, P; Legrand, V	1
Gupta, RN; Lew, M	1
Fukuzaki, H; Itoh, S; Kobayashi, K	1
Sanna, GP	1
Lawrie, TD	1
Almotrefi, AA; Baker, JB	1
Schmitz, W	1
Hillis, WS; Whiting, B	1
Somberg, JC	1
Doherty, JU; Josephson, ME; Kienzle, MG; Williams, PD; Zygmont, D	1
Duff, HJ; Oates, JA; Roden, DM; Woosley, RL	1
Mohiuddin, SM; Ross, WB	1
Lüderitz, B	1
Courtney, KR	1
Rosen, MR; Wit, AL	1
Block, PJ; Winkle, RA	1
Pottage, A	1
Colley, DG; Duff, HJ; Maffucci, R; Marney, S; Oates, JA; Primm, RK; Roden, DM; Woosley, RL	1
Rossi, L	1
Harrison, DC; Mead, RH	1
Hellestrand, KJ	1
Heger, JJ; Prystowsky, EN; Zipes, DP	1
Luck, JC; Mann, DE; Pratt, CM; Wyndham, CR	1
Ronfeld, RA	1
Jewitt, DE	1
Benchimol, A; Desser, KB	1
Cho, YW; Kuemmerle, HP; Singh, BN	1
Nademanee, K; Singh, BN	1
Witkowska, M	1
Mouselimis, N; Wester, HA	1
Atallah, G; Kirkorian, G; Moleur, P; Touboul, P	1
Benes, L; Cernusková, L; Csöllei, J; Svec, P; Tumová, I	1
Jarvi, EJ; Loi, CM; Vestal, RE; Wei, X	1
Conte Camerino, D; De Luca, A; Franchini, C; Lentini, G; Natuzzi, F; Tortorella, V	1
Camerino, DC; De Luca, A; Duranti, A; Falcone, G; Franchini, C; Lentini, G; Natuzzi, F; Tortorella, V	1
Dai, R; Friedman, FK; Thummel, KE; Vestal, RE; Wei, X; Zhai, S	1
Mikó-Hideg, Z; Takács, M; Tóth, G; Vámos, J	1
Kurihara, T; Nemoto, H	1
Blackburn-Munro, G; Erichsen, HK; Hao, JX; Xu, XJ	1
Camerino, DC; Corbo, F; De Luca, A; Desaphy, JF; Didonna, MP; Ferrannini, E; Franchini, C; Jockusch, H; Lentini, G; Liantonio, A; Natuzzi, F; Pierno, S; Tortorella, V	1
Carr, DB; Challapalli, V; Lau, J; McNicol, ED; Tremont-Lukats, IW	1
Carrieri, A; Corbo, F; Muraglia, M; Pacifico, C	1
Carbonara, R; Carratù, MR; Conte Camerino, D; Corbo, F; De Bellis, M; De Luca, A; Desaphy, JF; Farinato, A; Franchini, C; Massari, A; Muraglia, M; Pierno, S; Roussel, J	1

Reviews

29 review(s) available for tocainide and mexiletine

Article	Year
The role of antiarrhythmic drugs in prevention of sudden cardiac death. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide	1985
Ventricular arrhythmias. An assessment of newer therapeutic agents. Postgraduate medicine, 1989, May-01, Volume: 85, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide; United States	1989
Class IB antiarrhythmic drugs: tocainide, mexiletine, and moricizine. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1989, Volume: 141, Issue:5 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Tocainide	1989
Antiarrhythmic drug therapy. Recent advances and current status. Cardiology, 1985, Volume: 72, Issue:5-6 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil	1985
Clinical pharmacology of old and new antiarrhythmic drugs. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide	1985
Antiarrhythmic drugs. Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 2 Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1986
Cardiovascular drugs. I: Antidysrhythmic drugs. Therapeutic drug monitoring, 1986, Volume: 8, Issue:1 Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Cardiovascular Agents; Disopyramide; Drug Interactions; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Tocainide; Verapamil	1986
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment. Cardiology clinics, 1986, Volume: 4, Issue:2 Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil	1986
Antiarrhythmic drug therapy of ventricular arrhythmias. Current problems in cardiology, 1986, Volume: 11, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil	1986
Antiarrhythmic agents for chronic ventricular arrhythmias. Comprehensive therapy, 1987, Volume: 13, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine; Tocainide	1987
Class 1B agents lidocaine, mexiletine, tocainide, phenytoin. European heart journal, 1987, Volume: 8 Suppl A Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Phenytoin; Tocainide	1987
New antiarrhythmic drugs: tocainide, mexiletine, flecainide, encainide, and amiodarone. Mayo Clinic proceedings, 1987, Volume: 62, Issue:11 Topics: Administration, Oral; Amiodarone; Anilides; Anti-Arrhythmia Agents; Drug Interactions; Encainide; Flecainide; Heart Conduction System; Humans; Lidocaine; Mexiletine; Tachycardia; Tocainide	1987
Tocainide and mexiletine. Orally effective lidocaine analogues. Archives of internal medicine, 1985, Volume: 145, Issue:3 Topics: Administration, Oral; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Mexiletine; Propylamines; Tocainide	1985
Antiarrhythmic drug therapy (Part 2). Benefits and hazards. Chest, 1985, Volume: 88, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide	1985
Comparison of newer antiarrhythmic agents. American heart journal, 1980, Volume: 100, Issue:6 Pt 2 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Disopyramide; Humans; Mexiletine; Tocainide; Verapamil	1980
[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)]. Klinische Wochenschrift, 1980, Sep-15, Volume: 58, Issue:18 Topics: Action Potentials; Adrenergic beta-Antagonists; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Quinidine; Sodium; Tocainide	1980
Antiarrhythmic drug therapy for sustained ventricular tachycardia. Heart & lung : the journal of critical care, 1984, Volume: 13, Issue:6 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bethanidine; Calcium Channel Blockers; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Encainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Phenytoin; Piperidines; Procainamide; Quinidine; Tachycardia; Tocainide	1984
Electropharmacology of antiarrhythmic drugs. American heart journal, 1983, Volume: 106, Issue:4 Pt 2 Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Electric Conductivity; Heart Atria; Heart Ventricles; Humans; Lidocaine; Membrane Potentials; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Procainamide; Propranolol; Purkinje Fibers; Quinidine; Tocainide; Verapamil	1983
Hemodynamic effects of antiarrhythmic drugs. The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6 Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide	1983
Clinical profiles of newer class I antiarrhythmic agents--tocainide, mexiletine, encainide, flecainide and lorcainide. The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6 Topics: Administration, Oral; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Lidocaine; Mexiletine; Piperidines; Tocainide	1983
Therapy with investigational antiarrhythmic drugs. The Medical clinics of North America, 1984, Volume: 68, Issue:5 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Tocainide	1984
Comparison of the efficacy of newly developed antiarrhythmic drugs in the treatment of ventricular tachyarrhythmias. European heart journal, 1984, Volume: 5 Suppl B Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Coronary Disease; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Piperidines; Tachycardia; Tocainide; Ventricular Fibrillation	1984
Investigational antiarrhythmic drugs for the treatment of ventricular rhythm disturbances. Cardiology clinics, 1984, Volume: 2, Issue:1 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Tocainide	1984
Comparative pharmacokinetics of new antiarrhythmic drugs. American heart journal, 1980, Volume: 100, Issue:6 Pt 2 Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Humans; Kinetics; Mexiletine; Piperidines; Tocainide; Verapamil	1980
Hemodynamic effects of newer antiarrhythmic drugs. American heart journal, 1980, Volume: 100, Issue:6 Pt 2 Topics: Acebutolol; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Atenolol; Benzeneacetamides; Disopyramide; Dogs; Hemodynamics; Humans; Mexiletine; Piperidines; Tocainide; Verapamil	1980
[Clinical pharmacology of anti-arrhythymia agents. II. Lignocaine, mexiletine, tocainide, phenytoin]. Kardiologia polska, 1981, Volume: 24, Issue:11-12 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Mexiletine; Tocainide	1981
[New antiarrythmic drugs: mexiletine, tocainide, lorcainide, encainide, flecainide, propafenone, cipralan, sotalol]. Annales de cardiologie et d'angeiologie, 1982, Volume: 31, Issue:7 Topics: Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Sotalol; Tocainide	1982
[Na channel myotonia]. Ryoikibetsu shokogun shirizu, 2001, Issue:35 Topics: Chromosomes, Human, Pair 7; Diagnosis, Differential; Exons; Genes, Dominant; Humans; Mexiletine; Mutation; Myotonia; Prognosis; Sodium Channel Blockers; Sodium Channels; Tocainide	2001
Systemic administration of local anesthetic agents to relieve neuropathic pain. The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4 Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; Mexiletine; Nervous System Diseases; Pain; Randomized Controlled Trials as Topic; Tocainide	2005

Trials

7 trial(s) available for tocainide and mexiletine

Article	Year
Treatment of myotonia with antiarrhythmic drugs. Acta neurologica Scandinavica, 1992, Volume: 86, Issue:4 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Disopyramide; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Mexiletine; Middle Aged; Myotonia; Myotonia Congenita; Myotonic Dystrophy; Neurologic Examination; Phenytoin; Prospective Studies; Single-Blind Method; Tocainide	1992
The role of antiarrhythmic drugs in prevention of sudden cardiac death. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide	1985
[Combination of sotalol with the class I B substances mexiletine or tocainide in complex ventricular extrasystole]. Zeitschrift fur Kardiologie, 1987, Volume: 76, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Sotalol; Tocainide	1987
Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Drug Evaluation; Drug Resistance; Drug Therapy, Combination; Electric Stimulation; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Prospective Studies; Quinidine; Random Allocation; Tocainide	1989
Electrophysiologic testing of tocainide and mexiletine for ventricular tachycardia: assessment of the need to test both drugs. American heart journal, 1986, Volume: 112, Issue:5 Topics: Drug Evaluation; Heart Ventricles; Humans; Lidocaine; Mexiletine; Prospective Studies; Tachycardia; Tocainide	1986
Selection of an antiarrhythmic drug for a sudden-death-prevention trial. American heart journal, 1982, Volume: 103, Issue:4 Pt 2 Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Encainide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Moricizine; Morpholines; Phenothiazines; Piperidines; Tocainide; Verapamil	1982
[The effect of anti-arrhythmic drugs on myocardial function (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1982, Aug-27, Volume: 107, Issue:34 Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Depression, Chemical; Disopyramide; Echocardiography; Humans; Lidocaine; Mexiletine; Middle Aged; Myocardial Contraction; Placebos; Propafenone; Propiophenones; Tocainide	1982

Other Studies

52 other study(ies) available for tocainide and mexiletine

Article	Year
New antiarrhythmic agents. 2,2,5,5-Tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamindes. Journal of medicinal chemistry, 1986, Volume: 29, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Evaluation, Preclinical; Indicators and Reagents; Magnetic Resonance Spectroscopy; Nicotine; Ouabain; Rats; Spectrophotometry, Infrared; Structure-Activity Relationship	1986
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Newer antiarrhythmic drugs. Pacing and clinical electrophysiology : PACE, 1978, Volume: 1, Issue:4 Topics: Administration, Oral; Adult; Amiodarone; Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Child; Edrophonium; Electrophysiology; Heart Conduction System; Heart Ventricles; Humans; Injections, Intravenous; Lidocaine; Mexiletine; Recurrence; Tachycardia; Tocainide; Verapamil; Wolff-Parkinson-White Syndrome	1978
[Combination anti-arrhythmic drug therapy]. Zeitschrift fur Kardiologie, 1992, Volume: 81 Suppl 4 Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography, Ambulatory; Encainide; Flecainide; Humans; Mexiletine; Sotalol; Tachycardia; Tocainide	1992
Liquid chromatographic analysis of mexiletine in serum, with alternate application to tocainide, procainamide, and N-acetylprocainamide. Biomedical chromatography : BMC, 1991, Volume: 5, Issue:1 Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Lidocaine; Mexiletine; Procainamide; Tocainide	1991
Reversed-phase LC resolutions of chiral antiarrhythmic agents via derivatization with homochiral isothiocyanates. Chirality, 1990, Volume: 2, Issue:1 Topics: Anti-Arrhythmia Agents; Chromatography, Liquid; Flecainide; Humans; Indicators and Reagents; Lidocaine; Male; Mexiletine; Propafenone; Thiocyanates; Tocainide	1990
Antiarrhythmic drugs. Clinical pharmacology of the old and the new agents. Postgraduate medicine, 1985, Sep-15, Volume: 78, Issue:4 Topics: Acecainide; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Delayed-Action Preparations; Disopyramide; Heart Arrest; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Resuscitation; Tocainide	1985
Combination antiarrhythmic therapy for management of malignant ventricular arrhythmia. The American journal of cardiology, 1988, Nov-03, Volume: 62, Issue:14 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Quinidine; Tachycardia; Tocainide	1988
Lidocaine & tocainide & mexiletine. Annals of emergency medicine, 1989, Volume: 18, Issue:3 Topics: Drug Interactions; Humans; Lidocaine; Mexiletine; Tocainide	1989
Congestive heart failure induced by six of the newer antiarrhythmic drugs. Journal of the American College of Cardiology, 1989, Nov-01, Volume: 14, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Encainide; Female; Heart Failure; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Piperidines; Propafenone; Risk Factors; Stroke Volume; Tocainide	1989
The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Pain, 1989, Volume: 38, Issue:3 Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Injections, Intravenous; Lidocaine; Male; Mexiletine; Neural Conduction; Neuroma; Rats; Rats, Inbred Strains; Sciatic Nerve; Stress, Mechanical; Tocainide	1989
Mexiletine and tocainide: does response to one predict response to the other? Journal of the American College of Cardiology, 1986, Volume: 7, Issue:2 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electric Stimulation; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Propylamines; Stroke Volume; Tachycardia; Tocainide; Ventricular Fibrillation	1986
[Hemodynamic repercussions and clinical tolerance of 6 class I anti-arrhythmia agents in acute myocardial infarction]. Annales de cardiologie et d'angeiologie, 1986, Volume: 35, Issue:4 Topics: Ajmaline; Anti-Arrhythmia Agents; Benzeneacetamides; Fluorenes; Hemodynamics; Lidocaine; Mexiletine; Myocardial Infarction; Piperidines; Tocainide	1986
Second generation antiarrhythmic agents: have we reached antiarrhythmic Nirvana? Journal of the American College of Cardiology, 1987, Volume: 9, Issue:2 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide	1987
Mexitil and cross-allergenicity. The Nurse practitioner, 1987, Volume: 12, Issue:5 Topics: Cross Reactions; Humans; Lidocaine; Mexiletine; Tocainide	1987
Efficacy of class Ib (lidocaine-like) antiarrhythmic agents for prevention of sustained ventricular tachycardia secondary to coronary artery disease. The American journal of cardiology, 1987, Jun-01, Volume: 59, Issue:15 Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Electrophysiology; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Tachycardia; Tocainide; Ventricular Fibrillation	1987
Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle. Japanese heart journal, 1987, Volume: 28, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Guinea Pigs; Kinetics; Lidocaine; Mexiletine; Papillary Muscles; Structure-Activity Relationship; Tocainide	1987
Mexiletine and tocainide: a profile of two lidocaine analogs. Rational drug therapy, 1987, Volume: 21, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Heart; Humans; In Vitro Techniques; Lidocaine; Mexiletine; Tocainide	1987
Action of tocainide and mexiletine on the excitation threshold of myelinated nerves. European journal of pharmacology, 1987, Sep-11, Volume: 141, Issue:2 Topics: Action Potentials; Animals; Electrophysiology; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Myelin Sheath; Nerve Fibers; Rana esculenta; Sodium; Tocainide	1987
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias. Japanese circulation journal, 1985, Volume: 49, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil	1985
Haemodynamic effects of class I antiarrhythmic agents. Drugs, 1985, Volume: 29 Suppl 4 Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1985
Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent. Journal of chromatography, 1985, Nov-08, Volume: 344 Topics: Chromatography, Liquid; Drug Stability; Humans; Lidocaine; Mexiletine; o-Phthalaldehyde; Propylamines; Spectrometry, Fluorescence; Tocainide	1985
[Anti-arrhythmia agents (II): Mexiletine, aprindine, tocainide and amiodarone]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:11 Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Humans; Lidocaine; Mexiletine; Tocainide	1985
New drugs in the management of ventricular arrhythmias. Giornale italiano di cardiologia, 1984, Volume: 14, Issue:10 Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Drug Interactions; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide	1984
The antifibrillatory potency of aprindine, mexiletine, tocainide and lignocaine compared on Langendorff-perfused hearts of rabbits and guinea-pigs. The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:11 Topics: Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; In Vitro Techniques; Indenes; Lidocaine; Male; Mexiletine; Ouabain; Perfusion; Propylamines; Rabbits; Tocainide; Ventricular Fibrillation	1980
Antiarrhythmic drugs. British medical journal (Clinical research ed.), 1983, Apr-23, Volume: 286, Issue:6374 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil	1983
New directions in antiarrhythmic drug therapy. The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil	1984
Antiarrhythmic therapy: new additions and future expectations. Geriatrics, 1983, Volume: 38, Issue:1 Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Bretylium Tosylate; Disopyramide; Encainide; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil	1983
[Drug therapy of arrhythmia in coronary cardiopathy]. La Clinica terapeutica, 1983, Apr-15, Volume: 105, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Electrocardiography; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Tachycardia; Tocainide	1983
Depressant effects of drugs used in myotonia therapy. Proceedings of the Western Pharmacology Society, 1982, Volume: 25 Topics: Animals; In Vitro Techniques; Ion Channels; Lidocaine; Mexiletine; Muscle Contraction; Myotonia; Phenytoin; Procainamide; Quinidine; Rana catesbeiana; Tocainide	1982
Molecular basis for the antigenicity of lidocaine analogs: tocainide and mexiletine. American heart journal, 1984, Volume: 107, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Antigens; Cross Reactions; Drug Hypersensitivity; Female; Humans; Intradermal Tests; Lidocaine; Mexiletine; Propylamines; Structure-Activity Relationship; Tocainide	1984
Nursing care for survivors of sudden cardiac death. The Nursing clinics of North America, 1984, Volume: 19, Issue:3 Topics: Adaptation, Psychological; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Heart Arrest; Heart Conduction System; Humans; Lidocaine; Mexiletine; Moricizine; Nursing Assessment; Phenothiazines; Tocainide	1984
Drug therapy of cardiac arrhythmias. Cardiology clinics, 1983, Volume: 1, Issue:2 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Biological Availability; Encainide; Half-Life; Humans; Imidazoles; Intestinal Absorption; Kinetics; Lidocaine; Metabolic Clearance Rate; Mexiletine; Propafenone; Propiophenones; Protein Binding; Tachycardia; Tocainide	1983
New drugs for treating cardiac arrhythmias. Postgraduate medicine, 1981, Volume: 69, Issue:1 Topics: Acebutolol; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Encainide; Heart Ventricles; Humans; Mexiletine; Moricizine; Morpholines; Phenothiazines; Tocainide; Verapamil	1981
Clinical pharmacology of antiarrhythmic drugs: a review and overview, part II. International journal of clinical pharmacology, therapy, and toxicology, 1981, Volume: 19, Issue:5 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Propranolol; Tocainide	1981
Advances in antiarrhythmic therapy. The role of newer antiarrhythmic drugs. JAMA, 1982, Jan-08, Volume: 247, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Atrioventricular Node; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil	1982
Tocainide--an alternative to mexiletine. Drug and therapeutics bulletin, 1982, Jul-09, Volume: 20, Issue:14 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Tocainide	1982
Carbamate analogues of tocainide. Die Pharmazie, 1994, Volume: 49, Issue:9 Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Carbamates; Cardiac Complexes, Premature; Epinephrine; Guinea Pigs; Mexiletine; Ouabain; Rats; Tocainide	1994
Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Immunoblotting; In Vitro Techniques; Kinetics; Lidocaine; Male; Mexiletine; Microsomes, Liver; Oxidoreductases; Rats; Rats, Sprague-Dawley; Tocainide	1995
Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers. Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Mexiletine; Muscle, Skeletal; Patch-Clamp Techniques; Rana esculenta; Sodium Channels; Stereoisomerism; Tocainide	1995
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Mexiletine; Muscle, Skeletal; Patch-Clamp Techniques; Rana esculenta; Sodium Channel Blockers; Stereoisomerism; Tocainide	1997
Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2 Topics: Anti-Arrhythmia Agents; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Immunoblotting; In Vitro Techniques; Kinetics; Lidocaine; Mexiletine; Models, Molecular; Oxidoreductases; Tocainide	1999
Photochemical and chemical oxidation of mexiletine and tocainide. Structure elucidation of the major products. Archiv der Pharmazie, 2000, Volume: 333, Issue:2-3 Topics: Anti-Arrhythmia Agents; Magnetic Resonance Spectroscopy; Mexiletine; Oxidation-Reduction; Photochemistry; Tocainide	2000
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain. European journal of pharmacology, 2003, Jan-05, Volume: 458, Issue:3 Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Lamotrigine; Lidocaine; Male; Mexiletine; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Time Factors; Tocainide; Triazines	2003
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse. Neuromuscular disorders : NMD, 2004, Volume: 14, Issue:7 Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Conductivity; Electromyography; Female; In Vitro Techniques; Inhibitory Concentration 50; Male; Mexiletine; Mice; Mice, Mutant Strains; Muscle Contraction; Myotonic Disorders; Patch-Clamp Techniques; Sodium Channels; Structure-Activity Relationship; Time Factors; Tocainide	2004
2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Crystallography, X-Ray; Mexiletine; Protein Isoforms; Quantitative Structure-Activity Relationship; Sodium Channel Blockers; Sodium Channels; Substrate Specificity; Tocainide	2009
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity. Neuropharmacology, 2017, Volume: 113, Issue:Pt A Topics: Animals; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Humans; Male; Mexiletine; Muscle, Skeletal; Myotonia; NAV1.4 Voltage-Gated Sodium Channel; Rats; Rats, Wistar; Reflex, Righting; Rotarod Performance Test; Tocainide; Voltage-Gated Sodium Channel Blockers	2017